The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
The Economic Burden of Depression in the United States: How Did It Change Between 1990 and 2000?
Abstract
BACKGROUND: The economic burden of depression was estimated to be 43.7 billion dollars in 1990. A subsequent study reported a cost burden of 52.9 billion dollars using revised prevalence data and a refined workplace cost estimation approach. The objective of the current report is to provide a 10-year update of these estimates using the same methodological framework. METHOD: Using a human capital approach, we developed prevalence-based estimates of 3 major cost categories: (1) direct costs, (2) mortality costs arising from depression-related suicides, and (3) costs associated with depression in the workplace. Cost-of-illness estimates from 1990 were updated to reflect the experience in 2000 using current epidemiologic data and publicly available population, wage, and cost information. RESULTS: Whereas the treatment rate of depression increased by over 50%, its economic burden rose by only 7%, going from 77.4 billion dollars in 1990 (inflation-adjusted dollars) to 83.1 billion dollars in 2000. Of the 2000 total, 26.1 billion dollars (31%) were direct medical costs, 5.4 billion dollars (7%) were suicide-related mortality costs, and 51.5 billion dollars (62%) were workplace costs. CONCLUSION: The economic burden of depression remained relatively stable between 1990 and 2000, despite a dramatic increase in the proportion of depression sufferers who received treatment. Future research will incorporate additional costs associated with depression sufferers, including the excess costs of their coexisting psychiatric and medical conditions and attention to the role of painful conditions as a driver of these costs.
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“These studies typically find that MDD is associated with among the highest number of days out of role at the societal level of any physical or mental disorder due to its combination of comparatively high prevalence and comparatively strong individual-level association.60–62 In the WMH surveys, for example, 62,971 respondents across 24 countries were assessed for a wide range of common physical and”
From The Costs of Depression (2012) · cites this paper as [63]
In the citing paper
“A meta-review 202 reported an almost twenty-fold risk of suicide for persons with depression with a standardized mortality ratio (SMR) of 19·7%.”
From Time for united action on depression: a Lancet–World Psychiatric Association Commission (2022) · cites this paper as [202]
In the citing paper
“Importantly, it has been suggested that workplace impairment may contribute to more than 60 % of the MDD-related economic burden [47].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [47]
Citations
Cites
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370
Self-citationKessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988
Self-citationCost of Lost Productive Work Time Among US Workers With Depression
Stewart, W. F. (2003) · JAMA · doi:10.1001/jama.289.23.3135 · Cited by 1,421
Social consequences of psychiatric disorders, I: Educational attainment
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.7.1026 · Cited by 1,370
Self-citationA Hundred Cases of Suicide: Clinical Aspects
Barraclough, B. M., Bunch, J., Nelson, B., & Sainsbury, P. (1974) · British Journal of Psychiatry · doi:10.1192/bjp.125.4.355 · Cited by 1,283
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Self-citationMental disorders and comorbidity in suicide
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.6.935 · Cited by 861
National Trends in the Outpatient Treatment of Depression
Olfson, M. (2002) · JAMA · doi:10.1001/jama.287.2.203 · Cited by 847
National Ambulatory Medical Care Survey: 2001 summary.
Cherry, D. K., Burt, C. W., & Woodwell, D. A. (2003) · PubMed · Cited by 762
Comorbid depression and anxiety spectrum disorders
Gorman, J. M. (1996) · Depression and Anxiety · doi:10.1002/(sici)1520-6394(1996)4:4 · Cited by 629
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Ludwig, H., & Bode, L. (2012) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814338998_0007 · Cited by 4
Metadata
- Authors
- Greenberg, P. E., Kessler, R. C., Birnbaum, H. G., Leong, S. A., Lowe, S. W., Berglund, P. A., & Corey-Lisle, P. K.
- Affiliations
- Analysis Group (United States) (US)
- Harvard University (US)
- University of Michigan (US)
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2003-12-15
- Volume
- 64
- Issue
- 12
- Pages
- 1465-1475
- ISSN
- 0160-6689 (ISSN-L)
- OpenAlex
- W2011003051
- Cited by
- 1,280
- References
- 49
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 15 · 2023: 26 · 2022: 33 · 2021: 22 · 2020: 31 · 2019: 42 · 2018: 53 · 2017: 74 · 2016: 76 · 2015: 76 · 2014: 94 · 2013: 94 · 2012: 102
- FWCI
- 53.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- depression, economic burden, direct medical costs, human capital approach, treatment rates
- MeSH terms
- Costs and Cost Analysis, Cross-Sectional Studies, Depressive Disorder, Health Expenditures, Forecasting, Humans, Suicide, United States, Workplace, Cost of Illness
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