The DOI matches its Crossref record; 143 of the 143 references it cites were found in a registry or an index.
Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases
Open accessAbstract
Over the past decade, evidences of an integration of metabolic and inflammatory pathways, referred to as metaflammation in several aspects of metabolic syndrome, have been accumulating. Fatty acid-binding protein 4 (FABP4), also known as adipocyte FABP (A-FABP) or aP2, is mainly expressed in adipocytes and macrophages and plays an important role in the development of insulin resistance and atherosclerosis in relation to metaflammation. Despite lack of a typical secretory signal peptide, FABP4 has been shown to be released from adipocytes in a non-classical pathway associated with lipolysis, possibly acting as an adipokine. Elevation of circulating FABP4 levels is associated with obesity, insulin resistance, diabetes mellitus, hypertension, cardiac dysfunction, atherosclerosis, and cardiovascular events. Furthermore, ectopic expression and function of FABP4 in several types of cells and tissues have been recently demonstrated. Here, we discuss both the significant role of FABP4 in pathophysiological insights and its usefulness as a biomarker of metabolic and cardiovascular diseases.
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Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases
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Self-citationImmunologic and endocrine functions of adipose tissue: implications for kidney disease
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Metadata
- Authors
- Furuhashi, M., Saitoh, S., Shimamoto, K., & Miura, T.
- Venue
- Clinical Medicine Insights: Cardiology
- Publisher
- SAGE Publications
- Published
- 2014-01
- Volume
- 8s3
- Issue
- Suppl 3
- Pages
- CMC.S17067
- ISSN
- 1179-5468 (ISSN-L)
- OpenAlex
- W1974038454
- Cited by
- 489
- References
- 143
- FWCI
- 15.79
- Type
- journal article
- Language
- en
- Open access
- gold
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- Furuhashi, M., Saitoh, S., Shimamoto, K., & Miura, T. (2014). Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases. Clinical Medicine Insights: Cardiology. https://doi.org/10.4137/cmc.s17067
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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