Cited by 165Sleep and related disordersTreatment of Major DepressionCircadian rhythm and melatonin

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Comparative Effects of Mirtazapine and Fluoxetine on Sleep Physiology Measures in Patients With Major Depression and Insomnia

Winokur, Andrew, DeMartinis, Nicholas A., McNally, Daniel P., Gary, Ellen M., Cormier, Jennifer L., Gary, Keith A.·2003·The Journal of Clinical Psychiatry

DOI 10.4088/jcp.v64n1013

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Abstract

Background Sleep complaints are common in patients with major depressive disorder (MDD). Both MDD and antidepressant drugs characteristically alter objective sleep measures. This study compares the effects of mirtazapine and fluoxetine on sleep continuity measures in DSM-IV MDD patients with insomnia. Method Patients (N = 19) received initial baseline polysomnography evaluations over 2 consecutive nights. Subjects were randomly assigned to either fluoxetine (20-40 mg/day) or mirtazapine (15-45 mg/day) treatment for an 8-week, double-blind, double-dummy treatment trial. Single-night polysomnograms were conducted at weeks 1, 2, and 8, with depression ratings assessed at baseline and weeks 1, 2, 3, 4, 6, and 8. Statistical analysis was performed by repeated-measures analysis of variance followed by Dunnet's post hoc analyses. Results Patients receiving mirtazapine (N = 8) had significant improvement in objective sleep physiology measures at 8 weeks. Improvements in sleep latency, sleep efficiency, and wake after sleep onset were significant after only 2 weeks of mirtazapine treatment. No significant changes in sleep continuity measures were observed in the fluoxetine group (N = 11). Both groups improved clinically in mood and subjective sleep measures from baseline, with no differences between groups. Conclusion These data demonstrate the differential effects of mirtazapine and fluoxetine, with significant improvement in favor of mirtazapine, on objective sleep parameters in MDD…

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Background

Authors: Winokur, A., DeMartinis, N. A., McNally, D. P., Gary, E. M., Cormier, J. L., & Gary, K. A.
Affiliations: UConn Health (US)
ORCID: Winokur, Andrew
DeMartinis, Nicholas A.
Gary, Keith A.
Venue: The Journal of Clinical Psychiatry
Publisher: Physicians Postgraduate Press, Inc
Published: 2003-10-15
Volume: 64
Issue: 10
Pages: 1224-1229
ISSN: 0160-6689 (ISSN-L)
DOI: 10.4088/jcp.v64n1013
OpenAlex: W1984461780
Cited by: 165
References: 0
Citations by year: 2026: 3 · 2025: 4 · 2024: 4 · 2023: 8 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 9 · 2015: 5 · 2014: 5 · 2013: 10 · 2012: 14
FWCI: 13.34
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: mirtazapine, fluoxetine, major depressive disorder, insomnia, sleep continuity, sleep latency, sleep efficiency, wake after sleep onset, antidepressant effects on sleep, polysomnography
MeSH terms: Mirtazapine, Adult, Antidepressive Agents, Tricyclic, Major Depressive Disorder, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Female, Fluoxetine, Follow-Up Studies, Humans, Sleep Initiation and Maintenance Disorders, Male, Mianserin, Middle Aged, Treatment Outcome, Polysomnography, Antidepressive Agents, Second-Generation

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Comparative Effects of Mirtazapine and Fluoxetine on Sleep Physiology Measures in Patients With Major Depression and Insomnia

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