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Cited by 212Sperm and Testicular FunctionSmoking Behavior and CessationPrenatal Substance Exposure Effects

The hazardous effects of tobacco smoking on male fertility

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Qiao, Zhong-Dong, Dai, Jing-Bo, Wang, Zhao-Xia·2015·Asian Journal of Andrology
DOI 10.4103/1008-682x.150847PMC PMC4814952
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Abstract

The substantial harmful effects of tobacco smoking on fertility and reproduction have become apparent but are not generally appreciated. Tobacco smoke contains more than 4000 kinds of constituents, including nicotine, tar, carbonic monoxide, polycyclic aromatic hydrocarbons, and heavy metals. Because of the complexity of tobacco smoke components, the toxicological mechanism is notably complicated. Most studies have reported reduced semen quality, reproductive hormone system dysfunction and impaired spermatogenesis, sperm maturation, and spermatozoa function in smokers compared with nonsmokers. Underlying these effects, elevated oxidative stress, DNA damage, and cell apoptosis may play important roles collaboratively in the overall effect of tobacco smoking on male fertility. In this review, we strive to focus on both the phenotype of and the molecular mechanism underlying these harmful effects, although current studies regarding the mechanism remain insufficient.

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Sorted by citations

Authors
Qiao, Z.-D., Dai, J.-B., & Wang, Z.-X.
Affiliations
Shanghai Jiao Tong University (CN)
Venue
Asian Journal of Andrology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015
Volume
17
Issue
6
Pages
954
ISSN
1008-682X (ISSN-L)
DOI
10.4103/1008-682x.150847
PMC
PMC4814952
OpenAlex
W1924764290
Cited by
212
References
5
Citations by year
2026: 17 · 2025: 21 · 2024: 25 · 2023: 23 · 2022: 19 · 2021: 22 · 2020: 32 · 2019: 16 · 2018: 16 · 2017: 10 · 2016: 6 · 2015: 5
FWCI
1.86
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Asian Journal of Andrology (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Asian Journal of Andrology (cc-by-nc-sa)
Funders
Shanghai Jiao Tong University
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
smoking, male fertility, semen quality, spermatogenesis, oxidative stress, DNA damage, apoptosis, nicotine, polycyclic aromatic hydrocarbons, heavy metals, carbon monoxide
MeSH terms
Carbon Monoxide, DNA Damage, Fertility, Humans, Infertility, Male, Male, Nicotine, Polycyclic Aromatic Hydrocarbons, Smoke, Smoking, Spermatogenesis, Spermatozoa, Nicotiana, Oxidative Stress, Nicotinic Agonists, Metals, Heavy, Semen Analysis, Gasotransmitters

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