Cited by 247Gut microbiota and healthOral microbiology and periodontitis researchAdipokines, Inflammation, and Metabolic Diseases

Linking the Microbiota, Chronic Disease, and the Immune System

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Hand, Timothy W., Vujkovic-Cvijin, Ivan, Ridaura, Vanessa K., Belkaid, Yasmine·2016·Trends in Endocrinology & Metabolism

Abstract

Chronic inflammatory diseases (CIDs) are the most important causes of mortality in the world today and are on the rise. We now know that immune-driven inflammation is critical in the etiology of these diseases, though the environmental triggers and cellular mechanisms that lead to their development are still mysterious. Many CIDs are associated with significant shifts in the microbiota toward inflammatory configurations, which can affect the host both by inducing local and systemic inflammation and by alterations in microbiota-derived metabolites. This review discusses recent findings suggesting that shifts in the microbiota may contribute to chronic disease via effects on the immune system.

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Crossref · 10.1016/j.tem.2016.08.003

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  • These chronic diseases feature significant microbiome alterations thought to play a role in inducing local and systemic inflammation.

    “These diseases feature significant microbiome alterations, which are thought to play a role in inducing the consistent hallmarks of local and systemic inflammation (Hand et al., 2016).”

    From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Hand et al., 2016

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Authors
Hand, T. W., Vujkovic-Cvijin, I., Ridaura, V. K., & Belkaid, Y.
Affiliations
  • University of Pittsburgh (US)
  • National Institutes of Health (US)
Corresponding author
Hand, Timothy W.
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2016-12
Volume
27
Issue
12
Pages
831-843
ISSN
1043-2760 (ISSN-L)
OpenAlex
W2520134471
Cited by
247
References
135
Citations by year
2026: 6 · 2025: 20 · 2024: 15 · 2023: 32 · 2022: 33 · 2021: 42 · 2020: 38 · 2019: 27 · 2018: 20 · 2017: 13
FWCI
1.81
Type
journal article
Language
en
Open access
Locations
  • Trends in Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Allergy and Infectious Diseases (K22AI108719)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
gut microbiota, chronic inflammatory diseases, immune system, inflammation, gut microbiota metabolites, host-microbe interactions, chronic disease etiology
MeSH terms
Animals, Chronic Disease, Humans, Immune System, Metabolic Syndrome, Inflammasomes, Microbiota, Dysbiosis

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