Cited by 110Attention Deficit Hyperactivity DisorderSubstance Abuse Treatment and OutcomesNeuroethics, Human Enhancement, Biomedical Innovations

The Effect of Stimulant Treatment for ADHD on Later Substance Abuse and the Potential for Medication Misuse, Abuse, and Diversion

Faraone, Stephen V., Upadhyaya, Himanshu P.·2007·The Journal of Clinical Psychiatry

Abstract

This CME activity is expired. For more CME activities, visit CMEInstitute.com. Find more articles on this and other psychiatry and CNS topics: The Journal of Clinical Psychiatry The Primary Care Companion for CNS Disorders Article AbstractAttention-deficit/hyperactivity disorder (ADHD) is known tobe a strong risk factor for substance use disorders (SUD) in adolescence and inadulthood. Research shows that stimulant treatment does not increase the riskof SUD in adolescents or adults with ADHD but rather that stimulant treatmentsmay have a protective effect. However, 2 in 10 youths with ADHD misuse theirmedication. Recent evidence suggests that slow uptake of medication in thebrain allows for effective treatment without patients experiencing the euphoricqualities of immediate-release agents that lead to abuse or diversion. As aresult, extended-release products and different formulations, such aslisdexamfetamine dimesylate (LDX), are less likely to be misused and divertedand may have lower abuse potential. This CME activity is expired. For more CME activities, visit cme.psychiatrist.com. Find more articles on this and other psychiatry and CNS topics: The Journal of Clinical Psychiatry The Primary Care Companion for CNS Disorders

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Crossref · 10.4088/jcp.1107e28

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  • The literature supports the view that stimulant treatment for ADHD either has no impact on risk for substance abuse, or may even lower the risk of substance abuse by reducing the early onset of substance abuse in adolescents.

    “Despite concerns that pharmacotherapy with stimulant medication may be a risk factor for substance abuse, the literature supports the view that stimulant treatment for ADHD either has no impact in risk for substance abuse, or may even lower the risk of substance abuse by reducing the early onset of substance abuse in adolescents [206,254,257-259].”

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Authors
Faraone, S. V., & Upadhyaya, H. P.
Affiliations
Massachusetts General Hospital (US)
Venue
The Journal of Clinical Psychiatry
Published
2007-11-15
Volume
68
Issue
11
Pages
e28
ISSN
0160-6689 (ISSN-L)
OpenAlex
W2073345301
Cited by
110
References
0
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 8 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 8 · 2012: 15
FWCI
5.23
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroethics, Human Enhancement, Biomedical Innovations
Keywords
attention deficit hyperactivity disorder, stimulant medication, substance use disorders, medication misuse, drug diversion, sustained-release formulation, lisdexamfetamine dimesylate, abuse liability, adolescents, adults
MeSH terms
Lisdexamfetamine Dimesylate, Adolescent, Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Brain, Delayed-Action Preparations, Dextroamphetamine, Humans, Psychotropic Drugs, Risk Factors, Time Factors, Substance-Related Disorders

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