A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Magistretti, Pierre J.; Allaman, Igor

doi:10.1016/j.neuron.2015.03.035

Cited by 1,285Neuroscience and Neuropharmacology ResearchAdvanced MRI Techniques and ApplicationsNeuroinflammation and Neurodegeneration Mechanisms

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Open access

Magistretti, Pierre J., Allaman, Igor·2015·Neuron

DOI 10.1016/j.neuron.2015.03.035

Open this paper in CoChat — free account Open PDF

Abstract

The energy demands of the brain are high: they account for at least 20% of the body's energy consumption. Evolutionary studies indicate that the emergence of higher cognitive functions in humans is associated with an increased glucose utilization and expression of energy metabolism genes. Functional brain imaging techniques such as fMRI and PET, which are widely used in human neuroscience studies, detect signals that monitor energy delivery and use in register with neuronal activity. Recent technological advances in metabolic studies with cellular resolution have afforded decisive insights into the understanding of the cellular and molecular bases of the coupling between neuronal activity and energy metabolism and point at a key role of neuron-astrocyte metabolic interactions. This article reviews some of the most salient features emerging from recent studies and aims at providing an integration of brain energy metabolism across resolution scales.

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2015.03.035

Cites

203 of 203 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Neural tissue is metabolically expensive, consuming approximately 20% of the body's energy despite comprising only 2% of body mass.
“Neural tissue is metabolically expensive, consuming approximately 20% of the body’s energy despite comprising only 2% of body mass (Attwell and Laughlin 2001; Magistretti and Allaman 2015).”
From The myth of the Bayesian brain (2025) · cites this paper as Magistretti and Allaman 2015
The study developed a scalable method, scdemon, which uses sample decorrelation to annotate both ubiquitous and rare gene expression programs in each major cell type, and used annotated modules to identify functional programs associated with specific pathological variables, including a glycolysis- and energy-metabolism-linked program in glia associated with diffuse plaque burden.
“To further examine the cellular and regional heterogeneity of the human brain, we developed a scalable method, scdemon, which uses sample decorrelation to annotate both ubiquitous and rare gene expression programs in each major cell type, and used annotated modules to identify functional programs associated with specific pathological variables, including a glycolysis- and energy-metabolism-linked”
From Single-cell multiregion dissection of Alzheimer’s disease (2024) · cites this paper as [60]
In regions with high diffuse plaque, astrocytes upregulated glycolysis enzymes converting glucose-6-phosphate to pyruvate, while downregulating MPC1, the mitochondrial pyruvate transporter.
“In regions with high diffuse plaque, astrocytes upregulated glycolysis enzymes converting glucose-6-phosphate to pyruvate, while downregulating MPC1, the mitochondrial pyruvate transporter60 (Fig. 4n).”
From Single-cell multiregion dissection of Alzheimer’s disease (2024) · cites this paper as [60]

On the origin of cancer cells
Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425 · see citing works
Neurophysiological investigation of the basis of the fMRI signal
Logothetis, N. K., Pauls, J., Augath, M., Trinath, T., & Oeltermann, A. (2001) · Nature · doi:10.1038/35084005 · Cited by 6,542 · see citing works
Brain magnetic resonance imaging with contrast dependent on blood oxygenation.
Ogawa, S., Lee, T. M., Kay, A. R., & Tank, D. W. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9868 · Cited by 6,483 · see citing works
THE [ 14 C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1
Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10649.x · Cited by 6,000 · see citing works
A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β
Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824 · see citing works
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196 · see citing works
An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875 · see citing works
Glutamate uptake
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,068 · see citing works
An Energy Budget for Signaling in the Grey Matter of the Brain
Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543 · see citing works
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.014 · Cited by 3,233 · see citing works
A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129 · see citing works
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.
Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927 · see citing works
Self-citation
Glial and neuronal control of brain blood flow
Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010) · Nature · doi:10.1038/nature09613 · Cited by 2,511 · see citing works
Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation
Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313 · see citing works
Self-citation
The expensive-tissue hypothesis: The brain and the digestive system in human and primate evolution
Aiello, L. C., & Wheeler, P. (1995) · Current Anthropology · doi:10.1086/204350 · Cited by 2,291 · see citing works
Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields
Ogawa, S., Lee, T., Nayak, A. S., & Glynn, P. (1990) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910140108 · Cited by 2,269 · see citing works
Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects.
Fox, P. T., & Raichle, M. E. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.1140 · Cited by 2,056 · see citing works
Evolution of the Brain and Intelligence.
Radinsky, L., & Jerison, H. J. (1975) · Evolution · doi:10.2307/2407154 · Cited by 1,974 · see citing works
On the Regulation of the Blood‐supply of the Brain
Roy, C., & Sherrington, C. (1890) · The Journal of Physiology · doi:10.1113/jphysiol.1890.sp000321 · Cited by 1,834 · see citing works
Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity
Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988) · Science · doi:10.1126/science.3260686 · Cited by 1,796 · see citing works
Synaptic Energy Use and Supply
Harris, J. J., Jolivet, R., & Attwell, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.019 · Cited by 1,747 · see citing works
Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
Suzuki, A., Stern, S. A., Bozdagi, O., Huntley, G. W., Walker, R. H., Magistretti, P. J., & Alberini, C. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.018 · Cited by 1,711 · see citing works
Self-citation
Oligodendroglia metabolically support axons and contribute to neurodegeneration
Lee, Y., Morrison, B. M., Li, Y., Lengacher, S., Farah, M. H., Hoffman, P. N., Liu, Y., Tsingalia, A., Jin, L., Zhang, P.-W., et al. (2012) · Nature · doi:10.1038/nature11314 · Cited by 1,664 · see citing works
Self-citation
BRAIN WORK AND BRAIN IMAGING
Raichle, M. E., & Mintun, M. A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112819 · Cited by 1,630 · see citing works
Protoplasmic Astrocytes in CA1 Stratum Radiatum Occupy Separate Anatomical Domains
Bushong, E. A., Martone, M. E., Jones, Y. Z., & Ellisman, M. H. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00183.2002 · Cited by 1,578 · see citing works
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
Fünfschilling, U., Supplie, L. M., Mahad, D., Boretius, S., Saab, A. S., Edgar, J., Brinkmann, B. G., Kassmann, C. M., Tzvetanova, I. D., Möbius, W., et al. (2012) · Nature · doi:10.1038/nature11007 · Cited by 1,523 · see citing works
Brain magnetic resonance imaging with contrast-dependent oxygenation
Ogawa, S. (1990) · Medical Entomology and Zoology · Cited by 1,367 · see citing works
New roles for astrocytes: redefining the functional architecture of the brain.
Nedergaard, M., Ransom, B., & Goldman, S. A. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.008 · Cited by 1,334 · see citing works
The SLC2 (GLUT) family of membrane transporters
Mueckler, M., & Thorens, B. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.07.001 · Cited by 1,328 · see citing works
Glial regulation of the cerebral microvasculature
Iadecola, C., & Nedergaard, M. (2007) · Nature Neuroscience · doi:10.1038/nn2003 · Cited by 1,153 · see citing works
The cost of cortical computation.
Lennie, P. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00135-0 · Cited by 1,134 · see citing works
Fundamental Neuroscience
Arbuthnott, G. W. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01495-2 · Cited by 1,117 · see citing works
The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer
Bak, L. K., Schousboe, A., & Waagepetersen, H. S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03913.x · Cited by 1,114 · see citing works
Interactions Between Electrical Activity and Cortical Microcirculation Revealed by Imaging Spectroscopy: Implications for Functional Brain Mapping
Malonek, D., & Grinvald, A. (1996) · Science · doi:10.1126/science.272.5261.551 · Cited by 1,095 · see citing works
Metabolic coupling between glia and neurons
Tsacopoulos, M., & Magistretti, P. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-03-00877.1996 · Cited by 1,006 · see citing works
Self-citation
The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction
Mathiisen, T. M., Lehre, K. P., Danbolt, N. C., & Ottersen, O. P. (2010) · Glia · doi:10.1002/glia.20990 · Cited by 917 · see citing works
Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission
Rouach, N., Koulakoff, A., Abudara, V., Willecke, K., & Giaume, C. (2008) · Science · doi:10.1126/science.1164022 · Cited by 861 · see citing works
Primate Cognition
Seed, A. M., & Tomasello, M. (2010) · Topics in Cognitive Science · doi:10.1111/j.1756-8765.2010.01099.x · Cited by 851 · see citing works
The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1
Herrero-Mendez, A., Almeida, A., Fernández, E., Maestre, C., Moncada, S., & Bolaños, J. P. (2009) · Nature Cell Biology · doi:10.1038/ncb1881 · Cited by 844 · see citing works
Activity-driven local ATP synthesis is required for synaptic function
Rangaraju, V., Calloway, N., & Ryan, T. A. (2014) · Cell · doi:10.1016/j.cell.2013.12.042 · Cited by 836 · see citing works
Supply and demand in cerebral energy metabolism: the role of nutrient transporters
Simpson, I. A., Carruthers, A., & Vannucci, S. J. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600521 · Cited by 812 · see citing works
Activity-dependent regulation of energy metabolism by astrocytes: an update
Pellerin, L., Bouzier‐Sore, A., Aubert, A., Serres, S., Merle, M., Costalat, R., & Magistretti, P. J. (2007) · Glia · doi:10.1002/glia.20528 · Cited by 805 · see citing works
Self-citation
Astroglial networks: a step further in neuroglial and gliovascular interactions
Giaume, C., Koulakoff, A., Roux, L., Holcman, D., & Rouach, N. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2757 · Cited by 781 · see citing works
Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging
Magistretti, P. J., & Pellerin, L. (1999) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1999.0471 · Cited by 750 · see citing works
Self-citation
Monocarboxylate transporters in the central nervous system: distribution, regulation and function
Pierre, K., & Pellerin, L. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03168.x · Cited by 744 · see citing works
Neural activity triggers neuronal oxidative metabolism followed by astrocytic glycolysis
Kasischke, K. A., Vishwasrao, H. D., Fisher, P. J., Zipfel, W. R., & Webb, W. W. (2004) · Science · doi:10.1126/science.1096485 · Cited by 742 · see citing works
Neuron-glia metabolic coupling and plasticity
Magistretti, P. J. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2010.053157 · Cited by 739 · see citing works
Self-citation
Regional aerobic glycolysis in the human brain
Vaishnavi, S. N., Vlassenko, A. G., Rundle, M. M., Snyder, A. Z., Mintun, M. A., & Raichle, M. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010459107 · Cited by 738 · see citing works
Sweet Sixteen for ANLS
Pellerin, L., & Magistretti, P. J. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.149 · Cited by 726 · see citing works
Self-citation
Relative brain size and basal metabolic rate in terrestrial vertebrates
Martin, R. D. (1981) · Nature · doi:10.1038/293057a0 · Cited by 711 · see citing works
Behind the scenes of functional brain imaging: A historical and physiological perspective
Raichle, M. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.765 · Cited by 616 · see citing works
Coupling Mechanism and Significance of the BOLD Signal: A Status Report
Hillman, E. M. C. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014111 · Cited by 615 · see citing works
Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation.
Prichard, J. W., Rothman, D. L., Novotny, E. J., Petroff, O. A. C., Kuwabara, T., Avison, M. J., Howseman, A., Hanstock, C. C., & Shulman, R. G. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5829 · Cited by 612 · see citing works
Ratio of central nervous system to body metabolism in vertebrates: its constancy and functional basis
Mink, J. W., Blumenschine, R. J., & Adams, D. B. (1981) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1981.241.3.r203 · Cited by 597 · see citing works
Lactate-supported synaptic function in the rat hippocampal slice preparation.
Schurr, A., West, C. A., & Rigor, B. (1988) · Science · doi:10.1126/science.3375817 · Cited by 594 · see citing works
Gesammelte Abhandlungen zur wissenschaftlichen Medicin
Virchow, R. (1862) · Cited by 592 · see citing works
Energy metabolism in astrocytes: High rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis
Hertz, L., Peng, L., & Dienel, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600343 · Cited by 587 · see citing works
Signaling at the Gliovascular Interface
Simard, M., Arcuino, G., Takano, T., Liu, Q. S., & Nedergaard, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-27-09254.2003 · Cited by 586 · see citing works
Metabolic costs and evolutionary implications of human brain development
Kuzawa, C. W., Chugani, H. T., Grossman, L. I., Lipovich, L., Muzik, O., Hof, P. R., Wildman, D. E., Sherwood, C. C., Leonard, W. R., & Lange, N. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1323099111 · Cited by 585 · cited 1× · see citing works
“It also appears that brain energy metabolism is inversely correlated during development, suggesting that the high metabolic cost of brain function is compensated by a slowing of the body growth rate (Kuzawa et al., 2014).”
Background
Localization of Functional Activity in the Central Nervous System by Measurement of Glucose Utilization with Radioactive Deoxyglucose
Sokoloff, L. (1981) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/jcbfm.1981.4 · Cited by 560 · see citing works
Blood lactate is an important energy source for the human brain.
van Hall, G., Stømstad, M., Rasmussen, P., Jans, Ø., Zaar, M., Gam, C., Quistorff, B., Secher, N. H., & Nielsen, H. B. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.35 · Cited by 522 · see citing works
Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons
Yang, J., Ruchti, E., Petit, J.-M., Jourdain, P., Grenningloh, G., Allaman, I., & Magistretti, P. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322912111 · Cited by 504 · see citing works
Self-citation
Elevated gene expression levels distinguish human from non-human primate brains
Cáceres, M., Lachuer, J., Zapala, M. A., Redmond, J. C., Kudo, L., Geschwind, D. H., Lockhart, D. J., Preuss, T. M., & Barlow, C. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2135499100 · Cited by 491 · see citing works
The Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex
Lovatt, D., Sonnewald, U., Waagepetersen, H. S., Schousboe, A., He, W., Lin, J. H.-C., Han, X., Takano, T., Wang, S., Sim, F. J., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3404-07.2007 · Cited by 488 · see citing works
Brain lactate metabolism: the discoveries and the controversies
Dienel, G. A. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.175 · Cited by 479 · see citing works
Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing
Newman, L. A., Korol, D. L., & Gold, P. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028427 · Cited by 473 · see citing works
Fundamental Neuroscience
(2013) · Elsevier eBooks · doi:10.1016/c2010-0-65035-8 · Cited by 465 · see citing works
Aerobic glycolysis in the human brain is associated with development and neotenous gene expression
Goyal, M. S., Hawrylycz, M., Miller, J. A., Snyder, A. Z., & Raichle, M. E. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.020 · Cited by 459 · cited 1× · see citing works
“…dorsolateral prefrontal cortex, the superior andmedial frontal gyrus, or the precuneus and posterior cingulate cortex, where it accounts for up to 25% of glucose utilization, whereas in other areas, such as the cerebellum, it is virtually nonexistent (Bauernfeind et al., 2014; Goyal et al., 2014).”
Background
Oxidative phosphorylation, not glycolysis, powers presynaptic and postsynaptic mechanisms underlying brain information processing
Hall, C. N., Klein-Flugge, M. C., Howarth, C., & Attwell, D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0026-12.2012 · Cited by 451 · see citing works
In Vivo Evidence for Lactate as a Neuronal Energy Source
Wyss, M. T., Jolivet, R., Buck, A., Magistretti, P. J., & Weber, B. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0415-11.2011 · Cited by 438 · see citing works
Self-citation
Energy-Efficient Action Potentials in Hippocampal Mossy Fibers
Alle, H., Roth, A., & Geiger, J. R. P. (2009) · Science · doi:10.1126/science.1174331 · Cited by 429 · see citing works
Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain
Bittar, P. G., Charnay, Y., Pellerin, L., Bouras, C., & Magistretti, P. J. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199611000-00001 · Cited by 423 · see citing works
Self-citation
Effect of Photic Stimulation on Human Visual Cortex Lactate and Phosphates Using 1 H and 31 P Magnetic Resonance Spectroscopy
Sappey‐Marinier, D., Calabrese, G., Fein, G., Hugg, J. W., Biggins, C. A., & Weiner, M. W. (1992) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1992.82 · Cited by 413 · see citing works
Targeting LDH enzymes with a stiripentol analog to treat epilepsy
Sada, N., Lee, S., Katsu, T., Otsuki, T., & Inoue, T. (2015) · Science · doi:10.1126/science.aaa1299 · Cited by 413 · see citing works
Role of Astrocytes in Neurovascular Coupling
Petzold, G. C., & Murthy, V. N. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.009 · Cited by 409 · see citing works
Neuronal-glial glucose oxidation and glutamatergic-GABAergic function.
Hyder, F., Patel, A. B., Gjedde, A., Rothman, D. L., Behar, K. L., & Shulman, R. G. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600263 · Cited by 408 · see citing works
Evolution of the Brain and Intelligence
Gould, S. J. (1974) · Science · doi:10.1126/science.185.4149.400-a · Cited by 394 · see citing works
Monocarboxylic Acid Transport
Halestrap, A. P. (2013) · Comprehensive physiology · doi:10.1002/cphy.c130008 · Cited by 389 · see citing works
The glutamate‐glutamine cycle is not stoichiometric: Fates of glutamate in brain
McKenna, M. C. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21444 · Cited by 385 · see citing works
The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic13C Nuclear Magnetic Resonance Spectroscopy
Boumezbeur, F., Petersen, K. F., Cline, G. W., Mason, G. F., Behar, K. L., Shulman, G. I., & Rothman, D. L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2040-10.2010 · Cited by 362 · see citing works
Glycolysis: a bioenergetic or a survival pathway?
Bolaños, J. P., Almeida, Á., & Moncada, S. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.10.006 · Cited by 359 · see citing works
Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: a possible regulatory mechanism for the local control of energy metabolism.
Magistretti, P. J., Morrison, J. H., Shoemaker, W. J., Sapin, V., & Bloom, F. E. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.10.6535 · Cited by 351 · see citing works
Self-citation
Scaling of Brain Metabolism with a Fixed Energy Budget per Neuron: Implications for Neuronal Activity, Plasticity and Evolution
Herculano-Houzel, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017514 · Cited by 343 · see citing works
Evolution of increased glia–neuron ratios in the human frontal cortex
Sherwood, C. C., Stimpson, C. D., Raghanti, M. A., Wildman, D. E., Uddin, M., Grossman, L. I., Goodman, M., Redmond, J. C., Bonar, C. J., Erwin, J. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605843103 · Cited by 342 · see citing works
Lactate-mediated glia-neuronal signalling in the mammalian brain
Tang, F., Lane, S., KORSAK, A. S., Paton, J. F. R., Gourine, A. V., Kasparov, S., & Teschemacher, A. G. (2014) · Nature Communications · doi:10.1038/ncomms4284 · Cited by 340 · see citing works
The role of myelin and oligodendrocytes in axonal energy metabolism
Saab, A. S., Tzvetanova, I. D., & Nave, K. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.09.008 · Cited by 339 · see citing works
A Temporary Local Energy Pool Coupled to Neuronal Activity: Fluctuations of Extracellular Lactate Levels in Rat Brain Monitored with Rapid‐Response Enzyme‐Based Sensor
Hu, Y., & Wilson, G. S. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69041484.x · Cited by 337 · see citing works
Differential effects of electrical stimulation of sciatic nerve on metabolic activity in spinal cord and dorsal root ganglion in the rat.
Kadekaro, M., Crane, A. M., & Sokoloff, L. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.17.6010 · Cited by 337 · see citing works
Lactate is a Preferential Oxidative Energy Substrate over Glucose for Neurons in Culture
Bouzier-Sore, A.-K., Voisin, P., Canioni, P., Magistretti, P. J., & Pellerin, L. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000091761.61714.25 · Cited by 328 · see citing works
Self-citation
Metabolic signaling by lactate in the brain
Barros, L. F. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.04.002 · Cited by 326 · see citing works
Plasticity of Astrocytic Coverage and Glutamate Transporter Expression in Adult Mouse Cortex
Genoud, C., Quairiaux, C., Steiner, P., Hirling, H., Welker, E., & Knott, G. W. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040343 · Cited by 304 · see citing works
Neuroglia: the 150 years after
Kettenmann, H., & Verkhratsky, A. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.09.003 · Cited by 300 · see citing works
Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo
Itoh, Y., Esaki, T., Shimoji, K., Cook, M., Law, M. J., Kaufman, E., & Sokoloff, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831078100 · Cited by 297 · see citing works
Glial Glutamate Transporters Mediate a Functional Metabolic Crosstalk between Neurons and Astrocytes in the Mouse Developing Cortex
Voutsinos‐Porche, B., Bonvento, G., Tanaka, K., Steiner, P., Welker, E., Chatton, J., Magistretti, P. J., & Pellerin, L. (2003) · Neuron · doi:10.1016/s0896-6273(02)01170-4 · Cited by 293 · see citing works
Self-citation
Lactate: A Preferred Fuel for Human Brain Metabolism in Vivo
Smith, D., Pernet, A., Hallett, W. A., Bingham, E., Marsden, P. K., & Amiel, S. A. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000063991.19746.11 · Cited by 282 · see citing works
Neuroprotective Role of Lactate after Cerebral Ischemia
Berthet, C., Lei, H., Thévenet, J., Rolf Gruetter, A., Magistretti, P. J., & Hirt, L. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.97 · Cited by 282 · see citing works
Self-citation
Cortical energy demands of signaling and nonsignaling components in brain are conserved across mammalian species and activity levels
Hyder, F., Rothman, D. L., & Bennett, M. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214912110 · Cited by 271 · see citing works
Multifunctional role of astrocytes as gatekeepers of neuronal energy supply
Stobart, J. L., & Anderson, C. M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00038 · Cited by 266 · see citing works
Competition between glucose and lactate as oxidative energy substrates in both neurons and astrocytes: a comparative NMR study
Bouzier‐Sore, A., Voisin, P., Bouchaud, V., Bezancon, E., Franconi, J., & Pellerin, L. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05056.x · Cited by 265 · see citing works
Brain Lactate Is an Obligatory Aerobic Energy Substrate for Functional Recovery After Hypoxia: Further In Vitro Validation
Schurr, A., Payne, R. S., Miller, J. J., & Rigor, B. M. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69010423.x · Cited by 262 · see citing works
Direct measurement of glutamate release in the brain using a dual enzyme-based electrochemical sensor
Hu, Y., Mitchell, K. M., Albahadily, F., Michaelis, E. K., & Wilson, G. S. (1994) · Brain Research · doi:10.1016/0006-8993(94)90870-2 · Cited by 252 · see citing works
Metabolic Communication between Astrocytes and Neurons via Bicarbonate-Responsive Soluble Adenylyl Cyclase
Choi, H. B., Gordon, G. R., Zhou, N., Tai, C., Rungta, R. L., Martinez, J., Milner, T. A., Ryu, J. K., McLarnon, J. G., Tresguerres, M., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.032 · Cited by 242 · see citing works
Sister grouping of chimpanzees and humans as revealed by genome-wide phylogenetic analysis of brain gene expression profiles.
Uddin, M., Wildman, D. E., Liu, G., Xu, W., Johnson, R. M., Hof, P. R., Kapatos, G., Grossman, L. I., & Goodman, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308725100 · Cited by 238 · see citing works
Revisiting the role of neurons in neurovascular coupling
Cauli, B. (2010) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2010.00009 · Cited by 236 · see citing works
Characterization of the glycogenolysis elicited by vasoactive intestinal peptide, noradrenaline and adenosine in primary cultures of mouse cerebral cortical astrocytes
Sorg, O., & Magistretti, P. J. (1991) · Brain Research · doi:10.1016/0006-8993(91)91538-c · Cited by 236 · see citing works
Self-citation
The role(s) of astrocytes and astrocyte activity in neurometabolism, neurovascular coupling, and the production of functional neuroimaging signals
Figley, C. R., & Stroman, P. W. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07584.x · Cited by 232 · see citing works
Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles
Giaume, C., Leybaert, L., Naus, C. C. G., & Sáez, J. C. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00088 · Cited by 232 · see citing works
Glial Glycogen Stores Affect Neuronal Survival during Glucose Deprivation in vitro
Swanson, R. A., & Choi, D. W. (1993) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1993.19 · Cited by 231 · see citing works
Interpreting oxygenation-based neuroimaging signals: the importance and the challenge of understanding brain oxygen metabolism
Buxton, R. B. (2010) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2010.00008 · Cited by 229 · see citing works
Transfer of glycogen-derived lactate from astrocytes to axons via specific monocarboxylate transporters supports mouse optic nerve activity
Tekkök, S. B., Brown, A. M., Westenbroek, R., Pellerin, L., & Ransom, B. R. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20573 · Cited by 224 · see citing works
The neurochemical profile quantified by in vivo 1H NMR spectroscopy
Duarte, J. M. N., Lei, H., Mlynárik, V., & Rolf Gruetter, A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.038 · Cited by 222 · see citing works
Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex
Chuquet, J., Quilichini, P., Nimchinsky, E. A., & Buzsáki, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0762-10.2010 · Cited by 217 · see citing works
Nonlinear coupling between cerebral blood flow, oxygen consumption, and ATP production in human visual cortex.
Lin, A.-L., Fox, P. T., Hardies, J., Duong, T. Q., & Gao, J.-H. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909711107 · Cited by 213 · see citing works
Lactate Modulates the Activity of Primary Cortical Neurons through a Receptor-Mediated Pathway
Bozzo, L., Puyal, J., & Chatton, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071721 · Cited by 211 · see citing works
Glutamate Uptake Stimulates Na+,K+‐ATPase Activity in Astrocytes via Activation of a Distinct Subunit Highly Sensitive to Ouabain
Pellerin, L., & Magistretti, P. J. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69052132.x · Cited by 210 · see citing works
Self-citation
Brain glycogen—new perspectives on its metabolic function and regulation at the subcellular level
Obel, L. F., Müller, M. S., Walls, A. B., Sickmann, H. M., Bak, L. K., Waagepetersen, H. S., & Schousboe, A. (2012) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2012.00003 · Cited by 209 · see citing works
The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study
Gallagher, C., Carpenter, K. L. H., Grice, P., Howe, D. J., Mason, A., Timofeev, I. S., Menon, D. K., Kirkpatrick, P. J., Pickard, J. D., Sutherland, G. R., et al. (2009) · Brain · doi:10.1093/brain/awp202 · Cited by 201 · see citing works
Cerebral metabolic effects of exogenous lactate supplementation on the injured human brain
Bouzat, P., Sala, N., Suys, T., Zerlauth, J.-B., Marques-Vidal, P. M., Feihl, F., Bloch, J., Messerer, M., Levivier, M., Meuli, R. A., et al. (2014) · Intensive Care Medicine · doi:10.1007/s00134-013-3203-6 · Cited by 200 · see citing works
Self-citation
The in vivo neuron‐to‐astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulation
Mangia, S., Simpson, I. A., Vannucci, S. J., & Carruthers, A. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06003.x · Cited by 189 · see citing works
Accelerated evolution of the electron transport chain in anthropoid primates
Grossman, L. I., Wildman, D. E., Schmidt, T. R., & Goodman, M. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.09.002 · Cited by 186 · see citing works
Fast and Reversible Stimulation of Astrocytic Glycolysis by K+and a Delayed and Persistent Effect of Glutamate
Bittner, C. X., Valdebenito, R., Ruminot, I., Loaiza, A., Larenas, V., Sotelo-Hitschfeld, T., Moldenhauer, H. J., Martín, A. S., Gutiérrez, R., Zambrano, M., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5311-10.2011 · Cited by 186 · see citing works
Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle
Patel, A. B., Lai, J. C. K., Chowdhury, G. M. I., Hyder, F., Rothman, D. L., Shulman, R. G., & Behar, K. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1403576111 · Cited by 186 · see citing works
A mouse model for Glut-1 haploinsufficiency
Wang, D., Pascual, J. M., Yang, H., Engelstad, K., Mao, X., Cheng, J., Yoo, J. H., Noebels, J. L., & Vivo, D. C. D. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl032 · Cited by 185 · see citing works
Role of sodium and potassium ions in regulation of glucose metabolism in cultured astroglia.
Takahashi, S., Driscoll, B. F., Law, M. J., & Sokoloff, L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4616 · Cited by 184 · see citing works
Astrocyte Glycogen Sustains Neuronal Activity during Hypoglycemia: Studies with the Glycogen Phosphorylase Inhibitor CP-316,819 ([R-R*,S*]-5-Chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1 H-indole-2-carboxamide)
Suh, S. W., Bergher, J. P., Anderson, C. M., Treadway, J. L., Fosgerau, K., & Swanson, R. A. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.115550 · Cited by 178 · see citing works
Astrocytes generate Na + -mediated metabolic waves
Bernardinelli, Y., Magistretti, P. J., & Chatton, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405315101 · Cited by 178 · see citing works
Self-citation
Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons
Halim, N. D., Mcfate, T., Mohyeldin, A., Okagaki, P., Korotchkina, L. G., Patel, M. S., Jeoung, N. H., Harris, R. A., Schell, M. J., & Verma, A. (2010) · Glia · doi:10.1002/glia.20996 · Cited by 177 · see citing works
Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter
Brown, A. M., Sickmann, H. M., Fosgerau, K., Lund, T. M., Schousboe, A., Waagepetersen, H. S., & Ransom, B. R. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20335 · Cited by 169 · see citing works
Specializations of the granular prefrontal cortex of primates: Implications for cognitive processing
Elston, G. N., Benavides‐Piccione, R., Elston, A., Zietsch, B., Defelipe, J., Manger, P., Casagrande, V., & Kaas, J. H. (2006) · The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology · doi:10.1002/ar.a.20278 · Cited by 167 · see citing works
Endogenous Monocarboxylates Sustain Hippocampal Synaptic Function and Morphological Integrity during Energy Deprivation
Izumi, Y., Benz, A. M., Katsuki, H., & Zorumski, C. F. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-24-09448.1997 · Cited by 166 · see citing works
Global and regional brain metabolic scaling and its functional consequences.
Karbowski, J. (2007) · BMC Biology · doi:10.1186/1741-7007-5-18 · Cited by 161 · see citing works
Metabolic and Hemodynamic Events after Changes in Neuronal Activity: Current Hypotheses, Theoretical Predictions and in vivo NMR Experimental Findings
Mangia, S., Giove, F., Tkáč, I., Logothetis, N. K., Henry, P.-G., Olman, C. A., Maraviglia, B., Di Salle, F., & Uğurbil, K. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.134 · Cited by 161 · see citing works
New Evidence of Neuroprotection by Lactate after Transient Focal Cerebral Ischaemia: Extended Benefit after Intracerebroventricular Injection and Efficacy of Intravenous Administration
Berthet, C., Castillo, X., Magistretti, P. J., & Hirt, L. (2012) · Cerebrovascular Diseases · doi:10.1159/000343657 · Cited by 155 · see citing works
Self-citation
Cellular bases of functional brain imaging: insights from neuron-glia metabolic coupling11Published on the World Wide Web on 12 October 2000.
Magistretti, P. J. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02945-0 · Cited by 153 · see citing works
Self-citation
NBCe1 Mediates the Acute Stimulation of Astrocytic Glycolysis by Extracellular K +
Ruminot, I., Gutiérrez, R., Peña-Münzenmayer, G., Añazco, C. C., Sotelo-Hitschfeld, T., Lerchundi, R., Niemeyer, M. I., Shull, G. E., & Barros, L. F. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2310-11.2011 · Cited by 150 · see citing works
The redox switch/redox coupling hypothesis
Cerdán, S., Rodrigues, T. B., Sierra, A., Benito, M., Fonseca, L. L., Fonseca, C. P., & García-Martín, M. L. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.12.036 · Cited by 146 · see citing works
Net increase of lactate and glutamate concentration in activated human visual cortex detected with magnetic resonance spectroscopy at 7 tesla
Schaller, B., Ralf Mekle, A., Xin, L., Kunz, N., & Rolf Gruetter, A. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23194 · Cited by 146 · see citing works
K+ at concentrations reached in the extracellular space during neuronal activity promotes a Ca2+-dependent glycogen hydrolysis in mouse cerebral cortex
Hof, P. R., Pascale, E., & Magistretti, P. J. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-06-01922.1988 · Cited by 145 · see citing works
Self-citation
INVERSE ENZYMATIC CHANGES IN NEURONS AND GLIA DURING INCREASED FUNCTION AND HYPOXIA
Hamberger, A., & Hydén, H. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.16.3.521 · Cited by 144 · see citing works
Blockade of lactate transport exacerbates delayed neuronal damage in a rat model of cerebral ischemia
Schurr, A., Payne, R. S., Miller, J. J., Tseng, M. T., & Rigor, B. M. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02082-0 · Cited by 139 · see citing works
Glutamate mediates acute glucose transport inhibition in hippocampal neurons
Porras, O. H., Loaiza, A., & Barros, L. F. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1882-04.2004 · Cited by 139 · see citing works
Role of the Glyoxalase System in Astrocyte-Mediated Neuroprotection
Bélanger, M., Yang, J.-Y., Petit, J.-M., Laroche, T., Magistretti, P. J., & Allaman, I. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1249-11.2011 · Cited by 137 · see citing works
Self-citation
Unraveling the complex metabolic nature of astrocytes
Bouzier-Sore, A.-K., & Pellerin, L. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00179 · Cited by 134 · see citing works
Pyruvate participation in the low molecular weight trophic activity for central nervous system neurons in glia-conditioned media
Selak, I., Skaper, S. D., & Varon, S. S. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-01-00023.1985 · Cited by 133 · see citing works
13C MR Spectroscopy Study of Lactate as Substrate for Rat Brain
Qu, H., Haberg, A. K., Haraldseth, O., Unsgård, G., & Sonnewald, U. (2000) · Developmental Neuroscience · doi:10.1159/000017472 · Cited by 132 · see citing works
Advanced glycation endproducts and their pathogenic roles in neurological disorders
Münch, G. W., Westcott, B., Menini, T., & Gugliucci, A. (2010) · Amino Acids · doi:10.1007/s00726-010-0777-y · Cited by 132 · see citing works
Effects of lactate and pyruvate on glucose deprivation in rat hippocampal slices
Izumi, Y., Benz, A. M., Zorumski, C. F., & Olney, J. W. (1994) · Neuroreport · doi:10.1097/00001756-199401000-00021 · Cited by 132 · see citing works
Astrocyte regulation of cerebral vascular tone
Filosa, J. A., & Iddings, J. A. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00359.2013 · Cited by 124 · see citing works
Positron Emission Tomography
Raichle, M. E. (1983) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.06.030183.001341 · Cited by 124 · see citing works
A quantitative overview of glucose dynamics in the gliovascular unit
Barros, L. F., Bittner, C. X., Loaiza, A., & Porras, O. H. (2007) · Glia · doi:10.1002/glia.20375 · Cited by 122 · see citing works
Inhibition of Monocarboxylate Transporter 2 in the Retrotrapezoid Nucleus in Rats: A Test of the Astrocyte–Neuron Lactate-Shuttle Hypothesis
Erlichman, J. S., Hewitt, A. J., Damon, T., Hart, M. P., Kurascz, J., Li, A., & Leiter, J. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5430-07.2008 · Cited by 121 · see citing works
Arachidonic acid stimulates glucose uptake in cerebral cortical astrocytes.
Yu, N., Martin, J., Stella, N., & Magistretti, P. J. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4042 · Cited by 120 · see citing works
Self-citation
Brain Energy Metabolism
Allaman, I., & Magistretti, P. J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-385870-2.00012-3 · Cited by 113 · see citing works
Self-citation
13C NMR of Intermediary Metabolism: Implications for Systemic Physiology
Shulman, R. G., & Rothman, D. L. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.15 · Cited by 108 · see citing works
The aerobic brain: lactate decrease at the onset of neural activity
Mangia, S., Garreffa, G., Bianciardi, M., Giove, F., Salle, F. D., & Maraviglia, B. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00792-3 · Cited by 107 · see citing works
Glutamate Transport Decreases Mitochondrial pH and Modulates Oxidative Metabolism in Astrocytes
Azarias, G., Perreten, H., Lengacher, S., Poburko, D., Demaurex, N., Magistretti, P. J., & Chatton, J.-Y. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4378-10.2011 · Cited by 107 · see citing works
Self-citation
Higher Transport and Metabolism of Glucose in Astrocytes Compared with Neurons: A Multiphoton Study of Hippocampal and Cerebellar Tissue Slices
Jakoby, P., Schmidt, E. M., Ruminot, I., Gutierrez, R., Barros, L. F., & Deitmer, J. W. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs309 · Cited by 107 · see citing works
Is lactate a volume transmitter of metabolic states of the brain?
Bergersen, L. H., & GJEDDE, A. H. (2012) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2012.00005 · Cited by 106 · see citing works
The Metabolism of [3‐13C]Lactate in the Rat Brain Is Specific of a Pyruvate Carboxylase‐Deprived Compartment
Bouzier‐Sore, A., Thiaudière, E., Biran, M., Rouland, R., Canioni, P., & Merle, M. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750480.x · Cited by 105 · see citing works
Multi-timescale Modeling of Activity-Dependent Metabolic Coupling in the Neuron-Glia-Vasculature Ensemble
Jolivet, R., Coggan, J. S., Allaman, I., & Magistretti, P. J. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004036 · Cited by 105 · see citing works
Self-citation
Aerobic glycolysis in the primate brain: Reconsidering the implications for growth and maintenance
Bauernfeind, A. L., Barks, S. K., Duka, T., Grossman, L. I., Hof, P. R., & Sherwood, C. C. (2014) · Brain Structure and Function · doi:10.1007/s00429-013-0662-z · Cited by 105 · see citing works
The story of the initial dip in fMRI
Hu, X. P., & Yacoub, E. S. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.005 · Cited by 102 · see citing works
Rapid metabolic evolution in human prefrontal cortex
Fu, X., Giavalisco, P., Liu, X., Catchpole, G., Fu, N., Ning, Z., Guo, S., Zheng, Y., Somel, M., Pääbo, S., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019164108 · Cited by 99 · see citing works
A coherent neurobiological framework for functional neuroimaging provided by a model integrating compartmentalized energy metabolism
Aubert, A., Pellerin, L., Magistretti, P. J., & Costalat, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605864104 · Cited by 97 · see citing works
Self-citation
Noradrenaline- and vasoactive intestinal peptide-containing neuronal systems in neocortex: Functional convergence with contrasting morphology
Magistretti, P. J., & Morrison, J. H. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90338-7 · Cited by 94 · see citing works
Self-citation
SUBSTANCES WHICH SUPPORT RESPIRATION AND METABOLIC RESPONSE TO ELECTRICAL IMPULSES IN HUMAN CEREBRAL TISSUES
MCILWAIN, H. (1953) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.16.4.257 · Cited by 93 · see citing works
Changes in Glucose Uptake Rather than Lactate Shuttle Take Center Stage in Subserving Neuroenergetics: Evidence from Mathematical Modeling
DiNuzzo, M., Mangia, S., Maraviglia, B., & Giove, F. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.232 · Cited by 93 · see citing works
Exceptional Evolutionary Divergence of Human Muscle and Brain Metabolomes Parallels Human Cognitive and Physical Uniqueness
Bozek, K., Wei, Y., Yan, Z., Liu, X., Xiong, J., Sugimoto, M., Tomita, M., Pääbo, S., Pieszek, R., Sherwood, C. C., et al. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001871 · Cited by 93 · see citing works
A Guide to Delineate the Logic of Neurovascular Signaling in the Brain
Kleinfeld, D., Blinder, P., Drew, P. J., Driscoll, J. D., Muller, A., Tsai, P. S., & Shih, A. Y. (2011) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2011.00001 · Cited by 92 · see citing works
Local Injection of Antisense Oligonucleotides Targeted to the Glial Glutamate Transporter GLAST Decreases the Metabolic Response to Somatosensory Activation
Cholet, N., Pellerin, L., Welker, E., Lacombe, P. M., Seylaz, J., Magistretti, P. J., & Bonvento, G. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200104000-00009 · Cited by 90 · see citing works
Self-citation
Relationship between L-glutamate-regulated intracellular Na+ dynamics and ATP hydrolysis in astrocytes
Magistretti, P. J., & Chatton, J. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0171-6 · Cited by 88 · see citing works
Self-citation
Deciphering neuron-glia compartmentalization in cortical energy metabolism
Jolivet, R. (2009) · Frontiers in Neuroenergetics · doi:10.3389/neuro.14.004.2009 · Cited by 87 · see citing works
Comment on Recent Modeling Studies of Astrocyte–Neuron Metabolic Interactions
Jolivet, R., Allaman, I., Pellerin, L., Magistretti, P. J., & Weber, B. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.132 · Cited by 84 · see citing works
Self-citation
Cerebral glycolysis: a century of persistent misunderstanding and misconception
Schurr, A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00360 · Cited by 80 · see citing works
Lactate and the injured brain
Bouzat, P., & Oddo, M. (2014) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000072 · Cited by 79 · see citing works
Scaling laws in the mammalian neocortex: Does form provide clues to function?
Harrison, K. H., Hof, P. R., & Wang, S. S.-H. (2002) · Journal of Neurocytology · doi:10.1023/a:1024178127195 · Cited by 78 · see citing works
Variations in mitochondrial structure and content of neurons and neuroglia in rat brain: An electron microscopic study
Pysh, J. J., & Khan, T. A. (1972) · Brain Research · doi:10.1016/0006-8993(72)90762-7 · Cited by 78 · see citing works
The source of physiologically stimulated glutamate efflux from the striatum of conscious rats.
Miele, M., Boutelle, M. G., & Fillenz, M. (1996) · The Journal of Physiology · doi:10.1113/jphysiol.1996.sp021805 · Cited by 74 · see citing works
Aerobic production and utilization of lactate satisfy increased energy demands upon neuronal activation in hippocampal slices and provide neuroprotection against oxidative stress
Schurr, A. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00096 · Cited by 73 · see citing works
Astrocyte-neuron crosstalk regulates the expression and subcellular localization of carbohydrate metabolism enzymes
Mamczur, P., Borsuk, B., Paszko, J., Sas, Z., Mozrzymas, J., Wiśniewski, J. R., Gizak, A., & Rakus, D. (2015) · Glia · doi:10.1002/glia.22753 · Cited by 71 · see citing works
A KINETIC STUDY OF THE NEURON-GLIA RELATIONSHIP
Hydén, H., & Lange, P. W. (1962) · The Journal of Cell Biology · doi:10.1083/jcb.13.2.233 · Cited by 68 · see citing works
On-Site Energy Supply at Synapses through Monocarboxylate Transporters Maintains Excitatory Synaptic Transmission
Nagase, M., Takahashi, Y., Watabe, A. M., Kubo, Y., & Kato, F. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4687-12.2014 · Cited by 66 · see citing works
Dual-Gene, Dual-Cell Type Therapy against an Excitotoxic Insult by Bolstering Neuroenergetics
Bliss, T. M., Ip, M., Cheng, E., Minami, M., Pellerin, L., Magistretti, P. J., & Sapolsky, R. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0805-04.2004 · Cited by 63 · see citing works
Self-citation
Small is fast: astrocytic glucose and lactate metabolism at cellular resolution
Barros, L. F., Martín, A. S., Sotelo-Hitschfeld, T., Lerchundi, R., Fernández‐Moncada, I., Ruminot, I., Gutiérrez, R., Valdebenito, R., Ceballo, S., Alegría, K., et al. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00027 · Cited by 61 · see citing works
Glial Glutamate Transporters and Maturation of the Mouse Somatosensory Cortex
Voutsinos‐Porche, B. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.10.1110 · Cited by 57 · see citing works
Lactate Effectively Covers Energy Demands during Neuronal Network Activity in Neonatal Hippocampal Slices
Ivanov, A., Mukhtarov, M. R., Bregestovski, P. D., & Zilberter, Y. (2011) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2011.00002 · Cited by 55 · see citing works
Positive selection on gene expression in the human brain
Khaitovich, P., Tang, K., Franz, H., Kelso, J. F., Hellmann, I., Enard, W., Lachmann, M., & Pääbo, S. (2006) · Current Biology · doi:10.1016/j.cub.2006.03.082 · Cited by 54 · see citing works
Ex Vivo Analysis of Lactate and Glucose Metabolism in the Rat Brain under Different States of Depressed Activity
Serres, S., Bezançon, E., Franconi, J., & Merle, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409429200 · Cited by 52 · see citing works
Early acquisition of typical metabolic features upon differentiation of mouse neural stem cells into astrocytes
Brunet, J. F., Grollimund, L., Chatton, J., Lengacher, S., Magistretti, P. J., Villemure, J., & Pellerin, L. (2003) · Glia · doi:10.1002/glia.10348 · Cited by 52 · see citing works
Self-citation
Low-Cost Travel in Neurons
Magistretti, P. J. (2009) · Science · doi:10.1126/science.1180102 · Cited by 49 · see citing works
Self-citation
Brain glucose transporter (Glut3) haploinsufficiency does not impair mouse brain glucose uptake
Stuart, C. A., Ross, I. R., Howell, M. E. A., McCurry, M. P., Wood, T. G., Ceci, J. D., Kennel, S. J., & Wall, J. S. (2011) · Brain Research · doi:10.1016/j.brainres.2011.02.014 · Cited by 49 · see citing works
NEURONAL EXTENSION AND GLIAL SUPPLY: FUNCTIONAL SIGNIFICANCE OF GLIA
Friede, R. L., & Houten, W. H. V. (1962) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.48.5.817 · Cited by 43 · see citing works
Ex vivo NMR study of lactate metabolism in rat brain under various depressed states
Serres, S., Bezançon, E., Franconi, J., & Merle, M. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20277 · Cited by 43 · see citing works
β2‐ and β3‐Adrenoceptors activate glucose uptake in chick astrocytes by distinct mechanisms: a mechanism for memory enhancement?
Hutchinson, D. S., Summers, R. J., & Gibbs, M. E. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04789.x · Cited by 42 · see citing works
Adenosine triphosphate and arachidonic acid stimulate glycogenolysis in primary cultures of mouse cerebral cortical astrocytes
Sorg, O., Pellerin, L., Stolz, M., Beggah, S., & Magistretti, P. J. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)11410-x · Cited by 42 · see citing works
Self-citation
Glucose and lactate metabolism in the awake and stimulated rat: a 13C-NMR study
Sampol, D., Ostrofet, E., Jobin, M., Raffard, G., Sanchez, S., Bouchaud, V., Franconi, J., Bonvento, G., & Bouzier‐Sore, A. (2013) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2013.00005 · Cited by 39 · see citing works
Characterization of sustained BOLD activation in the rat barrel cortex and neurochemical consequences
Just, N., Xin, L., Frenkel, H., & Gruetter, R. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.02.042 · Cited by 35 · see citing works
Neuronal functions, feeding behavior, and energy balance inSlc2a3+/−mice
Schmidt, S., Richter, M., Montag, D., Sartorius, T., Gawlik, V., Hennige, A. M., Scherneck, S., Himmelbauer, H., Lutz, S. Z., Augustin, R., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90491.2008 · Cited by 34 · see citing works
Phylogenomic evidence of adaptive evolution in the ancestry of humans
Goodman, M., & Sterner, K. N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914626107 · Cited by 32 · see citing works
Glycogen function in adult central and peripheral nerves
Evans, R. D., Brown, A. M., & Ransom, B. R. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23229 · Cited by 30 · see citing works

Flagged first, then by citations

1 of the 204 references couldn’t be matched to a known paper.

Sorted by citations

Lactate in the brain: from metabolic end-product to signalling molecule
Magistretti, P. J., & Allaman, I. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.19 · Cited by 1,298 · see citing works
Self-citation
13 reasons why the brain is susceptible to oxidative stress
Cobley, J. N., Fiorello, M. L., & Bailey, D. M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.008 · Cited by 1,215 · see citing works
Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation
Johnson, E. C. B., Dammer, E. B., Duong, D. M., Ping, L., Zhou, M., Yin, L., Higginbotham, L. A., Guajardo, A., White, B., Troncoso, J. C., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0815-6 · Cited by 1,001 · see citing works
Brain Glucose Metabolism: Integration of Energetics with Function
Dienel, G. A. (2018) · Physiological Reviews · doi:10.1152/physrev.00062.2017 · Cited by 877 · see citing works
Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation
Lü, Y., Li, Z., Zhang, S., Zhang, T., Liu, Y., & Zhang, L. (2023) · Theranostics · doi:10.7150/thno.79876 · Cited by 717 · see citing works
In vivo evidence for a lactate gradient from astrocytes to neurons
Mächler, P., Wyss, M. T., Elsayed, M., Stobart, J., Gutierrez, R., von Faber-Castell, A., Kaelin, V., Zuend, M., San Martín, A., Romero-Gómez, I., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.010 · Cited by 571 · see citing works
Self-citation
An energetic view of stress: Focus on mitochondria
Picard, M. A., McEwen, B. S., Epel, E. S., & Sandi, C. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.01.001 · Cited by 565 · see citing works
Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective
González-Reyes, R. E., Nava-Mesa, M. O., Vargas-Sánchez, K., Ariza-Salamanca, D. F., & Mora-Muñoz, L. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00427 · Cited by 525 · see citing works
Neuroprotective Effect of Antioxidants in the Brain
Lee, K. H., Cha, M., & Lee, B. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197152 · Cited by 527 · see citing works
Neuron–glia interactions in the pathophysiology of epilepsy
Patel, D. C., Tewari, B. P., Chaunsali, L., & Sontheimer, H. W. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0126-4 · Cited by 461 · see citing works
Microbiota-derived metabolites as drivers of gut–brain communication
Ahmed, H., Leyrolle, Q., Koistinen, V., Kärkkäinen, O., Layé, S., Delzenne, N., & Hanhineva, K. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2102878 · Cited by 462 · see citing works
Direct cell reprogramming: approaches, mechanisms and progress
Wang, H., Yang, Y., Liu, J., & Li, Q. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00335-z · Cited by 438 · see citing works
Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes
Agarwal, A., Wu, P.-H., Hughes, E. G., Fukaya, M., Tischfield, M. A., Langseth, A. J., Wirtz, D., & Bergles, D. E. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.034 · Cited by 441 · see citing works
A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells
Maoz, B. M., Herland, A., Fitzgerald, E. A., Grevesse, T., Vidoudez, C., Pacheco, A. R., Sheehy, S. P., Park, T., Dauth, S., Mannix, R. J., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4226 · Cited by 428 · see citing works
Functional Near-Infrared Spectroscopy (fNIRS) for Assessing Cerebral Cortex Function During Human Behavior in Natural/Social Situations: A Concise Review
Quaresima, V., & Ferrari, M. (2016) · Organizational Research Methods · doi:10.1177/1094428116658959 · Cited by 423 · see citing works
Sex differences in the developing brain: insights from multimodal neuroimaging
Kaczkurkin, A. N., Raznahan, A., & Satterthwaite, T. D. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0111-z · Cited by 403 · see citing works
Epigenetic Regulation in Neurodegenerative Diseases
Berson, A., Nativio, R., Berger, S. L., & Bonini, N. M. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.05.005 · Cited by 386 · see citing works
Integrated proteomics reveals brain-based cerebrospinal fluid biomarkers in asymptomatic and symptomatic Alzheimer’s disease
Higginbotham, L., Ping, L., Dammer, E. B., Duong, D. M., Zhou, M., Gearing, M., Hurst, C., Glass, J. D., Factor, S. A., Johnson, E. C. B., et al. (2020) · Science Advances · doi:10.1126/sciadv.aaz9360 · Cited by 367 · see citing works
Mutant Huntingtin Disrupts the Nuclear Pore Complex
Grima, J. C., Daigle, J. G., Arbez, N., Cunningham, K. M., Zhang, K., Ochaba, J., Smith-Geater, C., Morozko, E. L., Stocksdale, J. T., Glatzer, J. C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.023 · Cited by 358 · see citing works
The Link Between Angiogenesis and Endothelial Metabolism
Potente, M., & Carmeliet, P. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105134 · Cited by 353 · see citing works
Altered cellular metabolism in gliomas — an emerging landscape of actionable co-dependency targets
Bi, J., Chowdhry, S., Wu, S., Zhang, W., Masui, K., & Mischel, P. S. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0226-5 · Cited by 348 · see citing works
Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling
Tauffenberger, A., Fiumelli, H., Almustafa, S., & Magistretti, P. J. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1877-6 · Cited by 345 · see citing works
Self-citation
Single-cell multiregion dissection of Alzheimer’s disease
Mathys, H., Boix, C. A., Akay, L. A., Xia, Z., Davila-Velderrain, J., Ng, A. P., Jiang, X., Abdelhady, G., Galani, K., Mantero, J., et al. (2024) · Nature · doi:10.1038/s41586-024-07606-7 · Cited by 343 · see citing works
Short Overview of ROS as Cell Function Regulators and Their Implications in Therapy Concepts
Milković, L., Gašparović, A. Č., Cindrić, M., Mouthuy, P., & Žarković, N. (2019) · Cells · doi:10.3390/cells8080793 · Cited by 330 · see citing works
Impairment of Glycolysis-Derived L-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer's Disease
Douce, J. L., Maugard, M., Veran, J., Matos, M., Jégo, P., Vigneron, P.-A., Faivre, É., Toussay, X., Vandenberghe, M. E., Balbastre, Y., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.004 · Cited by 326 · see citing works
Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases
Armada‐Moreira, A., Gomes, J. I., Pina, C. C., Savchak, O. K., Gonçalves‐Ribeiro, J., Rei, N., Pinto, S., Morais, T. P., Martins, R. S., Ribeiro, F. F., et al. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00090 · Cited by 323 · see citing works
Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease
Osborn, L. M., Kamphuis, W., Wadman, W. J., & Hol, E. M. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.001 · Cited by 312 · see citing works
The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases
Kausar, S., Wang, F., & Cui, H. (2018) · Cells · doi:10.3390/cells7120274 · Cited by 315 · see citing works
Microglial metabolic flexibility supports immune surveillance of the brain parenchyma
Bernier, L., York, E. M., Kamyabi, A., Choi, H. B., Weilinger, N. L., & MacVicar, B. A. (2020) · Nature Communications · doi:10.1038/s41467-020-15267-z · Cited by 302 · see citing works
Astrocytes as Key Regulators of Brain Energy Metabolism: New Therapeutic Perspectives
Béard, E., Lengacher, S., Dias, S., Magistretti, P. J., & Finsterwald, C. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.825816 · Cited by 309 · see citing works
Self-citation
Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
Hasel, P., Dando, O., Jiwaji, Z., Baxter, P. S., Todd, A., Heron, S., Márkus, N. M., McQueen, J., Hampton, D. W., Torvell, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15132 · Cited by 305 · see citing works
Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice
Bisht, K., Okojie, K. A., Sharma, K. P., Lentferink, D. H., Sun, Y., Chen, H., Uweru, J. O., Amancherla, S., Calcuttawala, Z., Campos-Salazar, A. B., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25590-8 · Cited by 296 · see citing works
Energy matters: presynaptic metabolism and the maintenance of synaptic transmission
Li, S., & Sheng, Z. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00535-8 · Cited by 273 · see citing works
Bioenergetics and redox adaptations of astrocytes to neuronal activity
Bolaños, J. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13486 · Cited by 262 · see citing works
Energy metabolism in ALS: an underappreciated opportunity?
Vandoorne, T., Bock, K. D., & Bosch, L. V. D. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1835-x · Cited by 260 · see citing works
Pleiotropic Mitochondria: The Influence of Mitochondria on Neuronal Development and Disease
Rangaraju, V., Lewis, T. L., Hirabayashi, Y., Bergami, M., Motori, E., Cartoni, R., Kwon, S., & Courchet, J. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1157-19.2019 · Cited by 257 · see citing works
Spatially aware dimension reduction for spatial transcriptomics
Shang, L., & Zhou, X. (2022) · Nature Communications · doi:10.1038/s41467-022-34879-1 · Cited by 242 · see citing works
Fatigue, Sleep, and Autoimmune and Related Disorders
Zielinski, M. R., Systrom, D. M., & Rose, N. R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01827 · Cited by 266 · see citing works
Antioxidant Therapy in Oxidative Stress-Induced Neurodegenerative Diseases: Role of Nanoparticle-Based Drug Delivery Systems in Clinical Translation
Ashok, A., Andrabi, S. S., Mansoor, S., Kuang, Y., Kwon, B. K., & Labhasetwar, V. D. (2022) · Antioxidants · doi:10.3390/antiox11020408 · Cited by 262 · see citing works
Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse
Frère, S. G. A., & Slutsky, I. (2018) · Neuron · doi:10.1016/j.neuron.2017.11.028 · Cited by 230 · see citing works
New insights into the role of mitochondrial dynamics in oxidative stress-induced diseases
Chen, S., Li, Q., Shi, H., Li, F., Duan, Y., & Guo, Q. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117084 · Cited by 234 · see citing works
RNA-binding proteins in neurodegeneration: mechanisms in aggregatePreprint
Conlon, E. G., & Manley, J. L. (2017) · Genes & Development · doi:10.1101/gad.304055.117 · Cited by 221 · see citing works
An astroglial basis of major depressive disorder? An overview
Wang, Q., Jie, W., Liu, J., Yang, J., & Gao, T. (2017) · Glia · doi:10.1002/glia.23143 · Cited by 222 · see citing works
Mitochondria, energy, and metabolism in neuronal health and disease
Trigo, D., Avelar, C., Fernandes, M., Sá, J., & Silva, O. A. B. D. C. E. (2022) · FEBS Letters · doi:10.1002/1873-3468.14298 · Cited by 218 · see citing works
Upregulated energy metabolism in the Drosophila mushroom body is the trigger for long-term memory
Plaçais, P.-Y., de Tredern, É., Scheunemann, L., Trannoy, S., Goguel, V., Han, K.-A., Isabel, G., & Préat, T. (2017) · Nature Communications · doi:10.1038/ncomms15510 · Cited by 211 · see citing works
Astrocytic mitochondrial ROS modulate brain metabolism and mouse behaviour
Vicente‐Gutiérrez, C., Bonora, N., Bobo-Jiménez, V., Jiménez-Blasco, D., López-Fabuel, I., Fernández, E., Joséphine, C., Bonvento, G., Enrı́quez, J. A., Almeida, Á., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0031-6 · Cited by 205 · see citing works
Astrocytic β 2 -adrenergic receptors mediate hippocampal long-term memory consolidation
Gao, V., Suzuki, A., Magistretti, P. J., Lengacher, S., Pollonini, G., Steinman, M. Q., & Alberini, C. M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605063113 · Cited by 207 · see citing works
Self-citation
Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders
Sasso, J. M., Ammar, R. M., Tenchov, R., Lemmel, S. A., Kelber, O., Grieswelle, M., & Zhou, Q. A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00127 · Cited by 217 · see citing works
Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood–brain barrier
Hladky, S. B., & Barrand, M. A. (2018) · Fluids and Barriers of the CNS · doi:10.1186/s12987-018-0113-6 · Cited by 206 · see citing works
Glia-neuron energy metabolism in health and diseases: New insights into the role of nervous system metabolic transporters
Jha, M. K., & Morrison, B. M. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.07.009 · Cited by 203 · see citing works
Connexin 43-Mediated Astroglial Metabolic Networks Contribute to the Regulation of the Sleep-Wake Cycle
Clasadonte, J., Scemes, E., Wang, Z., Boison, D., & Haydon, P. G. (2017) · Neuron · doi:10.1016/j.neuron.2017.08.022 · Cited by 200 · see citing works
Mitochondrial metabolism in astrocytes regulates brain bioenergetics, neurotransmission and redox balance
Rose, J., Brian, C., Pappa, A., Panayiotidis, M. I., & Franco, R. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.536682 · Cited by 196 · see citing works
Alternative Splicing in Neurogenesis and Brain Development
Su, C.-H., Dhananjaya, D., & Tarn, W. (2018) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2018.00012 · Cited by 192 · see citing works
Pathophysiological subtypes of Alzheimer’s disease based on cerebrospinal fluid proteomics
Tijms, B. M., Gobom, J., Reus, L. M., Jansen, I. E., Hong, S., Dobričić, V., Kilpert, F., ten Kate, M., Barkhof, F., Tsolaki, M., et al. (2020) · Brain · doi:10.1093/brain/awaa325 · Cited by 192 · see citing works
Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition
Morant-Ferrando, B., Jiménez-Blasco, D., Alonso-Batan, P., Agulla, J., Lapresa, R., García-Rodríguez, D., Yunta-Sanchez, S., López-Fabuel, I., Fernández, E., Carmeliet, P., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00835-6 · Cited by 193 · see citing works
Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization
Schild, T., Low, V., Blenis, J., & Gomes, A. P. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.02.001 · Cited by 185 · see citing works
Mitochondria, Metabolism, and Redox Mechanisms in Psychiatric Disorders
Kim, Y., Vadodaria, K. C., Lenkei, Z., Kato, T., Gage, F. H., Marchetto, M. C., & Santos, R. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7606 · Cited by 189 · see citing works
The neuropathobiology of multiple sclerosis
Woo, M. S., Engler, J. B., & Friese, M. A. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00823-z · Cited by 194 · see citing works
Oxidative stress and neurodegeneration: the involvement of iron
Carocci, A., Catalano, A. A., Sinicropi, M. S., & Genchi, G. (2018) · BioMetals · doi:10.1007/s10534-018-0126-2 · Cited by 180 · see citing works
Direct Neuronal Reprogramming: Achievements, Hurdles, and New Roads to Success
Gascón, S., Masserdotti, G., Russo, G. L., & Götz, M. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.06.011 · Cited by 177 · see citing works
The Interplay Among Oxidative Stress, Brain Insulin Resistance and AMPK Dysfunction Contribute to Neurodegeneration in Type 2 Diabetes and Alzheimer Disease
Barone, E., Domenico, F. D., Perluigi, M., & Butterfield, D. (2021) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2021.09.006 · Cited by 155 · see citing works
Increased glycolysis correlates with elevated immune activity in tumor immune microenvironment
Jiang, Z., Liu, Z., Li, M., Chen, C., & Wang, X. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.068 · Cited by 170 · see citing works
Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease
Johnson, E. C. B., Bian, S., Haque, R. U., Carter, E. K., Watson, C. M., Gordon, B. A., Ping, L., Duong, D. M., Epstein, M. P., McDade, E., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02476-4 · Cited by 170 · see citing works
Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte-neuron lactate shuttle in brain
Dienel, G. A. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24015 · Cited by 168 · see citing works
Glutamate and GABA Homeostasis and Neurometabolism in Major Depressive Disorder
Sarawagi, A., Soni, N. D., & Patel, A. B. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.637863 · Cited by 172 · see citing works
Energy Metabolism Decline in the Aging Brain—Pathogenesis of Neurodegenerative Disorders
Błaszczyk, J. W. (2020) · Metabolites · doi:10.3390/metabo10110450 · Cited by 162 · see citing works
Metabolic Dysfunction in Parkinson’s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism
Anandhan, A., Jacome, M. S., Lei, S., Hernández-Franco, P., Pappa, A., Panayiotidis, M. I., Powers, R., & Franco, R. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.03.009 · Cited by 161 · see citing works
Mitochondrial dysfunctions induce PANoptosis and ferroptosis in cerebral ischemia/reperfusion injury: from pathology to therapeutic potential
She, R., Liu, D., Liao, J., Wang, G., Ge, J., & Mei, Z. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1191629 · Cited by 161 · see citing works
mTOR/AMPK signaling in the brain: Cell metabolism, proteostasis and survival
Garza-Lombó, C., Schroder, A. L., Reyes‐Reyes, E. M., & Franco, R. (2018) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2018.05.002 · Cited by 159 · see citing works
The solute carrier transporters and the brain: Physiological and pharmacological implications
Hu, C., Tao, L., Cao, X., & Chen, L. (2019) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2019.09.002 · Cited by 157 · see citing works
Brain Fuel Utilization in the Developing Brain
Steiner, P. (2019) · Annals of Nutrition and Metabolism · doi:10.1159/000508054 · Cited by 159 · see citing works
Microglia-Specific Metabolic Changes in Neurodegeneration
Aldana, B. I. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.03.006 · Cited by 153 · see citing works
Brain energy metabolism: Astrocytes in neurodegenerative diseases.
Chen, Z., Yuan, Z., Yang, S., Zhu, Y., Xue, M., Zhang, J., & Leng, L. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13982 · Cited by 153 · see citing works
Respiration-Deficient Astrocytes Survive As Glycolytic Cells In Vivo
Supplie, L. M., Düking, T., Campbell, G., Diaz, F., Moraes, C. T., Götz, M., Hamprecht, B., Boretius, S., Mahad, D., & Nave, K.-A. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.0756-16.2017 · Cited by 153 · see citing works
Stress and Psychiatric Disorders: The Role of Mitochondria
Daniels, T. E., Olsen, E. M., & Tyrka, A. R. (2020) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-082719-104030 · Cited by 157 · see citing works
Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders
Gil-Martins, E., Barbosa, D. J., Silva, V., Remião, F., & Silva, R. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107554 · Cited by 152 · see citing works
Aerobic glycolysis is the predominant means of glucose metabolism in neuronal somata, which protects against oxidative damage
Wei, Y., Miao, Q., Zhang, Q., Mao, S., Li, M., Xu, X., Xia, X., Wei, K., Fan, Y., Zheng, X., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01476-4 · Cited by 153 · see citing works
Reactive Oxygen Species: Beyond Their Reactive Behavior
Tauffenberger, A., & Magistretti, P. J. (2021) · Neurochemical Research · doi:10.1007/s11064-020-03208-7 · Cited by 151 · see citing works
Self-citation
The Glutamate/ GABA ‐Glutamine Cycle: Insights, Updates, and Advances
Andersen, J. V. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70029 · Cited by 156 · see citing works
The Interconnected Mechanisms of Oxidative Stress and Neuroinflammation in Epilepsy
Parsons, A. L. M., Bucknor, E. M. V., Castroflorio, E., Soares, T. R., Oliver, P. L., & Rial, D. (2022) · Antioxidants · doi:10.3390/antiox11010157 · Cited by 147 · see citing works
Astroglial glutamate transporters coordinate excitatory signaling and brain energetics
Robinson, M. B., & Jackson, J. G. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.03.014 · Cited by 144 · see citing works
Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer’s disease: An integrative review
Millan, M. J. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.03.004 · Cited by 146 · see citing works
Glucose metabolism in nerve terminals
Ashrafi, G., & Ryan, T. A. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.03.007 · Cited by 146 · see citing works
Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease
Joshi, A. U., Saw, N. L., Shamloo, M., & Mochly‐Rosen, D. (2017) · Oncotarget · doi:10.18632/oncotarget.23640 · Cited by 146 · see citing works
3D neuronal mitochondrial morphology in axons, dendrites, and somata of the aging mouse hippocampus
Faitg, J., Lacefield, C., Davey, T., White, K., Laws, R., Kosmidis, S., Reeve, A. K., Kandel, E. R., Vincent, A. E., & Picard, M. A. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109509 · Cited by 139 · see citing works
Glial cells in Alzheimer’s disease: From neuropathological changes to therapeutic implications
Uddin, M. S., & Lim, L. W. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101622 · Cited by 149 · see citing works
Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome
Inak, G., Rybak‐Wolf, A., Lisowski, P., Pentimalli, T. M., Jüttner, R., Glažar, P., Uppal, K., Bottani, E., Brunetti, D., Secker, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22117-z · Cited by 145 · see citing works
The Energy Homeostasis Principle: Neuronal Energy Regulation Drives Local Network Dynamics Generating Behavior
Vergara, R. C., Jaramillo-Riveri, S., Luarte, A., Moënne‐Loccoz, C., Fuentes, R., Couve, A., & Maldonado, P. (2019) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2019.00049 · Cited by 143 · see citing works
Molecular Communication of a Dying Neuron in Stroke
Puig, B., Brenna, S., & Magnus, T. U. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092834 · Cited by 138 · see citing works
Insulin Resistance at the Crossroad of Alzheimer Disease Pathology: A Review
Berlanga‐Acosta, J., Guillén, G. E., Rodríguez-Rodríguez, N., Bringas-Vega, M. L., García-del-Barco-Herrera, D., Berlanga-Saez, J. O., Ojalvo, A. G., Valdés-Sosa, M. J., & Valdes-Sosa, P. A. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.560375 · Cited by 139 · see citing works
Synapses: The Brain’s Energy-Demanding Sites
Faria‐Pereira, A., & Morais, V. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073627 · Cited by 145 · see citing works
Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis
Deitmer, J. W., Theparambil, S. M., Ruminot, I., Noor, S. I., & Becker, H. M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01301 · Cited by 137 · see citing works
Imaging Adenosine Triphosphate (ATP)
Rajendran, M., Dane, E. L., Conley, J. M., & Tantama, M. (2016) · Biological Bulletin · doi:10.1086/689592 · Cited by 135 · see citing works
Astrocytes and Brain-Derived Neurotrophic Factor (BDNF).
Albini, M., Krawczun-Rygmaczewska, A., & Cesca, F. (2023) · Neurosciences research · doi:10.1016/j.neures.2023.02.001 · Cited by 123 · see citing works
Glycolytic Metabolism, Brain Resilience, and Alzheimer’s Disease
Zhang, X., Alshakhshir, N., & Zhao, L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.662242 · Cited by 134 · see citing works
Emerging Roles of Astrocytes in Neuro-Vascular Unit and the Tripartite Synapse With Emphasis on Reactive Gliosis in the Context of Alzheimer’s Disease
Liu, C.-Y., Yang, Y., Ju, W.-N., Wang, X., & Zhang, H.-L. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00193 · Cited by 131 · see citing works
Genes, Cells and Brain Areas of Intelligence
Goriounova, N. A., & Mansvelder, H. D. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00044 · Cited by 141 · see citing works
The neurovascular unit and systemic biology in stroke — implications for translation and treatment
Tiedt, S., Buchan, A. M., Dichgans, M., Lizasoaín, I., Moro, M. Á., & Lo, E. H. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00703-z · Cited by 130 · see citing works
Brain Iron Homeostasis: A Focus on Microglial Iron
Nnah, I. C., & Wessling‐Resnick, M. (2018) · Pharmaceuticals · doi:10.3390/ph11040129 · Cited by 125 · see citing works
The Role of Lactate-Mediated Metabolic Coupling between Astrocytes and Neurons in Long-Term Memory Formation
Steinman, M. Q., Gao, V., & Alberini, C. M. (2016) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2016.00010 · Cited by 122 · see citing works

Brain Energy Metabolism
Magistretti, P. J. (2004) · Elsevier eBooks · doi:10.1016/b978-012148660-0/50004-4 · Cited by 16 · see citing works
Self-citation
The Cellular Bases of Functional Brain Imaging: Evidence for Astrocyte-Neuron Metabolic Coupling
Magistretti, P. J., & Pellerin, L. (1997) · The Neuroscientist · doi:10.1177/107385849700300608 · Cited by 15 · see citing works
Self-citation
Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging
Magistretti, P. J., & Pellerin, L. (1999) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1999.0471 · Cited by 750 · see citing works
Self-citation
Cellular Bases of Brain Energy Metabolism and Their Relevance to Functional Brain Imaging: Evidence for a Prominent Role of Astrocytes
Magistretti, P. J., & Pellerin, L. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.1.50 · Cited by 243 · see citing works
Self-citation
Brain energy metabolism: focus on Astrocyte-neuron metabolic cooperation
Bélanger, M., Allaman, I., & Magistretti, P. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.016 · Cited by 2,313 · see citing works
Self-citation

Authors: Magistretti, P. J., & Allaman, I.
Affiliations: École Polytechnique Fédérale de Lausanne (CH)
Corresponding author: Magistretti, Pierre J.
ORCID: Magistretti, Pierre J.
Allaman, Igor
Venue: Neuron
Publisher: Elsevier BV
Published: 2015-05
Volume: 86
Issue: 4
Pages: 883-901
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2015.03.035
OpenAlex: W1797578063
Semantic Scholar: 5422412ef48292717365807c1d50dd7887db3879
Cited by: 1,285
References: 204
Citations by year: 2026: 148 · 2025: 145 · 2024: 136 · 2023: 117 · 2022: 145 · 2021: 128 · 2020: 125 · 2019: 99 · 2018: 103 · 2017: 75 · 2016: 49 · 2015: 14 · 2014: 1
FWCI: 9.55
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 385 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
IRIS (submittedVersion)
King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: brain energy metabolism, glucose utilization, neuronal activity, astrocytes, energy metabolism genes, functional MRI, PET, cellular resolution
MeSH terms: Animals, Astrocytes, Brain, Energy Metabolism, Glucose, Humans, Magnetic Resonance Imaging, Neurons

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks