Clinical outcomes of surgical treatment and longitudinal non-surgical observation of patients with subclinical Cushing’s syndrome and nonfunctioning adrenocortical adenoma
Open accessAbstract
AIMS: To investigate the outcomes of the surgical management and longitudinal assessment of patients with subclinical Cushing's syndrome (SCS) and nonfunctioning adrenocortical adenoma (NFA). MATERIALS AND METHODS: Between the years 1995 and 2008, 73 patients with asymptomatic adrenocortical adenoma were enrolled. They were informed of the risks and benefits of adrenalectomy and conservative management, and then chose the treatment. RESULTS: SCS was observed in 13 patients (17.8%) and NFA in 60 patients (82.2%). Tumor size in SCS was significantly larger than that in NFA (34.6 ± 9.7 mm vs. 24.5 ± 8.0 mm in diameter, P=0.001). Of the SCS patients, 7 also suffered from hypertension (HT), 2 from diabetes mellitus (DM) and 3 from hyperlipidemia (HL). After adrenalectomy, the insulin dose could be reduced in 2 (100%) patients with DM, in 5 (71.4%) of those with HT and in 2 (66.7%) of those with HL. In the NFA surveillance group, 1 (2.6%) case developed into SCS 3 years after the initial presentation and an increase in size of the tumor was observed in 1 (2.6%), with a mean follow-up of 51.2 months. CONCLUSIONS: Surgical resection may be beneficial for the control of SCS and is likely to provide improvement of concomitant HT, DM and HL. Although NFA can be managed conservatively, its size and hormonal activities may change longitudinally. Thus, long-term follow-up is necessary for NFA.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Most studies of surgical intervention for ACS involve small numbers and are retrospective, uncontrolled, and lack randomization.
“Several studies have reported the outcome of surgical intervention but most involve small numbers and are retrospective, uncontrolled, and lack randomization (230,243,250-253,255) (Table 7).”
From Adrenal incidentaloma (2020) · cites this paper as [252]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Management of the clinically inapparent adrenal mass ("incidentaloma")
Grumbach, M. M., Biller, B. M. K., Braunstein, G. D., Campbell, K. K., Carney, J. A., Godley, P. A., Harris, E. L., Lee, J. K. T., Oertel, Y. C., Posner, M. C., et al. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-138-5-200303040-00013 · Cited by 945 · see citing works
The clinically inapparent adrenal mass: update in diagnosis and management
Mansmann, G., Lau, J., Balk, E., Rothberg, M., Miyachi, Y., & Bornstein, S. R. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0031 · Cited by 781 · see citing works
Prevalence and natural history of adrenal incidentalomas
Barzon, L., Sonino, N., Fallo, F., Palu, G., & Boscaro, M. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1490273 · Cited by 642 · see citing works
Zeiger, M. A., Thompson, G. B., Duh, Q.-Y., Hamrahian, A. H., Angelos, P., Elaraj, D., Fishman, E., Kharlip, J., Zeiger, M. A., Thompson, G. B., et al. (2009) · Endocrine Practice · doi:10.4158/ep.15.s1.1 · Cited by 499 · see citing works
Rossi, R., Tauchmanovà, L., Luciano, A., Martino, M. D., Battista, C., Viscovo, L. D., Nuzzo, V., & Lombardi, G. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.4.6515 · Cited by 416 · see citing works
Tauchmanovà, L., Rossi, R., Biondi, B., Pulcrano, M., Nuzzo, V., Palmieri, E.-A., Fazio, S., & Lombardi, G. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2001-011766 · Cited by 400 · see citing works
Subclinical Cushing’s syndrome
Reincke, M. (2000) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70115-8 · Cited by 285 · see citing works
Risk Factors and Long-Term Follow-Up of Adrenal Incidentalomas1
Barzon, L., Scaroni, C. M., Sonino, N., Fallo, F., Paoletta, A., & Boscaro, M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.2.5444 · Cited by 255 · see citing works
Toniato, A., Merante-Boschin, I., Opocher, G., Pelizzo, M. R., Schiavi, F., & Ballotta, E. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e31819a47d2 · Cited by 245 · see citing works
Long-term follow-up study of patients with adrenal incidentalomas.
Libe, R., Dall'Asta, C., Barbetta, L., Baccarelli, A., Beck-Peccoz, P., & Ambrosi, B. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1470489 · Cited by 215 · see citing works
Bernini, G., Moretti, A., Iacconi, P., Miccoli, P., Nami, R., Lucani, B., & Salvetti, A. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1480213 · Cited by 105 · see citing works
EMRAL, R., UYSAL, A. R., ASIK, M., GULLU, S., CORAPCIOGLU, D., TONYUKUK, V., & ERDOGAN, G. (2003) · Endocrine Journal · doi:10.1507/endocrj.50.399 · Cited by 104 · see citing works
“Subclinical Cushing’s syndrome” is not subclinical: improvement after adrenalectomy in 9 patients
Mitchell, I. C., Auchus, R. J., Juneja, K., Chang, A. Y., Holt, S. A., Snyder, W. H., & Nwariaku, F. E. (2007) · Surgery · doi:10.1016/j.surg.2007.10.001 · Cited by 84 · see citing works
Subclinical Cushing's syndrome.
Terzolo, M., Reimondo, G., Bovio, S., & Angeli, A. (2004) · Pituitary · doi:10.1007/s11102-005-4024-6 · Cited by 80 · see citing works
Subclinical Cushing's syndrome
Terzolo, M., Bovio, S., Pia, A. R., Osella, G., Borretta, G., Angeli, A., & Reimondo, G. (2007) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302007000800013 · Cited by 67 · see citing works
The natural history of incidentally discovered adrenocortical adenomas: a retrospective evaluation.
Grossrubatscher, E., Vignati, F., Possa, M., & Loli, P. (2001) · Journal of Endocrinological Investigation · doi:10.1007/bf03343941 · Cited by 52 · see citing works
Systemic inflammatory response syndrome in open versus laparoscopic adrenalectomy
Mutoh, M., Takeyama, K., Nishiyama, N., Kunishima, Y., Matsukawa, M., Takahashi, S., Hotta, H., Itoh, N., & Tsukamoto, T. (2004) · Urology · doi:10.1016/j.urology.2004.04.042 · Cited by 21 · see citing works
Scintigraphic diagnosis of subclinical Cushingʼs Syndrome in patients with adrenal incidentalomas
Domínguez‐Gadea, L., DIEZ, L., Maroto, G. P., & CRESPO, A. (1996) · Nuclear Medicine Communications · doi:10.1097/00006231-199601000-00006 · Cited by 9 · see citing works
Nishida, S., Itoh, N., Sasao, T., Masumori, N., Taguchi, K., & Tsukamoto, T. (2007) · International Journal of Urology · doi:10.1111/j.1442-2042.2007.01792.x · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Sherlock, M., Scarsbrook, A., Abbas, A., Fraser, S., Limumpornpetch, P., Dineen, R., & Stewart, P. M. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa008 · Cited by 347 · see citing works
Bancos, I., Alahdab, F., Crowley, R. K., Chortis, V., Delivanis, D. A., Erickson, D., Natt, N., Terzolo, M., Arlt, W., Young, W. F., et al. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0465 · Cited by 167 · see citing works
Di Dalmazi, G., Berr, C. M., Fassnacht, M., Beuschlein, F., & Reincke, M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1401 · Cited by 139 · see citing works
Systematic review of surgical treatment of subclinical Cushing's syndrome
Iacobone, M., Citton, M., Scarpa, M., Viel, G., Boscaro, M., & Nitti, D. (2015) · British journal of surgery · doi:10.1002/bjs.9742 · Cited by 73 · see citing works
Adrenocortical tumors and insulin resistance: What is the first step?
Altieri, B., Tirabassi, G., Casa, S. D., Ronchi, C. L., Balercia, G., Orio, F., Pontecorvi, A., Colao, A., & Muscogiuri, G. (2015) · International Journal of Cancer · doi:10.1002/ijc.29950 · Cited by 37 · see citing works
Ricciato, M. P., Donna, V. D., Perotti, G., Pontecorvi, A., Bellantone, R. D. A., & Corsello, S. M. (2014) · World Journal of Surgery · doi:10.1007/s00268-014-2482-6 · Cited by 30 · see citing works
Khan, U. (2019) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_52_19 · Cited by 20 · see citing works
Clinical characterization of patients with primary aldosteronism plus subclinical Cushing’s syndrome
Yasuda, S., Hikima, Y., Kabeya, Y., Iida, S., Oikawa, Y., Isshiki, M., Inoue, I., Shimada, A., & Noda, M. (2020) · BMC Endocrine Disorders · doi:10.1186/s12902-020-0490-0 · Cited by 20 · see citing works
Wang, D., Ji, Z., Li, H., & Zhang, Y. (2017) · Cancer Biomarkers · doi:10.3233/cbm-170531 · Cited by 16 · see citing works
Mifepristone Accelerates HPA Axis Recovery in Secondary Adrenal Insufficiency
Cohan, P. (2016) · Case Reports in Endocrinology · doi:10.1155/2016/4709597 · Cited by 8 · see citing works
Proteome analysis of adrenal cortical tumors
Kim, H. M., Lee, Y. K., & Koo, J. S. (2016) · Expert Review of Proteomics · doi:10.1080/14789450.2016.1210008 · Cited by 6 · see citing works
Lirov, R., & Gauger, P. G. (2018) · Springer eBooks · doi:10.1007/978-981-10-1124-5_26 · Cited by 1 · see citing works
Adrenal Cortical Adenoma in the Spinal Canal: A Case Report and Review of the Literature
Nemir, J., Štenger, M., Jakovčević, A., Domazet, I., Njirić, N., & Paladino, J. (2019) · Journal of Neurological Surgery Part A Central European Neurosurgery · doi:10.1055/s-0038-1676595 · Cited by 1 · see citing works
- Authors
- Maehana, T., Tanaka, T., Itoh, N., Masumori, N., & Tsukamoto, T.
- Affiliations
- Sapporo Medical University (JP)
- Corresponding author
- Maehana, Takeshi
- Venue
- Indian Journal of Urology
- Published
- 2012
- Volume
- 28
- Issue
- 2
- Pages
- 179
- ISSN
- 0970-1591 (ISSN-L)
- PMC
- PMC3424895
- OpenAlex
- W1973120130
- Cited by
- 13
- References
- 18
- Citations by year
- 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 2
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Indian Journal of Urology (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- subclinical Cushing's syndrome, adrenalectomy, conservative treatment, tumor size, hypertension, diabetes mellitus, hyperlipidemia, insulin dose reduction, long-term follow-up
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
