The effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism in human
Abstract
The aim of this study was to examine the effects of Eleutherococcus senticosus (ES) supplementation on endurance capacity, cardiovascular functions and metabolism of recreationally trained males for 8 weeks. Nine recreationally trained males in college consumed 800 mg/d of ES or starch placebo (P) for 8 weeks according to a double-blind, randomized, placebo controlled and crossover design with a washout period of 4 weeks between the cycling trials. Subjects cycled at 75% VO2 peak until exhaustion. The examined physiological variables included endurance time, maximal heart rate during exhaustion exercise, VO2, rating of perceived exertion and respiratory exchange ratio. The biochemical variables including the plasma free fatty acid (FFA) and glucose were measured at rest, 15 min, 30 min and exhaustion. The major finding of this study was the VO2 peak of the subjects elevated 12% (P < 0.05), endurance time improved 23% (P < 0.05) and the highest heart rate increased 4% (P < 0.05) significantly. The second finding was at 30 min of 75% VO2 peak cycling, the production of plasma FFA was increased and the glucose level was decreased both significantly (P < 0.05) over 8-week ES supplementation. This is the first well-conducted study that shows that 8-week ES supplementation enhances endurance capacity, elevates cardiovascular functions and alters the metabolism for sparing glycogen in recreationally trained males.
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The intake of Eleutherococcus senticosus extract is not associated with serious side effects.
“moreover, the intake of Eleuterococcus senticosus extract is not associated with serious side effects [46,48,49,50,51,52,53,54,55].”
From Plant Adaptogens—History and Future Perspectives (2021) · cites this paper as [49]
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Plant Adaptogens—History and Future Perspectives
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Factors Influencing Substrate Oxidation During Submaximal Cycling: A Modelling Analysis
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- Authors
- Kuo, J.
- Affiliations
- Fu Jen Catholic University (TW)
- Corresponding author
- Kuo, Jip
- Venue
- The Chinese Journal of Physiology
- Publisher
- Medknow
- Published
- 2010-04-01
- Volume
- 53
- Issue
- 2
- Pages
- 105-111
- ISSN
- 0304-4920 (ISSN-L)
- OpenAlex
- W2156804237
- Cited by
- 31
- References
- 19
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 6 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 2 · 2017: 1 · 2015: 1 · 2014: 2 · 2013: 5 · 2012: 1
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Chinese Journal of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- Eleutherococcus senticosus, endurance capacity, peak oxygen uptake, cardiovascular function, free fatty acids, plasma glucose, glycogen sparing, exercise metabolism, endurance exercise, herbal supplementation
- MeSH terms
- Adolescent, Blood Glucose, Double-Blind Method, Drugs, Chinese Herbal, Fatty Acids, Nonesterified, Heart Rate, Humans, Male, Metabolism, Oxygen Consumption, Physical Endurance, Time Factors, Cross-Over Studies, Dietary Supplements, Eleutherococcus, Young Adult
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