Cited by 121Suicide and Self-Harm StudiesAutism Spectrum Disorder ResearchChild Nutrition and Feeding Issues

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Risk of Suicide Attempts Among Adolescents and Young Adults With Autism Spectrum Disorder: A Nationwide Longitudinal Follow-Up Study

Chen, Mu-Hong, Pan, Tai-Long, Lan, Wen-Hsuan, Hsu, Ju-Wei, Huang, Kai-Lin, Su, Tung-Ping, Li, Cheng-Ta, Lin, Wei-Chen, Wei, Han-Ting, Chen, Tzeng-Ji, Bai, Ya-Mei·2017·The Journal of Clinical Psychiatry

DOI 10.4088/jcp.16m11100

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Abstract

BACKGROUND: Previous studies reported a high prevalence of depression among patients with autism spectrum disorder (ASD) and suggested a relationship between ASD and suicidality. However, whether ASD independently increases the risk of attempted suicide regardless of depression has not been determined. METHODS: Using the Taiwan National Health Insurance Research Database, 5,618 adolescents aged 12-17 years and young adults aged 18-29 years with ASD (ICD-9-CM code: 299) and 22,472 age- and sex-matched controls were enrolled between 2001 and 2009 and followed to the end of 2011. Any suicide attempt was identified during the follow-up period. RESULTS: Patients with ASD had a higher incidence of suicide attempts (3.9% vs 0.7%, P < .001) than did those without ASD. Both adolescents (HR = 5.79; 95% CI, 3.98-8.41) and young adults (HR = 5.38; 95% CI, 3.58-8.06) with ASD were more likely to attempt suicide in later life after adjusting for demographic data and psychiatric comorbidities. Sensitivity analyses after excluding the first year (HR = 4.52; 95% CI, 3.39-6.03) or first 3 years (HR = 3.36; 95% CI, 2.40-4.70) of observation showed consistent findings. CONCLUSIONS: Patients with ASD had an increased risk of suicide attempts compared with those without ASD. ASD was an independent risk factor of attempted suicide. Further studies are needed to clarify the underlying pathophysiology between ASD and suicidality and to elucidate whether prompt intervention for ASD may reduce this risk.

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Authors: Chen, M.-H., Pan, T.-L., Lan, W.-H., Hsu, J.-W., Huang, K.-L., Su, T.-P., Li, C.-T., Lin, W.-C., Wei, H.-T., Chen, T.-J., & Bai, Y.-M.
Affiliations: Taipei Veterans General Hospital (TW)
Chang Gung University (TW)
ORCID: Chen, Mu-Hong
Pan, Tai-Long
Huang, Kai-Lin
Su, Tung-Ping
Li, Cheng-Ta
Chen, Tzeng-Ji
Bai, Ya-Mei
Venue: The Journal of Clinical Psychiatry
Publisher: Physicians Postgraduate Press, Inc
Published: 2017-12-27
Volume: 78
Issue: 9
Pages: e1174-e1179
ISSN: 0160-6689 (ISSN-L)
DOI: 10.4088/jcp.16m11100
OpenAlex: W2747034110
Cited by: 121
References: 0
Citations by year: 2026: 8 · 2025: 18 · 2024: 18 · 2023: 13 · 2022: 16 · 2021: 16 · 2020: 15 · 2019: 14 · 2018: 3
FWCI: 10.85
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Keywords: autism spectrum disorder, suicide attempts, suicidality, adolescents, young adults, depression, psychiatric comorbidity, risk factors
MeSH terms: Autism Spectrum Disorder, Adolescent, Adult, Child, Follow-Up Studies, Humans, Longitudinal Studies, Risk Factors, Suicide, Attempted, Taiwan, Case-Control Studies, Young Adult

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Risk of Suicide Attempts Among Adolescents and Young Adults With Autism Spectrum Disorder: A Nationwide Longitudinal Follow-Up Study

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