Androgen actions on central serotonin neurotransmission: relevance for mood, mental state and memory.

Fink, George; Sumner, Barbara; Rosie, Roberta; Wilson, Helen; McQueen, Judith

doi:10.1016/s0166-4328(99)00082-0

Cited by 200Neurotransmitter Receptor Influence on BehaviorEstrogen and related hormone effectsNeuroscience and Neuropharmacology Research

Androgen actions on central serotonin neurotransmission: relevance for mood, mental state and memory.

Fink, George, Sumner, Barbara, Rosie, Roberta, Wilson, Helen, McQueen, Judith·1999·Behavioural Brain Research

DOI 10.1016/s0166-4328(99)00082-0

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Abstract

Sex steroids exert potent effects on mood and mental state in the human. Our previous experimental findings in female rats suggest that these effects may be mediated, in part, by the action of estrogen on the 5-hydroxytryptamine2A receptor (5-HT(2A)R) and serotonin transporter (SERT) in brain. Here we review our recent findings on the effect of acute (approximately 32 h) testosterone manipulation on central 5-HT(2A)R and SERT in male rats. Castration decreased while testosterone or estrogen, but not 5alpha-dihydrotestosterone (5alpha-DHT), increased significantly the content of 5-HT(2A)R mRNA and SERT mRNA in the dorsal raphe nucleus (DR) and the density of 5-HT(2A)R and SERT binding sites in higher centers of the brain. The lack of effect of 5alpha-DHT, a potent androgen which cannot be converted to estrogen, suggests that the action of testosterone depends upon its conversion to estrogen by aromatase. This may also explain why estrogen, but not testosterone or 5alpha-DHT, increased the density of 5-HT(2A)R binding sites in the caudate-putamen, a brain region where aromatase is scarce. The estrogen induction of SERT mRNA is most prominent in the rostral DR and this together with the correlation between sensitivity of DR serotonin neurons to estrogen and neurotoxic amphetamine derivatives provides a potential topochemical handle with which to investigate testosterone/estrogen regulation of SERT gene expression. These findings are discussed in relation to the possible role of…

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Testosterone reduces total sleep time by direct central nervous system effects by altering serotonergic neurotransmission.
“Testosterone reduced total sleep time by direct central nervous system effects by altering serotonergic neurotransmission. [6]”
From Comparison of sleep in hypothyroid patients with normal controls (2017) · cites this paper as [6]
An equal gender distribution was used to minimize the effect of sex hormones on sleep in this study.
“Although hypothyroidism has increased incidence in females, an equal gender distribution was opted to minimize the effect of sex hormones on sleep in this study.”
From Comparison of sleep in hypothyroid patients with normal controls (2017) · cites this paper as [6]

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(1997) · doi:10.1002/(sici)1096-9861(19971201)388:4

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Fluoxetine treatment increases trabecular bone formation in mice
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Testosterone administration attenuates regional brain hypometabolism in women with anorexia nervosa
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Effects of estrogen and testosterone treatment on serotonin transporter binding in the brain of surgically postmenopausal women - a PET study
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60 YEARS OF NEUROENDOCRINOLOGY: MEMOIR: Harris' neuroendocrine revolution: of portal vessels and self-priming
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Saliva testosterone and cortisol in male depressive syndrome, a community study. The Sudurnesjamenn Study
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Boys' serotonin transporter genotype affects maternal behavior through self-control: A case of evocative gene–environment correlation
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Comparing the relative amount of testosterone required to restore sexual arousal, motivation, and performance in male rats
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Self-citation
Serotonin transporter (SERT) mRNA and binding site densities in male rat brain affected by sex steroids
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SEX STEROID CONTROL OF MOOD, MENTAL STATE AND MEMORY
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Raloxifene blocks estradiol induction of the serotonin transporter and 5-hydroxytryptamine2A receptor in female rat brain
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Self-citation
Oestrogen and Testosterone Modulate the Firing Activity of Dorsal Raphe Nucleus Serotonergic Neurones in Both Male and Female Rats
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Authors: Fink, G., Sumner, B., Rosie, R., Wilson, H., & McQueen, J.
Affiliations: University of Edinburgh (GB)
Corresponding author: Fink, George
ORCID: Fink, George
Venue: Behavioural Brain Research
Publisher: Elsevier BV
Published: 1999-11
Volume: 105
Issue: 1
Pages: 53-68
ISSN: 0166-4328 (ISSN-L)
DOI: 10.1016/s0166-4328(99)00082-0
OpenAlex: W2079234104
Cited by: 198
References: 98
Citations by year: 2026: 1 · 2025: 7 · 2024: 2 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 8 · 2015: 9 · 2014: 6 · 2013: 7 · 2012: 9
FWCI: 2.39
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Behavioural Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: testosterone, estrogen, 5-HT2A receptor, serotonin transporter, dorsal raphe nucleus, aromatase, sex steroids, mood disorders, schizophrenia, Alzheimer's disease, memory, caudate-putamen, amphetamine neurotoxicity, gene expression regulation
MeSH terms: Affect, Androgens, Animals, Arousal, Brain Mapping, Carrier Proteins, Caudate Nucleus, Estrogens, Female, Gene Expression Regulation, Humans, Male, Membrane Glycoproteins, Memory, Nerve Tissue Proteins, Synaptic Transmission, Putamen, Raphe Nuclei, Receptors, Serotonin, Serotonin, Sexual Behavior, Sexual Behavior, Animal, Membrane Transport Proteins, Receptor, Serotonin, 5-HT2A, Serotonin Plasma Membrane Transport Proteins, Rats

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Androgen actions on central serotonin neurotransmission: relevance for mood, mental state and memory.

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