Evaluation of cholesterol-lowering activity of standardized extract of Mangifera indica in albino Wistar rats
Open accessAbstract
INTRODUCTION: L. has been determined by earlier researchers and kernel, leaf and bark have shown significant activity. However, the specific cholesterol lowering activity of leaf methanol extract has not been determined. MATERIALS AND METHODS: leaves using high cholesterol diet model in albino Wistar rats. The acute oral toxicity at a dose of 5000 mg/ kg body weight was also determined in female albino Wistar rats. Phytoconstituents Iriflophenone 3-C-β-D-glucoside and mangiferin were quantified in methanol extracts of different varieties of mango leaves using high performance liquid chromatography. RESULTS AND DISCUSSION: leaves, at dose of 90 mg/kg body weight in rats and it was also found to be safe at dose of 5000 mg/kg rat body. Iriflophenone 3-C-β-D-glucoside and mangiferin were found to be in the range of 1.2 to 2.8% w/w and 3.9 to 4.6% w/w, respectively which along with 3 β taraxerol and other sterols could be contributing to the cholesterol lowering activity of mango leaves extract. CONCLUSIONS: The phytosterols rich extract of Mangifera indica leaves is a good source of nutraceutical ingredient that have the potential to lower serum cholesterol levels. SUMMARY: leaves methanolic extract showed significant cholesterol lowering activity in high cholesterol diet induced hypercholesterolaemia model in rats when evaluated at a dose of 90 mg/kg rat body weight. The extract was found to contain Iriflophenone 3-C-β-D-glucoside and mangiferin which along with 3 β taraxerol and other sterols could be contributing to the cholesterol lowering activity.
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In male Wistar rats, a standardized mango leaf extract has a more significant cholesterol-reducing effect compared to atorvastatin.
“Furthermore, in male Wistar rats, a standardized mango leaf extract demonstrated a more significant cholesterol-reducing effect compared to atorvastatin.”
From Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review (2023) · cites this paper as [85]
The Methods confirm that the study used male Wistar rats and compared mango leaf extract with atorvastatin. But the Discussion reports a 14% reduction in serum cholesterol with the extract versus 17% with atorvastatin, and describes the extract’s activity as comparable—not more effective. (LLM, conf=0.90)
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Experimental — accuracy not yet measuredThe cholesterol-reducing effect of standardized mango leaf extract in male Wistar rats is attributed to iriflophenone 3-C-β-d-glucoside, mangiferin, and 3β-taraxerol.
“This effect was attributed to three key molecules: iriflophenone 3-C-β-d-glucoside, mangiferin, and 3β-taraxerol [85].”
From Mangifera indica L., By-Products, and Mangiferin on Cardio-Metabolic and Other Health Conditions: A Systematic Review (2023) · cites this paper as [85]
The Methods section identifies male albino Wistar rats as the cholesterol-lowering study population, and the Abstract’s Results and Discussion reports a significant effect of the mango leaf extract. The Abstract’s Summary names all three compounds, but says they, along with other sterols, *could* contribute to the effect; it does not establish that the effect is attributable to those three molecules alone. Page numbers are unavailable in our copy. (LLM, conf=0.88)
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Cites
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Nutraceuticals for the treatment of hypercholesterolemia
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Pinneo, S., O'Mealy, C., Rosas Jr., M., Tsang, M., Liu, C., Kern, M., Hooshmand, S., & Hong, M. Y. (2022) · Journal of Medicinal Food · doi:10.1089/jmf.2021.0063 · Cited by 19 · see citing works
- Authors
- Dethe, S., Gururaja, G., Mundkinajeddu, D., Kumar, A., Allan, J., & Agarwal, A.
- Affiliations
- Manipal Academy of Higher Education (IN)
- Natural Remedies (India) (IN)
- Corresponding author
- Dethe, ShekharMichael
- Venue
- Pharmacognosy Research
- Publisher
- Manuscript Technomedia LLP
- Published
- 2017
- Volume
- 9
- Issue
- 1
- Pages
- 21
- ISSN
- 0974-8490 (ISSN-L)
- PMC
- PMC5330098
- OpenAlex
- W2586725383
- Cited by
- 39
- References
- 2
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 8 · 2019: 4 · 2018: 4 · 2017: 3
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Pharmacognosy Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- mango, mango leaf extract, cholesterol lowering, hypercholesterolemia, mangiferin, phytosterols, nutraceuticals, acute oral toxicity, methanol extract
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