The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.
PANoptosis: A Unique Innate Immune Inflammatory Cell Death Modality
Open accessAbstract
Innate immunity is the first response to protect against pathogens and cellular insults. Pattern recognition receptors sense pathogen- and damage-associated molecular patterns and induce an innate immune response characterized by inflammation and programmed cell death (PCD). In-depth characterization of innate immune PCD pathways has highlighted significant cross-talk. Recent advances led to the identification of a unique inflammatory PCD modality called PANoptosis, which is regulated by multifaceted PANoptosome complexes that are assembled by integrating components from other PCD pathways. The totality of biological effects observed in PANoptosis cannot be accounted for by any other PCD pathway alone. In this review, we briefly describe mechanisms of innate immune cell death, including molecular mechanisms of PANoptosis activation and regulation. We also highlight the PANoptosomes identified to date and provide an overview of the implications of PANoptosis in disease and therapeutic targeting. Improved understanding of innate immune-mediated cell death, PANoptosis, is critical to inform the next generation of treatment strategies.
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Cites
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Cited by
A 360° view of the inflammasome: Mechanisms of activation, cell death, and diseases
Barnett, K. C., Li, S., Liang, K., & Ting, J. P.-Y. (2023) · Cell · doi:10.1016/j.cell.2023.04.025 · Cited by 458
Apoptotic cell death in disease—Current understanding of the NCCD 2023
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Self-citationTherapeutic potential of PANoptosis: innate sensors, inflammasomes, and RIPKs in PANoptosomes
Pandeya, A., & Kanneganti, T.-D. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.10.001 · Cited by 303
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Metadata
- Authors
- Pandian, N., & Kanneganti, T.-D.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2022-11-01
- Volume
- 209
- Issue
- 9
- Pages
- 1625-1633
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W4306730830
- Cited by
- 285
- References
- 131
- FWCI
- 14.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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