Cited by 26Transcranial Magnetic Stimulation StudiesTreatment of Major DepressionElectroconvulsive Therapy Studies

Improvement Of Frontal Lobe Dysfunction And White Matter Integrity By rTMS In Treatment-Resistant Depression

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Tateishi, Hiroshi, Nishihara, Masashi, Kawaguchi, Atsushi, Matsushima, Jun, Murakawa, Toru, Haraguchi, Yoshinori, Kunitake, Yutaka, Maekawa, Toshihiko +4 more·2019·Neuropsychiatric Disease and Treatment

Abstract

AIM: The impairment experienced by many individuals with depression is closely related to the cognitive symptoms of the disorder. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation method providing a promising technique for improving cognitive symptoms in treatment-resistant depression (TRD). In the present study, we investigated whether a relationship exists between improvements in frontal lobe dysfunction induced by rTMS and improvement of white matter integrity revealed by diffusion tensor imaging (DTI) in TRD patients receiving rTMS treatment. METHODS: A total of 12 patients with TRD were enrolled in a high-frequency (10 Hz) rTMS study (August 2013-January 2019). Frontal lobe function and depressive symptoms were assessed at baseline and at the endpoint of rTMS treatment. Fractional anisotropy (FA), as a measure of white matter integrity obtained from DTI, was investigated using a region-of-interest (ROI) approach. RESULTS: rTMS treatment significantly improved depressive symptom scores and some subscales of frontal lobe dysfunction. Category scores in the Word Fluency Test and scores on part 3 of the Color Stroop Test were improved independently of the improvement of depressive symptoms. In the ROI analysis, none of the FA increases in any region were correlated with improvement of any frontal lobe function (n = 12). CONCLUSION: Although rTMS resulted in partial improvement of frontal lobe dysfunction as well as white matter integrity, we found no correlation between improved frontal lobe dysfunction and improved white matter integrity in TRD patients.

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Research works printed but not linked: 2

  1. [12]Li CX, Sun XL, Zou K, et al. Voxel based analysis of DTI in depression patients. Int J MRI. 2007; 1: 43– 48.
  2. [21]Avery D, Holtzheimer P, Fawaz W, et al. Repetitive transcranial magnetic stimulation (rTMS) is clinically effective in treatment-resistant major depression. Biol Psychiatry. 2004; 55: 718. 16139808

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Authors
Tateishi, H., Nishihara, M., Kawaguchi, A., Matsushima, J., Murakawa, T., Haraguchi, Y., Kunitake, Y., Maekawa, T., Kato, T. A., Asami, T., Mizoguchi, Y., & Monji, A.
Affiliations
  • Saga University (JP)
  • Kyushu University (JP)
Corresponding author
Tateishi, Hiroshi
Venue
Neuropsychiatric Disease and Treatment
Published
2019-11
Volume
Volume 15
Pages
3079-3087
ISSN
  • 1176-6328 (ISSN-L)
  • 1178-2021
OpenAlex
W2985716863
Cited by
26
References
38
Citations by year
2026: 1 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 4
FWCI
1.21
Type
journal article
Language
en
Open access
Locations
  • Neuropsychiatric Disease and Treatment (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Funders
Japan Society for the Promotion of Science (17K10307)
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Keywords
treatment-resistant depression, repetitive transcranial magnetic stimulation, frontal lobe dysfunction, white matter integrity, fractional anisotropy, cognitive symptoms of depression, high-frequency rTMS, diffusion tensor imaging

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