Effect of Lactobacillus Plantarum TWK10 on Improving Endurance Performance in Humans
Abstract
Microbiota is currently an important issue in disease and health and many studies have revealed it to play an important role in physiological homeostasis and health promotion. Lactobacillus plantarum (L. plantarum), isolated from Taiwan pickled vegetables, is a well-known probiotic microorganism. In a recent animal study, it was shown that supplementation of mice with L. plantarum TWK10 (TWK10) could increase muscle mass, improve exercise performance and exert anti-fatigue effects. In order to examine the ergogenic effect of TWK10 supplementation on endurance performance in humans, we conducted a human double-blind placebo-controlled clinical study. A total of sixteen adult subjects over 20 years of age were recruited and randomly allocated to the placebo or TWK10 group (n = 8 each). The TWK10 group received 6 weeks of supplementation. Physiological assessments were conducted by exhaustive treadmill exercise measurements and related biochemical indexes. After 6 weeks of supplementation, levels of lactic acid, blood ammonia, blood glucose, free fatty acid (FFA) and creatine kinase (CK) were evaluated during exhaustive exercise. We were able to show that the TWK10 group had significantly higher endurance performance and glucose content in a maximal treadmill running test compared to the placebo group (P < 0.05), suggesting that TWK10 supplementation may be beneficial to energy harvest. Taken together, our results suggest that TWK10 has the potential to be an aerobic exercise supplement for physiological adaptation or an ergogenic supplement with health benefits for amateur runners.
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In a six-week human double-blind placebo-controlled study, young healthy amateur runners supplemented with L. plantarum TWK10 had significantly higher endurance performance and glucose content in a maximal treadmill running test compared to placebo.
“The TWK10 group had significantly higher endurance performance and glucose content in a maximal treadmill running test compared to the placebo group (P < 0.05), indicating that TWK10 supplementation may be beneficial to energy harvest.”
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- Authors
- Huang, W.-C.
- Affiliations
- National Taipei University of Nursing and Health Science (TW)
- Corresponding author
- Huang, Wen-Ching
- ORCID
- Huang, Wen-Ching
- Venue
- The Chinese Journal of Physiology
- Publisher
- Medknow
- Published
- 2018-06-30
- Volume
- 61
- Issue
- 3
- Pages
- 163-170
- ISSN
- 0304-4920 (ISSN-L)
- OpenAlex
- W2883451797
- Cited by
- 78
- References
- 0
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 13 · 2023: 9 · 2022: 10 · 2021: 8 · 2020: 8 · 2019: 10 · 2018: 2
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Chinese Journal of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology, Taiwan (MOST106-2410-H227-007, NSC102-2628-B179-001-MY3)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- probiotics, endurance performance, ergogenic aids, lactic acid, blood glucose, creatine kinase, free fatty acids, blood ammonia, energy metabolism
- MeSH terms
- Adult, Ammonia, Blood Glucose, Creatine Kinase, Double-Blind Method, Energy Metabolism, Exercise Test, Fatty Acids, Nonesterified, Humans, Male, Physical Endurance, Taiwan, Time Factors, Biomarkers, Muscle, Skeletal, Muscle Fatigue, Lactic Acid, Probiotics, Lactiplantibacillus plantarum, Young Adult, Microbiota
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