Linking the Microbiota, Chronic Disease, and the Immune System
Open accessAbstract
Chronic inflammatory diseases (CIDs) are the most important causes of mortality in the world today and are on the rise. We now know that immune-driven inflammation is critical in the etiology of these diseases, though the environmental triggers and cellular mechanisms that lead to their development are still mysterious. Many CIDs are associated with significant shifts in the microbiota toward inflammatory configurations, which can affect the host both by inducing local and systemic inflammation and by alterations in microbiota-derived metabolites. This review discusses recent findings suggesting that shifts in the microbiota may contribute to chronic disease via effects on the immune system.
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These chronic diseases feature significant microbiome alterations thought to play a role in inducing local and systemic inflammation.
“These diseases feature significant microbiome alterations, which are thought to play a role in inducing the consistent hallmarks of local and systemic inflammation (Hand et al., 2016).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Hand et al., 2016
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- Authors
- Hand, T. W., Vujkovic-Cvijin, I., Ridaura, V. K., & Belkaid, Y.
- Affiliations
- University of Pittsburgh (US)
- National Institutes of Health (US)
- Corresponding author
- Hand, Timothy W.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 27
- Issue
- 12
- Pages
- 831-843
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC5116263
- OpenAlex
- W2520134471
- Cited by
- 247
- References
- 135
- Citations by year
- 2026: 6 · 2025: 20 · 2024: 15 · 2023: 32 · 2022: 33 · 2021: 42 · 2020: 38 · 2019: 27 · 2018: 20 · 2017: 13
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (K22AI108719)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- gut microbiota, chronic inflammatory diseases, immune system, inflammation, gut microbiota metabolites, host-microbe interactions, chronic disease etiology
- MeSH terms
- Animals, Chronic Disease, Humans, Immune System, Metabolic Syndrome, Inflammasomes, Microbiota, Dysbiosis
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