The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Acute Neuroendocrine Profile in Predicting Outcomes in Severe Traumatic Brain Injury: A Study from a Tertiary Care Center in South India
Abstract
Background: Pituitary dysfunction following severe traumatic brain injury (sTBI) is significant and may be correlated with the outcomes. Aims and Objectives: This study aimed to evaluate the early changes in pituitary hormone levels after sTBI and to correlate with outcomes in terms of severity and mortality. Methods: This was a prospective, observational study, involving consecutive patients of 16–60 years, with sTBI (Glasgow Coma Scale GCS < 9) presenting to the hospital within 24 h of trauma. Demographic and clinical data were collected. Serum samples were collected in the morning (08–10 am) on day 1 and day 4 for cortisol, thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), and prolactin (Chemiluminescence immunoassay). Outcome was assessed in terms of mortality (which included both immediate and at 3 months) and Glasgow outcome scale at 3 months. Results: 54 patients were studied. Mean cortisol on day 4 was 28.5 µg/dL in alive patients and 13.7 µg/dL in patients deceased at 3 months (P < 0.001). Patients who were deceased at 3 months had significantly lower T3 on day 4 (0.973 vs 1.4 ng/dL) and lower T4 (8.1 µg/L vs 6.1 µg/dL) as compared to patients who survived (P = 0.049 and 0.005, respectively). Acute phase TSH on day 4 levels were significantly lower in patients deceased at 3 months. There was no significant difference in the prolactin levels. Conclusion: Day 4 cortisol, T3, T4, and TSH correlated with the outcomes at 3 months and hence have predictive value post-sTBI.
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“The predictive power of cortisol is further supported by the findings of Kumar et al., who demonstrated positive correlation between mean cortisol on day 4 and survival at 3 months (Vishwa Kumar et al., 2021).”
From Acute neuroendocrine changes after traumatic brain injury (2024) · cites this paper as Vishwa Kumar et al., 2021
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“Specifically, lower levels of TSH, fT4, and fT3 observed on day 4, especially with the absence of increasing trends in these hormones were linked to poorer outcomes (measured by the Glasgow Outcome Scale) at 3 months (Vishwa Kumar et al., 2021).”
From Acute neuroendocrine changes after traumatic brain injury (2024) · cites this paper as Vishwa Kumar et al., 2021
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Acute neuro-endocrine profile and prediction of outcome after severe brain injury
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Cited by
Acute neuroendocrine changes after traumatic brain injury
Magyar-Sumegi, Z. D., Stankovics, L., Lendvai-Emmert, D., Czigler, A., Hegedus, E., Csendes, M., Toth, L., Ungvari, Z., Buki, A., & Toth, P. (2024) · Brain and Spine · doi:10.1016/j.bas.2024.102830 · Cited by 23
Metadata
- Authors
- Vishwa Kumar, K. S., Mudumba, V. S., Alugolu, R., & Anne, B.
- Venue
- Indian Journal of Endocrinology and Metabolism
- Published
- 2021-03
- Volume
- 25
- Issue
- 2
- Pages
- 95-102
- ISSN
- 2230-9500
- Cited by
- 4
- References
- 7
- Language
- en
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