L-asparaginase in the treatment of patients with acute lymphoblastic leukemia
Open accessAbstract
Acute lymphoblastic leukemia (ALL) is a hematologic malignancy that predominantly occurs in children between 2 and 10 years of age. L-asparaginase is an integral component of treatment for patients with ALL and since its introduction into pediatric treatment protocols in the 1960s, survival rates in children have progressively risen to nearly 90%. Outcomes for adolescent and young adult (AYA) patients, aged 15-39 years and diagnosed with ALL, have historically been less favorable. However, recent reports suggest substantially increased survival in AYA patients treated on pediatric-inspired protocols that include a greater cumulative dose of asparaginase. All currently available asparaginases share the same mechanism of action - the deamination and depletion of serum asparagine levels - yet each displays a markedly different pharmacokinetic profile. Pegylated asparaginase derived from the bacterium Escherichia coli is used as first-line therapy; however, up to 30% of patients develop a treatment-limiting hypersensitivity reaction. Patients who experience a hypersensitivity reaction to an E. coli-derived asparaginase can continue treatment with Erwinia chrysanthemi asparaginase. Erwinia asparaginase is immunologically distinct from E. coli-derived asparaginases and exhibits no cross-reactivity. Studies have shown that with adequate dosing, therapeutic levels of Erwinia asparaginase activity can be achieved, and patients switched to Erwinia asparaginase due to hypersensitivity can obtain outcomes similar to patients who do not experience a hypersensitivity reaction. Therapeutic drug monitoring may be required to ensure that therapeutic levels of asparaginase activity are maintained.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
L-asparaginase is effective in treating ALL and is included in standard chemotherapy regimens for the disease.
“L-asparaginase has been found to be effective in the treatment of ALL and is included in standard chemotherapy regimens for this disease (Table 1)(Egler et al., 2016).”
From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Egler et al., 2016
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Treatment of Acute Lymphoblastic Leukemia
Pui, C., & Evans, W. E. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052603 · Cited by 1,983 · see citing works
Pui, C.-H., Robison, L. L., & Look, A. T. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60457-2 · Cited by 1,564 · see citing works
Hunger, S. P., Lu, X., Devidas, M., Camitta, B. M., Gaynon, P. S., Winick, N. J., Reaman, G. H., & Carroll, W. L. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.37.8018 · Cited by 1,177 · see citing works
Silverman, L. B. (2001) · Blood · doi:10.1182/blood.v97.5.1211 · Cited by 869 · see citing works
Results of Treatment With Hyper-CVAD, a Dose-Intensive Regimen, in Adult Acute Lymphocytic Leukemia
Kantarjian, H. M., O'Brien, S. M., Smith, T. L., Cortes, J. E., Giles, F. J., Beran, M., Pierce, S. A., Huh, Y. O., Andreeff, M., Koller, C. A., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.3.547 · Cited by 796 · see citing works
Armstrong, J. K., Hempel, G., Koling, S., Chan, L. S., Fisher, T., Meiselman, H. J., & Garratty, G. (2007) · Cancer · doi:10.1002/cncr.22739 · Cited by 699 · see citing works
Kantarjian, H. M., Thomas, D. A., O'Brien, S. M., Cortes, J. E., Giles, F. J., Jeha, S., Bueso-Ramos, C., Pierce, S. A., Shan, J., Koller, C. A., et al. (2004) · Cancer · doi:10.1002/cncr.20668 · Cited by 638 · see citing works
Boissel, N., Auclerc, M.-F., Lhéritier, V., Pérel, Y., Thomas, X., Leblanc, T. M., Rousselot, P. H., Cayuela, J., Gabert, J. A., Fegueux, N., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.02.053 · Cited by 606 · see citing works
L‐asparaginase treatment in acute lymphoblastic leukemia: A focus on <i>Erwinia</i> asparaginase
Pieters, R., Hunger, S. P., Boos, J., Rizzari, C., Silverman, L., Baruchel, A., Goekbuget, N., Schrappe, M., & Pui, C. (2011) · Cancer · doi:10.1002/cncr.25489 · Cited by 569 · see citing works
Huguet, F., Leguay, T., Raffoux, E., Thomas, X., Beldjord, K., Delabesse, É., Chevallier, P., Buzyn, A., Delannoy, A., Chalandon, Y., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.6916 · Cited by 566 · see citing works
Outcome of Treatment in Adults With Acute Lymphoblastic Leukemia: Analysis of the LALA-94 Trial
Thomas, X., Boiron, J.-M., Huguet, F., Dombret, H., Bradstock, K. F., Vey, N., Kovacsovics, T. J., Delannoy, A., Fegueux, N., Fenaux, P., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.10.050 · Cited by 550 · see citing works
Stock, W., La, M., Sanford, B. L., Bloomfield, C. D., Vardiman, J. W., Gaynon, P. S., Larson, R. A., & Nachman, J. B. (2008) · Blood · doi:10.1182/blood-2008-01-130237 · Cited by 533 · see citing works
Avramis, V. I., Sencer, S., Periclou, A. P., Sather, H. N., Bostrom, B., Cohen, L. J., Ettinger, A. G., Ettinger, L. J., Franklin, J. L., Gaynon, P. S., et al. (2002) · Blood · doi:10.1182/blood.v99.6.1986 · Cited by 492 · see citing works
REGRESSION OF TRANSPLANTED LYMPHOMAS INDUCED IN VIVO BY MEANS OF NORMAL GUINEA PIG SERUM
Kidd, J. G. (1953) · The Journal of Experimental Medicine · doi:10.1084/jem.98.6.565 · Cited by 411 · see citing works
Duval, M. (2002) · Blood · doi:10.1182/blood.v99.8.2734 · Cited by 409 · see citing works
Moghrabi, A., Levy, D. E., Asselin, B. L., Barr, R. D., Clavell, L. A., Hurwitz, C. A., Samson, Y., Schorin, M. A., Dalton, V. K., Lipshultz, S. E., et al. (2006) · Blood · doi:10.1182/blood-2006-06-027714 · Cited by 399 · see citing works
Caruso, V., Iacoviello, L., Castelnuovo, A. F. D., Storti, S., Mariani, G., de Gaetano, G., & Donati, M. B. (2006) · Blood · doi:10.1182/blood-2006-04-015511 · Cited by 388 · see citing works
EVIDENCE THAT THE L -ASPARAGINASE OF GUINEA PIG SERUM IS RESPONSIBLE FOR ITS ANTILYMPHOMA EFFECTS
Broome, J. D. (1963) · The Journal of Experimental Medicine · doi:10.1084/jem.118.1.99 · Cited by 349 · see citing works
Amylon, M. D., Shuster, J. J., Pullen, J., Berard, C. W., Link, M., Wharam, M. D., Katz, J., Yu, A. L.-T., Laver, J. H., Ravindranath, Y., et al. (1999) · Leukemia · doi:10.1038/sj.leu.2401310 · Cited by 346 · see citing works
Comparative pharmacokinetic studies of three asparaginase preparations.
Asselin, B. L., Whitin, J. C., Coppola, D. J., Rupp, I. P., Sallan, S. E., & Cohen, H. J. (1993) · Journal of Clinical Oncology · doi:10.1200/jco.1993.11.9.1780 · Cited by 331 · see citing works
DeAngelo, D. J., Stevenson, K. E., Dahlberg, S. E., Silverman, L. B., Couban, S., Supko, J. G., Amrein, P. C., Ballen, K. K., Seftel, M. D., Turner, A. R., et al. (2014) · Leukemia · doi:10.1038/leu.2014.229 · Cited by 330 · see citing works
de Bont, J. M., van der Holt, B., Dekker, A. W., den Berg, A. V. D. D.-V., Sonneveld, P., & Pieters, R. (2004) · Leukemia · doi:10.1038/sj.leu.2403538 · Cited by 322 · see citing works
L-asparaginase therapy for leukemia and other malignant neoplasms. Remission in human leukemia
Hill, J. M. (1967) · JAMA · doi:10.1001/jama.202.9.882 · Cited by 322 · see citing works
Vrooman, L. M., Stevenson, K. E., Supko, J. G., O'Brien, J., Dahlberg, S. E., Asselin, B. L., Athale, U. H., Clavell, L. A., Kelly, K. M., Kutok, J. L., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.43.2070 · Cited by 312 · see citing works
Ribera, J., Oriol, A., Sanz, M. Á., Tormo, M., Fernández, P., del Potro, E., Abella, E., Bueno, J., Parody, R., Bastida, P., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.13.7265 · Cited by 263 · see citing works
Ramanujachar, R., Richards, S. M., Hann, I. M., Goldstone, A. H., Mitchell, C., Vora, A. J., Rowe, J. M., & Webb, D. K. H. (2006) · Pediatric Blood & Cancer · doi:10.1002/pbc.20749 · Cited by 256 · see citing works
Outcome with the hyper-CVAD regimens in lymphoblastic lymphoma
Thomas, D. A., O'Brien, S. M., Cortes, J. E., Giles, F. J., Faderl, S. H., Verstovšek, S., Ferrajoli, A., Koller, C. A., Beran, M., Pierce, S. A., et al. (2004) · Blood · doi:10.1182/blood-2003-12-4428 · Cited by 256 · see citing works
Pharmacokinetic/Pharmacodynamic Relationships of Asparaginase Formulations
Avramis, V. I., & Panosyan, E. H. (2005) · Clinical Pharmacokinetics · doi:10.2165/00003088-200544040-00003 · Cited by 241 · see citing works
Panosyan, E. H., Seibel, N. L., Martín‐Aragón, S., Gaynon, P. S., Avramis, I. A., Sather, H. N., Franklin, J. L., Nachman, J. B., Ettinger, L. J., La, M., et al. (2004) · Journal of Pediatric Hematology/Oncology · doi:10.1097/00043426-200404000-00002 · Cited by 236 · see citing works
Pulte, D. D., Gondos, Á., & Brenner, H. (2008) · Blood · doi:10.1182/blood-2008-06-164863 · Cited by 234 · see citing works
Stock, W., Douer, D., DeAngelo, D. J., Arellano, M. L., Advani, A. S., Damon, L. E., Kovacsovics, T. J., Litzow, M. R., Rytting, M., Borthakur, G. M., et al. (2011) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2011.596963 · Cited by 230 · see citing works
Tong, W. H., Pieters, R., Kaspers, G. J. L., Loo, D. M. W. M. T., Bierings, M., van den Bos, C., Kollen, W. J. W., Hop, W. C. J., Lanvers‐Kaminsky, C., Relling, M. V., et al. (2014) · Blood · doi:10.1182/blood-2013-10-534347 · Cited by 225 · see citing works
Boos, J., Werber, G., Ahlke, E., Schulze-Westhoff, P., Nowak‐Göttl, U., Würthwein, G., Verspohl, E. J., Ritter, J., & Jürgens, H. (1996) · European Journal of Cancer · doi:10.1016/0959-8049(96)00131-1 · Cited by 218 · see citing works
L-Asparaginase and PEG Asparaginase— Past, Present, and Future
Keating, M. J., Holmes, R., Lerner, S. A., & Ho, D. H. (1993) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199309149129 · Cited by 217 · see citing works
Pession, A., Valsecchi, M. G., Masera, G., Kamps, W. A., Magyarosy, E., Rizzari, C., van Wering, E. R., Nigro, L. L., van der Does, A., Locatelli, F., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.11.411 · Cited by 203 · see citing works
Sallan, S. E., Hitchcock‐Bryan, S., Gelber, R. D., Cassady, J. R., Frei, E., & Nathan, D. (1983) · PubMed · Cited by 201 · see citing works
Ortega, J. A., Nesbit, M. E., Donaldson, M. H., Hittle, R. E., Weiner, J. M., Karon, M. R., & Hammond, D. (1977) · PubMed · Cited by 186 · see citing works
Woo, M. H., Hak, L. J., Storm, M. C., Sandlund, J. T., Ribeiro, R. C., Rivera, G. K., Rubnitz, J. E., Harrison, P. L., Wang, B., Evans, W. E., et al. (2000) · Journal of Clinical Oncology · doi:10.1200/jco.2000.18.7.1525 · Cited by 182 · see citing works
L -Asparaginase: Clinical, Biochemical, Pharmacological, and Immunological Studies
Capizzi, R. L., BERTINO, J. R., SKEEL, R. T., CREASEY, W. A., ZANES, R., OLAYON, C., PETERSON, R. G., & HANDSCHUMACHER, R. E. (1971) · Annals of Internal Medicine · doi:10.7326/0003-4819-74-6-893 · Cited by 180 · see citing works
Cornelissen, J. J., van der Holt, B., Verhoef, G. E. G., Veer, M. B. V., van Oers, M. H. J., Schouten, H. C., Ossenkoppele, G. J., Sonneveld, P., Maertens, J. A., Kooy, M. V. M., et al. (2008) · Blood · doi:10.1182/blood-2008-07-168625 · Cited by 173 · see citing works
Douer, D., Yampolsky, H., Cohen, L. J., Watkins, K., Levine, A. M., Periclou, A. P., & Avramis, V. I. (2006) · Blood · doi:10.1182/blood-2006-07-035006 · Cited by 168 · see citing works
Riccardi, R., Holcenberg, J. S., Glaubiger, D. L., Wood, J. H., & Poplack, D. G. (1981) · PubMed · Cited by 167 · see citing works
Vrooman, L. M., Supko, J. G., Neuberg, D. S., Asselin, B. L., Athale, U. H., Clavell, L. A., Kelly, K. M., Laverdière, C., Michon, B., Schorin, M. A., et al. (2009) · Pediatric Blood & Cancer · doi:10.1002/pbc.22225 · Cited by 162 · see citing works
EVIDENCE THAT THE L -ASPARAGINASE OF GUINEA PIG SERUM IS RESPONSIBLE FOR ITS ANTILYMPHOMA EFFECTS
Broome, J. D. (1963) · The Journal of Experimental Medicine · doi:10.1084/jem.118.1.121 · Cited by 159 · see citing works
Abshire, T. C., Pollock, B. H., Billett, A. L., Bradley, P., & Buchanan, G. R. (2000) · Blood · doi:10.1182/blood.v96.5.1709 · Cited by 152 · see citing works
Killander, D., Dohlwitz, A., Engstedt, L., Franzén, S., Gahrton, G., GULLBRING, B., Holm, G., Holmgren, A., Höglund, S., KILLANDER, A., et al. (1976) · Cancer · doi:10.1002/1097-0142(197601)37:1 · Cited by 143 · see citing works
Angiolillo, A. L., Schore, R. J., Devidas, M., Borowitz, M. J., Carroll, A. J., Gastier, J. M., Heerema, N. A., Keilani, T., Lane, A. R., Loh, M. L., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2014.55.5763 · Cited by 135 · see citing works
Improved Prognosis for Older Adolescents With Acute Lymphoblastic Leukemia
Pui, C., Pei, D., Campana, D., Bowman, W. P., Sandlund, J. T., Kaste, S. C., Ribeiro, R. C., Rubnitz, J. E., Coustan‐Smith, E., Jeha, S., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.32.0325 · Cited by 135 · see citing works
SUPPRESSION OF MURINE LEUKEMIAS BY L -ASPARAGINASE
Boyse, E. A., Old, L. J., Campbell, H. A., & Mashburn, L. T. (1967) · The Journal of Experimental Medicine · doi:10.1084/jem.125.1.17 · Cited by 134 · see citing works
Raetz, E. A., & Salzer, W. L. (2010) · Journal of Pediatric Hematology/Oncology · doi:10.1097/mph.0b013e3181e6f003 · Cited by 132 · see citing works
Woo, M., Hak, L., Storm, M., Evans, W., Sandlund, J. T., Rivera, G. K., Wang, B., Pui, C., & Relling, M. V. (1998) · Leukemia · doi:10.1038/sj.leu.2401162 · Cited by 128 · see citing works
Pulte, D. D., Gondos, Á., & Brenner, H. (2008) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn276 · Cited by 126 · see citing works
Wang, B., Relling, M. V., Storm, M., Woo, M. H., Ribeiro, R. C., Pui, C.-H., & Hak, L. J. (2003) · Leukemia · doi:10.1038/sj.leu.2403011 · Cited by 124 · see citing works
Two L-asparaginases from E. coli and their action against tumors.
Schwartz, J. H., Reeves, J. Y., & Broome, J. D. (1966) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.56.5.1516 · Cited by 123 · see citing works
Müller, H., Löning, L., Horn, A., Schwabe, D., Gunkel, M., Schrappe, M., von Schütz, V., Henze, G., da Palma, J. C., Ritter, J., et al. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02187.x · Cited by 120 · see citing works
Ahlke, E., ̈TTL, U. N., Schulze-Westhoff, P., WERBER, G., ̈RSTE, H. B., Würthwein, G., ̈RGENS, H. J., & Boos, J. (1997) · British Journal of Haematology · doi:10.1046/j.1365-2141.1997.d01-2089.x · Cited by 117 · see citing works
Appel, I. M., Kazemier, K. M., Boos, J., Lanvers, C., Huijmans, J. G. N., Veerman, A. J. P., van Wering, E., den Boer, M. L., & Pieters, R. (2008) · Leukemia · doi:10.1038/leu.2008.165 · Cited by 116 · see citing works
Clinical utility and implications of asparaginase antibodies in acute lymphoblastic leukemia
Liu, C., Kawedia, J. D., Cheng, C., Pei, D., Fernandez, C. A., Cai, X., Crews, K. R., Kaste, S. C., Panetta, J. C., Wp, B., et al. (2012) · Leukemia · doi:10.1038/leu.2012.102 · Cited by 113 · see citing works
Rizzari, C., Zucchetti, M., Conter, V., Diomede, L., Bruno, A., Gavazzi, L. M., Paganini, M., Sparano, P., Nigro, L. L., Aricò, M., et al. (2000) · Annals of Oncology · doi:10.1023/a:1008368916800 · Cited by 112 · see citing works
Stock, W., Luger, S. M., Advani, A. S., Geyer, S. M., Harvey, R. C., Mullighan, C. G., Willman, C. L., Malnassy, G., Parker, E., Laumann, K. M., et al. (2014) · Blood · doi:10.1182/blood.v124.21.796.796 · Cited by 105 · see citing works
Rytting, M., Thomas, D. A., O'Brien, S. M., Ravandi‐Kashani, F., Jabbour, E. J., Franklin, A. R. K., Kadia, T. M., Pemmaraju, N., Daver, N. G., Ferrajoli, A., et al. (2014) · Cancer · doi:10.1002/cncr.28930 · Cited by 100 · see citing works
Müller, H., Beier, R., Löning, L., Blütters‐Sawatzki, R., Dörffel, W., Maass, E., Müller-Weihrich, S., Scheel‐Walter, H., Scherer, F., Stahnke, K., et al. (2001) · British Journal of Haematology · doi:10.1046/j.1365-2141.2001.03009.x · Cited by 95 · see citing works
Kamisaki, Y., Wada, H., Yagura, T., Matsushima, A., & Inada, Y. (1981) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32435-3 · Cited by 93 · see citing works
A NEW L-ASPARAGINASE WITH ANTITUMOUR ACTIVITY
Wade, H. E., Elsworth, R., Herbert, D., Keppie, J., & Sargeant, K. P. (1968) · The Lancet · doi:10.1016/s0140-6736(68)90977-x · Cited by 93 · see citing works
Zalewska‐Szewczyk, B., Andrzejewski, W., Mlynarski, W. M., Jędrychowska-Dańska, K., Witas, H. W., & Bodalski, J. (2007) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190701292049 · Cited by 88 · see citing works
Immunological responses to l-asparaginase
Peterson, R. G., Handschumacher, R. E., & Mitchell, M. S. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106579 · Cited by 87 · see citing works
BCG in the treatment of acute lymphocytic leukemia
Heyn, R., Joo, P., Karon, M. R., Nesbit, M., Shore, N., Breslow, N., Weiner, J., Reed, A., & Hammond, D. (1975) · Blood · doi:10.1182/blood.v46.3.431.431 · Cited by 82 · see citing works
Salzer, W. L., Asselin, B. L., Supko, J. G., Devidas, M., Kaiser, N. A., Plourde, P. V., Winick, N. J., Reaman, G. H., Raetz, E. A., Carroll, W. L., et al. (2013) · Blood · doi:10.1182/blood-2013-01-480822 · Cited by 81 · see citing works
Rijneveld, A. W., van der Holt, B., Daenen, S. M. G. J., Biemond, B. J., de Weerdt, O., Muus, P., Maertens, J. A., Mattijssen, V., Demuynck, H., Legdeur, M. C. J. C., et al. (2011) · Leukemia · doi:10.1038/leu.2011.141 · Cited by 78 · see citing works
Panetta, J. C., Gajjar, A. J., Hijiya, N., Hak, L. J., Chen, C., Liu, W., Pui, C., & Relling, M. V. (2009) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2009.162 · Cited by 76 · see citing works
Cheung, N. V., Chau, I. Y., & Coccia, P. F. (1986) · PubMed · Cited by 71 · see citing works
THE HYPER-CVAD REGIMEN IN ADULT ACUTE LYMPHOCYTIC LEUKEMIA
Garcia‐Manero, G., & Kantarjian, H. M. (2000) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(05)70192-1 · Cited by 70 · see citing works
Safety profile of asparaginaseErwinia chrysanthemiin a large compassionate‐use trial
Plourde, P. V., Jeha, S., Hijiya, N., Keller, F. G., Silverman, L. B., Rheingold, S. R., Dreyer, Z. E., Dahl, G. V. H., Mercedes, T., Lai, C., et al. (2014) · Pediatric Blood & Cancer · doi:10.1002/pbc.24938 · Cited by 64 · see citing works
Willer, A., Gerß, J., König, T., Franke, D., Kühnel, H., Henze, G., von Stackelberg, A., Möricke, A., Schrappe, M., Boos, J., et al. (2011) · Blood · doi:10.1182/blood-2011-07-367904 · Cited by 64 · see citing works
Pinheiro, J. P. V., Ahlke, E., Nowak‐Göttl, U., Hempel, G., Müller, H.-J., Lümkemann, K., Schrappe, M., Rath, B., Fleischhack, G., Mann, G. B., et al. (1999) · British Journal of Haematology · doi:10.1046/j.1365-2141.1999.01192.x · Cited by 63 · see citing works
Ho, D. H., Whitecar, J. P., Luce, J. K., & Frei, E. (1970) · PubMed · Cited by 61 · see citing works
Sutow, W. W., Garcia, F., Starling, K. A., Williams, T. E., Lane, D. M., & Gehan, E. A. (1971) · Cancer · doi:10.1002/1097-0142(1971)28:4 · Cited by 60 · see citing works
L-asparaginase activity in plasma and other biological fluids
Schwartz, M. K., Lash, E. D., Oettgen, H. F., & Tomao, F. A. (1970) · Cancer · doi:10.1002/1097-0142(197002)25:2 · Cited by 59 · see citing works
Albertsen, B. K., Schrøder, H. D., Ingerslev, J., Jakobsen, P., Avramis, V. I., Müller, H., Carlsen, N. T., & Schmiegelow, K. (2001) · British Journal of Haematology · doi:10.1046/j.1365-2141.2001.03148.x · Cited by 58 · see citing works
Chromosomes and causation of human cancer and leukemia. II. Karyotypes of human solid tumors
Yamada, K., Takagi, N., & Sandberg, A. A. (1966) · Cancer · doi:10.1002/1097-0142(196612)19:12 · Cited by 57 · see citing works
Antibody formation during intravenous and intramuscular therapy with Erwinia asparaginase*
Albertsen, B. K., Schrøder, H. D., Jakobsen, P., Avramis, V. I., Müller, H., Schmiegelow, K., & Carlsen, N. T. (2002) · Medical and Pediatric Oncology · doi:10.1002/mpo.10096 · Cited by 56 · see citing works
Vrooman, L. M., Kirov, I. I., Dreyer, Z. E., Kelly, M. E., Hijiya, N., Brown, P. A., Drachtman, R. A., Messinger, Y. H., Ritchey, A. K., Hale, G. A., et al. (2015) · Pediatric Blood & Cancer · doi:10.1002/pbc.25757 · Cited by 52 · see citing works
Therapeutic drug monitoring of asparaginase in the ALL‐BFM 2000 protocol between 2000 and 2007
Schrey, D., Borghorst, S., Lanvers‐Kaminsky, C., Hempel, G., Gerß, J., Möricke, A., Schrappe, M., & Boos, J. (2010) · Pediatric Blood & Cancer · doi:10.1002/pbc.22417 · Cited by 52 · see citing works
A Metabolic Difference Between Two Lines of Lymphoma 6C3HED Cells in Relation to Asparagine.
Sobin, L. H., & Kidd, J. G. (1965) · Experimental Biology and Medicine · doi:10.3181/00379727-119-30169 · Cited by 49 · see citing works
Monitoring of Erwinia asparaginase therapy in childhood ALL in the Nordic countries
Albertsen, B. K., Schrøder, H. D., Jakobsen, P., Müller, H., Carlsen, N. T., & Schmiegelow, K. (2001) · British Journal of Clinical Pharmacology · doi:10.1046/j.0306-5251.2001.01464.x · Cited by 47 · see citing works
Sallan, S. E., Gelber, R. D., Kimball, V., Donnelly, M., & Cohen, H. J. (1990) · Hämatologie und Bluttransfusion · doi:10.1007/978-3-642-74643-7_83 · Cited by 46 · see citing works
Clinical application of asparaginase activity levels following treatment with pegaspargase
Bleyer, A., Asselin, B. L., Koontz, S. E., & Hunger, S. P. (2014) · Pediatric Blood & Cancer · doi:10.1002/pbc.25299 · Cited by 45 · see citing works
Ko, R. H., Jones, T. L., Radvinsky, D., Robison, N. J., Gaynon, P. S., Panosyan, E. H., Avramis, I. A., Avramis, V. I., Rubin, J., Ettinger, L. J., et al. (2015) · Cancer · doi:10.1002/cncr.29641 · Cited by 36 · see citing works
Development of anti‐asparaginase antibodies in childhood acute lymphoblastic leukemia
Zalewska‐Szewczyk, B., Andrzejewski, W., & Bodalski, J. (2004) · Pediatric Blood & Cancer · doi:10.1002/pbc.20064 · Cited by 33 · see citing works
Amino acid requirements in vitro of human leukemic cells.
Onuma, T., Waligunda, J. A., & Holland, J. F. (1971) · PubMed · Cited by 32 · see citing works
Pharmacokinetics of Erwinia asparaginase after intravenous and intramuscular administration
Albertsen, B. K., Jakobsen, P., Schrøder, H. D., Schmiegelow, K., & Carlsen, N. (2001) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800100286 · Cited by 32 · see citing works
Alacacıoğlu, İ., Medeni, S. S., Özsan, G. H., Payzın, B., Sevindik, Ö. G., Acar, C., Katgı, A., Ozdemirkan, F., Pişkin, Ö., Özcan, M. A., et al. (2014) · Chemotherapy · doi:10.1159/000375258 · Cited by 29 · see citing works
Morris, K. L., Weston, H., Mollee, P. N., Marlton, P. V., Gill, D. S., & Kennedy, G. (2010) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2010.532889 · Cited by 29 · see citing works
Büyükaşık, Y., Acar, K., Kelkitli, E., Uz, B., Şerefhanoğlu, S., Özdemir, E., Pamukçuoğlu, M., Atay, H., Bektaş, Ö., Sucak, G. T., et al. (2013) · Acta Haematologica · doi:10.1159/000351172 · Cited by 27 · see citing works
Clinical Pharmacology of Intramuscularly Administered l ‐Asparaginase
Ho, D. H., Yap, H. Y., Brown, N. S., Benjamin, R. S., FRIEREICH, E. J., Blumenschein, G. R., & Bodey, G. P. (1981) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1981.tb01752.x · Cited by 24 · see citing works
L-Asparginase induced cortical venous thrombosis in a patient with acute leukemia.
Dubashi, B., & Jain, A. (2012) · PubMed · doi:10.4103/0976-500x.95531 · Cited by 8 · see citing works
Flagged first, then by citations
3 of the 99 references couldn’t be matched to a known paper.
Research works printed but not linked: 6
- [1]Gaynon P Schrappe M Cairo M Perkins S Childhood ALL Hematological Malignancies in Children, Adolescents and Young Adults 2012 Hackensack, NJ World Scientific Publishing Company 197 235
- [2]Howlader N Noone AM Krapcho M Garshell J Neyman N Altekruse SF National Cancer Institute. Section 28: Childhood cancer by site, incidence, survival, and mortality SEER Cancer Statistics Review, 1975-2011 2014 Bethesda, MD National Cancer Institute
- [7]Broome JD Evidence that the L-asparaginase of guinea pig serum is responsible for its antilymphoma effects. I. Properties of the L-asparaginase of guinea pig serum in relation to those of the antilymphoma substance J Exp Med 1963 118 99 120 14015821 PMC2137570
- [21]Clarkson B Krakoff I Burchenal J Karnofsky D Golbey R Dowling M Clinical results of treatment with E. coli L-asparaginase in adults with leukemia, lymphoma, and solid tumors Cancer 1970 25 279 305 4905154
- [55]Oettgen HF Stephenson PA Schwartz MK Leeper RD Tallai L Tan CC Toxicity of E. coli L-asparaginase in man Cancer 1970 25 253 78 4905153
- [71]Schwartz MK Lash ED Oettgen HF Tomato FA L-asparaginase activity in plasma and other biological fluids Cancer 1970 25 244 52 4905152
Cited by
Sorted by citations
Targeting Metabolism for Cancer Therapy
Luengo, A., Gui, D. Y., & Vander Heiden, M. G. (2017) · Cell Chemical Biology · doi:10.1016/j.chembiol.2017.08.028 · Cited by 971 · see citing works
Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors
Andrejeva, G., & Rathmell, J. C. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.004 · Cited by 368 · see citing works
Comparative features and outcomes between paediatric T-cell and B-cell acute lymphoblastic leukaemia
Teachey, D. T., & Pui, C. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30031-2 · Cited by 295 · see citing works
Emerging therapies in cancer metabolism
Xiao, Y., Yu, T., Xu, Y., Ding, R., Wang, Y.-P., Jiang, Y., & Shao, Z. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.07.006 · Cited by 267 · see citing works
Abou‐Alfa, G. K., Qin, S., Ryoo, B., Lu, S., Yen, C.-J., Feng, Y., Lim, H. Y., Izzo, F., Colombo, M., Sarker, D., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy101 · Cited by 236 · see citing works
Qeshmi, F. I., Homaei, A. A., Fernandes, P. C. D. B., & Javadpour, S. (2018) · Microbiological Research · doi:10.1016/j.micres.2018.01.011 · Cited by 157 · see citing works
Improving the Efficiency of Vγ9Vδ2 T-Cell Immunotherapy in Cancer
Hoeres, T., Smetak, M., Pretscher, D., & Wilhelm, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00800 · Cited by 154 · see citing works
Aspartic Acid in Health and Disease
Holeček, M. (2023) · Nutrients · doi:10.3390/nu15184023 · Cited by 151 · see citing works
Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take
Altea‐Manzano, P., Cuadros, A. M., Broadfield, L. A., & Fendt, S. (2020) · EMBO Reports · doi:10.15252/embr.202050635 · Cited by 119 · see citing works
Chand, S., Mahajan, R. V., Prasad, J. P., Sahoo, D. K., Mihooliya, K. N., Dhar, M. S., & Sharma, G. D. (2020) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.1888 · Cited by 106 · see citing works
Structural and biochemical properties of L‐asparaginase
Lubkowski, J. T., & Wlodawer, A. (2021) · FEBS Journal · doi:10.1111/febs.16042 · Cited by 106 · see citing works
Current Use of Asparaginase in Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Maese, L. D., & Rau, R. E. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.902117 · Cited by 99 · see citing works
Design of a mucin-selective protease for targeted degradation of cancer-associated mucins
Pedram, K., Shon, D. J., Tender, G. S., Mantuano, N. R., Northey, J. J., Metcalf, K. J., Wisnovsky, S., Riley, N. M., Forcina, G. C., Malaker, S. A., et al. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-01840-6 · Cited by 89 · see citing works
Microbial therapeutic enzymes: A promising area of biopharmaceuticals
Vachher, M., Sen, A., Kapila, R., & Nigam, A. (2021) · Current Research in Biotechnology · doi:10.1016/j.crbiot.2021.05.006 · Cited by 89 · see citing works
Dhankhar, R., Gupta, V., Kumar, S., Kapoor, R. K., & Gulati, P. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10432-2 · Cited by 85 · see citing works
Wang, Y., Ma, S., & Ruzzo, W. L. (2020) · Scientific Reports · doi:10.1038/s41598-020-60384-w · Cited by 79 · see citing works
Recouvreux, M. V., Grenier, S. F., Zhang, Y., Esparza, E., Lambies, G., Galapate, C. M., Maganti, S., Duong‐Polk, K., Bhullar, D., Naeem, R. F., et al. (2023) · Nature Cancer · doi:10.1038/s43018-023-00649-1 · Cited by 77 · see citing works
Targeting cancer metabolic pathways for improving chemotherapy and immunotherapy
Luo, Z., Eichinger, K. M., Zhang, A., & Li, S. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216396 · Cited by 70 · see citing works
Juluri, K. R., Siu, C., & Cassaday, R. D. (2022) · Blood and Lymphatic Cancer Targets and Therapy · doi:10.2147/blctt.s342052 · Cited by 69 · see citing works
Mechanism of Catalysis by l -Asparaginase
Lubkowski, J. T., Vanegas, J. M., Chan, W., Lorenzi, P. L., Weinstein, J. N., Sukharev, S., Fushman, D., Rempe, S. B., Anishkin, A., & Wlodawer, A. (2020) · Biochemistry · doi:10.1021/acs.biochem.0c00116 · Cited by 65 · see citing works
Asparaginase pharmacology: challenges still to be faced
Lanvers‐Kaminsky, C. (2017) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-016-3236-y · Cited by 61 · see citing works
Radha, R., Arumugam, N., & Gummadi, S. N. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.12.165 · Cited by 61 · see citing works
Asparaginase-induced hepatotoxicity: rapid development of cholestasis and hepatic steatosis
for the Drug-Induced Liver Injury Network, Kamal, N., Koh, C., Samala, N. R., Fontana, R. J., Stolz, A., Durazo, F. A., Hayashi, P. H., Phillips, E. J., Wang, T., et al. (2019) · Hepatology International · doi:10.1007/s12072-019-09971-2 · Cited by 60 · see citing works
Pant, A., Cao, S., & Yang, Z. (2019) · Journal of Virology · doi:10.1128/jvi.01834-18 · Cited by 56 · see citing works
Al-Mahayri, Z. N., AlAhmad, M. M., & Ali, B. R. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.710163 · Cited by 56 · see citing works
Costa-Silva, T. A., Costa, I. M., Biasoto, H. P., Lima, G. M., Silva, C., Pessoa, A., & Monteiro, G. (2020) · Blood Reviews · doi:10.1016/j.blre.2020.100651 · Cited by 54 · see citing works
Johnston, K., Pachnis, P., Tasdogan, A., Faubert, B., Zacharias, L. G., Vu, H., Rodgers-Augustyniak, L. A., Johnson, A., Huang, F., Ricciardo, S., et al. (2021) · Med · doi:10.1016/j.medj.2021.01.002 · Cited by 49 · see citing works
Fernández-García, J., Franco, F., Parik, S., Altea‐Manzano, P., Pane, A. A., Broekaert, D., Elsen, J. V., Conza, G. D., Vermeire, I., Schalley, T., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111639 · Cited by 50 · see citing works
Amino Acid Degrading Enzymes and their Application in Cancer Therapy
Pokrovsky, V. S., Chepikova, O. E., Давыдов, Д. Ж., Zamyatnin, A. A., Lukashev, A. N., & Lukasheva, E. V. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666171006132729 · Cited by 50 · see citing works
Medication-induced hyperglycemia: pediatric perspective
Tosur, M., Colindres, J. V., Astudillo, M., REDONDO, M. J., & Lyons, S. K. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2019-000801 · Cited by 49 · see citing works
Polyethylene Glycol Nanoparticles as Promising Tools for Anticancer Therapeutics
Mohapatra, A., Uthaman, S., & Park, I. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816963-6.00010-8 · Cited by 48 · see citing works
A systematic review on endophytic fungi and its role in the commercial applications
Devi, R., Verma, R., Dhalaria, R., Kumar, A., Kumar, D., Puri, S., Thakur, M., Chauhan, S., Chauhan, P. P., Nepovimová, E., et al. (2023) · Planta · doi:10.1007/s00425-023-04087-2 · Cited by 47 · see citing works
Bender, C., Maese, L. D., Carter‐Febres, M., & Verma, A. R. (2021) · Blood and Lymphatic Cancer Targets and Therapy · doi:10.2147/blctt.s245210 · Cited by 47 · see citing works
SLC5A3-Dependent Myo-inositol Auxotrophy in Acute Myeloid Leukemia
Wei, Y., Huang, Y.-H., Skopelitis, D. S., Iyer, S. V., Costa, A. S. H., Yang, Z., Kramer, M., Adelman, E. R., Klingbeil, O., Demerdash, O. E., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1849 · Cited by 48 · see citing works
Optimizing use of L-asparaginase–based treatment of adults with acute lymphoblastic leukemia
Douer, D., Gökbuget, N., Stock, W., & Boissel, N. (2021) · Blood Reviews · doi:10.1016/j.blre.2021.100908 · Cited by 46 · see citing works
Antithrombin Therapy: Current State and Future Outlook
Rodgers, G. M., & Mahajerin, A. (2023) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/10760296231205279 · Cited by 46 · see citing works
Fatima, N., Khan, M. M., & Khan, I. A. (2019) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2019.05.001 · Cited by 42 · see citing works
Harnessing the Co-vulnerabilities of Amino Acid-Restricted Cancers
Pathria, G., & Ronai, Z. A. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.009 · Cited by 42 · see citing works
Moldovan, O.-L., Rusu, A., Tanase, C., & Vari, C.-E. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112290 · Cited by 42 · see citing works
Can recombinant technology address asparaginase Erwinia chrysanthemi shortages?
Maese, L. D., Rizzari, C., Coleman, R., Power, A., van der Sluis, I. M., & Rau, R. E. (2021) · Pediatric Blood & Cancer · doi:10.1002/pbc.29169 · Cited by 42 · see citing works
Karigane, D., & Takubo, K. (2017) · International Journal of Hematology · doi:10.1007/s12185-017-2261-x · Cited by 40 · see citing works
Bone morbidity in pediatric acute lymphoblastic leukemia
Ahn, M. B., & Suh, B. (2020) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2020.25.1.1 · Cited by 39 · see citing works
Moubasher, H., Balbool, B. A., Helmy, Y. A., Alsuhaibani, A. M., Atta, A. A., Sheir, D. H., & Abdel-Azeem, A. M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19020680 · Cited by 39 · see citing works
MAPK signaling regulates c-MYC for melanoma cell adaptation to asparagine restriction
Pathria, G., Verma, S. K., Yin, J., Scott, D. A., & Ronai, Z. A. (2021) · EMBO Reports · doi:10.15252/embr.202051436 · Cited by 37 · see citing works
Zhou, R., Liang, T., Li, T., Huang, J., & Chen, C. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1070069 · Cited by 37 · see citing works
Chepikova, O. E., Malin, D., Strekalova, E., Lukasheva, E. V., Zamyatnin, A. A., & Cryns, V. L. (2020) · Breast Cancer Research and Treatment · doi:10.1007/s10549-020-05801-4 · Cited by 36 · see citing works
Geometric considerations support the double‐displacement catalytic mechanism of l ‐asparaginase
Lubkowski, J. T., & Wlodawer, A. (2019) · Protein Science · doi:10.1002/pro.3709 · Cited by 35 · see citing works
Agnello, G., Alters, S. E., & Rowlinson, S. W. (2019) · Translational research · doi:10.1016/j.trsl.2019.12.005 · Cited by 34 · see citing works
Targeting Protein Synthesis in Colorectal Cancer
Schmidt, S., Denk, S., & Wiegering, A. (2020) · Cancers · doi:10.3390/cancers12051298 · Cited by 34 · see citing works
Protease Enzymes: Highlights on Potential of Proteases as Therapeutics Agents
Shankar, R., Upadhyay, P. K., & Kumar, M. (2021) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-021-10167-2 · Cited by 34 · see citing works
Stentz, R., Jones, E. J., Juodeikis, R., Wegmann, U., Guirro, M., Goldson, A. J., Brion, A., Booth, C., Sudhakar, P., Brown, I. R., et al. (2022) · Applied and Environmental Microbiology · doi:10.1128/aem.00533-22 · Cited by 34 · see citing works
Pokrovsky, V. S., & Vinnikov, D. V. (2017) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2017.1344100 · Cited by 34 · see citing works
Blackman, A. L., Boutin, A., Shimanovsky, A., Baker, W. J., & Forcello, N. (2017) · Journal of Oncology Pharmacy Practice · doi:10.1177/1078155217710714 · Cited by 33 · see citing works
Battistel, A. P., da Rocha, B. S., dos Santos, M. T., Daudt, L. E., & Michalowski, M. B. (2020) · Hematology Transfusion and Cell Therapy · doi:10.1016/j.htct.2019.10.007 · Cited by 32 · see citing works
A pan-cancer transcriptomic study showing tumor specific alterations in central metabolism
Sheraj, I., Güray, T., & Banerjee, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-93003-3 · Cited by 29 · see citing works
L-Lysine α-Oxidase: Enzyme with Anticancer Properties
Lukasheva, E. V., Babayeva, G. A., Karshieva, S. S., Zhdanov, D. D., & Pokrovsky, V. S. (2021) · Pharmaceuticals · doi:10.3390/ph14111070 · Cited by 31 · see citing works
Belén, L. H., Lissabet, J. F. B., Rangel‐Yagui, C. D. O., Effer, B. R., Monteiro, G., Pessoa, A., & Farías, J. G. (2019) · Biologicals · doi:10.1016/j.biologicals.2019.03.003 · Cited by 31 · see citing works
Zhdanov, D. D., Pokrovsky, V. S., Pokrovskaya, M. V., Alexandrova, S. S., Eldarov, M. A., Grishin, D. V., Basharov, M. M., Gladilina, Y. A., Podobed, O. V., & Sokolov, N. N. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.078 · Cited by 30 · see citing works
Microbial cell disruption methods for efficient release of enzyme L-asparaginase
Costa-Silva, T. A., Flores-Santos, J. C., Freire, R. K. B., Vitolo, M. I., & Pessoa, A. (2018) · Preparative Biochemistry & Biotechnology · doi:10.1080/10826068.2018.1487850 · Cited by 30 · see citing works
Cardoso, S. L., de Freitas, M. M., Souza, P. M., Homem-de-Mello, M., Silveira, D., Fonseca-Bazzo, Y. M., Filho, E. X. F., Pessoa, A., & Magalhães, P. O. (2020) · Brazilian Journal of Microbiology · doi:10.1007/s42770-020-00269-2 · Cited by 30 · see citing works
Acute myeloid leukaemia niche regulates response to L‐asparaginase
Michelozzi, I. M., Granata, V., Ponti, G. D., Alberti, G., Tomasoni, C., Antolini, L., Gambacorti-Passerini, C. B., Gentner, B., Dazzi, F., Biondi, A., et al. (2019) · British Journal of Haematology · doi:10.1111/bjh.15920 · Cited by 28 · see citing works
Lanvers‐Kaminsky, C., Rüffer, A., Würthwein, G., Gerß, J., Zucchetti, M., Ballerini, A., Attarbaschi, A., Smíšek, P., Nath, C. E., Lee, S., et al. (2017) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0000000000000472 · Cited by 27 · see citing works
Lin, T., Hernandez‐Illas, M., Rey, A., Jenkins, J., Chandula, R., Silverman, J. A., & Choi, M. R. (2020) · Clinical and Translational Science · doi:10.1111/cts.12947 · Cited by 27 · see citing works
Crespo‐Solís, E., Espinosa-Bautista, K. A., Alvarado‐Ibarra, M., Rozen‐Fuller, E., Pérez‐Rocha, F., Nava‐Gómez, C., Ortiz‐Zepeda, M., Álvarez-Vera, J. L., Peñafiel, C. O. R., Meillón‐García, L. A., et al. (2018) · Cancer Medicine · doi:10.1002/cam4.1513 · Cited by 26 · see citing works
Shortages and price variability of essential cytotoxic medicines for treating children with cancers
Martei, Y. M., Iwamoto, K., Barr, R. D., Wiernkowski, J. T., & Robertson, J. (2020) · BMJ Global Health · doi:10.1136/bmjgh-2020-003282 · Cited by 28 · see citing works
Costa, I. M., Moura, D. C., Lima, G. M., Pessoa, A., dos Santos, C. O., de Oliveira, M. A., & Monteiro, G. (2021) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.6933 · Cited by 26 · see citing works
Human L‑asparaginase: Acquiring knowledge of its activation (Review)
Morais, S. D., & de Souza, T. D. A. C. B. (2021) · International Journal of Oncology · doi:10.3892/ijo.2021.5191 · Cited by 25 · see citing works
Expression and Functional Characterization of Pseudomonas aeruginosa Recombinant l.Asparaginase
Saeed, H. M. S., Soudan, H., Sharkawy, A. S. E., Farag, A., Embaby, A. M., & Ataya, F. S. (2018) · The Protein Journal · doi:10.1007/s10930-018-9789-3 · Cited by 24 · see citing works
Long, Z., Feng, G., Zhao, N., Wu, L., & Zhu, H. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.10926 · Cited by 23 · see citing works
Angka, L., de Souza, C. T., Baxter, K. E., Khan, S., Market, M., Martel, A. B., Tai, L., Kennedy, M. A., Bell, J. C., & Auer, R. C. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.05.024 · Cited by 22 · see citing works
Cancer-Induced Metabolic Rewiring of Tumor Endothelial Cells
Lidonnici, J., Santoro, M. M., & Oberkersch, R. E. (2022) · Cancers · doi:10.3390/cancers14112735 · Cited by 22 · see citing works
Shakerdi, L. A., & Ryan, A. (2023) · Journal of Clinical Pathology · doi:10.1136/jcp-2022-208644 · Cited by 23 · see citing works
van der Sluis, I. M., de Groot‐Kruseman, H., Loo, D. M. W. M. T., Tissing, W. J. E., van den Bos, C., Kaspers, G. J. L., Bierings, M., Kollen, W. J. W., König, T., Pichlmeier, U., et al. (2018) · Pediatric Blood & Cancer · doi:10.1002/pbc.27083 · Cited by 22 · see citing works
Slippy-Sloppy translation: a tale of programmed and induced-ribosomal frameshifting
Champagne, J., Mordente, K., Nagel, R., & Agami, R. (2022) · Trends in Genetics · doi:10.1016/j.tig.2022.05.009 · Cited by 22 · see citing works
Peg-Grafted Liposomes for L-Asparaginase Encapsulation
Guimarães, M. D. S., Cachumba, J. J. M., Bueno, C. Z., Torres‐Obreque, K. M., Lara, G. V. R., Monteiro, G., Barbosa, L. R. S., Pessoa, A., & Rangel‐Yagui, C. D. O. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14091819 · Cited by 22 · see citing works
Metabolic crosstalk between stromal and malignant cells in the bone marrow niche
Tirado, H. A., Balasundaram, N., Laaouimir, L., Erdem, A., & van Gastel, N. (2023) · Bone Reports · doi:10.1016/j.bonr.2023.101669 · Cited by 22 · see citing works
Kumar, S., Darnal, S., Patial, V., Kumar, V., & Singh, D. P. (2022) · Fermentation · doi:10.3390/fermentation8100568 · Cited by 20 · see citing works
Taghavinia, F., Teymouri, F., Farokhrouz, F., Bagherabad, E. H., Farjami, S., Karimi, E., Oskoueian, E., Le, H. H., & Shakeri, M. (2022) · Animals · doi:10.3390/ani12243492 · Cited by 20 · see citing works
Emerging biological therapies to treat acute lymphoblastic leukemia
Huguet, F., & Tavitian, S. (2016) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2016.1257606 · Cited by 20 · see citing works
Diversity of the culturable endophytic fungi producing L-asparaginase in arid Sinai, Egypt
Balbool, B. A., & Abdel-Azeem, A. M. (2019) · Italian Journal of Mycology · doi:10.6092/issn.2531-7342/10063 · Cited by 20 · see citing works
Gibson, A., Hernández, C. H., Tejada, F. N. H., Kawedia, J. D., Rytting, M., & Cuglievan, B. (2021) · Pediatric Drugs · doi:10.1007/s40272-021-00463-1 · Cited by 19 · see citing works
Pennesi, E., Brivio, E., Ammerlaan, A. C. J., Jiang, Y., van der Velden, V. H. J., Beverloo, H. B., Sleight, B., Locatelli, F., Brethon, B., Rössig, C., et al. (2024) · Haematologica · doi:10.3324/haematol.2023.284409 · Cited by 19 · see citing works
Zlotnikov, I. D., Ezhov, A. A., Dobryakova, N. V., & Kudryashova, E. V. (2024) · Gels · doi:10.3390/gels10030157 · Cited by 19 · see citing works
Saito, T., Wei, Y., Wen, L., Srinivasan, C., Wolthers, B. O., Tsai, C., Harris, M. H., Stevenson, K. E., Byersdorfer, C. A., Murayi, J. O., et al. (2021) · Metabolomics · doi:10.1007/s11306-021-01814-2 · Cited by 19 · see citing works
Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents
Asrorov, A. M., Muhitdinov, B. I., Tu, B., Mirzaakhmedov, S. Y., Wang, H., & Huang, Y. (2022) · Molecules · doi:10.3390/molecules27123836 · Cited by 18 · see citing works
Gagné, V., St-Onge, P., Beaulieu, P., Laverdière, C., Leclerc, J., Tran, T. H., Sallan, S. E., Neuberg, D. S., Silverman, L. B., Sinnett, D., et al. (2020) · Pharmacogenomics · doi:10.2217/pgs-2019-0195 · Cited by 18 · see citing works
Space for Calaspargase? A New Asparaginase for Acute Lymphoblastic Leukemia
Lew, G. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-2975 · Cited by 18 · see citing works
Lin, T., Dumas, T., Kaullen, J. D., Berry, N. S., Choi, M. R., Zomorodi, K., & Silverman, J. A. (2021) · Clinical Pharmacology in Drug Development · doi:10.1002/cpdd.1002 · Cited by 17 · see citing works
Dobryakova, N. V., Zhdanov, D. D., Sokolov, N. N., Александрова, С. С., Pokrovskaya, M. V., & Kudryashova, E. V. (2022) · Pharmaceuticals · doi:10.3390/ph15040406 · Cited by 17 · see citing works
Enzyme Engineering Strategies for the Bioenhancement of l-Asparaginase Used as a Biopharmaceutical
Miranda, J., Lefin, N., Beltrán, J. F., Belén, L. H., Tsipa, A., Farías, J. G., & Zamorano, M. (2023) · BioDrugs · doi:10.1007/s40259-023-00622-5 · Cited by 17 · see citing works
Pharmacogenomics in Pediatric Acute Lymphoblastic Leukemia: Promises and Limitations
Al-Mahayri, Z. N., Patrinos, G. P., & Ali, B. R. (2017) · Pharmacogenomics · doi:10.2217/pgs-2017-0005 · Cited by 17 · see citing works
de Araújo, T. S., Scapin, S. M. N., de Andrade, W., Fasciotti, M., de Magalhães, M. T. Q., Almeida, M. S., & Lima, L. M. T. R. (2021) · Biophysical Chemistry · doi:10.1016/j.bpc.2021.106554 · Cited by 17 · see citing works
Sengupta, S., Biswas, M., Gandhi, K., Gupta, S. K., Gera, P. B., Gota, V., & Sonawane, A. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.101909 · Cited by 16 · see citing works
1-C Metabolism—Serine, Glycine, Folates—In Acute Myeloid Leukemia
Mahmood, K., & Emadi, A. (2021) · Pharmaceuticals · doi:10.3390/ph14030190 · Cited by 16 · see citing works
Cancer incidence and survival trends among infants in the United States from 1975 to 2014
Wang, H., de Grubb, M. C. M., Gonzalez, S. J., Zoorob, R., Chai, W., & Du, X. L. (2021) · Pediatric Blood & Cancer · doi:10.1002/pbc.28917 · Cited by 15 · see citing works
Waste management using marine microorganisms
Haripriyaa, M., & Suthindhiran, K. (2024) · Sustainable Environment · doi:10.1080/27658511.2024.2324574 · Cited by 15 · see citing works
Stability of Therapeutic Enzymes: Challenges and Recent Advances
Ghosh, S., Alam, S., Rathore, A. S., & Khare, S. K. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-7709-9_7 · Cited by 15 · see citing works
Targeting metabolic dependencies in pediatric cancer
Issaq, S. H., & Heske, C. M. (2019) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000853 · Cited by 15 · see citing works
Lee, C.-H., & Grey, F. E. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00280 · Cited by 18 · see citing works
Single-Cell Metabolomics in Hematopoiesis and Hematological Malignancies
Zuo, F., Yu, J., & He, X. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.931393 · Cited by 16 · see citing works
- Authors
- Egler, R. A., Ahuja, S. P., & Matloub, Y.
- Affiliations
- Rainbow Babies & Children's Hospital (US)
- Corresponding author
- Egler, Rachel A.
- ORCID
- Ahuja, Sanjay P.
- Venue
- Journal of Pharmacology and Pharmacotherapeutics
- Publisher
- SAGE Publications
- Published
- 2016-06
- Volume
- 7
- Issue
- 2
- Pages
- 62-71
- ISSN
- 0976-500X (ISSN-L)
- 0976-5018
- PMC
- PMC4936081
- OpenAlex
- W2471256249
- Cited by
- 334
- References
- 99
- Citations by year
- 2026: 24 · 2025: 28 · 2024: 42 · 2023: 50 · 2022: 36 · 2021: 55 · 2020: 37 · 2019: 26 · 2018: 17 · 2017: 17 · 2016: 1
- FWCI
- 20.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Pharmacology and Pharmacotherapeutics (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Health Sciences › Medicine › Genetics › Chronic Lymphocytic Leukemia Research
- Keywords
- L-asparaginase, acute lymphoblastic leukemia, childhood acute lymphoblastic leukemia, adolescent and young adult leukemia, pegylated asparaginase, hypersensitivity, cross-reactivity, pharmacokinetics, therapeutic drug monitoring, survival outcomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
