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Cited by 129Transcranial Magnetic Stimulation StudiesTreatment of Major DepressionElectroconvulsive Therapy Studies

Transcranial Magnetic Stimulation in the Acute Treatment of Major Depressive Disorder: Clinical Response in an Open-Label Extension Trial

Avery, David H., Isenberg, Keithe E., Sampson, Shirlene M., Janicak, Philip G., Lisanby, Sarah H., Maixner, Daniel F., Loo, Colleen, Thase, Michael E. +2 more·2008·The Journal of Clinical Psychiatry
DOI 10.4088/jcp.v69n0315
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Abstract

BACKGROUND: This report describes the results of an open-label extension study of active trans-cranial magnetic stimulation (TMS) in medication-resistant patients with major depressive disorder who did not benefit from an initial course of therapy in a previously reported 6-week, randomized controlled study of active versus sham TMS. METHOD: Patients with DSM-IV-defined major depressive disorder were actively enrolled in the study from February 2004 through September 2005 and treated with left prefrontal TMS administered 5 times per week at 10 pulses per second, at 120% of motor threshold, for a total of 3000 pulses/session. The primary outcome was the baseline to endpoint change score on the Montgomery-Asberg Depression Rating Scale (MADRS). RESULTS: In those patients who received sham in the preceding randomized controlled trial (N = 85), the mean reduction in MADRS scores after 6 weeks of open-label active TMS was -17.0 (95% CI = -14.0 to -19.9). Further, at 6 weeks, 36 (42.4%) of these patients achieved response on the MADRS, and 17 patients (20.0%) remitted (MADRS score < 10). For those patients who received and did not respond to active TMS in the preceding randomized controlled trial (N = 73), the mean reduction in MADRS scores was -12.5 (95% CI = -9.7 to -15.4), and response and remission rates were 26.0% and 11.0%, respectively, after 6 weeks of additional open-label TMS treatment. CONCLUSIONS: This open-label study provides further evidence that TMS is a safe and effective treatment of major depressive disorder. Furthermore, continued active TMS provided additional benefit to some patients who failed to respond to 4 weeks of treatment, suggesting that longer courses of treatment may confer additional therapeutic benefit. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00104611.

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  • The effects of tDCS on neuronal excitability have been demonstrated in numerous neuroimaging and physiological studies, providing a sound neurobiological basis for its use for neuromodulation in patient populations.

    “The effects of tDCS on neuronal excitability have now been demonstrated in numerous neuroimaging and physiological studies, providing a sound neurobiological basis for its use for neuromodulation in patient populations.1,3”

    From Transcranial direct current stimulation for depression: 3-week, randomised, sham-controlled trial (2012) · cites this paper as [1]

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Authors
Avery, D. H., Isenberg, K. E., Sampson, S. M., Janicak, P. G., Lisanby, S. H., Maixner, D. F., Loo, C., Thase, M. E., Demitrack, M. A., & George, M. S.
Affiliations
  • University of Washington (US)
  • Washington University in St. Louis (US)
  • Rush University (US)
  • Columbia University (US)
  • University of Michigan (US)
  • UNSW Sydney (AU)
  • University of Pennsylvania (US)
  • Neuronetics (United States) (US)
  • Medical University of South Carolina (US)
ORCID
Venue
The Journal of Clinical Psychiatry
Publisher
Physicians Postgraduate Press, Inc
Published
2008-03-15
Volume
69
Issue
3
Pages
441-451
ISSN
0160-6689 (ISSN-L)
DOI
10.4088/jcp.v69n0315
OpenAlex
W2042052693
Cited by
129
References
21
Citations by year
2026: 2 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 4 · 2019: 1 · 2018: 7 · 2017: 7 · 2016: 2 · 2015: 7 · 2014: 10 · 2013: 8 · 2012: 10
FWCI
8.52
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Keywords
transcranial magnetic stimulation, major depressive disorder, treatment-resistant depression, left prefrontal cortex, open-label extension, treatment response, remission, treatment duration, Montgomery-Asberg Depression Rating Scale
MeSH terms
Adolescent, Adult, Aged, Cognition Disorders, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Surveys and Questionnaires, Remission Induction, Severity of Illness Index, Treatment Outcome, Diagnostic and Statistical Manual of Mental Disorders, Transcranial Magnetic Stimulation

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