Metabolism of Very Long-Chain Fatty Acids: Genes and Pathophysiology

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Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance

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Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine ceramides

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Functional Characterization of Two Elongases of Very Long-Chain Fatty Acid from Tenebrio molitor L. (Coleoptera: Tenebrionidae)

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Enantiomers of phospholipids and cholesterol: A key to decipher lipid‐lipid interplay in membrane

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The Selective Peroxisome Proliferator‐Activated Receptor Gamma Modulator CHS‐131 Improves Liver Histopathology and Metabolism in a Mouse Model of Obesity and Nonalcoholic Steatohepatitis

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Alterations in Glycerolipid and Fatty Acid Metabolic Pathways in Alzheimer's Disease Identified by Urinary Metabolic Profiling: A Pilot Study

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The effects of LXR agonist T0901317 and LXR antagonist GSK2033 on morphogenesis and lipid properties in full thickness skin models

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Genome-wide identification and analysis of elongase of very long chain fatty acid genes in the silkworm, Bombyx mori

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Enantiomeric separation of triacylglycerols containing very long chain fatty acids

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Transcriptomic and biochemical analyses revealed the improved growth, lipid metabolism, and flesh quality of grass carp ( Ctenopharyngodon idellus ) by dietary Eucommia ulmoides bark and leaf supplementation

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Lifestyle Factors Associated with Circulating Very Long-Chain Saturated Fatty Acids in Humans: A Systematic Review of Observational Studies

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The elongation of very long-chain fatty acid 6 gene product catalyses elongation of n -13 : 0 and n -15 : 0 odd-chain SFA in human cells

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Bioengineered Plants Can Be an Alternative Source of Omega-3 Fatty Acids for Human Health

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Side-chain deuterated cholesterol as a molecular probe to determine membrane order and cholesterol partitioning

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Saturation of cholesteryl esters produced by human meibomian gland epithelial cells after treatment with rosiglitazone

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Comprehensive stratum corneum ceramide profiling reveals reduced acylceramides in ichthyosis patient with CERS3 mutations

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Examining Heat Treatment for Stabilization of the Lipidome

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Prenatal Choline Supplement in a Maternal Obesity Model Modulates Offspring Hepatic Lipidomes

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Inhibition of Mdmx (Mdm4) in vivo induces anti-obesity effects

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Identification of genes mediating branched chain fatty acid elongation

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Identification of a fatty acid synthase gene (FAS1) from Laodelphax striatellus planthoppers contributing to fecundity

Cheng, J., Yu, P., Xia, X., Zhang, R., Wang, L., Fang, J., Hoffmann, A. A., & Luo, G. (2022) · Insect Science · doi:10.1111/1744-7917.13125 · Cited by 16

Biosignatures of defective sebaceous gland activity in sebum‐rich and sebum‐poor skin areas in adult atopic dermatitis

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Understanding the Impact of Polyunsaturated Fatty Acids on Age-Related Macular Degeneration: A Review

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Dietary ceramide 2-aminoethylphosphonate, a marine sphingophosphonolipid, improves skin barrier function in hairless mice

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Rearrangements of Blood and Tissue Fatty Acid Profile in Colorectal Cancer - Molecular Mechanism and Diagnostic Potential

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An optimized method for measuring fatty acids and cholesterol in stable isotope-labeled cells

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Ins and Outs of Interpreting Lipidomic Results

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Parallel Reaction Monitoring reveals structure-specific ceramide alterations in the zebrafish

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Peroxisomes attenuate cytotoxicity of very long-chain fatty acids

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Parallel evolution in Crassostrea oysters along the latitudinal gradient is associated with variation in multiple genes involved in adipogenesis

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Stage-Specific De Novo Synthesis of Very-Long-Chain Dihydroceramides Confers Dormancy to Entamoeba Parasites

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Hepatic ELOVL3 is dispensable for lipid metabolism in mice

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Application of quantitative trait locus mapping and transcriptomics to studies of the senescence-accelerated phenotype in rats

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Very long chain fatty acids are an important marker of nutritional status in patients with anorexia nervosa: a case control study

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Identification of the Key Pathways and Genes Involved in the Wax Biosynthesis of the Chinese White Wax Scale Insect (Ericerus pela Chavannes) by Integrated Weighted Gene Coexpression Network Analysis

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Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Downregulates ELOVL1 Gene Expression and Fatty Acid Synthesis in Goat Fetal Fibroblasts

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Effect of selenium and methods of protein extraction on the proteomic profile of Saccharomyces yeast

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Fatty Acid Profile and Lipid Quality Indexes of the Meat and Backfat from Porkers Supplemented with EM Bokashi Probiotic

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Sphingolipids containing very long-chain fatty acids regulate Ypt7 function during the tethering stage of vacuole fusion

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Rapamycin Inhibits Expression of Elongation of Very-long-chain Fatty Acids 1 and Synthesis of Docosahexaenoic Acid in Bovine Mammary Epithelial Cells

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Evaluation of Cell Harvesting Techniques to Optimize Lipidomic Analysis from Human Meibomian Gland Epithelial Cells in Culture

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Targeted metabolomic profiling indicates structure-based perturbations in serum phospholipids in children with acetaminophen overdose

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Elucidation of the Synthetic Mechanism of Acylceramide, an Essential Lipid for Skin Barrier Function

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Pathophysiology of X-Linked Adrenoleukodystrophy: Updates on Molecular Mechanisms

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Biomarkers predictive of long-term fertility found in vaginal lipidome of gilts at weaning

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The Antipsychotic Risperidone Alters Dihydroceramide and Ceramide Composition and Plasma Membrane Function in Leukocytes In Vitro and In Vivo

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Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy

Bougnères, P., & Le Stunff, C. (2025) · Genes · doi:10.3390/genes16050590 · Cited by 11

Widespread tissue distribution and synthetic pathway of polyunsaturated C24:2 sphingolipids in mammals

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β-Glucosylation of cholesterol reduces sterol-sphingomyelin interactions

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SIRT5 reduces the inflammatory response and barrier dysfunction in IL-17A-induced epidermal keratinocytes

Wang, C., He, D., & Shi, C. (2023) · Allergologia et Immunopathologia · doi:10.15586/aei.v51i1.675 · Cited by 10

Catalytic mechanism of trans-2-enoyl-CoA reductases in the fatty acid elongation cycle and its cooperative action with fatty acid elongases

Kato, R., Takenaka, Y., Ohno, Y., & Kihara, A. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.105656 · Cited by 10

Targeting Oligodendrocyte Dynamics and Remyelination: Emerging Therapies and Personalized Approaches in Multiple Sclerosis Management

Sharma, T., Mehan, S., Tiwari, A., Khan, Z., Gupta, G. D., & Narula, A. S. (2024) · Current Neurovascular Research · doi:10.2174/0115672026336440240822063430 · Cited by 9

Gut microbe-derived pentadecanoic acid could represent a novel health-promoter via multiple pathways

Yang, Y., Fu, Y., & Wu, C. (2025) · Food & Function · doi:10.1039/d5fo01278c · Cited by 9

STAMP2 is required for human adipose-derived stem cell differentiation and adipocyte-facilitated prostate cancer growth in vivo

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Trans-2-enoyl-CoA reductase limits Ca2+ accumulation in the endoplasmic reticulum by inhibiting the Ca2+ pump SERCA2b

Uchida, Y., Yamamoto, Y., & Sakisaka, T. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100310 · Cited by 9

Elovl5 Expression in the Central Nervous System of the Adult Mouse

Balbo, I., Montarolo, F., Boda, E., Tempia, F., & Hoxha, E. (2021) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2021.669073 · Cited by 9

The Hard Choice about Dry Pet Food: Comparison of Protein and Lipid Nutritional Qualities and Digestibility of Three Different Chicken-Based Formulations

Montegiove, N., Calzoni, E., Cesaretti, A., Pellegrino, R. M., Emiliani, C., Pellegrino, A., & Leonardi, L. (2022) · Animals · doi:10.3390/ani12121538 · Cited by 9

The very long‐chain fatty acid elongase FgElo2 governs tebuconazole sensitivity and virulence in Fusarium graminearum

Wang, H., Chen, Y., Hou, T., Jian, Y., & Ma, Z. (2022) · Environmental Microbiology · doi:10.1111/1462-2920.16212 · Cited by 9

Rapid screening of very long-chain fatty acids from microorganisms

Řezanka, T., Vítová, M., Lukavský, J., Nedbalová, L., & Kolouchová, I. (2019) · Journal of Chromatography A · doi:10.1016/j.chroma.2019.460365 · Cited by 9

ELOVL1 is upregulated and promotes tumor growth in hepatocellular carcinoma through regulating PI3K-AKT-mTOR signaling

Qin, L., Song, C.-Z., Yuan, F.-Y., Wang, X.-F., Yang, Y., Ma, Y., & Chen, Z. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34961 · Cited by 8

Integrative Analysis of Transcriptomics and Proteomics for Screening Genes and Regulatory Networks Associated with Lambda-Cyhalothrin Resistance in the Plant Bug Lygus pratensis Linnaeus (Hemiptera: Miridae)

Chen, J., Huo, Z., Sun, F., Zhang, L.-Q., Han, H., Zhu, J., & Tan, Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041745 · Cited by 8

Nervonic acid in infant nutrition: a forward-looking approach to enhancing neurodevelopmental outcomes

Destaillats, F., de Oliveira, M. C., Rakitsky, W. G., Zhou, X., & Parker, L. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1635266 · Cited by 10

Dietary Fatty Acids Modulate Gut Microbiota-Derived Trimethylamine-N-Oxide: Potential Mechanisms and Future Perspective

Kilic, E., & Başaran, P. (2025) · Nutrients · doi:10.3390/nu17233787 · Cited by 11

Lipid Dyshomeostasis and Inherited Cerebellar Ataxia

Zhao, J., Zhang, H., Fan, X., Yu, X., & Huai, J. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02826-2 · Cited by 9

Genome-Wide Investigation and Functional Analysis Reveal That CsKCS3 and CsKCS18 Are Required for Tea Cuticle Wax Formation

Mo, L., Yao, X., Tang, H., Li, Y., Jiao, Y., He, Y., Jiang, Y., Tian, S., & Lu, L. (2023) · Foods · doi:10.3390/foods12102011 · Cited by 8

Selenium-dependent glutathione peroxidase 1 regulates transcription of elongase 3 in murine tissues

Sun, Z., Wu, K., Feng, C., & Lei, X. G. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.09.010 · Cited by 8

The 3-hydroxyacyl-CoA dehydratase 1/2 form complex with trans-2-enoyl-CoA reductase involved in substrates transfer in very long chain fatty acid elongation

Zhou, Y., Lv, R., Ye, R. D., Ren, R., & Yu, L. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149588 · Cited by 8

Proteome-metabolome profiling of wax gland complex reveals functional changes in honeybee, Apis mellifera L.

Xu, R., Ma, B., Yang, Y., Dong, X., Li, J., Xu, X., & Fang, Y. (2024) · iScience · doi:10.1016/j.isci.2024.109279 · Cited by 8

Multi-tissue metabolomics reveal mtDNA- and diet-specific metabolite profiles in a mouse model of cardiometabolic disease

Shastry, A., Wilkinson, M., Miller, D. M., Kuriakose, M., Veeneman, J., Smith, M. R., Hindmarch, C. C. T., & Dunham‐Snary, K. J. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103541 · Cited by 8

Increased expression of ELOVL7 contributes to production of inflammatory cytokines in THP-1 cell-derived M1-like macrophages

Inoue, Y., Kamiya, T., & Hara, H. (2023) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.22-69 · Cited by 8

The transcription factor ATML1 maintains giant cell identity by inducing synthesis of its own long-chain fatty acid-containing ligandsPreprint

Vadde, B. V. L., Russell, N. J., Bagde, S. R., Askey, B. C., Saint-Antoine, M., Brownfield, B. A., Mughal, S., Apprill, L. E., Khosla, A., Clark, F. K., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.14.584694 · Cited by 8

Lipid Compositions of Liquid-Ordered and Liquid-Disordered Phases in Ternary Membranes of Sphingomyelin, Cholesterol, and Dioleoylphosphatidylcholine Determined by 2H NMR: Stearoyl-Sphingomyelin Compared with Its Palmitoyl Counterpart

Hanashima, S., Yamanaka, A., Ibata, Y., Yasuda, T., Umegawa, Y., & Murata, M. (2024) · Langmuir · doi:10.1021/acs.langmuir.4c03104 · Cited by 7

Targeting ABCD1-ACOX1-MET/IGF1R axis suppresses multiple myeloma

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Comparison of skin barrier abnormalities and epidermal ceramide profiles among three ω-O-acylceramide synthesis-deficient mouse strains

Yamamoto, Y., Sassa, T., & Kihara, A. (2023) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2023.12.003 · Cited by 7

Nervonic acid alleviates stroke and its associated poststroke depression behaviors

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Depth-Dependent Segmental Melting of the Sphingomyelin Alkyl Chain in Lipid Bilayers

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