The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Homeostatic Regulation of Blood Neutrophil Counts
Open accessAbstract
Blood neutrophil counts are determined by the differentiation and proliferation of precursor cells, the release of mature neutrophils from the bone marrow, margination, trafficking and transmigration through the endothelial lining, neutrophil apoptosis, and uptake by phagocytes. This brief review summarizes the regulation of blood neutrophil counts, which is in part controlled by G-CSF, IL-17, and IL-23. Neutrophils are retained in the bone marrow through interaction of CXCL12 with its receptor CXCR4. The relevance of this mechanism is illustrated by rare diseases in which disrupting the desensitization of CXCR4 results in failure to release mature neutrophils from bone marrow. Although blood neutrophil numbers in inbred mouse strains and individual human subjects are tightly controlled, their large variation among outbred populations suggests genetic factors. One example is benign ethnic neutropenia, which is found in some African Americans. Reduced and elevated neutrophil counts, even within the normal range, are associated with excess all-cause mortality.
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Cites
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Cited by
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
Rosales, C. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00113 · Cited by 1,334
Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response
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Clearance of apoptotic neutrophils and resolution of inflammation
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Basic biology and role of interleukin‐17 in immunity and inflammation
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Metadata
- Authors
- von Vietinghoff, S., & Ley, K.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-10
- Volume
- 181
- Issue
- 8
- Pages
- 5183-5188
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2157673587
- Cited by
- 292
- References
- 12
- FWCI
- 9.49
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
