Improvement Of Frontal Lobe Dysfunction And White Matter Integrity By rTMS In Treatment-Resistant Depression
Open accessAbstract
AIM: The impairment experienced by many individuals with depression is closely related to the cognitive symptoms of the disorder. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation method providing a promising technique for improving cognitive symptoms in treatment-resistant depression (TRD). In the present study, we investigated whether a relationship exists between improvements in frontal lobe dysfunction induced by rTMS and improvement of white matter integrity revealed by diffusion tensor imaging (DTI) in TRD patients receiving rTMS treatment. METHODS: A total of 12 patients with TRD were enrolled in a high-frequency (10 Hz) rTMS study (August 2013-January 2019). Frontal lobe function and depressive symptoms were assessed at baseline and at the endpoint of rTMS treatment. Fractional anisotropy (FA), as a measure of white matter integrity obtained from DTI, was investigated using a region-of-interest (ROI) approach. RESULTS: rTMS treatment significantly improved depressive symptom scores and some subscales of frontal lobe dysfunction. Category scores in the Word Fluency Test and scores on part 3 of the Color Stroop Test were improved independently of the improvement of depressive symptoms. In the ROI analysis, none of the FA increases in any region were correlated with improvement of any frontal lobe function (n = 12). CONCLUSION: Although rTMS resulted in partial improvement of frontal lobe dysfunction as well as white matter integrity, we found no correlation between improved frontal lobe dysfunction and improved white matter integrity in TRD patients.
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A recent small study (n = 12) of rTMS for TRD found that rTMS treatment, independent of improvement in depression severity, significantly improved semantic fluency and inhibition abilities.
“A recent small study (n = 12) of rTMS for TRD (Tateishi et al., 2019) found that rTMS treatment, independent of improvement in depression severity, significantly improved semantic fluency and inhibition abilities.”
From Neurocognitive effects of theta burst stimulation for treatment-resistant depression in adults: A systematic review and recommendations for future research (2025) · cites this paper as Tateishi et al., 2019
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- Authors
- Tateishi, H., Nishihara, M., Kawaguchi, A., Matsushima, J., Murakawa, T., Haraguchi, Y., Kunitake, Y., Maekawa, T., Kato, T. A., Asami, T., Mizoguchi, Y., & Monji, A.
- Affiliations
- Saga University (JP)
- Kyushu University (JP)
- Corresponding author
- Tateishi, Hiroshi
- ORCID
- Venue
- Neuropsychiatric Disease and Treatment
- Publisher
- Informa UK Limited
- Published
- 2019-11
- Volume
- Volume 15
- Pages
- 3079-3087
- ISSN
- 1176-6328 (ISSN-L)
- 1178-2021
- PMC
- PMC6842748
- OpenAlex
- W2985716863
- Cited by
- 26
- References
- 38
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 7 · 2021: 4
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Neuropsychiatric Disease and Treatment (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- Japan Society for the Promotion of Science (17K10307)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- treatment-resistant depression, repetitive transcranial magnetic stimulation, frontal lobe dysfunction, white matter integrity, fractional anisotropy, cognitive symptoms of depression, high-frequency rTMS, diffusion tensor imaging
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