Obesity: A neuroimmunometabolic perspective

Obesity is associated with macrophage accumulation in adipose tissue

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The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function

Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481 · see citing works

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664 · see citing works

Identification and Importance of Brown Adipose Tissue in Adult Humans

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

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TLR4 links innate immunity and fatty acid-induced insulin resistance

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Differential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents

Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061 · see citing works

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

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Macrophages, inflammation, and insulin resistance

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MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682 · see citing works

The adipocyte-secreted protein Acrp30 enhances hepatic insulin action

Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526 · see citing works

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

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Protection from obesity-induced insulin resistance in mice lacking TNF-α function

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Inflammatory mechanisms linking obesity and metabolic disease

Saltiel, A. R., & Olefsky, J. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92035 · Cited by 2,212 · see citing works

Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice

Fruebis, J., Tsao, T., Javorschi, S., Ebbets-Reed, D., Erickson, M., Yen, F. T., Bihain, B. E., & Lodish, H. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2005 · Cited by 1,987 · see citing works

Interleukin 4 potently enhances murine macrophage mannose receptor activity: A marker of alternative immunologic macrophage activation

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Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

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The role of neuropeptide Y in the antiobesity action of the obese gene product

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CCR2 modulates inflammatory and metabolic effects of high-fat feeding

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CCR2 modulates inflammatory and metabolic effects of high-fat feeding

Weisberg, S. P. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24335c1 · Cited by 1,424 · see citing works

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

Wu, D., Molofsky, A. B., Liang, H.-E., Ricardo-González, R. R., Jouihan, H. A., Bando, J. K., Chawla, A., & Locksley, R. M. (2011) · Science · doi:10.1126/science.1201475 · Cited by 1,361 · see citing works

The role of estrogens in control of energy balance and glucose homeostasis

Mauvais-Jarvis, F., Clegg, D. J., & Hevener, A. L. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1055 · Cited by 1,329 · see citing works

Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages

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Metabolic Instruction of Immunity

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Monocyte chemoattractant protein 1 in obesity and insulin resistance

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Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

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Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin

Pajvani, U. B., Du, X., Combs, T. P., Berg, A. H., Rajala, M. W., Schulthess, T., Engel, J., Brownlee, M., & Scherer, P. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207198200 · Cited by 1,090 · see citing works

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

Lu, D., Willard, D. H., Patel, I. R., Kadwell, S. H., Overton, L. K., Kost, T., Luther, M., Chen, W., Woychik, R. P., Wilkison, W. O., et al. (1994) · Nature · doi:10.1038/371799a0 · Cited by 1,075 · see citing works

Type 2 innate lymphoid cells control eosinophil homeostasis

Nussbaum, J. C., Dyken, S. J. V., von Moltke, J., Cheng, L. E., Mohapatra, A., Molofsky, A. B., Thornton, E. E., Krummel, M. F., Chawla, A., Liang, H.-E., et al. (2013) · Nature · doi:10.1038/nature12526 · Cited by 1,069 · see citing works

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

Nguyen, K. D., Qiu, Y., Cui, X., Goh, Y. P. S., Mwangi, J., David, T., Mukundan, L., Brombacher, F., Locksley, R. M., & Chawla, A. (2011) · Nature · doi:10.1038/nature10653 · Cited by 1,038 · see citing works

A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways

Nguyen, M. T. A., Favelyukis, S., Nguyen, A.-K., Reichart, D., Scott, P. A., Jenn, A., Liu-Bryan, R., Glass, C. K., Neels, J. G., & Olefsky, J. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706762200 · Cited by 1,035 · see citing works

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

Cypess, A. M., Weiner, L. S., Roberts‐Toler, C., Franquet, E., Kessler, S., Kahn, P. A., English, J., Chatman, K., Trauger, S. A., Doria, A., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.009 · Cited by 1,024 · see citing works

Receptor-mediated regional sympathetic nerve activation by leptin.

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Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

Talukdar, S., Oh, D. Y., Bandyopadhyay, G. K., Li, D., Xu, J., McNelis, J., Lu, M. M., Li, P., Yan, Q., Zhu, Y., et al. (2012) · Nature Medicine · doi:10.1038/nm.2885 · Cited by 966 · see citing works

Fibrosis and adipose tissue dysfunction.

Sun, K., Tordjman, J., Clément, K., & Scherer, P. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.016 · Cited by 960 · see citing works

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

Pal, D., Dasgupta, S., Kundu, R., Maitra, S., Das, G., Mukhopadhyay, S., Ray, S., Majumdar, S. S., & Bhattacharya, S. (2012) · Nature Medicine · doi:10.1038/nm.2851 · Cited by 922 · see citing works

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

Lumeng, C. N.-K., DelProposto, J. B., Westcott, D. J., & Saltiel, A. R. (2008) · Diabetes · doi:10.2337/db08-0872 · Cited by 919 · see citing works

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

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Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

Molofsky, A. B., Nussbaum, J. C., Liang, H.-E., Dyken, S. J. V., Cheng, L. E., Mohapatra, A., Chawla, A., & Locksley, R. M. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121964 · Cited by 879 · see citing works

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

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Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages

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Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes

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Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord

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TNF‐α and adipocyte biology

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Reduced Adipose Tissue Oxygenation in Human Obesity

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βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance

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A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia

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Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus

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Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue

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Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids

Rogero, M. M., & Calder, P. C. (2018) · Nutrients · doi:10.3390/nu10040432 · Cited by 720 · see citing works

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

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Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization

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Selective deletion of leptin receptor in neurons leads to obesity

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The role of peripheral immune cells in the CNS in steady state and disease

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Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype

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UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

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Local Inflammation and Hypoxia Abolish the Protective Anticontractile Properties of Perivascular Fat in Obese Patients

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Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation

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GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK

Beiroa, D., Imbernon, M., Gallego, R., Senra, A., Herranz, D., Villarroya, F., Serrano, M., Fernø, J., Salvador, J., Escalada, J., et al. (2014) · Diabetes · doi:10.2337/db14-0302 · Cited by 602 · see citing works

Human Leptin Stimulates Proliferation and Activation of Human Circulating Monocytes

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Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

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Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction

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Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

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Selective deletion of leptin receptor in neurons leads to obesity

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Tumor Necrosis Factor-α Suppresses Adipocyte-Specific Genes and Activates Expression of Preadipocyte Genes in 3T3-L1 Adipocytes

Ruan, H., Hacohen, N., Golub, T. R., Parijs, L. V., & Lodish, H. F. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1319 · Cited by 531 · see citing works

Proinflammatory Phenotype of Perivascular Adipocytes

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Melanocortin receptors in leptin effects

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Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine

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Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis

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Sfrp5 Is an Anti-Inflammatory Adipokine That Modulates Metabolic Dysfunction in Obesity

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Leptin targets in the mouse brain

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Adipocyte lipolysis and insulin resistance

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Adiponectin differentially regulates cytokines in porcine macrophages

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Sympathetic and sensory innervation of brown adipose tissue

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Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

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Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing

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Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK

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Role of innate and adaptive immunity in obesity-associated metabolic disease

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CNS origins of the sympathetic nervous system outflow to brown adipose tissue

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Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus

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Fat and Iron Don't Mix

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Macrophages Can Drive Sympathetic Excitability in the Early Stages of Hypertension

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ON THE BIOLOGICAL ROLE OF LEPTIN

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Neuroimmunometabolism in Health and Disease

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A Tale of Three Systems: Toward a Neuroimmunoendocrine Model of Obesity

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