Associations of Leisure-Time and Occupational Physical Activity and Cardiorespiratory Fitness With Incident and Recurrent Major Depressive Disorder, Depressive Symptoms, and Incident Anxiety in a General Population
Abstract
OBJECTIVE: Physical activity and cardiorespiratory fitness may help prevent depression and anxiety. Previous studies have been limited by error-prone measurements. We examined whether self-reported physical activity domains and peak exercise capacity (peakVO₂) are associated with incident and recurrent major depressive disorder (MDD), depressive symptoms, and anxiety disorders. METHODS: This was a prospective population-based study of 1,080 adult men and women (25-83 years) with a median follow-up of 4.5 years and measures of physical activity during leisure time, sports, and work (Baecke questionnaire); a measure of depressive symptoms (Beck Depression Inventory II); symptom-limited cycle ergometer testing (peakVO₂, oxygen uptake at anaerobic threshold [VO₂@AT], maximum power output at peak exertion); and a structured psychiatric interview (Munich Composite International Diagnostic Interview). Baseline data were collected between 2002 and 2006, and follow-up data, between 2007 and 2010. RESULTS: After adjustment for age, sex, education, smoking, alcohol consumption, and waist circumference, the relative risks for incident MDD per standard deviation (SD) increase in leisure-time physical activity, physical activity during sport, physical activity at work, peakVO₂, VO₂@AT, and maximum power output were 1.002 (95% confidence interval, 0.90 to 1.12), 1.02 (0.90 to 1.15), 0.94 (0.80 to 1.10), 0.71 (0.52 to 0.98), 0.83 (0.66 to 1.04), and 0.71 (0.52 to 0.96), respectively. PeakVO₂, VO₂@AT, and maximum power output were associated with recurrent MDD, depressive symptoms, and anxiety. PeakVO₂ was more strongly related to the co-occurrence of MDD and anxiety (adjusted odds ratio [OR] = 0.45 [0.24 to 0.84]) than depression or anxiety alone (OR = 0.71 [0.53 to 0.94]). CONCLUSIONS: Greater cardiorespiratory fitness but not domain-specific physical activity was associated with a lower incidence of MDD and clinical anxiety.
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Several studies of the general population have found that people who engage in more physical activity have a reduced risk of being diagnosed with an anxiety disorder and less frequent and severe anxiety symptoms.
“Several studies of the general population have found that people who engage in more PA have a reduced risk of being diagnosed with an anxiety disorder and less frequent and severe anxiety symptoms [47–52].”
From Moving to Beat Anxiety: Epidemiology and Therapeutic Issues with Physical Activity for Anxiety (2018) · cites this paper as [47]
People who are more physically active may be less likely to have anxiety disorders.
“Recent epidemiological data further suggests that people who are more active may be less likely to have anxiety disorders.”
From Moving to Beat Anxiety: Epidemiology and Therapeutic Issues with Physical Activity for Anxiety (2018) · cites this paper as [47]
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- Authors
- Baumeister, S. E., Leitzmann, M. F., Bahls, M., Dörr, M., Schmid, D., Schomerus, G., Appel, K., Markus, M. R. P., Völzke, H., Gläser, S., & Grabe, H.-J.
- Affiliations
- Universitätsmedizin Greifswald (DE)
- University of Regensburg (DE)
- ORCID
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2017-01-25
- Volume
- 78
- Issue
- 01
- Pages
- e41-e47
- ISSN
- 0160-6689 (ISSN-L)
- OpenAlex
- W2582238443
- Cited by
- 72
- References
- 0
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 19 · 2020: 8 · 2019: 10 · 2018: 2 · 2015: 1
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- major depressive disorder, depressive symptoms, anxiety disorders, cardiorespiratory fitness, peak oxygen uptake, peak exercise capacity, leisure-time physical activity, occupational physical activity, sports participation, depression recurrence, comorbid depression and anxiety, Baecke questionnaire, cycle ergometry, peak power, depression prevention, general adult population
- MeSH terms
- Cardiorespiratory Fitness, Adult, Aged, Anxiety Disorders, Depression, Major Depressive Disorder, Female, Germany, Health Surveys, Humans, Leisure Activities, Male, Middle Aged, Occupations, Prospective Studies, Recurrence, Statistics as Topic, Cohort Studies, Exercise, Incidence, Young Adult
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