Adrenalectomy may improve cardiovascular and metabolic impairment and ameliorate quality of life in patients with adrenal incidentalomas and subclinical Cushing’s syndrome
Abstract
Background Adrenalectomy represents the definitive treatment in clinically evident Cushing's syndrome; however, the most appropriate treatment for patients with subclinical Cushing's syndrome (SCS) with an adrenal incidentaloma remains controversial. This study was aimed to assess whether adrenalectomy may improve cardiovascular and metabolic impairment and quality of life compared with conservative management.Methods Twenty patients with adrenal incidentaloma underwent laparoscopic adrenalectomy for SCS, whereas 15 were managed conservatively. Hormonal laboratory parameters of corticosteroid secretion, arterial blood pressure (BP), glycometabolic profile, and quality of life (by the SF-36 questionnaire) were compared at baseline and the end of follow-up.Results The 2 groups were equivalent concerning all the examined parameters at baseline. In the operative group, laboratory corticosteroid parameters normalized in all patients but not in the conservative-management group (P < .001). In operated patients, a decrease in BP occurred in 53% of patients, glycometabolic control improved in 50%, and body mass index decreased; in contrast, no improvement or some worsening occurred in the conservative-management group (P < .01). SF-36 evaluation improved in the operative group (P < .05).Conclusion Adrenalectomy can be more beneficial than conservative management in SCS and may achieve remission of laboratory hormonal abnormalities and improve BP, glycemic control, body mass index, and quality of life.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Most studies of surgical intervention for ACS involve small numbers and are retrospective, uncontrolled, and lack randomization.
“Several studies have reported the outcome of surgical intervention but most involve small numbers and are retrospective, uncontrolled, and lack randomization (230,243,250-253,255) (Table 7).”
From Adrenal incidentaloma (2020) · cites this paper as [251]
Cites
The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline.
Nieman, L. K., Biller, B. M. K., Findling, J. W., Newell-Price, J., Savage, M. O., Stewart, P. M., & Montori, V. M. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0125 · Cited by 2,718 · see citing works
The Italian SF-36 Health Survey
Apolone, G., & Mosconi, P. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00094-8 · Cited by 1,150 · see citing works
A Survey on Adrenal Incidentaloma in Italy
Mantero, F. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.2.637 · Cited by 907 · see citing works
Zeiger, M. A., Thompson, G. B., Duh, Q.-Y., Hamrahian, A. H., Angelos, P., Elaraj, D., Fishman, E., Kharlip, J., Zeiger, M. A., Thompson, G. B., et al. (2009) · Endocrine Practice · doi:10.4158/ep.15.s1.1 · Cited by 499 · see citing works
Rossi, R., Tauchmanovà, L., Luciano, A., Martino, M. D., Battista, C., Viscovo, L. D., Nuzzo, V., & Lombardi, G. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.4.6515 · Cited by 416 · see citing works
Tauchmanovà, L., Rossi, R., Biondi, B., Pulcrano, M., Nuzzo, V., Palmieri, E.-A., Fazio, S., & Lombardi, G. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2001-011766 · Cited by 400 · see citing works
(2002) · PubMed · Cited by 326 · see citing works
Adrenal incidentaloma: a new cause of the metabolic syndrome?
Terzolo, M., Pia, A., Alì, A., Osella, G., Reimondo, G., Bovio, S., Daffara, F., Procopio, M., Paccotti, P., Borretta, G., et al. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8277 · Cited by 322 · see citing works
Subclinical Cushing’s syndrome
Reincke, M. (2000) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70115-8 · Cited by 285 · see citing works
Diagnosis and Treatment of Subclinical Hypercortisolism
Chiodini, I. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2722 · Cited by 279 · cited 8× · see citing works
“Adrenalectomy represents the definitive treatment in clinically evident Cushing’s syndrome, whereas the most appropriate treatment for patients with adrenal incidentalomas and SCS remains controversial.(12)”
InfluentialToniato, A., Merante-Boschin, I., Opocher, G., Pelizzo, M. R., Schiavi, F., & Ballotta, E. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e31819a47d2 · Cited by 245 · see citing works
Results of Laparoscopic Adrenalectomy for Large and Potentially Malignant Tumors
Henry, J., Sebag, F. A., Iacobone, M., & Mirallié, É. (2002) · World Journal of Surgery · doi:10.1007/s00268-002-6666-0 · Cited by 223 · see citing works
Subclinical Cushing's syndrome in adrenal incidentaloma.
Terzolo, Osella, Alì, Borretta, Cesario, Paccotti, & Angeli, A. (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00357.x · Cited by 198 · see citing works
Chiodini, I., Morelli, V., Salcuni, A. S., Eller-Vainicher, C., Torlontano, M., Coletti, F., Iorio, L., Cuttitta, A., Ambrosio, A., Vicentini, L., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2387 · Cited by 191 · see citing works
Subclinical Cushing’s syndrome in adrenal incidentalomas
Terzolo, M., Bovio, S., Reimondo, G., Pia, A., Osella, G., Borretta, G., & Angeli, A. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2005.01.008 · Cited by 179 · see citing works
Chiodini, I., Morelli, V., Masserini, B., Salcuni, A. S., Eller-Vainicher, C., Viti, R., Coletti, F., Guglielmi, G., Battista, C., Carnevale, V., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0468 · Cited by 168 · see citing works
Development of overt Cushing’s syndrome in patients with adrenal incidentaloma
Barzon, L., Fallo, F., Sonino, N., & Boscaro, M. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1460061 · Cited by 162 · see citing works
The improvement of insulin resistance in patients with adrenal incidentaloma by surgical resection
Midorikawa, S., Sanada, H., Hashimoto, S., Suzuki, T., & Watanabe, T. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01274.x · Cited by 134 · see citing works
Bernini, G., Moretti, A., Iacconi, P., Miccoli, P., Nami, R., Lucani, B., & Salvetti, A. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1480213 · Cited by 105 · see citing works
Erbil, Y., Ademoğlu, E., Özbey, N., Barbaros, U., Yanık, B. T., Salmaslıoğlu, A., Bozbora, A., & Özarmağan, S. (2006) · World Journal of Surgery · doi:10.1007/s00268-005-0681-x · Cited by 102 · see citing works
The Role of Unilateral Adrenalectomy in ACTH‐Independent Macronodular Adrenal Hyperplasia (AIMAH)
Iacobone, M., Albiger, N. M. E., Scaroni, C. M., Mantero, F., Fassina, A., Viel, G., Frego, M., & Favia, G. (2008) · World Journal of Surgery · doi:10.1007/s00268-007-9408-5 · Cited by 97 · see citing works
The diagnosis of Cushing’s syndrome
Carroll, T. B., & Findling, J. W. (2010) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-010-9143-3 · Cited by 95 · see citing works
“Subclinical Cushing’s syndrome” is not subclinical: improvement after adrenalectomy in 9 patients
Mitchell, I. C., Auchus, R. J., Juneja, K., Chang, A. Y., Holt, S. A., Snyder, W. H., & Nwariaku, F. E. (2007) · Surgery · doi:10.1016/j.surg.2007.10.001 · Cited by 84 · see citing works
Sereg, M., Szappanos, Á., Tőke, J., Karlinger, K., Feldman, K., Kaszper, É., Varga, I., Gláz, E., Rácz, K., & Tóth, M. (2009) · European Journal of Endocrinology · doi:10.1530/eje-08-0707 · Cited by 81 · see citing works
Subclinical Cushing's syndrome in adrenal incidentalomas
Sippel, R. S., & Chen, H. (2004) · Surgical Clinics of North America · doi:10.1016/j.suc.2004.01.001 · Cited by 72 · see citing works
Leçons retenues après 274 surrénalectomies laparoscopiques
Henry, J. F., Sebag, F. A., Iacobone, M., Hubbard, J., & Maweja, S. (2002) · Annales de Chirurgie · doi:10.1016/s0003-3944(02)00831-3 · Cited by 38 · see citing works
lacobone, M., Mantero, F., Basso, S. M. M., Lumachi, F., & Favia, G. (2005) · Journal of Endocrinological Investigation · doi:10.1007/bf03347198 · Cited by 32 · see citing works
Flagged first, then by citations
1 of the 28 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Fassnacht, M., Arlt, W., Bancos, I., Dralle, H., Newell-Price, J., Sahdev, A., Tabarin, A., Terzolo, M., Tsagarakis, S., & Dekkers, O. M. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0467 · Cited by 1,566 · see citing works
Faßnacht, M., Tsagarakis, S., Terzolo, M., Tabarin, A., Sahdev, A., Newell-Price, J. D. C., Pelsma, I. C. M., Marina, L., Lorenz, K., Bancos, I., et al. (2023) · European Journal of Endocrinology · doi:10.1093/ejendo/lvad066 · Cited by 849 · see citing works
Sherlock, M., Scarsbrook, A., Abbas, A., Fraser, S., Limumpornpetch, P., Dineen, R., & Stewart, P. M. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa008 · Cited by 347 · see citing works
“Several studies have reported the outcome of surgical intervention but most involve small numbers and are retrospective, uncontrolled, and lack randomization (230,243,250-253,255) (Table 7).”
BackgroundElhassan, Y. S., Alahdab, F., Prete, A., Delivanis, D. A., Khanna, A., Prokop, L., Murad, M. H., O'Reilly, M. W., Arlt, W., & Bancos, I. (2019) · Annals of Internal Medicine · doi:10.7326/m18-3630 · Cited by 263 · see citing works
Long-term follow-up in adrenal incidentalomas: an Italian multicenter study
Morelli, V., Reimondo, G., Giordano, R., Della Casa, S., Policola, C., Palmieri, S., Salcuni, A. S., Dolci, A., Mendola, M., Arosio, M., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3527 · Cited by 223 · see citing works
“Some studies (22-26), but not all (27, 28), reported an improvement of the metabolic complications of SH (AH, weight, and glycemic control) and of the quality of life after adrenalectomy, while a worsening of these conditions in untreated patients.”
BackgroundMetabolic comorbidities in Cushing's syndrome
Ferraù, F., & Korbonits, M. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0354 · Cited by 223 · see citing works
Bancos, I., Alahdab, F., Crowley, R. K., Chortis, V., Delivanis, D. A., Erickson, D., Natt, N., Terzolo, M., Arlt, W., Young, W. F., et al. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0465 · Cited by 167 · see citing works
“Most studies reassessed patients at least 6 months after the surgery (n=17, Table 3) with a median follow up of 28 (1-109) months (median or mean follow up was reported only in 11 studies).”
Kebebew, E. (2021) · New England Journal of Medicine · doi:10.1056/nejmcp2031112 · Cited by 155 · see citing works
Glucose Metabolism Abnormalities in Cushing Syndrome: From Molecular Basis to Clinical Management
Scaroni, C., Zilio, M., Foti, M., & Boscaro, M. (2017) · Endocrine Reviews · doi:10.1210/er.2016-1105 · Cited by 140 · see citing works
Pelsma, I. C. M., Fassnacht, M., Tsagarakis, S., Terzolo, M., Tabarin, A., Sahdev, A., Newell-Price, J., Marina, L., Lorenz, K., Bancos, I., et al. (2023) · European Journal of Endocrinology · doi:10.1093/ejendo/lvad134 · Cited by 130 · see citing works
“65,68,69,72,73 Pooled RR for the improvement of dyslipidemia in patients with MACS was 3.2 (1.2-8.8) comparing surgery to conservative management, as is shown in Figure 6C.”
InfluentialSubclinical hypercortisolism: a state, a syndrome, or a disease?
Dalmazi, G. D., Pasquali, R., Beuschlein, F., & Reincke, M. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0272 · Cited by 124 · see citing works
Di Dalmazi, G., Berr, C. M., Fassnacht, M., Beuschlein, F., & Reincke, M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1401 · Cited by 139 · see citing works
Systematic review of surgical treatment of subclinical Cushing's syndrome
Iacobone, M., Citton, M., Scarpa, M., Viel, G., Boscaro, M., & Nitti, D. (2015) · British journal of surgery · doi:10.1002/bjs.9742 · Cited by 73 · see citing works
Outcome of surgical treatment of primary aldosteronism
Citton, M., Viel, G., Rossi, G. P., Mantero, F., Nitti, D., & Iacobone, M. (2015) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-014-1269-4 · Cited by 61 · see citing works
Cardiovascular complications of mild autonomous cortisol secretion
Aresta, C., Favero, V., Morelli, V., Giovanelli, L., Parazzoli, C., Falchetti, A., Pugliese, F., Gennari, L., Vescini, F., Salcuni, A. S., et al. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101494 · Cited by 53 · see citing works
Morelli, V., Ghielmetti, A., Caldiroli, A., Grassi, S., Siri, F. M., Caletti, E., Mucci, F., Aresta, C., Passeri, E., Pugliese, F., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa695 · Cited by 49 · see citing works
“Subsequently, the possibility of a QoL improvement after adrenalectomy in SH patients has been reported (25), suggesting that the QoL impairment could be a further consequence of SH.”
BackgroundRagnarsson, O., Mattsson, A. F., Monson, J. P., Filipsson Nyström, H., Åkerblad, A.-C., Kołtowska-Häggström, M., & Johannsson, G. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0397 · Cited by 46 · see citing works
Quality of life in patients with adrenal disease: A systematic review
Ho, W., & Druce, M. (2017) · Clinical Endocrinology · doi:10.1111/cen.13719 · Cited by 41 · see citing works
Update on subclinical Cushing's syndrome
Nieman, L. K. (2015) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000159 · Cited by 40 · see citing works
“As an example, one recent report found postoperative improvement in biochemical parameters (ACTH, UFC), blood pressure, fasting glucose, and HgbA1c [20].”
BackgroundAdrenocortical tumors and insulin resistance: What is the first step?
Altieri, B., Tirabassi, G., Casa, S. D., Ronchi, C. L., Balercia, G., Orio, F., Pontecorvi, A., Colao, A., & Muscogiuri, G. (2015) · International Journal of Cancer · doi:10.1002/ijc.29950 · Cited by 37 · see citing works
Daily salivary cortisol and cortisone rhythm in patients with adrenal incidentaloma
Ceccato, F., Barbot, M., Albiger, N., Antonelli, G., Zilio, M., Todeschini, M., Regazzo, D., Plebani, M., Lacognata, C., Iacobone, M., et al. (2018) · Endocrine · doi:10.1007/s12020-017-1421-3 · Cited by 38 · see citing works
Yener, S., BARIŞ, M. M., Peker, A., Demir, Ö., Ozgen, B., & Seçil, M. (2017) · Clinical Endocrinology · doi:10.1111/cen.13408 · Cited by 37 · see citing works
Subclinical hypercortisolism in adrenal incidentaloma
Debono, M., & Newell-Price, J. D. C. (2015) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000151 · Cited by 37 · see citing works
Subclinical Cushing’s syndrome: Current concepts and trends
Zografos, G. N., Perysinakis, I., & Vassilatou, E. (2014) · HORMONES · doi:10.14310/horm.2002.1506 · Cited by 33 · see citing works
Frequently asked questions and answers (if any) in patients with adrenal incidentaloma
Ceccato, F., Barbot, M., Scaroni, C. M., & Boscaro, M. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01615-3 · Cited by 34 · see citing works
Recent Updates on the Management of Adrenal Incidentalomas
Park, S. S., & Kim, J. H. (2023) · Endocrinology and Metabolism · doi:10.3803/enm.2023.1779 · Cited by 37 · see citing works
Management of adrenal incidentaloma: the role of adrenalectomy may be underestimated
Ye, Y., Yuan, X., Chen, M., Dai, Y., Qin, Z., & Zheng, F. (2016) · BMC Surgery · doi:10.1186/s12893-016-0154-1 · Cited by 33 · see citing works
“and metabolic disorders [10–14].”
BackgroundEvaluation and Treatment of Patients With Hypercortisolism: A Review.
Miller, B., & Auchus, R. (2020) · JAMA Surgery · doi:10.1001/jamasurg.2020.3280 · Cited by 28 · see citing works
Kim, B., Chun, A. R., Kim, K.-J., Jung, C., Kang, S. K., Mok, J., & Kim, C. (2014) · Endocrinology and Metabolism · doi:10.3803/enm.2014.29.4.457 · Cited by 32 · see citing works
Outcome of adrenalectomy for subclinical hypercortisolism and Cushing syndrome
Raffaelli, M., Crea, C. D., D’Amato, G., Gallucci, P., Lombardi, C. P., & Bellantone, R. D. A. (2016) · Surgery · doi:10.1016/j.surg.2016.07.042 · Cited by 32 · see citing works
Management of adrenal incidentaloma
Ménégaux, F., Chéreau, N., Peix, J.-L., Christou, N., Lifante, J. C., Paladino, N. C., Sebag, F. A., Ghander, C., Trésallet, C., & Mathonnet, M. (2014) · Journal of Visceral Surgery · doi:10.1016/j.jviscsurg.2014.07.002 · Cited by 31 · see citing works
Castro, M. A., Ojeda, C. M., Ramírez, M. N. S., Santos, V. G. D., Corrales, E. P., & Fernández-Argüeso, M. (2022) · Endocrine · doi:10.1007/s12020-022-03120-w · Cited by 30 · see citing works
Ricciato, M. P., Donna, V. D., Perotti, G., Pontecorvi, A., Bellantone, R. D. A., & Corsello, S. M. (2014) · World Journal of Surgery · doi:10.1007/s00268-014-2482-6 · Cited by 30 · see citing works
Possible, probable, and certain hypercortisolism: A continuum in the risk of comorbidity
Castro, M. A., Corrales, E. P., & Lamas, C. (2023) · Annales d Endocrinologie · doi:10.1016/j.ando.2023.01.005 · Cited by 35 · see citing works
Castro, M. A., Reincke, M., & Lamas, C. (2023) · Biomedicines · doi:10.3390/biomedicines11123115 · Cited by 24 · see citing works
The impact of an adrenal incidentaloma algorithm on the evaluation of adrenal nodules
Eldeiry, L. S., Alfisher, M. M., Callahan, C. F., Hanna, N. N., & Garber, J. R. (2018) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2018.07.001 · Cited by 24 · see citing works
Patients' Perception On Clinical Outcome And Quality Of Life After A Diagnosis Of Cushing Syndrome
Papoian, V., Biller, B. M. K., Webb, S. M., Campbell, K. K., Hodin, R. A., & Phitayakorn, R. (2015) · Endocrine Practice · doi:10.4158/ep15855.or · Cited by 24 · see citing works
Khadembashiri, M. M., Mohseni, S., Harandi, H., Sani, M. P., Khadembashiri, M. A., Atlasi, R., SeyedAlinaghi, S., Mohajeri‐Tehrani, M. R., & Larijani, B. A. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1374711 · Cited by 23 · see citing works
Age and the metabolic syndrome affect salivary Cortisol rhythm: data from a community sample
Ceccato, F., Barbot, M., Zilio, M., Ferasin, S., Lazzari, P. D., Lizzul, L., Boscaro, M., & Scaroni, C. M. (2015) · HORMONES · doi:10.14310/horm.2002.1591 · Cited by 22 · see citing works
Kang, M., Ku, J. H., Kwak, C. H., Kim, H. H., & Jeong, C. W. (2017) · Cancer Research and Treatment · doi:10.4143/crt.2017.248 · Cited by 22 · see citing works
“Approximately 10% of the overall population in the United States is prescribed statins, while its prevalence is increasing to 45% in the older population aged 65 years and over [2].”
Kawate, H., Kohno, M., Matsuda, Y., Akehi, Y., Tanabe, M., Horiuchi, T., Ohnaka, K., Nomura, M., Yanase, T., & Takayanagi, R. (2014) · Endocrine Journal · doi:10.1507/endocrj.ej14-0155 · Cited by 21 · see citing works
Comorbidities in Mild Autonomous Cortisol Secretion – A Clinical Review of Literature
Czapla-Iskrzycka, A., Świątkowska−Stodulska, R., & Sworczak, K. (2022) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-1827-4113 · Cited by 20 · see citing works
Khan, U. (2019) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_52_19 · Cited by 20 · see citing works
Broersen, L. H. A., Andela, C. D., Dekkers, O. M., Pereira, A. M., & Biermasz, N. R. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-01054 · Cited by 42 · see citing works
Adrenal Mass: Insight Into Pathogenesis and a Common Link With Insulin Resistance
Muscogiuri, G., Martino, M. C. D., Negri, M., Pivonello, C., Simeoli, C., Orio, F., Pivonello, R., & Colao, A. A. L. (2017) · Endocrinology · doi:10.1210/en.2016-1804 · Cited by 18 · see citing works
“(16) reported that laparoscopic adrenalectomy was associated with a sig-”
BackgroundApproach to the Patient with Subclinical Cushing’s Syndrome
Ivović, M., Marina, L., Šojat, A. S., Tančić‐Gajić, M., Arizanović, Z., Kendereški, A., & Vujović, S. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200813134328 · Cited by 18 · see citing works
Nationwide review of hormonally active adrenal tumors highlights high morbidity in pheochromocytoma
Parikh, P. P., Rubio, G. A., Farrá, J. C., & Lew, J. I. (2017) · Journal of Surgical Research · doi:10.1016/j.jss.2017.04.011 · Cited by 17 · see citing works
Wang, D., Ji, Z., Li, H., & Zhang, Y. (2017) · Cancer Biomarkers · doi:10.3233/cbm-170531 · Cited by 16 · see citing works
“The difference of diagnostic criteria is an important reason for the controversial findings [17].”
Management of hypertension and heart failure in patients with Addison's disease
Inder, W. J., Meyer, C., & Hunt, P. J. (2015) · Clinical Endocrinology · doi:10.1111/cen.12592 · Cited by 20 · see citing works
Cardiac Hypertrophy and Related Dysfunctions in Cushing Syndrome Patients—Literature Review
Kanzaki, A., Kadoya, M., Katayama, S., & Koyama, H. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11237035 · Cited by 14 · see citing works
Ren, X., Nan, M., & Zhang, X. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1399311 · Cited by 14 · see citing works
“Studies have suggested that cardiovascular risk factors worsened in patients with MACS in the medically managed group (14, 15, 23, 44).”
BackgroundHealth-Related Quality of Life in Adrenocortical Carcinoma
Steenaard, R. V., Michon, L. A., & Haak, H. R. (2019) · Cancers · doi:10.3390/cancers11101500 · Cited by 14 · see citing works
“Studies on benign and malignant cortisol-producing adrenal tumors showed an improvement of HRQoL after surgery due to recovery of hormonal status [11,13,41].”
BackgroundKnoble, N. B., Nayroles, G., Cheng, C., & Arnould, B. (2018) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-018-0958-4 · Cited by 14 · see citing works
When to Intervene for Subclinical Cushing's Syndrome
Hsieh, L. B., MacKinney, E. C., & Wang, T. S. (2019) · Surgical Clinics of North America · doi:10.1016/j.suc.2019.04.011 · Cited by 14 · see citing works
Markers of Subclinical Cardiovascular Disease in Patients with Adrenal Incidentaloma
Szychlińska, M., Baranowska-Jurkun, A., Matuszewski, W., Wołos-Kłosowicz, K., & Bandurska-Stankiewicz, E. M. (2020) · Medicina · doi:10.3390/medicina56020069 · Cited by 14 · see citing works
Wang, D., Li, H., Zhang, Y., Wang, L., & Ji, Z. (2018) · Surgical Laparoscopy Endoscopy & Percutaneous Techniques · doi:10.1097/sle.0000000000000585 · Cited by 13 · see citing works
Evaluation of Adrenal Incidentaloma
Hu, J., Kassu, R. A., Titanji, B. N., & Kebebew, E. (2024) · Surgical Clinics of North America · doi:10.1016/j.suc.2024.02.012 · Cited by 11 · see citing works
Tsentidis, C., Bampilis, A., Ntova, V., Fragkos, D., Panos, C., Limniati, C., & Kassi, G. (2018) · Hormone and Metabolic Research · doi:10.1055/a-0754-6464 · Cited by 11 · see citing works
“Patients with subclinical cortisol hypersecretion have higher incidence of cardiovascular events and increased mortality risk compared to healthy controls, while surgical resection of suspected adenomas improved metabolic and cardiovascular profile in many series [1, 16, 19, 20], but not in all [21].”
BackgroundHan, M., Cao, X., Zhao, C., Yang, L., Yin, N., Shen, P., Zhang, J., Gao, F., Ren, Y., Liang, D., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.544752 · Cited by 10 · see citing works
Lui, M. S., Shirali, A. S., Huang, B. L., Fisher, S. B., & Perrier, N. D. (2022) · Surgical Oncology Clinics of North America · doi:10.1016/j.soc.2022.08.004 · Cited by 10 · see citing works
Approach to the Patient with an Incidental Adrenal Mass
He, X., Peter, P. R., & Auchus, R. J. (2021) · Medical Clinics of North America · doi:10.1016/j.mcna.2021.06.009 · Cited by 10 · see citing works
Mintziori, G., Georgiou, T., Anagnostis, P. G., Adamidou, F., Efstathiadou, Z. A., Panagiotou, A., & Kita, M. D. (2018) · Hormone and Metabolic Research · doi:10.1055/a-0630-1397 · Cited by 9 · see citing works
“Only five out of twelve patients with autonomous cortisol secretion underwent adrenalectomy in the aforementioned study, however this improvement in metabolic factors after surgery has been confirmed by other cohort studies [22, 23].”
ResultRagnarsson, Ó., Trimpou, P., Oleröd, G., & Landin‐Wilhelmsen, K. (2015) · Steroids · doi:10.1016/j.steroids.2015.06.007 · Cited by 9 · see citing works
“Even mildly, pathologically increased endogenous cortisol production has negative impact on QoL [8], cardiovascular [9] and skeletal health [10,11].”
BackgroundVilléon, B. D. L., Bonnet, S., Gouya, H., Groussin, L., Tenenbaum, F., Gaujoux, S., & Dousset, B. E. (2016) · Surgery · doi:10.1016/j.surg.2016.03.008 · Cited by 9 · see citing works
Ueland, G. Å., Methlie, P., Heie, A., Stokland, A. M., Dahle, A. L., Sævik, Å. B., Løvås, K., & Husebye, E. S. (2023) · European Journal of Endocrinology · doi:10.1093/ejendo/lvad076 · Cited by 8 · see citing works
Khawandanah, D., El-Asmar, N., & Arafah, B. M. (2018) · Endocrine · doi:10.1007/s12020-018-1769-z · Cited by 8 · see citing works
Do adrenal incidentalomas have an impact on mental health? A comprehensive review
Kaštelan, D., & Dušek, T. (2025) · European Journal of Endocrinology · doi:10.1093/ejendo/lvaf011 · Cited by 7 · see citing works
Ueland, G. Å., Ragnarsson, Ó., Heie, A., Kjellbom, A., Lindgren, O., Muth, A., Palazzo, F. F., Poulsen, P. L., Rolighed, L., Thordarson, H. B., et al. (2025) · Endocrine Connections · doi:10.1530/ec-25-0361 · Cited by 7 · see citing works
“Lacobone et al. demonstrated in 2012 signi fi cant improvements in SF-36 quality of life scores in patients undergoing adrenalectomy compared to conservative management (13); however, to date, no randomized controlled trials on quality of life have been conducted in this fi eld.”
InfluentialSzychlińska, M., Rzeczkowska, M., Gontarz-Nowak, K., Matuszewski, W., & Bandurska-Stankiewicz, E. M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12144612 · Cited by 7 · see citing works
“In such patients weight loss, lowered blood pressure, as well as lowered lipid and fasting glucose levels have been observed after surgery [42,43].”
BackgroundScreening of hypercortisolism among patients with hypertension: an Italian nationwide survey
Dalmazi, G. D., Goi, J., Burrello, J., Tucci, L., Cicero, A. F. G., Mancusi, C., Moia, E. C., Iaccarino, G., Borghi, C., Muiesan, M. L., et al. (2024) · Journal of Endocrinological Investigation · doi:10.1007/s40618-024-02387-2 · Cited by 6 · see citing works
Dovirak, O., Mao, J., Taylor, K., Chang, P., & Wagner, A. A. (2016) · Surgical Laparoscopy Endoscopy & Percutaneous Techniques · doi:10.1097/sle.0000000000000290 · Cited by 6 · see citing works
Lin, D., Lin, J., Hu, X., Liu, Y., Zhang, J., Zhang, L., Jiang, J., Li, X., & Guo, J. (2021) · Translational Andrology and Urology · doi:10.21037/tau-20-1108 · Cited by 5 · see citing works
“Compared to a conservative approach, adrenalectomy can effectively al leviate metabolic disturbances caused by SCS but may lead to adrenal insufficiency (AI) (12-17).”
BackgroundTurcu, A. F., & Auchus, R. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-45950-9_10 · Cited by 4 · see citing works
Cardiovascular and metabolic consequences in patients with asymptomatic adrenal adenomas
Hamidi, O. (2021) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000628 · Cited by 4 · see citing works
Szychlińska, M., Rzeczkowska, M., Matuszewski, W., & Bandurska-Stankiewicz, E. M. (2023) · Endokrynologia Polska · doi:10.5603/ep.95139 · Cited by 4 · see citing works
Thompson, L. H., Nordenström, E., Almquist, M., & Bergenfelz, A. O. J. (2019) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-019-01844-4 · Cited by 3 · see citing works
Evaluación diagnóstica y terapéutica del incidentaloma suprarrenal
Gomez, R. M., Chervin, R. A., Pardes, E., Lupi, S., Surraco, M. E., Herrera, J., Schurman, L., & Gonzáles, C. (2016) · Revista Argentina de Endocrinología y Metabolismo · doi:10.1016/j.raem.2015.12.001 · Cited by 3 · see citing works
Long-term cardiometabolic outcomes of primary bilateral macronodular adrenal hyperplasia
Zhou, H., Zhang, P., Yin, Y., Liu, L., Li, J., Xu, H., Yu, F., Su, X., Lyu, Z., Gu, W., et al. (2025) · Journal of Endocrinological Investigation · doi:10.1007/s40618-025-02561-0 · Cited by 2 · see citing works
“Our study demonstrated that surgical intervention effectively improved BP and glycemic control in patients with PBMAH and MACS, aligning with several prior studies on patients with MACS [20, 34–36].”
Bilateral Adrenal Nodules Presenting With Mild Autonomous Cortisol Secretion
Sandooja, R., Hamidi, O., Zhang, C. D., Dogra, P., Athimulam, S., Rahimi, L., Villavicencio, C. A., Chacko, S. R., Young, W. F., & Bancos, I. (2025) · Endocrine Practice · doi:10.1016/j.eprac.2025.06.019 · Cited by 2 · see citing works
Conduite à tenir devant un incidentalome surrénalien
Ménégaux, F., Chéreau, N., Peix, J.-L., Christou, N., Lifante, J. C., Paladino, N. C., Sebag, F. A., Ghander, C., Trésallet, C., & Mathonnet, M. (2014) · Journal de Chirurgie Viscérale · doi:10.1016/j.jchirv.2014.05.005 · Cited by 2 · see citing works
Egan, R. J., & Scott-Coombes, D. M. (2018) · Springer eBooks · doi:10.1007/978-981-10-1124-5_25 · Cited by 2 · see citing works
The effect of adrenalectomy on the patients with Mild Autonomous Cortisol Secretion
Köstek, M., Roy, R., Gillis, A., Chen, H. Y., & Lindeman, B. M. (2026) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2026.116922 · Cited by 1 · see citing works
Should the Monitoring Protocols for Adrenal Incidentalomas be Changed?
Mateo-Gavira, I., Vílchez-López, F. J., Larrán-Escandón, L., Ojeda-Schuldt, M. B., Tinoco, C. L., & Aguilar‐Diosdado, M. (2014) · Cirugía Española (English Edition) · doi:10.1016/j.cireng.2013.09.030 · Cited by 1 · see citing works
“Although some studies support surgery, 9 intervention was not chosen because the patients were older than 60 years, had diabetes and hypertension, were well-controlled on pharmacological treatment, and there was no evidence of the potential benefit that surgery would provide.”
Iacobone, M., & Torresan, F. (2021) · Springer eBooks · doi:10.1007/978-3-030-84737-1_19 · Cited by 1 · see citing works
Advances in our understanding of the prognosis of adrenal incidentaloma
Mackay, I., & Aspinall, S. R. (2016) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2016.1233055 · Cited by 1 · see citing works
“reported that adrenalectomy in patients with AI and SH improved hypertension, glycemic control, body mass index (BMI), and quality of life (QOL), measured by SF-36, in 20 patients compared to 15 controls managed conservatively [78].”
MethodLirov, R., & Gauger, P. G. (2018) · Springer eBooks · doi:10.1007/978-981-10-1124-5_26 · Cited by 1 · see citing works
¿Deberían modificarse los protocolos diagnóstico-terapéuticos de los incidentalomas suprarrenales?
Mateo-Gavira, I., Vílchez-López, F. J., Larrán-Escandón, L., Ojeda-Schuldt, M. B., Tinoco, C. L., & Aguilar‐Diosdado, M. (2014) · Cirugía Española · doi:10.1016/j.ciresp.2013.09.016
L'incidentalome surrénalien, étude du statut métabolique et de la fibrinolyse
Thebert, J. (2015) · HAL
Management Scheme for Adrenal Incidentalomas: Who Gets What?
Callender, G. G., & Udelsman, R. (2016) · Current Surgery Reports · doi:10.1007/s40137-016-0145-2
Operative Techniques for Adrenal Neoplasms
Patel, D. (2016) · Springer eBooks · doi:10.1007/978-3-319-44136-8_13
Carşote, M., Ghemigian, A. M., Valea, A., Dumitrascu, A. S., Chiriţă, C., & Poiană, C. (2015) · Ars medica tomitana · doi:10.1515/arsm-2015-0032
Kang, M., Baek, M., Lee, J., & Jeong, B. C. (2017) · Journal of Urologic Oncology · doi:10.22465/kjuo.2017.15.3.137
“Given the variability in diagnostic criteria and optimal management of SCS, the most appropriate treatment for SCS patients remains a highly controversial issue,10 although a few studies provide evidence that surgical treatment may be associated with a positive effect on the long-term clinical and metabolic outcomes i…”
BackgroundInfluentialHamidi, M., Mavros, M. N., Devon, K. M., Kulkarni, G. S., Law, C., Urbach, D. R., Hallet, J. I., & Pasternak, J. D. (2020) · Springer eBooks · doi:10.1007/978-3-030-48363-0_1
Aouinati, Y., Mjabber, A., Haraj, N. E., Aziz, S. E., & Chadli, A. (2021) · Pan African Medical Journal · doi:10.11604/pamj.2021.38.367.26040
“4 compact and spongiform cells on the microscopic level [19], which is in favor of macronodular hyperplasia the latter must not be confused with”
BackgroundTrandafir, A.-I., Stanciu, M., Albu, S. E., Stoian, V. R., CIOFU, I., Persu, C., Nistor, C., & Carşote, M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12134244
“Notably, adrenalectomy should be considered when deciding on an anti-osteoporosis strategy (including in cases of unilateral adrenal removal for patients with bilateral AIs) since improvement of bone status is expected after surgery [68,70]; however, some authors showed no remarkable post-operative benefits regarding…”
BackgroundInfluentialIncidentally Found Adrenal Masses: When Should We Worry?
Tritos, N. A. (2023) · Endocrine Practice · doi:10.1016/j.eprac.2023.09.010
FIGURES 45 in Two new species of Ascidae (Acarina: Mesostigmata) from India
Bhattacharyya, A. K. (2003) · INFM-OAR (INFN Catania) · doi:10.5281/zenodo.157114
Ruggiero, B., Zhu, G., Swan, L., Suntornlohanakul, O., Xu, M., Ronchi, C. L., Elhassan, Y., Yates, D., & Prete, A. (2026) · European Journal of Endocrinology · doi:10.1093/ejendo/lvag072
Devaraja, V., Rajoo, S., Valayatham, V. M., & Hui, F. S. (2026) · Journal of the ASEAN Federation of Endocrine Societies · doi:10.15605/jafes.041.01.5143
“11,12 Consequently, the optimal management and long-term follow-up of AI patients remain subjects of debate.”
- Authors
- Iacobone, M., Citton, M., Viel, G., Boetto, R., Bonadio, I., Mondi, I., Tropea, S., Nitti, D., & Favia, G.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Iacobone, Maurizio
- Venue
- Surgery
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 152
- Issue
- 6
- Pages
- 991-997
- ISSN
- 0039-6060 (ISSN-L)
- OpenAlex
- W2008606130
- Cited by
- 101
- References
- 28
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 10 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 8 · 2016: 11 · 2015: 13 · 2014: 12
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Surgery (publishedVersion)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- adrenalectomy, adrenal incidentaloma, subclinical Cushing's syndrome, conservative treatment, cardiovascular dysfunction, metabolic dysfunction, quality of life, blood pressure, body mass index, corticosteroid secretion, laparoscopic adrenalectomy
- MeSH terms
- Adrenal Cortex Neoplasms, Adrenalectomy, Adult, Aged, Blood Glucose, Blood Pressure, Cushing Syndrome, Female, Glycated Hemoglobin, Humans, Lipids, Male, Middle Aged, Quality of Life, Body Mass Index, Adrenocortical Adenoma, Metabolic Syndrome, Incidental Findings
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
