Cited by 211Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesDementia and Cognitive Impairment Research

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Cognitive Impairment in Patients With Depression: Awareness, Assessment, and Management: (Academic Highlights)

Culpepper, Larry, Lam, Raymond W., McIntyre, Roger S.·2017·The Journal of Clinical Psychiatry

DOI 10.4088/jcp.tk16043ah5c

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Abstract

Article Abstract †‹†‹ Click to enlarge page Cognitive impairment is a common, often persistent, symptom of major depressive disorder (MDD) that is disproportionately represented in patients who have not returned to full psychosocial functioning. The ultimate goal of treatment in depression is full functional recovery, and assessing patients for cognitive impairment and selecting treatments that address cognitive dysfunction should lead to improved functional outcomes. Unfortunately, many clinicians use screening and assessment tools that are not suited for measuring cognitive impairment in patients with depression. The new THINC-it assessment tool is the first instrument that provides objective and subjective data on dysfunction in all the cognitive domains commonly affected by depression. In regard to treatment, several pharmacologic and nonpharmacologic interventions have been investigated as treatments for cognitive dysfunction in individuals with MDD. However very few studies of treatments for cognitive function in patients with MDD have been adequate, in terms of sample size and study methods, to guide clinical practice. The best evidence supports the moderate efficacy of some antidepressants, cognitive-behavioral therapy, and exercise. From the Department of Family Medicine, Boston University, Massachusetts (Dr Culpepper); the Department of Mood and Anxiety Disorders, The University of British Columbia, Vancouver, Canada (Dr Lam); and the Mood Disorders Psychopharmacology Unit, University of Toronto, Ontario, Canada (Dr McIntyre). †‹†‹†‹†‹

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Szyszkowska, J., & Bala, A. (2023) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2023.05.351 · Cited by 11
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Post-mortem MRI-based volumetry of the hippocampus in forensic cases of decedents with severe mental illness
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Olivola, M., Mazzoni, F., Tarantino, B., Guffanti, A., Marcatili, M., Macellaro, M., Girone, N., Martiadis, V., Raffone, F., Prodi, T., et al. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1736114 · Cited by 10
Cognitive Screening and Hearing Assessment in Patients With Chronic Tinnitus
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Bidirectional Association between Sarcopenia and Depressive Symptoms among Chinese Middle- and Older-Aged Adults: Longitudinal Observational Study
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An overview of major depression disorder: The endocannabinoid system as a potential target for therapy
Zarazúa, S., Vicente-Martínez, J. G., Pinos‐Rodríguez, J. M., & Arévalo-Villalobos, J. I. (2024) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.14089 · Cited by 7
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“Major depressive disorder (MDD) is a severe mental illness that re-sults in disabilities in numerous aspects of psychosocial functioning (Culpepper et al., 2017).”
Neurocognitive outcomes of HIV-associated tuberculous meningitis
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Complex executive functions assessed by the trail making test (TMT) part B improve more than those assessed by the TMT part A or digit span backward task during vagus nerve stimulation in patients with drug-resistant epilepsy
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Cognitive function in physically healthy, unmedicated individuals with major depression: Relationship with depressive symptoms and antidepressant response
Ou, A., Wu, G. W. Y., Kassel, M. T., Mackin, R. S., Rampersaud, R., Reus, V. I., Mellon, S. H., & Wolkowitz, O. M. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.02.115 · Cited by 6
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Authors: Culpepper, L., Lam, R. W., & McIntyre, R. S.
Affiliations: Boston University (US)
University of British Columbia (CA)
University of Toronto (CA)
ORCID: Culpepper, Larry
Lam, Raymond W.
McIntyre, Roger S.
Venue: The Journal of Clinical Psychiatry
Publisher: Physicians Postgraduate Press, Inc
Published: 2017-12-27
Volume: 78
Issue: 9
Pages: 1383-1394
ISSN: 0160-6689 (ISSN-L)
DOI: 10.4088/jcp.tk16043ah5c
OpenAlex: W2776397410
Cited by: 211
References: 0
Citations by year: 2026: 23 · 2025: 33 · 2024: 38 · 2023: 34 · 2022: 35 · 2021: 21 · 2020: 14 · 2019: 8 · 2018: 5
FWCI: 5.16
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: cognitive impairment, major depressive disorder, cognitive screening, antidepressants, cognitive behavioral therapy, physical activity, functional recovery, treatment selection
MeSH terms: Antidepressive Agents, Major Depressive Disorder, Humans, Cognitive Dysfunction

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Cognitive Impairment in Patients With Depression: Awareness, Assessment, and Management: (Academic Highlights)

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