Lisdexamfetamine dimesylate: the first long-acting prodrug stimulant treatment for attention deficit/hyperactivity disorder

Diagnostic and Statistical Manual of Mental Disorders

Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works

The Prevalence and Correlates of Adult ADHD in the United States: Results From the National Comorbidity Survey Replication

Kessler, R. C., Adler, L., Barkley, R., Biederman, J., Conners, C. K., Demler, O., Faraone, S. V., Greenhill, L. L., Howes, M. J., Secnik, K., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.4.716 · Cited by 3,886 · see citing works

Attention-deficit hyperactivity disorder

Biederman, J., & Faraone, S. V. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66915-2 · Cited by 1,463 · see citing works

Does stimulant therapy of attention-deficit/hyperactivity disorder beget later substance abuse? A meta-analytic review of the literature

Wilens, T. E., Faraone, S. V., Biederman, J., & Gunawardene, S. (2003) · Pediatrics · doi:10.1542/peds.111.1.179 · Cited by 872 · see citing works

Neuropsychopharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder: a review and integration

Solanto, M. V. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00175-7 · Cited by 677 · see citing works

Clinical practice guideline: treatment of the school-aged child with attention-deficit/hyperactivity disorder.

Attention-Deficit, S. O., & Disorder, H. (2001) · Pediatrics · doi:10.1542/peds.108.4.1033 · Cited by 636 · see citing works

Functional Impairments in Adults With Self-Reports of Diagnosed ADHD: A Controlled Study of 1001 Adults in the Community

Biederman, J., Faraone, S. V., Spencer, T. J., Mick, E., Monuteaux, M. C., & Aleardi, M. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0403 · Cited by 565 · see citing works

What Is the Prevalence of Adult ADHD? Results of a Population Screen of 966 Adults

Faraone, S. V., & Biederman, J. (2005) · Journal of Attention Disorders · doi:10.1177/1087054705281478 · Cited by 503 · see citing works

Variables That Affect the Clinical Use and Abuse of Methylphenidate in the Treatment of ADHD

Volkow, N. D., & Swanson, J. M. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.11.1909 · Cited by 475 · see citing works

Efficacy and tolerability of lisdexamfetamine dimesylate (NRP-104) in children with attention-deficit/hyperactivity disorder: A Phase III, multicenter, randomized, double-blind, forced-dose, parallel-group study

Biederman, J., Krishnan, S., Zhang, Y., McGough, J. J., & Findling, R. L. (2007) · Clinical Therapeutics · doi:10.1016/s0149-2918(07)80083-x · Cited by 404 · see citing works

Lisdexamfetamine Dimesylate and Mixed Amphetamine Salts Extended-Release in Children with ADHD: A Double-Blind, Placebo-Controlled, Crossover Analog Classroom Study

Biederman, J., Boellner, S. W., Childress, A., Lopez, F. A., Krishnan, S., & Zhang, Y. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.04.015 · Cited by 356 · see citing works

Clinical and Diagnostic Implications of Lifetime Attention-Deficit/Hyperactivity Disorder Comorbidity in Adults with Bipolar Disorder: Data from the First 1000 STEP-BD Participants

Nierenberg, A. A., Miyahara, S., Spencer, T., Wisniewski, S. R., Otto, M. W., Simon, N. M., Pollack, M. H., Ostacher, M. J., Yan, L. J., Siegel, R. S., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.036 · Cited by 283 · see citing works

The neuropsychopharmacology of attention-deficit/hyperactivity disorder

Pliszka, S. R. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.026 · Cited by 276 · see citing works

Development of a New Once-a-Day Formulation of Methylphenidate for the Treatment of Attention-deficit/Hyperactivity Disorder: Proof-of-Concept and Proof-of-Product Studies

Swanson, J., Gupta, S., Lam, A., Shoulson, I., Lerner, M., Modi, N., Lindemulder, E., & Wigal, S. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.2.204 · Cited by 248 · see citing works

Comparing the efficacy of medications for ADHD using meta-analysis.

(2006) · PubMed Central · Cited by 230 · see citing works

PET Study Examining Pharmacokinetics, Detection and Likeability, and Dopamine Transporter Receptor Occupancy of Short- and Long-Acting Oral Methylphenidate

Spencer, T. J., Biederman, J., E. Ciccone, P., Madras, B. K., Dougherty, D. D., Bonab, A. A., Livni, E., Parasrampuria, D. A., & Fischman, A. J. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.3.387 · Cited by 206 · see citing works

The Effect of Stimulant Treatment for ADHD on Later Substance Abuse and the Potential for Medication Misuse, Abuse, and Diversion

Faraone, S. V., & Upadhyaya, H. P. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.1107e28 · Cited by 110 · see citing works

A Randomized, Double-Blind, Placebo-Controlled, Laboratory Classroom Assessment of Methylphenidate Transdermal System in Children With ADHD

McGough, J. J., Wigal, S. B., Abikoff, H., Turnbow, J. M., Posner, K., & Moon, E. (2006) · Journal of Attention Disorders · doi:10.1177/1087054705284089 · Cited by 103 · see citing works

Human pharmacology of intravenous lisdexamfetamine dimesylate: abuse liability in adult stimulant abusers

Jasinski, D., & Krishnan, S. (2009) · Journal of Psychopharmacology · doi:10.1177/0269881108093841 · Cited by 100 · see citing works

Pharmacokinetics of SLI381 (ADDERALL XR), an Extended-Release Formulation of Adderall

McGough, J. J., Biederman, J., Greenhill, L. L., McCracken, J. T., Spencer, T. J., Posner, K., Wigal, S. B., GORNBEIN, J. A., Tulloch, S. J., & Swanson, J. M. (2003) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000046850.56865.cb · Cited by 80 · see citing works

Relative Bioavailability of Lisdexamfetamine 70‐mg Capsules in Fasted and Fed Healthy Adult Volunteers and in Solution: A Single‐Dose, Crossover Pharmacokinetic Study

Krishnan, S., & Zhang, Y. (2008) · The Journal of Clinical Pharmacology · doi:10.1177/0091270007310381 · Cited by 73 · see citing works

New Formulations of Stimulants for Attention-Deficit Hyperactivity Disorder

Connor, D. F., & Steingard, R. J. (2004) · CNS Drugs · doi:10.2165/00023210-200418140-00005 · Cited by 71 · see citing works

Long-Term Effects of Methylphenidate Transdermal Delivery System Treatment of ADHD on Growth

FARAONE, S. V., & GIEFER, E. E. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31806ad1d7 · Cited by 55 · see citing works

Lisdexamfetamine

Blick, S. K. A., & Keating, G. M. (2007) · Pediatric Drugs · doi:10.2165/00148581-200709020-00007 · Cited by 50 · see citing works

Attention deficit hyperactivity disorder: guidelines for investigating efficacy of pharmacological intervention

Buitelaar, J. K., Montgomery, S. A., & Zwieten-Boot, B. J. V. (2003) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(03)00047-6 · Cited by 25 · see citing works

History and current perspectives on the use of drug formulations to decrease the abuse of prescription drugs

Schuster, C. R. (2006) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2006.01.006 · Cited by 23 · see citing works

Abuse Liability Of Intravenous Lisdexamfetamine Dimesylate [LDX; NRP104]

Jasinski, D. R., Krishnan, S. M., & Kehner, G. B. (2006) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-200610000-00058 · Cited by 8 · see citing works

Welcome progress in the diagnosis and treatment of ADHD in adolescence

Baren, M., & Stein, M. A. (2003) · Contemporary pediatrics · Cited by 8 · see citing works

Improvements in Symptoms of Attention-Deficit/Hyperactivity Disorder in School-Aged Children with Lisdexamfetamine Dimesylate [LDX; NRP104] and Mixed Amphetamine Salts Extended-Release vs. Placebo

Biederman, J., Boellner, S. W., Childress, A. C., López, F. A., Krishnan, S. M., & Mandler, H. D. (2006) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-200610000-00056 · Cited by 5 · see citing works

Attention‐Deficit‐Hyperactivity Disorder: An Update

Dopheide, J. A., & Pliszka, S. R. (2009) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.29.6.656 · Cited by 645 · see citing works

A Review of the Pathophysiology, Etiology, and Treatment of Attention-Deficit Hyperactivity Disorder (ADHD)

Sharma, A., & Couture, J. (2014) · Annals of Pharmacotherapy · doi:10.1177/1060028013510699 · Cited by 516 · see citing works

Attention deficit hyperactivity disorder in adults

Rösler, M., Casas, M., Konofal, É., & Buitelaar, J. K. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.483249 · Cited by 140 · see citing works

Randomized, double-blind, placebo-controlled, crossover study of the efficacy and safety of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder: novel findings using a simulated adult workplace environment design

Wigal, T., Brams, M., Gasior, M., Gao, J., Squires, L., Giblin, J., & 316 Study Group (2010) · Behavioral and Brain Functions · doi:10.1186/1744-9081-6-34 · Cited by 136 · see citing works

A 13-hour laboratory school study of lisdexamfetamine dimesylate in school-aged children with attention-deficit/hyperactivity disorder

the 311 Study Group, Wigal, S. B., Kollins, S. H., Childress, A. C., & Squires, L. (2009) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/1753-2000-3-17 · Cited by 112 · see citing works

Pharmacokinetics of lisdexamfetamine dimesylate and its active metabolite, d-amphetamine, with increasing oral doses of lisdexamfetamine dimesylate in children with attention-deficit/hyperactivity disorder: A single-dose, randomized, open-label, crossover study

Boellner, S. W., Stark, J. G., Krishnan, S., & Zhang, Y. (2010) · Clinical Therapeutics · doi:10.1016/j.clinthera.2010.02.011 · Cited by 72 · see citing works

Diagnosing and treating attention‐deficit/hyperactivity disorder in adults

Faraone, S. V., & Antshel, K. M. (2008) · World Psychiatry · doi:10.1002/j.2051-5545.2008.tb00179.x · Cited by 66 · see citing works

Pharmacological Treatment of ADHD in Addicted Patients: What Does the Literature Tell Us?

Carpentier, P., & Levin, F. (2017) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000122 · Cited by 46 · see citing works

Guanfacine Extended Release: A Novel Treatment for Attention-Deficit/Hyperactivity Disorder in Children and Adolescents

Faraone, S. V., McBurnett, K., Sallee, F. R., Steeber, J., & López, F. A. (2013) · Clinical Therapeutics · doi:10.1016/j.clinthera.2013.09.005 · Cited by 44 · see citing works

Effects of Lisdexamfetamine Dimesylate Treatment for ADHD on Growth

Faraone, S. V., Spencer, T. J., Kollins, S. H., & Glatt, S. J. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-201001000-00006 · Cited by 39 · see citing works

Lisdexamfetamine Dimesylate: A Review in Paediatric ADHD

Frampton, J. E. (2018) · Drugs · doi:10.1007/s40265-018-0936-0 · Cited by 34 · see citing works

Understanding the Effect Size of Lisdexamfetamine Dimesylate for Treating ADHD in Children and Adults

Faraone, S. V. (2010) · Journal of Attention Disorders · doi:10.1177/1087054710379738 · Cited by 32 · see citing works

Duration of effect of oral long-acting stimulant medications for ADHD throughout the day

Brams, M., Moon, E., Pucci, M., & López, F. A. (2010) · Current Medical Research and Opinion · doi:10.1185/03007995.2010.488553 · Cited by 30 · see citing works

Exploratory meta-analysis on lisdexamfetamine versus placebo in adult ADHD

Maneeton, B., Maneeton, N., Suttajit, S., Reungyos, J., Srisurapanont, M., & Martin, S. (2014) · Drug Design, Development and Therapy · doi:10.2147/dddt.s68393 · Cited by 27 · see citing works

ADHD with comorbid substance use disorder: review of treatment

Magon, R., & Müller, U. (2012) · Advances in Psychiatric Treatment · doi:10.1192/apt.bp.111.009340 · Cited by 27 · see citing works

Long-term treatment outcomes with lisdexamfetamine dimesylate for adults with attention-deficit/hyperactivity disorder stratified by baseline severity

Ginsberg, L., Katic, A., Adeyi, B., Dirks, B., Babcock, T., Lasser, R., Scheckner, B., & Adler, L. A. (2011) · Current Medical Research and Opinion · doi:10.1185/03007995.2011.567256 · Cited by 26 · see citing works

Efficacy and tolerability of lisdexamfetamine dimesylate in children with attention-deficit/hyperactivity disorder: sex and age effects and effect size across the day

Wigal, S. B., Kollins, S. H., Childress, A. C., & Adeyi, B. (2010) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/1753-2000-4-32 · Cited by 23 · see citing works

Effects of Lisdexamfetamine Dimesylate Treatment for ADHD on Growth

Faraone, S. V., Spencer, T. J., Kollins, S. H., & Glatt, S. J. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2009.10.003 · Cited by 13 · see citing works

Lisdexamfetamine Dimesylate: In Attention-Deficit Hyperactivity Disorder in Adults

Weber, J., & Siddiqui, M. A. A. (2009) · CNS Drugs · doi:10.2165/00023210-200923050-00005 · Cited by 13 · see citing works

Physicochemical Property Trends of Marketed Prodrugs

Landis, M. S. (2013) · Therapeutic Delivery · doi:10.4155/tde.12.150 · Cited by 11 · see citing works

The rationality for using prodrug approach in drug discovery programs for new xenobiotics: opportunities and challenges

Srinivas, N. R. (2011) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-011-0035-z · Cited by 11 · see citing works

Dose Response Effects of Lisdexamfetamine Dimesylate Treatment in Adults With ADHD

Faraone, S. V., Spencer, T. J., Kollins, S. H., Glatt, S. J., & Goodman, D. (2011) · Journal of Attention Disorders · doi:10.1177/1087054711403716 · Cited by 9 · see citing works

Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung im Erwachsenenalter

Krause, J. (2009) · Psychiatrie und Psychotherapie · doi:10.1007/s11326-009-0050-8 · Cited by 7 · see citing works

Attention Deficit Hyperactivity Disorder

Greydanus, D. E. (2011) · Springer eBooks · doi:10.1007/978-94-007-0627-9_8 · Cited by 3 · see citing works

Treatment

Kooij, J. J. S. (2021) · Springer eBooks · doi:10.1007/978-3-030-82812-7_4 · Cited by 2 · see citing works

Treatment

Kooij, J. J. S. (2012) · Springer eBooks · doi:10.1007/978-1-4471-4138-9_4 · Cited by 1 · see citing works

ADHD

Carpentier, P. J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3375-0_22 · Cited by 1 · see citing works

Central Nervous System Stimulants

Vardanyan, R., & Hruby, V. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-411492-0.00008-0 · Cited by 1 · see citing works

crossover study of the efficacy and safety of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder: novel findings using a simulated adult workplace environment design

Wigal, T. L., Brams, M. N., Gasior, M., Gao, J., Squires, L. A., & Giblin, J. M. (2010)

Efeitos da sibutramina e do metilfenidato em modelo animal do Transtorno do Déficit de Atenção e Hiperatividade (TDAH) induzido em camundongos por etanol no período pós-natal

Bertaglia, E. B. (2017) · doi:10.11606/d.10.2017.tde-22062017-121424

Current awareness in human psychopharmacology

(2008) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.971

Identification, Synthesis, and Control Strategy of Process-Related Impurities in the Development and Manufacturing of Bis-Boc-Lisdexamfetamine

Pakhurde, A. H., Haldankar, S., More, P. S., Gole, P. L., Bhatt, J. G., Patil, P. S., Kishore, D. V. P., Lad, N. P., & Kotharkar, S. A. (2025) · Russian Journal of General Chemistry · doi:10.1134/s1070363225605010

Central nervous system stimulants

Vardanyan, R., & Vardanyan, G. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33869-4.00010-7

Lisdexamfetamine Dimesylate: In Attention-Deficit Hyperactivity Disorder in Adults

Weber, J., & Siddiqui, M. A. A. (2009) · CNS Drugs · doi:10.2165/00023210-200923050-00005 · Cited by 13 · see citing works

REVIEW ARTICLE

(2016)

Lisdexamfetamine: A Prodrug Stimulant for ADHD

Howland, R. H. (2008) · Journal of Psychosocial Nursing and Mental Health Services · doi:10.3928/02793695-20080801-05 · Cited by 7 · see citing works

Lisdexamfetamine dimesylate: the first prodrug stimulant.

(2007) · PubMed Central · Cited by 24 · see citing works

Lisdexamfetamine in the treatment of adolescents and children with attention-deficit/hyperactivity disorder

Najib, J. (2012) · Adolescent Health, Medicine and Therapeutics · doi:10.2147/ahmt.s19815 · Cited by 8 · see citing works