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Cited by 411Sperm and Testicular FunctionHormonal and reproductive studiesEstrogen and related hormone effects

The DOI matches its Crossref record; 109 of the 109 references it cites were found in a registry or an index.

The role of estradiol in male reproductive function

Open access
Ramasamy, Ranjith, Schulster, Michael, Bernie, AaronM·2016·Asian Journal of Andrology
DOI 10.4103/1008-682x.173932PMC PMC4854098
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Abstract

Traditionally, testosterone and estrogen have been considered to be male and female sex hormones, respectively. However, estradiol, the predominant form of estrogen, also plays a critical role in male sexual function. Estradiol in men is essential for modulating libido, erectile function, and spermatogenesis. Estrogen receptors, as well as aromatase, the enzyme that converts testosterone to estrogen, are abundant in brain, penis, and testis, organs important for sexual function. In the brain, estradiol synthesis is increased in areas related to sexual arousal. In addition, in the penis, estrogen receptors are found throughout the corpus cavernosum with high concentration around neurovascular bundles. Low testosterone and elevated estrogen increase the incidence of erectile dysfunction independently of one another. In the testes, spermatogenesis is modulated at every level by estrogen, starting with the hypothalamus-pituitary-gonadal axis, followed by the Leydig, Sertoli, and germ cells, and finishing with the ductal epithelium, epididymis, and mature sperm. Regulation of testicular cells by estradiol shows both an inhibitory and a stimulatory influence, indicating an intricate symphony of dose-dependent and temporally sensitive modulation. Our goal in this review is to elucidate the overall contribution of estradiol to male sexual function by looking at the hormone's effects on erectile function, spermatogenesis, and libido.

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Crossref · 10.4103/1008-682x.173932

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Figure 1 The role of estrogen in male reproduction.
Figure 1 The role of estrogen in male reproduction.CC BY-NC-SA · PubMed Central
Figure 2 The role of estradiol in spermatogenesis.
Figure 2 The role of estradiol in spermatogenesis.CC BY-NC-SA · PubMed Central

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Research works printed but not linked: 1

  1. Dean, 2005, Physiology of penile erection and pathophysiology of erectile dysfunction, Urol Clin North Am, 379

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Metadata

Authors
Ramasamy, R., Schulster, M., & Bernie, A.
Affiliations
  • University of Miami (US)
  • NewYork–Presbyterian Hospital (US)
Corresponding author
Ramasamy, Ranjith
ORCID
Ramasamy, Ranjith
Venue
Asian Journal of Andrology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2016
Volume
18
Issue
3
Pages
435
ISSN
1008-682X (ISSN-L)
DOI
10.4103/1008-682x.173932
PMC
PMC4854098
OpenAlex
W2339490711
Cited by
411
References
107
Citations by year
2026: 27 · 2025: 36 · 2024: 59 · 2023: 41 · 2022: 59 · 2021: 58 · 2020: 49 · 2019: 31 · 2018: 25 · 2017: 21 · 2016: 5
FWCI
3.92
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Asian Journal of Andrology (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords
estradiol, male reproductive function, erectile function, erectile dysfunction, spermatogenesis, sexual desire, estrogen receptor, aromatase, testosterone, hypothalamic-pituitary-gonadal axis, Leydig cells, Sertoli cells, corpus cavernosum, sexual arousal
MeSH terms
Aromatase, Estradiol, Germ Cells, Humans, Hypothalamo-Hypophyseal System, Leydig Cells, Libido, Male, Penile Erection, Sertoli Cells, Spermatogenesis, Testis, Testosterone

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