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Cited by 58Muscle metabolism and nutritionSports Performance and TrainingCardiovascular and exercise physiology

Impact of carbohydrate supplementation during endurance training on glycogen storage and performance

Nybo, L., Pedersen, K., Christensen, B., Aagaard, P., Brandt, N., Kiens, B.·2009·Acta Physiologica
DOI 10.1111/j.1748-1716.2009.01996.x
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Abstract

Aim: Glucose ingestion may improve exercise endurance, but it apparently also influences the transcription rate of several metabolic genes and it alters muscle metabolism during an acute exercise bout. Therefore, we investigated how chronic training responses are affected by glucose ingestion. Methods: In previously untrained males performance and various muscular adaptations were evaluated before and after 8 weeks of supervised endurance training conducted either with (n = 8; CHO group) or without (n = 7; placebo) glucose supplementation. Results: The two groups achieved similar improvements in maximal oxygen uptake and peak power output during incremental cycling (both parameters elevated by 17% on average) and both groups lost ∼3 kg of fat mass during the 8 weeks of training. An equal reduction in respiratory exchange ratio (0.02 units) during submaximal exercise was observed in both groups. Beta‐hydroxyacyl‐CoA‐dehydrogenase activity was increased in both groups, however, to a larger extent in the placebo group (45 ± 11%) than CHO (23 ± 9%, P < 0.05). GLUT‐4 protein expression increased by 74 ± 14% in the placebo group and 45 ± 14% in CHO (both P < 0.05), while resting muscle glycogen increased (P < 0.05) to a larger extent in the placebo group (96 ± 4%) than CHO (33 ± 2%). Conclusion: These results show that carbohydrate supplementation consumed during exercise training influences various muscular training adaptations, but improvements in cardiorespiratory fitness and reductions in fat mass are not affected.

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Authors
Nybo, L., Pedersen, K., Christensen, B., Aagaard, P., Brandt, N., & Kiens, B.
Affiliations
University of Copenhagen (DK)
Corresponding author
Nybo, L.
ORCID
Venue
Acta Physiologica
Publisher
Wiley
Published
2009-09-02
Volume
197
Issue
2
Pages
117-127
ISSN
  • 1748-1708 (ISSN-L)
  • 1748-1716
DOI
10.1111/j.1748-1716.2009.01996.x
OpenAlex
W2121346825
Cited by
58
References
41
Citations by year
2026: 1 · 2025: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 5 · 2012: 2
FWCI
2.67
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Acta Physiologica (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
carbohydrate supplementation, endurance training, muscle glycogen storage, exercise performance, beta-hydroxyacyl-CoA dehydrogenase, fat loss, cardiorespiratory fitness, muscle metabolism, fat oxidation
MeSH terms
Adaptation, Physiological, Adult, Dietary Carbohydrates, Energy Metabolism, Glucose, Glycogen, Humans, Lipids, Male, Oxygen Consumption, Physical Endurance, Reference Values, Triglycerides, 3-Hydroxyacyl CoA Dehydrogenases, Exercise, Matched-Pair Analysis, Muscle, Skeletal

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