Hypoxia-inducible Factor 1α (HIF-1α)-mediated Hypoxia Increases BACE1 Expression and β-Amyloid Generation

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876 · see citing works

Purification and cloning of amyloid precursor protein β-secretase from human brain

Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., Doan, M., Dovey, H. F., Frigon, N., Hong, J., et al. (1999) · Nature · doi:10.1038/990114 · Cited by 1,612 · see citing works

HIF‐1α is required for solid tumor formation and embryonic vascularization

Ryan, H. E., Lo, J., & Johnson, R. S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3005 · Cited by 1,579 · see citing works

Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity

Yan, R., Bienkowski, M. J., Shuck, M. E., Miao, H., Tory, M. C., Pauley, A. M., Brashler, J. R., Stratman, N. C., Mathews, W. R., Buhl, A. E., et al. (1999) · Nature · doi:10.1038/990107 · Cited by 1,438 · see citing works

Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease

Lammich, S., Kojro, E., Postina, R., Gilbert, S., Pfeiffer, R., Jasionowski, M., Haass, C., & Fahrenholz, F. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3922 · Cited by 1,132 · see citing works

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

Hussain, I., Powell, D., Howlett, D. R., Tew, D. G., Meek, T. D., Chapman, C., Gloger, I. S., Murphy, K. E., Southan, C. D., Ryan, D. M., et al. (1999) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0811 · Cited by 1,080 · see citing works

Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor

Buxbaum, J. D., Liu, K.-N., Luo, Y., Slack, J. L., Stocking, K. L., Peschon, J. J., Johnson, R. S., Castner, B. J., Cerretti, D. P., & Black, R. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.27765 · Cited by 933 · see citing works

BACE1 is the major β-secretase for generation of Aβ peptides by neurons

Cai, H., Wang, Y.-S., McCarthy, D., Wen, H., Borchelt, D., Price, D. L., & Wong, P. (2001) · Nature Neuroscience · doi:10.1038/85064 · Cited by 791 · see citing works

Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

Yang, L.-B., Lindholm, K., Yan, R., Citron, M., Xia, W., Yang, X.-L., Beach, T., Sue, L., Wong, P., Price, D., et al. (2003) · Nature Medicine · doi:10.1038/nm0103-3 · Cited by 729 · see citing works

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating <i>BACE1</i> gene expression

Sun, X., He, G., Qing, H., Zhou, W., Dobie, F., Cai, F., Staufenbiel, M., Huang, L. E., & Song, W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606298103 · Cited by 605 · see citing works

BACE1 Deficiency Rescues Memory Deficits and Cholinergic Dysfunction in a Mouse Model of Alzheimer's Disease

Ohno, M., Sametsky, E. A., Younkin, L. H., Oakley, H., Younkin, S. G., Citron, M., Vassar, R., & Disterhoft, J. F. (2004) · Neuron · doi:10.1016/s0896-6273(03)00810-9 · Cited by 549 · see citing works

The role of cerebral ischemia in Alzheimer’s disease

Kalaria, R. N. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00125-1 · Cited by 522 · see citing works

Amyloid β peptide load is correlated with increased β-secretase activity in sporadic Alzheimer's disease patients

Li, R., Lindholm, K., Yang, L., Yue, X., Citron, M., Yan, R., Beach, T. G., Sue, L. I., Sabbagh, M. N., Cai, H., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0205689101 · Cited by 493 · see citing works

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

Buxbaum, J. D., Gandy, S., Cicchetti, P., Ehrlich, M. E., Czernik, A. J., Fracasso, R. P., Ramabhadran, T. V., Unterbeck, A., & Greengard, P. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.15.6003 · Cited by 450 · see citing works

Dementia after ischemic stroke: A population-based study in Rochester, Minnesota (1960-1984)

Kokmen, E., Whisnant, J. P., O'Fallon, W. M., Chu, C.-P., & Beard, C. M. (1996) · Neurology · doi:10.1212/wnl.46.1.154 · Cited by 434 · see citing works

BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein

Farzan, M., Schnitzler, C. E., Vasilieva, N. Y., Leung, D. G., & Choe, H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.160115697 · Cited by 409 · see citing works

The amyloid precursor protein: beyond amyloid.

Zheng, H., & Koo, E. H. (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-5 · Cited by 403 · see citing works

Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ

Sastre, M., Dewachter, I., Rossner, S., Bogdanovic, N., Rosen, E., Borghgraef, P., Evert, B. O., Dumitrescu-Ozimek, L., Thal, D. R., Landreth, G., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503839103 · Cited by 373 · see citing works

Risk of dementia after stroke in a hospitalized cohort

Tatemichi, T. K., Paik, M. C., Bagiella, E., Desmond, D. W., Stern, Y., Sano, M. C., Hauser, W. A., & Mayeux, R. P. (1994) · Neurology · doi:10.1212/wnl.44.10.1885 · Cited by 309 · see citing works

Generation of Alzheimer β-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

Xu, H., Sweeney, D. A., Wang, R., Thinakaran, G., Lo, A., Sisodia, S. S., Greengard, P., & Gandy, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3748 · Cited by 281 · see citing works

HIF-1, An Oxygen and Metal Responsive Transcription Factor

Maxwell, P. H., & Salnikow, K. (2004) · Cancer Biology & Therapy · doi:10.4161/cbt.3.1.547 · Cited by 258 · see citing works

Brain-Specific Knock-Out of Hypoxia-Inducible Factor-1α Reduces Rather Than Increases Hypoxic-Ischemic Damage

Helton, R., Cui, J., Scheel, J. R., Ellison, J. A., Ames, C. P., Gibson, C. L., Blouw, B., Ouyang, L., Dragatsis, I., Zeitlin, S. O., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4555-04.2005 · Cited by 240 · see citing works

Transcriptional Regulation of BACE1, the β-Amyloid Precursor Protein β-Secretase, by Sp1

Christensen, M. A., Zhou, W., Qing, H., Lehman, A., Philipsen, S., & Song, W. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.865-874.2004 · Cited by 221 · see citing works

Increased β-secretase activity and expression in rats following transient cerebral ischemia

Wen, Y., Onyewuchi, O., Yang, S., Liu, R., & Simpkins, J. W. (2004) · Brain Research · doi:10.1016/j.brainres.2003.09.086 · Cited by 188 · see citing works

BACE2 Functions as an Alternative α-Secretase in Cells

Yan, R., Munzner, J. B., Shuck, M. E., & Bienkowski, M. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105583200 · Cited by 183 · see citing works

The Transmembrane Domain of the Alzheimer's β-Secretase (BACE1) Determines Its Late Golgi Localization and Access to β-Amyloid Precursor Protein (APP) Substrate

Yan, R., Han, P., Miao, H., Greengard, P., & Xu, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104350200 · Cited by 179 · see citing works

Stable Association of Presenilin Derivatives and Absence of Presenilin Interactions with APP

Thinakaran, G., Regard, J. B., Bouton, C. M. L. S., Harris, C. L., Price, D. L., Borchelt, D., & Sisodia, S. S. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0171 · Cited by 173 · see citing works

BACE1 (β-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time

Luo, Y. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00104-9 · Cited by 169 · see citing works

Pathological and physiological functions of presenilins

Vetrivel, K. S., Zhang, Y., Xu, H., & Thinakaran, G. (2006) · Molecular Neurodegeneration · doi:10.1186/1750-1326-1-4 · Cited by 158 · see citing works

Hypoperfusion induces overexpression of β-amyloid precursor protein mRNA in a focal ischemic rodent model

Shi, J., Yang, S., Stubley, L., Day, A. L., & Simpkins, J. W. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02113-7 · Cited by 154 · see citing works

Interactions between Alzheimer's disease and cerebral ischemia—focus on inflammation

Koistinaho, M., & Koıstınaho, J. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.014 · Cited by 148 · see citing works

BACE overexpression alters the subcellular processing of APP and inhibits Aβ deposition in vivo

Lee, E. B., Zhang, B., Liu, K., Greenbaum, E. A., Doms, R. W., Trojanowski, J. Q., & Lee, V. M.-Y. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200407070 · Cited by 140 · see citing works

Expression and Distribution of Beta Amyloid Precursor Protein and Beta Amyloid Peptide in Reactive Astrocytes After Transient Middle Cerebral Artery Occlusion

Nihashi, T., Inao, S., Kawai, T., Sugimoto, T., Niwa, M., Hata, N., Hayashi, S., Yoshida, J., Kajita, Y., & Kabeya, R. (2001) · Acta Neurochirurgica · doi:10.1007/s007010170109 · Cited by 114 · see citing works

Transcriptional regulation of APH‐1A and increased γ‐secretase cleavage of APP and Notch by HIF‐1 and hypoxia

Wang, R., Zhang, Y., Zhang, X., Liu, R., Zhang, X., Hong, S., Xia, K., Xia, J., Zhang, Z., & Xu, H. (2006) · The FASEB Journal · doi:10.1096/fj.06-5839fje · Cited by 110 · see citing works

A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses

Chun, Y., Choi, E., Yeo, E.-J., Lee, J.-H., Kim, M.-S., & Park, J. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.22.4051 · Cited by 93 · see citing works

The transcription factor Yin Yang 1 is an activator of BACE1 expression

Nowak, K., Lange‐Dohna, C., Zeitschel, U., Günther, A., Lüscher, B., Robitzki, A. A., Perez‐Polo, R. J., & Roßner, S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03692.x · Cited by 90 · see citing works

Expression and activity of β-site amyloid precursor protein cleaving enzyme in Alzheimer's disease

Johnston, J. A., Liu, W. W., Todd, S., Coulson, D. T. R., Murphy, S., Irvine, G. B., & Passmore, A. P. (2005) · Biochemical Society Transactions · doi:10.1042/bst20051096 · Cited by 76 · see citing works

Accelerated accumulation of N‐ and C‐terminal βAPP fragments and delayed recovery of microtubule‐associated protein 1B expression following stroke in aged rats

Badan, I., Dinca, I., Buchhold, B., Suofu, Y., Walker, L. C., Gratz, M., Platt, D., Kessler, C., & Popa‐Wagner, A. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03323.x · Cited by 70 · see citing works

Increased BACE1 maturation contributes to the pathogenesis of Alzheimer's disease in Down syndrome

Sun, X., Tong, Y., Qing, H., Chen, C.-H., & Song, W. (2006) · The FASEB Journal · doi:10.1096/fj.05-5628com · Cited by 63 · see citing works

Altered processing of amyloid precursor protein in the human neuroblastoma SH-SY5Y by chronic hypoxia

Webster, N. J., Green, K. N., Peers, C., & Vaughan, P. F. T. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01236.x · Cited by 56 · see citing works

Knockdown of hypoxia‐inducible factor‐1α by siRNA inhibits C2C12 myoblast differentiation

Ono, Y., Sensui, H., Sakamoto, Y., & Nagatomi, R. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20804 · Cited by 50 · see citing works

Cellular and molecular basis of b-amyloid precursor protein metabolism (Y2K update)

Jeffrey, P. G. (2000) · Frontiers in bioscience · doi:10.2741/greenfield · Cited by 38 · see citing works

Altered processing of the amyloid precursor protein and decreased expression of ADAM 10 by chronic hypoxia in SH-SY5Y: no role for the stress-activated JNK and p38 signalling pathways

Webster, N. J., Green, K. N., Settle, V. J., Peers, C., & Vaughan, P. F. T. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.06.042 · Cited by 38 · see citing works

Chronic hypoxia in the human neuroblastoma SH-SY5Y causes reduced expression of the putative α-secretases, ADAM10 and TACE, without altering their mRNA levels

Marshall, A. J., Rattray, M., & Vaughan, P. F. T. (2006) · Brain Research · doi:10.1016/j.brainres.2006.05.008 · Cited by 37 · see citing works

Transcriptional Regulation of PEN-2, a Key Component of the γ-Secretase Complex, by CREB

Wang, R., Zhang, Y., Sun, P., Liu, R., Zhang, X., Zhang, X., Xia, K., Xia, J., Xu, H., & Zhang, Z. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.4.1347-1354.2006 · Cited by 36 · see citing works

Effect of Ischemic Neuronal Insults on Amyloid Precursor Protein Processing

Lee, P. H., Hwang, E. M., Hong, H., Boo, J. H., Mook‐Jung, I., & Huh, K. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9086-y · Cited by 27 · see citing works

Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders

Zlokovic, B. V. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3114 · Cited by 2,969 · see citing works

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

Bezprozvanny, I., & Mattson, M. P. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.005 · Cited by 938 · see citing works

A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

Wang, J., Gu, B. J., Masters, C. L., & Wang, Y.-J. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.111 · Cited by 808 · see citing works

Sleep, Cognitive impairment, and Alzheimer's disease: a systematic review and meta-analysis

Bubu, O. M., Brannick, M., Mortimer, J., Umasabor-Bubu, O., Sebastião, Y. V., Wen, Y., Schwartz, S., Borenstein, A. R., Wu, Y., Morgan, D., et al. (2017) · Sleep · doi:10.1093/sleep/zsw032 · Cited by 673 · see citing works

Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes

Nortley, R., Korte, N., Izquierdo, P., Hirunpattarasilp, C., Mishra, A., Jaunmuktane, Z., Kyrargyri, V., Pfeiffer, T., Khennouf, L., Madry, C., et al. (2019) · Science · doi:10.1126/science.aav9518 · Cited by 682 · see citing works

A review of the molecular aspects of melatonin’s anti‐inflammatory actions: recent insights and new perspectives

Mauriz, J. L., Collado, P. S., Veneroso, C. E., Reiter, R. J., & González‐Gallego, J. (2012) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2012.01014.x · Cited by 627 · see citing works

The Alzheimer's disease Beta-secretase enzyme, BACE1

Cole, S. L., & Vassar, R. (2007) · Molecular Neurodegeneration · doi:10.1186/1750-1326-2-22 · Cited by 550 · see citing works

The β-Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

Vassar, R., Kovacs, D. M., Yan, R., & Wong, P. C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3657-09.2009 · Cited by 577 · see citing works

Molecular Pathogenesis of Alzheimer's Disease: An Update

Sanabria‐Castro, A., Echeverría, I. A., & Bonilla, C. M. (2017) · Annals of Neurosciences · doi:10.1159/000464422 · Cited by 419 · see citing works

BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

Vassar, R. (2014) · Alzheimer's Research & Therapy · doi:10.1186/s13195-014-0089-7 · Cited by 393 · see citing works

Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process

De Strooper, B. (2010) · Physiological Reviews · doi:10.1152/physrev.00023.2009 · Cited by 455 · see citing works

Obstructive sleep apnea, cognition and Alzheimer's disease: A systematic review integrating three decades of multidisciplinary research

Bubu, O. M., Andrade, A. G., Umasabor-Bubu, O. Q., Hogan, M. M., Turner, A. D., de Leon, M. J., Ogedegbe, G., Ayappa, I., Jean-Louis G, G., Jackson, M. L., et al. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2019.101250 · Cited by 389 · see citing works

Pin1, a new player in the fate of HIF-1α degradation: an hypothetical mechanism inside vascular damage as Alzheimer’s disease risk factor

Lonati, E., Brambilla, A., Milani, C., Masserini, M., Palestini, P., & Bulbarelli, A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00001 · Cited by 347 · see citing works

Cerebrovascular disease in ageing and Alzheimer’s disease

Love, S., & Miners, J. S. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1522-0 · Cited by 299 · see citing works

Impact of sleep on the risk of cognitive decline and dementia

Spira, A. P., Chen-Edinboro, L. P., Wu, M. N., & Yaffe, K. S. (2014) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000106 · Cited by 310 · see citing works

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease

Sadleir, K. R., Kandalepas, P. C., Buggia-Prévot, V., Nicholson, D. A., Thinakaran, G., & Vassar, R. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1558-9 · Cited by 294 · see citing works

Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin

Rosales‐Corral, S., Acuña-Castroviejo, D., Coto‐Montes, A. M., Boga, J. A., Manchester, L. C., Fuentes‐Broto, L., Korkmaz, A., Ma, S., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00937.x · Cited by 293 · see citing works

Natural polyphenols against neurodegenerative disorders: Potentials and pitfalls

Ebrahimi, A., & Schluesener, H. J. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.01.006 · Cited by 276 · see citing works

Traumatic brain injury: A risk factor for Alzheimer's disease

Sivanandam, T. M., & Thakur, M. K. (2012) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.02.013 · Cited by 326 · see citing works

Vascular dysfunction in the pathogenesis of Alzheimer's disease — A review of endothelium-mediated mechanisms and ensuing vicious circles

Marco, L. Y. D., Venneri, A., Farkas, E., Evans, P. C., Marzo, A., & Frangi, A. F. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.08.014 · Cited by 258 · see citing works

Neurovascular Unit Dysfunction and Neurodegenerative Disorders

Yu, X., Ji, C., & Shao, A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00334 · Cited by 244 · see citing works

The up‐regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

Guglielmotto, M., Aragno, M., Autelli, R., Giliberto, L., Novo, E., Colombatto, S., Danni, O., Parola, M., Smith, M. A., Perry, G. L., et al. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05858.x · Cited by 243 · see citing works

Antihypertensive Drugs, Prevention of Cognitive Decline and Dementia: A Systematic Review of Observational Studies, Randomized Controlled Trials and Meta-Analyses, with Discussion of Potential Mechanisms

Rouch, L., Cestac, P., Hanon, O., Cool, C., Helmer, C., Bouhanick, B., Chamontin, B., Dartigues, J.-F., Vellas, B. J., & Andrieu, S. (2015) · CNS Drugs · doi:10.1007/s40263-015-0230-6 · Cited by 237 · see citing works

AMP‐activated protein kinase: a potential player in Alzheimer’s disease

Salminen, A., Kaarniranta, K., Haapasalo, A., Soininen, H. S., & Hiltunen, M. O. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07331.x · Cited by 223 · see citing works

Hypoxia increases Aβ generation by altering β- and γ-cleavage of APP

Li, L., Zhang, X., Yang, D., Luo, G., Chen, S., & Le, W. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.10.011 · Cited by 220 · see citing works

Evidence of neurodegeneration in obstructive sleep apnea: Relationship between obstructive sleep apnea and cognitive dysfunction in the elderly

Daulatzai, M. A. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23634 · Cited by 215 · see citing works

Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease

Salminen, A., Kauppinen, A., & Kaarniranta, K. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13932 · Cited by 206 · see citing works

Post-mortem assessment of hypoperfusion of cerebral cortex in Alzheimer’s disease and vascular dementia

Thomas, T. L., Miners, J. S., & Love, S. (2015) · Brain · doi:10.1093/brain/awv025 · Cited by 190 · see citing works

Pathological role of hypoxia in Alzheimer's disease

Zhang, X., & Le, W. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.07.033 · Cited by 189 · see citing works

Cerebral Microvascular Injury: A Potentially Treatable Endophenotype of Traumatic Brain Injury-Induced Neurodegeneration

Sandsmark, D. K., Bashir, A., Wellington, C. L., & Diaz-Arrastia, R. R. (2019) · Neuron · doi:10.1016/j.neuron.2019.06.002 · Cited by 178 · see citing works

From Chronic Cerebral Hypoperfusion to Alzheimer-Like Brain Pathology and Neurodegeneration

Zhao, Y., & Gong, C.-X. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0127-9 · Cited by 180 · see citing works

Cerebrospinal Fluid Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Combination with Subcortical and Cortical Biomarkers in Vascular Dementia and Alzheimer's Disease

Bjerke, M., Zetterberg, H., Edman, Å., Blennow, K., Wallin, A., & Andreasson, U. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-110566 · Cited by 180 · see citing works

Blood pressure and the risk for dementia—A double edged sword

Kennelly, S. P., Lawlor, B. A., & Kenny, R. A. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2008.11.001 · Cited by 173 · see citing works

Mitochondria-targeted catalase reduces abnormal APP processing, amyloid production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension

Mao, P., Mańczak, M., Calkins, M. J., Truong, Q., Reddy, T. P., Reddy, A. P., Shirendeb, U. P., Lo, H., Rabinovitch, P. S., & Reddy, P. H. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds128 · Cited by 174 · see citing works

Interactions between APP secretases and inflammatory mediators

Sastre, M., Walter, J., & Gentleman, S. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-25 · Cited by 172 · see citing works

Cell‐specific blood–brain barrier regulation in health and disease: a focus on hypoxia

Engelhardt, S., Patkar, S., & Ogunshola, O. O. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12489 · Cited by 165 · see citing works

BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease

Chami, L., & Checler, F. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-52 · Cited by 168 · see citing works

Obstructive Sleep Apnea and Longitudinal Alzheimer's Disease Biomarker Changes

Bubu, O. M., Pirraglia, E., Andrade, A. G., Sharma, R. A., Giménez, S., Umasabor‐Bubu, O. Q., Hogan, M. M., Shim, A., Mukhtar, F., Sharma, N. K., et al. (2018) · SLEEP · doi:10.1093/sleep/zsz048 · Cited by 165 · see citing works

Review: Blood pressure and dementia — a comprehensive review

Kennelly, S., LAWLOR, B. A., & Kenny, R. A. (2009) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285609103483 · Cited by 160 · see citing works

Chronic Intermittent Hypoxia/Reoxygenation Facilitate Amyloid-β Generation in Mice

Shiota, S., Takekawa, H., Matsumoto, S., Takeda, K., Nurwidya, F., Yoshioka, Y., Takahashi, F., Hattori, N., Tabira, T., Mochizuki, H., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130419 · Cited by 155 · see citing works

Obstructive sleep apnea decreases central nervous system–derived proteins in the cerebrospinal fluid

Ju, Y. S., Finn, M. B., Sutphen, C. L., Herries, E. M., Jerome, G. M., Ladenson, J. H., Crimmins, D. L., Fagan, A. M., & Holtzman, D. M. (2016) · Annals of Neurology · doi:10.1002/ana.24672 · Cited by 160 · see citing works

Impaired Aβ clearance: a potential link between atherosclerosis and Alzheimer’s disease

Gupta, A. K., & Iadecola, C. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00115 · Cited by 158 · see citing works

Oxidative Stress and Transcriptional Regulation in Alzheimer Disease

Shi, Q., & Gibson, G. E. (2007) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31815721c3 · Cited by 156 · see citing works

From Mitochondrial Dysfunction to Amyloid Beta Formation: Novel Insights into the Pathogenesis of Alzheimer’s Disease

Leuner, K., Müller, W. E., & Reichert, A. S. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8307-4 · Cited by 155 · see citing works

Hypoxia‐inducible factors as neuroprotective agent in Alzheimer's disease

(2016) · doi:10.1111/1440-1681.12717 · Cited by 150 · see citing works

Insulin-Degrading Enzyme Sorting in Exosomes: A Secretory Pathway for a Key Brain Amyloid-β Degrading Protease

Bulloj, A., Leal, M. C., Xu, H., Castaño, E. M., & Morelli, L. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1206 · Cited by 149 · see citing works

The Vascular Hypothesis of Alzheimer’s Disease: A Key to Preclinical Prediction of Dementia Using Neuroimaging

de la Torre, J. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180004 · Cited by 147 · see citing works

Osmotin attenuates amyloid beta-induced memory impairment, tau phosphorylation and neurodegeneration in the mouse hippocampus

Ali, T., Yoon, G. H., Shah, S. A., Lee, H. Y., & Kim, M. O. (2015) · Scientific Reports · doi:10.1038/srep11708 · Cited by 146 · see citing works

The relationship between iron dyshomeostasis and amyloidogenesis in Alzheimer's disease: Two sides of the same coin

Peters, D. G., Connor, J. R., & Meadowcroft, M. D. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.08.007 · Cited by 145 · see citing works

Intracranial atherosclerosis as a contributing factor to Alzheimer's disease dementia

Roher, A. E., Tyas, S. L., Maarouf, C. L., Daugs, I. D., Kokjohn, T. A., Emmerling, M. R., Garami, Z. F., Bëlohlávek, M., Sabbagh, M. N., Sue, L. I., et al. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.08.228 · Cited by 144 · see citing works

Treatment of sleep apnoea syndrome decreases cognitive decline in patients with Alzheimer's disease

Troussière, A., Charley, C. M., Salleron, J., Richard, F., Delbeuck, X., Derambure, P., Pasquier, F., & Bombois, S. (2014) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-307544 · Cited by 143 · see citing works

Transcranial Doppler ultrasound blood flow velocity and pulsatility index as systemic indicators for Alzheimer's disease

Roher, A. E., Garami, Z. F., Tyas, S. L., Maarouf, C. L., Kokjohn, T. A., Bëlohlávek, M., Vedders, L. J., Connor, D. J., Sabbagh, M. N., Beach, T. G., et al. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.09.002 · Cited by 138 · see citing works

Oligemic Hypoperfusion Differentially Affects Tau and Amyloid-β

Koike, M. A., Green, K. N., Blurton-Jones, M., & LaFerla, F. M. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090750 · Cited by 130 · see citing works

Oxidative stress mediates the pathogenic effect of different Alzheimer’s disease risk factors

Guglielmotto, M. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/neuro.24.003.2010 · Cited by 133 · see citing works

Forebrain-dominant deficit in cerebrovascular reactivity in Alzheimer's disease

Yezhuvath, U. S., Uh, J., Cheng, Y., Martin‐Cook, K., Weiner, M., Diaz-Arrastia, R. R., van Osch, M. J. P., & Lu, H. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.02.005 · Cited by 131 · see citing works

Alzheimer's β-Secretase (BACE1) Regulates the cAMP/PKA/CREB Pathway Independently of β-Amyloid

Chen, Y., Huang, X., Zhang, Y., Rockenstein, E. M., Bu, G., Golde, T. E., Masliah, E., & Xu, H. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0757-12.2012 · Cited by 131 · see citing works

Pathological changes within the cerebral vasculature in Alzheimer’s disease: New perspectives

Fisher, R. A., Miners, J. S., & Love, S. (2022) · Brain Pathology · doi:10.1111/bpa.13061 · Cited by 127 · see citing works

Cardiovascular risk factors, cortisol, and amyloid‐β deposition in Alzheimer's Disease Neuroimaging Initiative

Toledo, J. B., Toledo, E., Weiner, M. W., Jack, C. R., Jagust, W., Lee, V. M. ‐., Shaw, L. M. J., & Trojanowski, J. Q. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.08.008 · Cited by 130 · see citing works

Hypoxia-Inducible Factor (HIF) in Ischemic Stroke and Neurodegenerative Disease

Mitroshina, Е. V., Saviuk, M. O., Ponimaskin, E. G., & Vedunova, M. V. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.703084 · Cited by 130 · see citing works

Vascular risk factors and Alzheimer’s disease

Cechetto, D. F., Hachinski, V., & Whitehead, S. N. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.5.743 · Cited by 129 · see citing works

Contribution of hypoxia to Alzheimer’s disease: is HIF-1α a mediator of neurodegeneration?

Ogunshola, O. O., & Antoniou, X. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0141-0 · Cited by 128 · see citing works

Cerebrovascular disease, beta-amyloid, and cognition in aging

Marchant, N. L., Reed, B. R., DeCarli, C. S., Madison, C. M., Weiner, M. W., Chui, H. C., & Jagust, W. J. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.10.001 · Cited by 127 · see citing works

Central artery stiffness, neuropsychological function, and cerebral perfusion in sedentary and endurance-trained middle-aged adults

Tarumi, T., Gonzales, M. M., Fallow, B. A., Nualnim, N., Pyron, M. I., Tanaka, H., & Haley, A. P. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e328364decc · Cited by 127 · see citing works

High-fat diet exacerbates cognitive decline in mouse models of Alzheimer's disease and mixed dementia in a sex-dependent manner

Gannon, O. J., Robison, L. S., Salinero, A. E., Abi-Ghanem, C., Mansour, F. M., Kelly, R. D., Tyagi, A., Brawley, R. R., Ogg, J. D., & Zuloaga, K. L. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02466-2 · Cited by 127 · see citing works

Causes and consequences of baseline cerebral blood flow reductions in Alzheimer’s disease

Bracko, O., Hernández, J. C. C., Park, L., Nishimura, N., & Schaffer, C. B. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20982383 · Cited by 122 · see citing works

BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer’s Disease Pathology

Koelsch, G. (2017) · Molecules · doi:10.3390/molecules22101723 · Cited by 125 · see citing works

Extracellular Vesicle as a Source of Alzheimer’s Biomarkers: Opportunities and Challenges

Lee, S., Mankhong, S., & Kang, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071728 · Cited by 125 · see citing works

The Aging Brain and Cognition

Marchant, N. L., Reed, B., Sanossian, N., Madison, C. M., Kriger, S., Dhada, R., Mack, W. J., DeCarli, C. S., Weiner, M. W., Mungas, D., et al. (2013) · JAMA Neurology · doi:10.1001/2013.jamaneurol.405 · Cited by 123 · see citing works

Amyloid Beta Resistance in Nerve Cell Lines Is Mediated by the Warburg Effect

Newington, J. T., Pitts, A., Chien, A., Arseneault, R., Schubert, D. A., & Cumming, R. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019191 · Cited by 121 · see citing works

Hypoxia-Induced Down-Regulation of Neprilysin by Histone Modification in Mouse Primary Cortical and Hippocampal Neurons

Wang, Z., Yang, D., Zhang, X., Li, T., Li, J., Tang, Y., & Le, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019229 · Cited by 119 · see citing works

γ-Secretase Substrate Concentration Modulates the Aβ42/Aβ40 Ratio

Yin, Y. I., Bassit, B., Zhu, L., Yang, X., Wang, C., & Li, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704601200 · Cited by 116 · see citing works

Brain Ischemia Activates β- and γ-Secretase Cleavage of Amyloid Precursor Protein: Significance in Sporadic Alzheimer’s Disease

Pluta, R. M., Furmaga-Jabłońska, W., Maciejewski, R., Ułamek-Kozioł, M., & Jabłoński, M. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8360-z · Cited by 114 · see citing works

Amyloid-β Production: Major Link Between Oxidative Stress and BACE1

Tamagno, E., Guglielmotto, M., Monteleone, D., & Tabaton, M. (2011) · Neurotoxicity Research · doi:10.1007/s12640-011-9283-6 · Cited by 115 · see citing works

Involvement of calpain in the neuropathogenesis of Alzheimer’s disease

Mahaman, Y. A. R., Huang, F., Afewerky, H. K., Salissou, M. T. M., Bishwajit, G., & Wang, X. (2018) · Medicinal Research Reviews · doi:10.1002/med.21534 · Cited by 107 · see citing works

Death by a Thousand Cuts in Alzheimer’s Disease: Hypoxia—The Prodrome

Daulatzai, M. A. (2013) · Neurotoxicity Research · doi:10.1007/s12640-013-9379-2 · Cited by 111 · see citing works

The magic of the hypoxia-signaling cascade

Benizri, E. I., Ginouvès, A., & Berra, E. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7472-0 · Cited by 111 · see citing works

Endothelin-1 is Elevated in Alzheimer's Disease and Upregulated by Amyloid-β

Palmer, J. C., Barker, R., Kehoe, P. G., & Love, S. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-111760 · Cited by 110 · see citing works

Calpain Activation Promotes BACE1 Expression, Amyloid Precursor Protein Processing, and Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease

Liang, B., Duan, B.-Y., Zhou, X., Gong, J., & Luo, Z. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.117960 · Cited by 109 · see citing works

Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer’s Disease

Parodi‐Rullán, R. M., Sone, J. Y., & Fossati, S. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190357 · Cited by 108 · see citing works

Chronic cerebral hypoperfusion accelerates amyloid β deposition in APPSwInd transgenic mice

Kitaguchi, H., Tomimoto, H., Ihara, M., Shibata, M., Uemura, K., Kalaria, R. N., Kihara, T., Asada-Utsugi, M., Kinoshita, A., & Takahashi, R. (2009) · Brain Research · doi:10.1016/j.brainres.2009.07.078 · Cited by 108 · see citing works

Understanding the Role of Hypoxia Inducible Factor During Neurodegeneration for New Therapeutics Opportunities

Merelli, A., Rodríguez, J., Folch, J., Regueiro, M. R., Camins, A., & Lazarowski, A. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180110130253 · Cited by 105 · see citing works

Serum amyloid-beta levels are increased in patients with obstructive sleep apnea syndrome

Bu, X.-L., Liu, Y.-H., Wang, Q.-H., Jiao, S.-S., Zeng, F., Yao, X., Gao, D., Chen, J.-C., & Wang, Y.-J. (2015) · Scientific Reports · doi:10.1038/srep13917 · Cited by 98 · see citing works

The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: Characterizing a new regulatory motif

Maloney, B., & Lahiri, D. K. (2011) · Gene · doi:10.1016/j.gene.2011.06.004 · Cited by 105 · see citing works

Cerebral Small Vessel Disease and Alzheimer's Disease: A Review

Kim, H. W., Hong, J., & Jeon, J. C. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00927 · Cited by 108 · see citing works

Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape

Salminen, A., Haapasalo, A., Kauppinen, A., Kaarniranta, K., Soininen, H. S., & Hiltunen, M. O. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.001 · Cited by 105 · see citing works

Differential regulation of BACE1 expression by oxidative and nitrosative signals

Kwak, Y.-D., Wang, R., Li, J. J., Zhang, Y., Xu, H., & Liao, F. (2011) · Molecular Neurodegeneration · doi:10.1186/1750-1326-6-17 · Cited by 102 · see citing works

BACE1: More than just a β‐secretase

Taylor, H. A., Przemyłska, L., Clavane, E. M., & Meakin, P. J. (2022) · Obesity Reviews · doi:10.1111/obr.13430 · Cited by 102 · see citing works

Cerebral small vessel disease and the risk of Alzheimer’s disease: A systematic review

Liu, Y., Braidy, N., Poljak, A., Chan, D. K. Y., & Sachdev, P. S. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.06.002 · Cited by 103 · see citing works

The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer’s Disease

Cole, S. L., & Vassar, R. (2007) · Current Genomics · doi:10.2174/138920207783769512 · Cited by 97 · see citing works

Kinetics and molecular docking studies of fucosterol and fucoxanthin, BACE1 inhibitors from brown algae Undaria pinnatifida and Ecklonia stolonifera

Jung, H. A., Ali, M. Y., Choi, R. J., Jeong, H. O., Chung, H. Y., & Choi, J. S. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.01.014 · Cited by 99 · see citing works

BACE1 Structure and Function in Health and Alzheimers Disease

Cole, S., & Vassar, R. (2008) · Current Alzheimer Research · doi:10.2174/156720508783954758 · Cited by 96 · see citing works

Regulation of β‐site APP‐cleaving enzyme 1 gene expression and its role in Alzheimer’s Disease

Sun, X., Bromley‐Brits, K., & Song, W. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07515.x · Cited by 97 · see citing works

The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer’s Disease and Beyond

Dislich, B., & Lichtenthaler, S. F. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00008 · Cited by 98 · see citing works

Correlating Cognitive Decline with White Matter Lesion and BrainAtrophy Magnetic Resonance Imaging Measurements in Alzheimer’s Disease

Bilello, M., Doshi, J. J., Nabavizadeh, S. A., Toledo, J. B., Erus, G., Xie, S. X., Trojanowski, J. Q., Han, X., & Davatzikos, C. A. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150400 · Cited by 90 · see citing works

Can sleep apnea cause Alzheimer's disease?

Pan, W., & Kastin, A. J. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.019 · Cited by 89 · see citing works

Matrix Metalloproteinase (MMP)-9 Induced by Wnt Signaling Increases the Proliferation and Migration of Embryonic Neural Stem Cells at Low O2 Levels

Ingraham, C. A., Park, G. C., Makarenkova, H. P., & Crossin, K. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.229427 · Cited by 88 · see citing works

Synaptic protein levels altered in vascular dementia

Sinclair, L. I., Tayler, H. M., & Love, S. (2015) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12215 · Cited by 87 · see citing works

The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer’s disease

Pimentel‐Coelho, P. M., & Rivest, S. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08126.x · Cited by 85 · see citing works

IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function

Montemurro, C., Nomoto, H., Pei, L., Parekh, V. S., Vongbunyong, K. E., Vadrevu, S., Gurlo, T., Butler, A. E., Subramaniam, R., Ritou, E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10444-1 · Cited by 85 · see citing works

Function, regulation and therapeutic properties of β-secretase (BACE1)

Willem, M., Lammich, S., & Haass, C. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.01.003 · Cited by 86 · see citing works

The up‐regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

Guglielmotto, M., Aragno, M., Autelli, R., Giliberto, L., Novo, E., Colombatto, S., Danni, O., Parola, M., Smith, M. A., Perry, G. L., et al. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05858.x · Cited by 243 · see citing works

Hypoxia Inducible Factor-1α binds and activates γ-secretase for Aβ production under hypoxia and cerebral hypoperfusion

Alexander, C., Li, T., Hattori, Y., Chiu, D., Frost, G. R., Jonas, L., Liu, C., Anderson, C. J., Wong, E., Park, L., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01676-7 · Cited by 64 · see citing works

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating <i>BACE1</i> gene expression

Sun, X., He, G., Qing, H., Zhou, W., Dobie, F., Cai, F., Staufenbiel, M., Huang, L. E., & Song, W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606298103 · Cited by 605 · see citing works

Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease

Salminen, A., Kauppinen, A., & Kaarniranta, K. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13932 · Cited by 206 · see citing works

P2–039: Hypoxia–induced increase in amyloid–β peptide in cortical astrocytes does not depend on increased BACE–1 expression

Boyle, J. P., Boycott, H. E., KHAN, A. R., Rapley, H., Stanton, C. M., & Peers, C. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.876