The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Brown Adipose Tissue as a Regulator of Energy Expenditure and Body Fat in Humans
Open accessAbstract
Brown adipose tissue (BAT) is recognized as the major site of sympathetically activated nonshivering thermogenesis during cold exposure and after spontaneous hyperphagia, thereby controling whole-body energy expenditure and body fat. In adult humans, BAT has long been believed to be absent or negligible, but recent studies using fluorodeoxyglucose-positron emission tomography, in combination with computed tomography, demonstrated the existence of metabolically active BAT in healthy adult humans. Human BAT is activated by acute cold exposure, being positively correlated to cold-induced increases in energy expenditure. The metabolic activity of BAT differs among individuals, being lower in older and obese individuals. Thus, BAT is recognized as a regulator of whole-body energy expenditure and body fat in humans as in small rodents, and a hopeful target combating obesity and related disorders. In fact, there are some food ingredients such as capsaicin and capsinoids, which have potential to activate and recruit BAT via activity on the specific receptor, transient receptor potential channels, thereby increasing energy expenditure and decreasing body fat modestly and consistently.
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“It has been demonstrated by several groups that there is a meal‐associated thermogenesis 101, 102, 103.”
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Cites
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433
Identification and Importance of Brown Adipose Tissue in Adult Humans
Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399
Cold-Activated Brown Adipose Tissue in Healthy Men
van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Wu, J., Boström, P., Sparks, L. M., Li, Y., Choi, J. H., Giang, A.-H., Khandekar, M. J., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,406
Functional Brown Adipose Tissue in Healthy Adults
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058
High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans
Saito, M., Okamatsu-Ogura, Y., Matsushita, M., Watanabe, K., Yoneshiro, T., Nio-Kobayashi, J., Iwanaga, T., Miyagawa, M., Kameya, T., Nakada, K., et al. (2009) · Diabetes · doi:10.2337/db09-0530 · Cited by 1,848
Self-citationUnexpected evidence for active brown adipose tissue in adult humans
Nedergaard, J., Bengtsson, T., & Cannon, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00691.2006 · Cited by 1,824
Towards a molecular understanding of adaptive thermogenesis
Lowell, B. B., & Spiegelman, B. M. (2000) · Nature · doi:10.1038/35007527 · Cited by 1,630
Brown adipose tissue activity controls triglyceride clearance
Bartelt, A., Bruns, O. T., Reimer, R., Hohenberg, H., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Weller, H., Waurisch, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2297 · Cited by 1,608
A role for brown adipose tissue in diet-induced thermogenesis
Rothwell, N. J., & Stock, M. J. (1979) · Nature · doi:10.1038/281031a0 · Cited by 1,606
Flagged first, then by citations
Research works printed but not linked: 8
- Ricquier, 2000, Biochem J, 345, 161, 10.1042/0264-6021:3450161 · DOI
- Heaton, 1972, J Anat, 112, 35
- Cohade, 2003, J Nucl Med, 44, 170
- Saito, 2007, Int J Obes (Lond), 31, S32
- Yoneshiro, Int J Obes (Lond)
- Vallerand, 1987, Am J Physiol, 253, E179
- Vallerand, 1990, Am J Physiol, 259, R1043
- Shimizu, 1993, Am J Physiol, 264, E890
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Items 101–147 of 147
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Brioschi, M. L., Yeng, L. T., Araújo, J. O. O. T. Q. F., Pezzucchi, M. Z., & Teixeira, M. J. (2014) · Pan American Journal of Medical Thermology · doi:10.18073/2358-4696/pajmt.v1n2p71-80 · Cited by 4
Steinach, M., & Gunga, H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-386947-0.00006-x · Cited by 4
Influence of body composition on energy metabolism in females with constitutional thinness
Isacco, L., Bailly, M., Lambert, C., Beraud, D., Duclos, M., Verney, J., Boirie, Y., & Thivel, D. (2025) · European Journal of Clinical Nutrition · doi:10.1038/s41430-025-01598-x · Cited by 3
Banzo, J., Ubieto, M. Á., Berisa, M. F., Andrés, A., Mateo, M. L., Tardín, L., Parra, A., Razola, P., & PRATS, E. (2013) · Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) · doi:10.1016/j.remnie.2013.09.011 · Cited by 3
Can thermogenic adipocytes protect from obesity?
Medvedev, L. N., & Elsukova, E. I. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0443-7 · Cited by 3
Brown Adipose Tissue as a Therapeutic Target for Obesity: From Mice to Humans
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Self-citationBrown adipose expansion and remission of glycemic dysfunction in obese SM/J micePreprint
Carson, C., Macias-Velasco, J. F., Gunawardana, S., Miranda, M. A., Oyama, S., Schmidt, H., Wayhart, J. P., & Lawson, H. A. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/724369 · Cited by 4
Zhang, L., Li, Y., Gao, W., Li, Z., Wu, T., Lang, C., Rui, L., & Zhang, W. (2025) · EMBO Reports · doi:10.1038/s44319-025-00398-5 · Cited by 2
NOTCH Signaling Networks in Perivascular Adipose Tissue
Potts, C. M., Yang, C., & Liaw, L. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.321690 · Cited by 2
Exposure to predator threat engages sympathetic nervous system outflow to skeletal muscle
Gorrell, E., Shemery, A., Franks, L., Samman, N., Zendlo, M., Welch, E. C., Ridley, C., Davis, A., Titus, A. R., Heemstra, L. A., et al. (2025) · Autonomic Neuroscience · doi:10.1016/j.autneu.2025.103304 · Cited by 2
Purmorphamine exerts anti-obesity effects by enhancing secretin-activated brown fat thermogenesis
Zhang, F., Tao, Z., Nawabjan, S. A., Xiang, M., Deng, X. Y., Li, Y., Zhang, L., & Chow, B. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116628 · Cited by 2
Gu, Y., He, W., Li, W., Cai, J., Wang, Z., Li, K., Qin, G., Gu, X., Lin, X., Ma, L., et al. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01249-8 · Cited by 2
Steinach, M., & Gunga, H. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815942-2.00006-7 · Cited by 2
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Abidin, K. R., Lesmana, R., Syamsunarno, M. R. A. A., & Dharma, K. K. (2022) · Pharmacognosy Journal · doi:10.5530/pj.2022.14.130 · Cited by 2
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Taoka, H., & 渡辺, 光. (2017) · Springer eBooks · doi:10.1007/978-4-431-56062-3_15 · Cited by 1
Heme oxygenase/carbon monoxide in thermoregulation and neuroenergetics
Cárnio, E. C., & Branco, L. G. S. (2026) · Neurochemistry International · doi:10.1016/j.neuint.2026.106205 · Cited by 1
p27Kip1 Deficiency Impairs Brown Adipose Tissue Function Favouring Fat Accumulation in Mice
Colón-Mesa, I., Sáinź, N., Corrales, P., Collantes, M., Kaldis, P., Martínez, J. A., Medina‐Gómez, G., Moreno-Aliaga, M. J., & Escoté, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032664 · Cited by 1
Iida, T., Ueda, Y., Tsukada, H., Fukumoto, D., & Hamaoka, T. (2023) · Journal of Biophotonics · doi:10.1002/jbio.202300183 · Cited by 1
Cold Exposure Rejuvenates the Metabolic Phenotype of Panx1−/− Mice
Molica, F., Ehrlich, A., Pelli, G., Rusiecka, O. M., Montessuit, C., Chanson, M., & Kwak, B. R. (2024) · Biomolecules · doi:10.3390/biom14091058 · Cited by 1
Timosaponin AⅢ inhibits ectopic lipid deposition and enhances the browning of white adipose tissue
Zhao, W., Wang, X., Liu, Y., Lu, L., Ding, Y., & Zhang, T. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177506 · Cited by 1
Food Function Study of Obesity and Fat Energy Metabolism
Kawada, T. (2014) · Nippon Eiyo Shokuryo Gakkaishi · doi:10.4327/jsnfs.67.119 · Cited by 1
Braunes Fettgewebe: Die neue Waffe gegen Adipositas?
Fenzl, A., & Kiefer, F. W. (2013) · Journal für Kardiologie (Krause & Pachernegg GmbH)
van Dijk, M. (2014) · TvPO · doi:10.1007/s12503-014-0096-y
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Honek, J. (2014) · Figshare
Mila-Kierzenkowska, C., Boraczyński, T., & Rusiecki, J. (2013)
Metabolic adaptation of white adipose tissue to nutritional and environmental challenges
Hoevenaars, F. P. M. (2014) · doi:10.18174/300419
Magdalon, J. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2017.tde-19012017-155521
Kozak-Nurczyk, P., Nurczyk, K., Prystupa, A., Szczęśniak, G., & Panasiuk, L. (2018) · Medycyna Ogólna i Nauki o Zdrowiu · doi:10.26444/monz/99047
Effect of brown adipose tissue activation on myocardial fluorine-18-fluorodeoxyglucose uptake
Alenezi, S. A., Dannoon, S. F., Alnafisi, N., Asa'ad, S. M., Osman, M., & Elgazzar, A. H. (2020) · World Journal of Nuclear Medicine · doi:10.4103/wjnm.wjnm_16_19
Taher, J. (2017) · TSpace (University of Toronto)
Chi, Z.-C. (2022) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v30.i11.465
Aita, S., Matsushita, M., Yoneshiro, T., Hatano, T., Kameya, T., Ohkubo, I., & Saito, M. (2022) · Research Square · doi:10.21203/rs.3.rs-1762974/v1
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Ely, E. V., Kapinski, A. T., Paradi, S. G., Tang, R., Guilak, F., & Collins, K. H. (2023) · European Cells and Materials · doi:10.22203/ecm.v046a09
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Park, K. H. (2024) · Korean Journal of Neuromuscular Disorders · doi:10.46518/kjnmd.2024.16.1.1
McHugh, C. T., Garside, J. C., Barkes, J., Frank, J., Dragicevich, C. J., Yuan, H., & Branca, R. T. (2020) · Figshare · doi:10.6084/m9.figshare.13204577
Jurado‐Fasoli, L., Martínez‐Téllez, B., Köhler, I., Ruiz, J. R., & Osuna‐Prieto, F. J. (2026) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-026-01155-5
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Lal, R., Soni, N., Agarwal, K., Kondepudi, K. K., Khare, P., Zimmermann, K., Karbownik‐Lewińska, M., Gesing, A., Aggarwal, V., Chopra, K., et al. (2026) · The FASEB Journal · doi:10.1096/fj.202600519rrrr
Metadata
- Authors
- Saito, M.
- Affiliations
- Tenshi College (JP)
- Corresponding author
- Saito, Masayuki
- ORCID
- Saito, Masayuki
- Venue
- Diabetes & Metabolism Journal
- Publisher
- Korean Diabetes Association
- Published
- 2013
- Volume
- 37
- Issue
- 1
- Pages
- 22
- ISSN
- 2233-6079 (ISSN-L)
- 2233-6087
- PMC
- PMC3579148
- OpenAlex
- W2168695748
- Cited by
- 146
- References
- 55
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 6 · 2023: 13 · 2022: 10 · 2021: 7 · 2020: 9 · 2019: 10 · 2018: 8 · 2017: 13 · 2016: 14 · 2015: 19 · 2014: 11 · 2013: 12
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Diabetes & Metabolism Journal (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (24240092)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- brown adipose tissue, non-shivering thermogenesis, energy expenditure, fat mass, cold exposure, obesity, capsaicin, capsinoids, TRP channels, aging
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