Tunneling nanotubes: A new route for the exchange of components between animal cells

Gerdes, Hans-Hermann; Bukoreshtliev, Nickolay V.; Barroso, João F.V.

doi:10.1016/j.febslet.2007.03.071

Cited by 304Extracellular vesicles in diseaseCellular transport and secretionCaveolin-1 and cellular processes

Tunneling nanotubes: A new route for the exchange of components between animal cells

Gerdes, Hans-Hermann, Bukoreshtliev, Nickolay V., Barroso, João F.V.·2007·FEBS Letters

DOI 10.1016/j.febslet.2007.03.071

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Abstract

Recently, highly sensitive nanotubular structures mediating membrane continuity between mammalian cells have been discovered. With respect to their peculiar architecture, these membrane channels were termed tunneling nanotubes (TNTs). TNTs could form de novo between animal cells leading to the generation of complex cellular networks. They have been shown to facilitate the intercellular transfer of organelles as well as, on a limited scale, of membrane components and cytoplasmic molecules. It has been proposed that TNTs represent a novel and general biological principle of cell‐to‐cell communication and it becomes increasingly apparent that they fulfill important functions in the physiological processes of multicellular organisms.

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HIV-1 and HTLV-1 cell-to-cell transmission via TNT has been reported.
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Background
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Authors: Gerdes, H.-H., Bukoreshtliev, N. V., & Barroso, J. F. V.
Affiliations: University of Bergen (NO)
Corresponding author: Gerdes, Hans-Hermann
Venue: FEBS Letters
Publisher: Wiley
Published: 2007-04-04
Volume: 581
Issue: 11
Pages: 2194-2201
ISSN: 0014-5793 (ISSN-L)
1873-3468
DOI: 10.1016/j.febslet.2007.03.071
OpenAlex: W2044320361
Cited by: 304
References: 61
Citations by year: 2026: 9 · 2025: 6 · 2024: 18 · 2023: 11 · 2022: 18 · 2021: 20 · 2020: 18 · 2019: 18 · 2018: 21 · 2017: 16 · 2016: 14 · 2015: 13 · 2014: 11 · 2013: 14 · 2012: 22
FWCI: 1.34
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: FEBS Letters (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Keywords: tunneling nanotubes, intercellular communication, membrane continuity, organelle transfer, multicellular organisms
MeSH terms: Animals, Biological Transport, Cell Communication, Cell Membrane, Humans, Plasmodesmata, Nanotubes

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Tunneling nanotubes: A new route for the exchange of components between animal cells

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