The DOI matches its Crossref record; 181 of the 181 references it cites were found in a registry or an index.
Lipid Droplets as Signaling Platforms Linking Metabolic and Cellular Functions
Abstract
The main cells of the adipose tissue of animals, adipocytes, are characterized by the presence of large cytosolic lipid droplets (LDs) that store triglyceride (TG) and cholesterol. However, most cells have LDs and the ability to store lipids. LDs have a well-known central role in storage and provision of fatty acids and cholesterol. However, the complexity of the regulation of lipid metabolism on the surface of the LDs is still a matter of intense study. Beyond this role, a number of recent studies have suggested that LDs have major functions in other cellular processes, such as protein storage and degradation, infection, and immunity. Thus, our perception of LDs has been radically transformed from simple globules of fat to highly dynamic organelles of unexpected complexity. Here, we compiled some recent evidence supporting the emerging view that LDs act as platforms connecting a number of relevant metabolic and cellular functions.
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“Interestingly, in other model systems, lipid droplets (the storage site of CE) have been shown to be active signaling organelles that regulate proteasome activity (Arrese et al., 2014, Keembiyehetty et al., 2011).”
From Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons (2019) · cites this paper as Arrese et al., 2014
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Insect Fat Body: Energy, Metabolism, and Regulation
Arrese, E. L., & Soulages, J. L. (2010) · Annual Review of Entomology · doi:10.1146/annurev-ento-112408-085356 · Cited by 2,514
Self-citationLipid Droplets and Cellular Lipid Metabolism
Walther, T. C., & Farese, R. V. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061009-102430 · Cited by 1,722
The lipid droplet is an important organelle for hepatitis C virus production
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FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling
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Lipid Droplets Finally Get a Little R-E-S-P-E-C-T
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Cited by
The Role of Cholesterol in the Pathogenesis of NASH
Ioannou, G. N. (2016) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.11.008 · Cited by 498
van der Kant, R., Langness, V. F., Herrera, C. M., Williams, D. A., Fong, L. K., Leestemaker, Y., Steenvoorden, E., Rynearson, K. D., Brouwers, J. F., Helms, J. B., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2018.12.013 · Cited by 350
Lipid droplets in neurodegenerative disorders
Farmer, B. C., Walsh, A. E., Kluemper, J. C., & Johnson, L. A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00742 · Cited by 270
Granneman, J. G., Kimler, V. A., Zhang, H., Ye, X., Luo, X., Postlethwait, J. H., & Thummel, R. (2017) · eLife · doi:10.7554/elife.21771 · Cited by 77
Metadata
- Authors
- Arrese, E. L., Saudale, F. Z., & Soulages, J. L.
- Affiliations
- Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK, USA.
- Venue
- Lipid Insights
- Publisher
- SAGE Publications
- Published
- 2014-01
- Volume
- 7
- ISSN
- 1178-6353
- PMC
- PMC4161058
- Cited by
- 54
- References
- 181
- Language
- en
- Licence
- journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
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