Cited by 69Electrolyte and hormonal disordersTraumatic Brain Injury and Neurovascular DisturbancesPituitary Gland Disorders and Treatments

Pituitary dysfunction following traumatic brain injury or subarachnoid haemorrhage – In “Endocrine Management in the Intensive Care Unit”

Hannon, M.J., Sherlock, M., Thompson, C.J.·2011·Best Practice & Research Clinical Endocrinology & Metabolism

Abstract

Traumatic brain injury and subarachnoid haemorrhage are important causes of morbidity and mortality in the developed world. There is a large body of evidence that demonstrates that both conditions may adversely affect pituitary function in both the acute and chronic phases of recovery. Diagnosis of hypopituitarism and accurate treatment of pituitary disorders offers the opportunity to improve mortality and outcome in both traumatic brain injury and subarachnoid haemorrhage. In this article, we will review the history and pathophysiology of pituitary function in the acute phase following traumatic brain injury and subarachnoid haemorrhage, and we will discuss in detail three key aspects of pituitary dysfunction which occur in the early course of TBI; acute cortisol deficiency, diabetes insipidus and SIAD.

Integrity signals

Registry

Crossref · 10.1016/j.beem.2011.06.001

Cites

134 of 134 references verified0 citation errors · 0 not checkable

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  • Provocative testing, such as the cosyntropin stimulation test, is not reliable in the first 6 weeks after TBI.

    “provocative testing (such as the cosyntropin stimulation test, the gold standard in the chronic period) is not reliable in the first 6 weeks after an injury”

    From Neuroendocrine Disruptions Following Head Injury (2023) · cites this paper as [7]

  • Chronic pituitary dysfunction is reported in up to 42% of children and adolescents after TBI.

    “and up to 42% of children and adolescents [6-9].”

    From Neuroendocrine Disruptions Following Head Injury (2023) · cites this paper as [7]

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Authors
Hannon, M. J., Sherlock, M., & Thompson, C. J.
Affiliations
Royal College of Surgeons in Ireland (IE)
Corresponding author
Thompson, C.J.
Venue
Best Practice & Research Clinical Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2011-10
Volume
25
Issue
5
Pages
783-798
ISSN
1521-690X (ISSN-L)
OpenAlex
W2049746238
Cited by
69
References
134
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 2 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 6 · 2012: 2
FWCI
0.78
Type
journal article
Language
en
Open access
closed
Locations
  • Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords
pituitary dysfunction, traumatic brain injury, subarachnoid hemorrhage, hypopituitarism, cortisol deficiency, diabetes insipidus, syndrome of inappropriate antidiuretic hormone secretion, intensive care unit management
MeSH terms
Brain Injuries, Critical Care, Humans, Hypothalamo-Hypophyseal System, Pituitary Diseases, Pituitary Gland, Pituitary-Adrenal System, Subarachnoid Hemorrhage

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