Pituitary dysfunction following traumatic brain injury or subarachnoid haemorrhage – In “Endocrine Management in the Intensive Care Unit”
Abstract
Traumatic brain injury and subarachnoid haemorrhage are important causes of morbidity and mortality in the developed world. There is a large body of evidence that demonstrates that both conditions may adversely affect pituitary function in both the acute and chronic phases of recovery. Diagnosis of hypopituitarism and accurate treatment of pituitary disorders offers the opportunity to improve mortality and outcome in both traumatic brain injury and subarachnoid haemorrhage. In this article, we will review the history and pathophysiology of pituitary function in the acute phase following traumatic brain injury and subarachnoid haemorrhage, and we will discuss in detail three key aspects of pituitary dysfunction which occur in the early course of TBI; acute cortisol deficiency, diabetes insipidus and SIAD.
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Provocative testing, such as the cosyntropin stimulation test, is not reliable in the first 6 weeks after TBI.
“provocative testing (such as the cosyntropin stimulation test, the gold standard in the chronic period) is not reliable in the first 6 weeks after an injury”
From Neuroendocrine Disruptions Following Head Injury (2023) · cites this paper as [7]
Chronic pituitary dysfunction is reported in up to 42% of children and adolescents after TBI.
“and up to 42% of children and adolescents [6-9].”
From Neuroendocrine Disruptions Following Head Injury (2023) · cites this paper as [7]
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- Authors
- Hannon, M. J., Sherlock, M., & Thompson, C. J.
- Affiliations
- Royal College of Surgeons in Ireland (IE)
- Corresponding author
- Thompson, C.J.
- Venue
- Best Practice & Research Clinical Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 25
- Issue
- 5
- Pages
- 783-798
- ISSN
- 1521-690X (ISSN-L)
- OpenAlex
- W2049746238
- Cited by
- 69
- References
- 134
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 2 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 6 · 2012: 2
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- pituitary dysfunction, traumatic brain injury, subarachnoid hemorrhage, hypopituitarism, cortisol deficiency, diabetes insipidus, syndrome of inappropriate antidiuretic hormone secretion, intensive care unit management
- MeSH terms
- Brain Injuries, Critical Care, Humans, Hypothalamo-Hypophyseal System, Pituitary Diseases, Pituitary Gland, Pituitary-Adrenal System, Subarachnoid Hemorrhage
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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