National patterns of medication treatment for depression, 1987 to 2001
Open accessAbstract
BACKGROUND: We investigated trends in antidepressant use, as well as broader changes in depression treatment, following the availability of selective serotonin reuptake inhibitors (SSRIs). METHOD: Using data from the National Disease and Therapeutic Index, a nationally representative survey of U.S. office-based physicians conducted by IMS HEALTH, we analyzed trends in antidepressant prescribing patterns from 1987 through the third quarter of 2001. Annual sample sizes of physician visits by patients reported to have depression ranged from 3901 visits in 1987 to 6639 in 1998. Outcomes examined included the frequency of depression visits, the likelihood of antidepressant therapy, and the use of specific medications. RESULTS: The estimated national number of physician visits by patients with depression increased from 14.4 million visits in 1987 to 24.5 million in 2001 (annualized). The rate of antidepressant medication treatment in these patients also increased from 70% in 1987 to 89% in 2001. In 1987, tricyclic antidepressants were prescribed to 47% of patients with depression. The most common individual antidepressants were amitriptyline (14%), trazodone (12%), doxepin (8%), and desipramine (6%). In 1989, a year after its introduction, fluoxetine was prescribed to 21% of patients with depression. The introduction of other SSRIs led aggregate SSRI use to grow to 38% in 1992, 60% in 1996, and 69% in 2000. In 2001, sertraline (18%), paroxetine (16%), fluoxetine (14%), citalopram (13%), and bupropion (9%) were the leading antidepressants, while tricyclics were used in only 2% of patients. The use of benzodiazepines in depression declined from 21% of patients in 1987 to 8% in 2001. CONCLUSION: The increasing therapeutic dominance of SSRIs may have contributed to other changes in depression treatment, including declining benzodiazepine use, increased aggregate antidepressant treatment rates, and increased reporting of depression.
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In the US, an old study based on office-based physician survey depicted the trend of antidepressant prescriptions for depression up to 2001, by which time SSRIs had clearly outnumbered TCAs.
“In the US an old study (33) based on office-based physician survey depicted the trend of antidepressant prescriptions for depression up to 2001, by which time SSRIs had clearly outnumbered TCAs.”
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Patkar, A. A., Portland, K. B., & Pae, C. (2012) · Neuropsychiatry · doi:10.2217/npy.12.9 · Cited by 5 · see citing works
Depresja w praktyce lekarza POZ – diagnostyka i farmakoterapia
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A Comparison of Sexual Side Effects of Antidepressants With and Without Naltrexone
Thapa, M., Petrakis, I. L., & Ralevski, E. (2017) · Journal of Dual Diagnosis · doi:10.1080/15504263.2017.1326650 · Cited by 5 · see citing works
Passive Addiction and Teratogenic Effects
Woodward, L. J., McPherson, C. C., & Volpe, J. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-42876-7.00038-7 · Cited by 4 · see citing works
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Provider Characteristics Related to Antidepressant Use in Older People
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- Authors
- Stafford, R. S., MacDonald, E. A., & Finkelstein, S. N.
- Affiliations
- Harvard University (US)
- Massachusetts Institute of Technology (US)
- Stanford University (US)
- Venue
- The Primary Care Companion For CNS Disorders
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2001-12-01
- Volume
- 3
- Issue
- 6
- Pages
- 232-235
- ISSN
- 2155-7772 (ISSN-L)
- 2155-7780
- PMC
- PMC181191
- OpenAlex
- W2086557231
- Cited by
- 94
- References
- 18
- Citations by year
- 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 3 · 2012: 5
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- The Primary Care Companion For CNS Disorders (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
- Keywords
- depression, antidepressant prescribing, selective serotonin reuptake inhibitors, tricyclic antidepressants, benzodiazepines, fluoxetine, sertraline, paroxetine, citalopram, bupropion, physician visits
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