Protective effects of a polysaccharide from Spirulina platensis on dopaminergic neurons in an MPTP-induced Parkinson′s disease model in C57BL/6J mice
Open accessAbstract
The present study aimed to determine whether a polysaccharide obtained from Spirulina platensis shows protective effects on dopaminergic neurons. A Parkinson's disease model was established through the intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in C57BL/6J mice. Prior to the MPTP injection, some mice were pretreated with intraperitoneal injections of a polysaccharide derived from Spirulina platensis once daily for 10 days. The results showed that the immunoreactive staining and mRNA expression of the dopamine transporter and tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, in the substantia nigra, were significantly increased in mice pretreated with 800 mg/kg of the polysaccharide compared with those in MPTP-treated mice. The activities of superoxide dismutase and glutathione peroxidase in the serum and midbrain were also increased significantly in mice injected with MPTP after pretreatment with the polysaccharide from Spirulina platensis. By contrast, the activity of monoamine oxidase B in serum and midbrain maintained unchanged. These experimental findings indicate that the polysaccharide obtained from Spirulina platensis plays a protective role against the MPTP-induced loss of dopaminergic neurons in C57BL/6J mice, and that the antioxidative properties of this polysaccharide likely underlie its neuroprotective effect.
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Pretreatment with polysaccharide derived from S. platensis significantly increased immunoreactive staining and mRNA expression of the dopamine transporter and tyrosine hydroxylase in the substantia nigra of MPTP-treated mice.
“Pretreatment with polysaccharide derived from S. platensis significantly increased immunoreactive staining and mRNA expression of the dopamine transporter (DAT) and tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, in the substantia nigra of MPTP-treated mice.”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [91]
The antioxidant capabilities of S. platensis polysaccharide could be the reason for its neuroprotective effect.
“suggesting that the antioxidant capabilities of this polysaccharide could be the reason for its neuroprotective effect [91].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [91]
In MPTP-treated mice, S. platensis polysaccharide significantly increased SOD and GPx activities in serum and midbrain, in contrast to monoamine oxidase B activity.
“Moreover, in contrast to the activity of monoamine oxidase B (MAO B), the activities of SOD and GPx in the serum and midbrain were increased significantly”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [91]
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- Authors
- Zhang, F., Xie, J.-X., Lu, J., & Zhang, J.-G.
- Affiliations
- Qingdao University (CN)
- Xian Yang Central Hospital (CN)
- Taishan Medical University (CN)
- Corresponding author
- Zhang, Fang
- ORCID
- Zhang, Fang
- Venue
- Neural Regeneration Research
- Published
- 2015
- Volume
- 10
- Issue
- 2
- Pages
- 308
- ISSN
- 1673-5374 (ISSN-L)
- PMC
- PMC4392681
- OpenAlex
- W1982785439
- Cited by
- 57
- References
- 22
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 10 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 5
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Neural Regeneration Research (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- 中国神经再生研究：英文版
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- Spirulina platensis, polysaccharides, Parkinson's disease, MPTP, dopaminergic neurons, neuroprotection, substantia nigra, dopamine transporter, tyrosine hydroxylase, antioxidant activity, superoxide dismutase, glutathione peroxidase, monoamine oxidase B, C57BL/6J mice
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