Cited by 73Physical Activity and HealthCardiovascular and exercise physiologyCardiac Health and Mental Health

Associations of Leisure-Time and Occupational Physical Activity and Cardiorespiratory Fitness With Incident and Recurrent Major Depressive Disorder, Depressive Symptoms, and Incident Anxiety in a General Population

Baumeister, Sebastian E., Leitzmann, Michael F., Bahls, Martin, Dörr, Marcus, Schmid, Daniela, Schomerus, Georg, Appel, Katja, Markus, Marcello R. P. +3 more·2017·The Journal of Clinical Psychiatry

Abstract

OBJECTIVE: Physical activity and cardiorespiratory fitness may help prevent depression and anxiety. Previous studies have been limited by error-prone measurements. We examined whether self-reported physical activity domains and peak exercise capacity (peakVO₂) are associated with incident and recurrent major depressive disorder (MDD), depressive symptoms, and anxiety disorders. METHODS: This was a prospective population-based study of 1,080 adult men and women (25-83 years) with a median follow-up of 4.5 years and measures of physical activity during leisure time, sports, and work (Baecke questionnaire); a measure of depressive symptoms (Beck Depression Inventory II); symptom-limited cycle ergometer testing (peakVO₂, oxygen uptake at anaerobic threshold [VO₂@AT], maximum power output at peak exertion); and a structured psychiatric interview (Munich Composite International Diagnostic Interview). Baseline data were collected between 2002 and 2006, and follow-up data, between 2007 and 2010. RESULTS: After adjustment for age, sex, education, smoking, alcohol consumption, and waist circumference, the relative risks for incident MDD per standard deviation (SD) increase in leisure-time physical activity, physical activity during sport, physical activity at work, peakVO₂, VO₂@AT, and maximum power output were 1.002 (95% confidence interval, 0.90 to 1.12), 1.02 (0.90 to 1.15), 0.94 (0.80 to 1.10), 0.71 (0.52 to 0.98), 0.83 (0.66 to 1.04), and 0.71 (0.52 to 0.96), respectively. PeakVO₂, VO₂@AT, and maximum power output were associated with recurrent MDD, depressive symptoms, and anxiety. PeakVO₂ was more strongly related to the co-occurrence of MDD and anxiety (adjusted odds ratio [OR] = 0.45 [0.24 to 0.84]) than depression or anxiety alone (OR = 0.71 [0.53 to 0.94]). CONCLUSIONS: Greater cardiorespiratory fitness but not domain-specific physical activity was associated with a lower incidence of MDD and clinical anxiety.

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Crossref · 10.4088/jcp.15m10474

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Authors
Baumeister, S. E., Leitzmann, M. F., Bahls, M., Dörr, M., Schmid, D., Schomerus, G., Appel, K., Markus, M. R. P., Völzke, H., Gläser, S., & Grabe, H.-J.
Affiliations
  • Universitätsmedizin Greifswald (DE)
  • University of Regensburg (DE)
Venue
The Journal of Clinical Psychiatry
Published
2017-01-25
Volume
78
Issue
01
Pages
e41-e47
ISSN
0160-6689 (ISSN-L)
OpenAlex
W2582238443
Cited by
72
References
0
Citations by year
2026: 7 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 19 · 2020: 8 · 2019: 10 · 2018: 2 · 2015: 1
FWCI
4.04
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords
major depressive disorder, depressive symptoms, anxiety disorders, cardiorespiratory fitness, peak oxygen uptake, peak exercise capacity, leisure-time physical activity, occupational physical activity, sports participation, depression recurrence, comorbid depression and anxiety, Baecke questionnaire, cycle ergometry, peak power, depression prevention, general adult population
MeSH terms
Cardiorespiratory Fitness, Adult, Aged, Anxiety Disorders, Depression, Major Depressive Disorder, Female, Germany, Health Surveys, Humans, Leisure Activities, Male, Middle Aged, Occupations, Prospective Studies, Recurrence, Statistics as Topic, Cohort Studies, Exercise, Incidence, Young Adult

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