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Cited by 25Neuroinflammation and Neurodegeneration MechanismsImmune cells in cancerTryptophan and brain disorders

Metabolic reprogramming of the inflammatory response in the nervous system: the crossover between inflammation and metabolism

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Amo-Aparicio, Jesus, Dinarello, Charles A., Lopez-Vales, Ruben·2024·Neural Regeneration Research
DOI 10.4103/1673-5374.391330PMC PMC11034585
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Abstract

Metabolism is a fundamental process by which biochemicals are broken down to produce energy (catabolism) or used to build macromolecules (anabolism). Metabolism has received renewed attention as a mechanism that generates molecules that modulate multiple cellular responses. This was first identified in cancer cells as the Warburg effect, but it is also present in immunocompetent cells. Studies have revealed a bidirectional influence of cellular metabolism and immune cell function, highlighting the significance of metabolic reprogramming in immune cell activation and effector functions. Metabolic processes such as glycolysis, oxidative phosphorylation, and fatty acid oxidation have been shown to undergo dynamic changes during immune cell response, facilitating the energetic and biosynthetic demands. This review aims to provide a better understanding of the metabolic reprogramming that occurs in different immune cells upon activation, with a special focus on central nervous system disorders. Understanding the metabolic changes of the immune response not only provides insights into the fundamental mechanisms that regulate immune cell function but also opens new approaches for therapeutic strategies aimed at manipulating the immune system.

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Crossref · 10.4103/1673-5374.391330

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  • Pharmacological targeting of metabolic pathways to modulate microglial activation has shown promise in preclinical studies.

    “Similarly, pharmacological targeting of metabolic pathways to modulate microglial activation has shown promise in preclinical studies (Amo-Aparicio et al., 2024; Gao et al., 2023; Lepiarz-Raba et al., 2023).”

    From Older adult APOE4 mice exhibit modest immunometabolic adaptation following microglial APOE2 replacement (2027) · cites this paper as Amo-Aparicio et al., 2024

    The Alzheimer’s disease section (page not provided) reports that 2-DG blocked microglial cytokine release and that IFNγ restored metabolic signaling and some microglial functions in 5XFAD mice. It calls restoration of microglial metabolism a potential therapeutic target, but does not clearly establish that pharmacological targeting of metabolic pathways has shown therapeutic promise across preclinical studies. (LLM, conf=0.80)

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Cited by

Sorted by citations

Authors
Amo-Aparicio, J., Dinarello, C. A., & Lopez-Vales, R.
Affiliations
  • Department of Medicine, University of Colorado, Aurora, CO, USA
  • University of Colorado Anschutz (US)
  • Institute of Neurosciences, and Department Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, Bellaterra, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Spain
ORCID
Venue
Neural Regeneration Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2023-12-21
Volume
19
Issue
10
Pages
2189-2201
ISSN
  • 1673-5374 (ISSN-L)
  • 1876-7958
DOI
10.4103/1673-5374.391330
PMC
PMC11034585
OpenAlex
W4390112831
Cited by
25
References
16
Citations by year
2026: 15 · 2025: 9 · 2024: 1
FWCI
2.47
Type
journal article
Language
en
Open access
Licence
cc-by-nc-sa
Locations
  • Neural Regeneration Research (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion, cc-by-nc-sa)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Institució Catalana de Recerca i Estudis Avançats
  • Ministerio de Ciencia e Innovación (.13039/501100011033, 501100011033, PID2020)
  • National Institutes of Health (15614, AI‐15614)
  • Agencia Estatal de Investigación (501100011033, 13039, .13039/501100011033)
  • National Institute of Allergy and Infectious Diseases (R56AI015614, R01AI015614)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
metabolic reprogramming, neuroinflammation, immune cell metabolism, Warburg effect, glycolysis, oxidative phosphorylation, fatty acid oxidation, immune cell activation, central nervous system disorders, energy metabolism, immunometabolism

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