Effect of Eleutherococcus senticosus on submaximal and maximal exercise performance
Abstract
We investigated the effect of Eleutherococcus senticosus Maxim L (ESML) on performance during submaximal and maximal aerobic exercise. Twenty highly trained distance runners randomly assigned in matched pairs to either an experimental (ESML) or placebo (PL) group, participated in an 8-wk double-blind study during which they completed five trails of a 10-min treadmill run at their 10 km (10K) race pace and a maximal treadmill test (T(max)). Following a baseline trail, ESML and PL consumed, respectively, 3.4 ml of ESML extract or placebo daily for 6 wk. Subjects were tested every 2 wk during supplementation and 2 wk following withdrawal. Heart rate (HR), oxygen consumption (VO2), expired minute volume (VE), ventilatory equivalent for oxygen (VE/VO2), respiratory exchange ratio (RER), and rating of perceived exertion (RPE) were measured during the 10K and T(max) tests. Resting, post-10K and post-T(max) blood samples were analyzed for serum lactate. No significant differences were observed between ESML and PL for: HR, VO2, VE, VE/VO2, RER, or RPE; T(max) time to exhaustion; or serum lactate. The data do not support an ergogenic effect of ESML supplementation on selected metabolic, performance, or psychologic parameters associated with submaximal and maximal aerobic exercise tasks.
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The intake of Eleutherococcus senticosus extract is not associated with serious side effects.
“moreover, the intake of Eleuterococcus senticosus extract is not associated with serious side effects [46,48,49,50,51,52,53,54,55].”
From Plant Adaptogens—History and Future Perspectives (2021) · cites this paper as [48]
Cites
Psychophysical bases of perceived exertion
BORG, G. A. V. (1982) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198205000-00012 · Cited by 16,580 · see citing works
New Substances of Plant Origin Which Increase Nonspecific Resistance
Brekhman, I. I., & Dardymov, I. V. (1969) · Annual Review of Pharmacology · doi:10.1146/annurev.pa.09.040169.002223 · Cited by 595 · see citing works
Recent advances on ginseng research in China
Liu, C., & Pei-Gen, X. (1992) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(92)90057-x · Cited by 423 · see citing works
What do commercial ginseng preparations contain?
Cui, J., Garle, M., Eneroth, P. H. E., & Björkhem, I. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91322-6 · Cited by 145 · see citing works
Evaluation of the Ergogenic Properties of Ginseng
Bahrke, M. S., & Morgan, W. P. (1994) · Sports Medicine · doi:10.2165/00007256-199418040-00003 · Cited by 143 · see citing works
Ginseng--is there a use in clinical medicine?
Chong, S. K. F., & Oberholzer, V. G. (1988) · Postgraduate Medical Journal · doi:10.1136/pgmj.64.757.841 · Cited by 83 · see citing works
Баранов, А. И. (1982) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(82)90055-1 · Cited by 69 · see citing works
Pieralisi, G., Ripari, P., & Vecchiet, L. (1991) · PubMed · Cited by 62 · see citing works
Effect of<i>Eleutheroccocus senticosus</i>Extract on Human Physical Working Capacity
Asano, K., Takahashi, T., Miyashita, M., Matsuzaka, A., Muramatsu, S., Kuboyama, M., Kugo, H., & Imai, J. (1986) · Planta Medica · doi:10.1055/s-2007-969114 · Cited by 53 · see citing works
Natural Products and the Athlete: Facts and Folklore
Barron, R. L., & Vanscoy, G. J. (1993) · Annals of Pharmacotherapy · doi:10.1177/106002809302700516 · Cited by 21 · see citing works
EFFECTS OF GINSENG ON REPEATED BOUTS OF EXHAUSTIVE EXERCISE
Teves, M. A., Wright, J. E., Welch, M. J., Patton, J. F., Mello, R. P., Rock, P. B., Knapik, J., Vogel, J. A., & DerMarderosian, A. H. (1983) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198315020-00350 · Cited by 16 · see citing works
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Selected herbals and human exercise performance
Bucci, L. R. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/72.2.624s · Cited by 274 · see citing works
Gagnier, J. J., Boon, H. S., Rochon, P. A., Moher, D., Barnes, J., & Bombardier, C. (2006) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2005.12.020 · Cited by 214 · see citing works
Dietary Supplements and Sports Performance: Herbals
Williams, M. H. (2006) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-3-1-1 · Cited by 158 · see citing works
Self-citationSaifeldeen, K. (2004) · Emergency Medicine Journal · doi:10.1136/emj.2003.012336 · Cited by 145 · see citing works
Evaluation of the Ergogenic Properties of Ginseng
Bahrke, M. S., & Morgan, W. P. (2000) · Sports Medicine · doi:10.2165/00007256-200029020-00004 · Cited by 124 · see citing works
Plant Adaptogens—History and Future Perspectives
Todorova, V., Ivanov, K., Delattre, C., Nalbantova, V., Karcheva-Bahchevanska, D., & Ivanova, S. (2021) · Nutrients · doi:10.3390/nu13082861 · Cited by 121 · see citing works
Ginsengs: A review of safety and efficacy
Mahady, G. B., Gyllenhaal, C., Fong, H. H. S., & Farnsworth, N. R. (2000) · Nutrition in Clinical Care · doi:10.1046/j.1523-5408.2000.00020.x · Cited by 102 · see citing works
Yoon, T. J., Yoo, Y. C., Lee, S., Shin, K., Choi, W.-H., Hwang, S.-H., Ha, E. S., Jo, S., Kim, S., & Park, W.-M. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.03.052 · Cited by 80 · see citing works
Greenway, F. L., de Jonge, L., Blanchard, D., Frisard, M. I., & Smith, S. R. (2004) · Obesity Research · doi:10.1038/oby.2004.144 · Cited by 76 · see citing works
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Varela, M. (2004) · Emergency Medicine Journal · doi:10.1136/emj.2002.002402 · Cited by 74 · see citing works
Feasibility of exercising adults with asthma: a randomized pilot study
Boyd, A. W., Yang, C. T., Estell, K., Tuggle, C., Gerald, L. B., Dransfield, M., Bamman, M. M., Bonner, J. A., Atkinson, T. P., & Schwiebert, L. M. (2012) · Allergy Asthma and Clinical Immunology · doi:10.1186/1710-1492-8-13 · Cited by 71 · see citing works
Ginseng Supplementation Does Not Enhance Healthy Young Adults’ Peak Aerobic Exercise Performance
Allen, J. D., McLung, J., Nelson, A. G., & Welsch, M. A. (1998) · Journal of the American College of Nutrition · doi:10.1080/07315724.1998.10718795 · Cited by 71 · see citing works
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Walker, A. (2004) · Emergency Medicine Journal · doi:10.1136/emj.2002.002121 · Cited by 62 · see citing works
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Kwon, O. (2004) · Emergency Medicine Journal · doi:10.1136/emj.2002.002014 · Cited by 57 · see citing works
Todorova, V., Ivanov, K., & Ivanova, S. (2021) · Plants · doi:10.3390/plants11010064 · Cited by 56 · see citing works
d’Unienville, N. M. A., Blake, H. T., Coates, A. M., Hill, A. M., Nelson, M. J., & Buckley, J. D. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-021-00472-y · Cited by 56 · see citing works
Končić, M. Z., & Tomczyk, M. (2013) · Current Drug Targets · doi:10.2174/1389450111314090016 · Cited by 53 · see citing works
Wu, F., Li, H., Zhao, L., Li, X., You, J., Jiang, Q., Li, S., Jin, L., & Xu, Y. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.05.026 · Cited by 49 · see citing works
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Donald, M. J. (2004) · Emergency Medicine Journal · doi:10.1136/emj.2003.008730 · Cited by 46 · see citing works
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Fang, J. Q., Yan, F., Kong, X., Ruan, Z., Liu, Z. Q., Huang, R., Li, T. J., Geng, M., Yang, F. J., Zhang, Y. Z., et al. (2008) · Livestock Science · doi:10.1016/j.livsci.2008.11.020 · Cited by 45 · see citing works
Lin, Q., Jin, L., Cao, Z., Lu, Y., Xue, H., & Xu, Y. (2008) · Phytotherapy Research · doi:10.1002/ptr.2341 · Cited by 41 · see citing works
Biondo, P. D., Robbins, S., Walsh, J. D., McCargar, L. J., Harber, V. J., & Field, C. J. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-080 · Cited by 40 · see citing works
Ha, E. S., Hwang, S. H., Shin, K., Yu, K., Lee, K.-H., Choi, J. S., Park, W.-M., & Yoon, T. J. (2004) · Archives of Pharmacal Research · doi:10.1007/bf02980109 · Cited by 37 · see citing works
Assessment of the Effects of Eleutherococcus Senticosus on Endurance Performance
Goulet, E. D. B., & Dionne, I. J. (2005) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.15.1.75 · Cited by 34 · see citing works
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Kuo, J. (2010) · The Chinese Journal of Physiology · doi:10.4077/cjp.2010.amk018 · Cited by 31 · see citing works
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Senchina, D. S., Shah, N. B., Doty, D. M., Sanderson, C. R., & Hallam, J. E. (2009) · PubMed · Cited by 27 · see citing works
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Taylor, D. M., Parish, D., Thompson, L., & Cavaliere, M. (2004) · Emergency Medicine Journal · doi:10.1136/emj.2002.003251 · Cited by 27 · see citing works
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Goodyear, P. W. A. (2004) · Emergency Medicine Journal · doi:10.1136/emj.2002.004051 · Cited by 26 · see citing works
Study designs of randomized controlled trials not based on Chinese medicine theory are improper
Yan, J., Engle, V. F., He, Y., Jiao, Y., & Gu, W. (2009) · Chinese Medicine · doi:10.1186/1749-8546-4-3 · Cited by 22 · see citing works
Acanthopanax senticosus inhibits nitric oxide production in murine macrophages In Vitro and In Vivo
Lin, Q., Jin, L., Ma, Y., Shi, M., & Xu, Y. (2007) · Phytotherapy Research · doi:10.1002/ptr.2171 · Cited by 22 · see citing works
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Arouca, A. B., & Kassisse, D. M. G. (2013) · Health · doi:10.4236/health.2013.59205 · Cited by 16 · see citing works
Takahashi, Y., Tanaka, M., Murai, R., Kuribayashi, K., Kobayashi, D., Yanagihara, N., & Watanabe, N. (2014) · Phytotherapy Research · doi:10.1002/ptr.5157 · Cited by 16 · see citing works
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Li, T. S. C. (2001) · HortTechnology · doi:10.21273/horttech.11.1.79 · Cited by 12 · see citing works
Patyra, A., Kołtun-Jasion, M., Kupniewska, K., Parzonko, A., & Kiss, A. K. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1683795 · Cited by 10 · see citing works
Palisin, T. E., & Stacy, J. J. (2006) · Current Sports Medicine Reports · doi:10.1097/01.csmr.0000306509.57644.71 · Cited by 10 · see citing works
Wasuntarawat, C., Pengnet, S., Walaikavinan, N., Kamkaew, N., Bualoang, T., Toskulkao, C., & McConell, G. K. (2010) · Journal of Sports Sciences · doi:10.1080/02640414.2010.506221 · Cited by 10 · see citing works
Kim, Y. H., Bae, D.-B., Lee, J. S., 박선옥, Lee, S.-J., Cho, O.-H., & Lee, O. (2013) · Journal of the Korean Society of Food Science and Nutrition · doi:10.3746/jkfn.2013.42.12.2082 · Cited by 10 · see citing works
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Schulz, V., Hänsel, R., & Tyler, V. E. (2001) · Springer eBooks · doi:10.1007/978-3-642-98093-0_9 · Cited by 9 · see citing works
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Khandelwal, S. (2004) · Emergency Medicine Journal · doi:10.1136/emj.2003.006734 · Cited by 8 · see citing works
Yoon, T. J., & Jo, S. Y. (2010) · The Korean Journal of Food And Nutrition · Cited by 8 · see citing works
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Marques, L. C. (1998) · UNIFESP Institutional Repository (Universidade Federal de São Paulo) · Cited by 8 · see citing works
Williams, M. H., & Leutholtz, B. C. (2000) · Wiley eBooks · doi:10.1002/9780470693766.ch26 · Cited by 8 · see citing works
Self-citationLee, J., Shin, Y., Bae, J.-S., Min, Y., Yang, H., Seo, H.-S., Kwon, D., Kang, J.-Y., & Song, Y. (2010) · Food Science and Biotechnology · doi:10.1007/s10068-010-0094-y · Cited by 6 · see citing works
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Burke, L. M. (2003) · Cited by 5 · see citing works
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Li, T. S. C. (2003) · Elsevier eBooks · doi:10.1533/9781855736900.38 · Cited by 4 · see citing works
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Bauer, R. (1998) · Pharmazie in unserer Zeit · doi:10.1002/pauz.19980270405 · Cited by 4 · see citing works
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Stansbury, J., Saunders, P. R., & Winston, D. H. (2012) · Journal of Restorative Medicine · doi:10.14200/jrm.2012.1.1007 · Cited by 4 · see citing works
Maldi, P. C., Alves, F. M., Alves, A. G. P., Baptista, T. J. R., & Silva, M. S. (2022) · Science & Sports · doi:10.1016/j.scispo.2021.08.011 · Cited by 3 · see citing works
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- Authors
- DOWLING, E. A., REDONDO, D. R., BRANCH, J. D., JONES, S., McNABB, G., & WILLIAMS, M. H.
- Affiliations
- Old Dominion University (US)
- ORCID
- BRANCH, J. DAVID
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 1996-04
- Volume
- 28
- Issue
- 4
- Pages
- 482-489
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W2003522862
- Cited by
- 78
- References
- 11
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 7 · 2012: 2
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Medicinal Plants and Bioactive Compounds
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- Eleutherococcus senticosus, Siberian ginseng, ergogenic aids, endurance performance, submaximal aerobic exercise, maximal aerobic exercise, long-distance runners, oxygen consumption, heart rate, respiratory exchange ratio, rating of perceived exertion, serum lactate, time to exhaustion, herbal supplementation
- MeSH terms
- Adult, Double-Blind Method, Female, Panax, Heart Rate, Humans, Male, Oxygen Consumption, Physical Fitness, Plants, Medicinal, Respiration, Running, Exercise
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