Biochemical predictors in presentations to the emergency department after a suicide attemp
Open accessAbstract
OBJECTIVE: This study was conducted with an aim to determine whether biochemical parameters could be used to identify the individuals at risk of suicide. METHODS: The experimental group consisted of a total of 46 patients that presented to the emergency department after a suicide attempt. 45 healthy individuals constituted the control group. All subjects were evaluated by using the Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), and the Beck Scale for Suicidal Ideation (BSSI). All subjects were evaluated for leukocyte count, mean platelet volume (MPV), C-reactive protein (CRP), cholesterol, triglyceride levels and neutrophil-lymphocyte ratio (NLR). The Vitamin D levels of the subjects in the experimental group were also measured. RESULTS: The BAI (p < 0.01), BDI (p < 0.01), and BSSI (p < 0.01) scores of the two groups were significantly different. The two groups were also significantly different in terms of CRP (p < 0.01), cholesterol (p < 0.05), NLR (p < 0.01), MPV (p < 0.01), triglyceride (p < 0.01) and leukocyte (p < 0.01) results. The vitamin D levels of the experimental group were found to be below normal vitamin D levels. High CRP levels were found to be a predictor of anxiety symptoms, and MPV and triglyceride levels were found to be predictors of depressive symptoms. CONCLUSION: We believe that biochemical parameters can be used to identify people with increased suicide risk, and suicide rates can be reduced by ensuring that these patients receive mental health care in the early period (Tab. 5, Ref. 42).
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In Yagci and Avci, NLR was higher in suicide attempt than in healthy controls.
“NLR was higher in SA than in HC”
In Yagci and Avci, NLR positively correlated between BDI, BAI, and BSSI, but this correlation was not statistically significant.
“NLR positively correlated between BDI, BAI, and BSSI. However, this correlation was not statistically significant”
Five included studies were conducted in Turkey, one in India, two in Spain, one in Sweden, one in Israel, and one in Thailand.
“Five studies were conducted in Turkey [8, 20, 30–32], one in India [27], two in Spain [4, 29], one in Sweden [28], one in Israel [26], and one in Thailand [9].”
Regarding PLR, two studies reported that PLR was higher in depressed patients (including SA, SI, and nSI) vs HC.
“Regarding the PLR index, two studies reported that PLR was higher in depressed patients (including SA, SI, and nSI) vs HC [23, 30].”
In three studies, NLR was higher in depressed patients with a history of SA vs HC.
“In three studies, NLR was reported to be higher in depressed patients with a history of SA vs HC [9, 20, 30].”
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Percentages, sums and reported differences re-computed from the paper’s own numbers.
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- Authors
- Yagci, I., & Avci, S.
- Venue
- Bratislava Medical Journal
- Published
- 2021
- Volume
- 122
- Issue
- 03
- Pages
- 224-229
- ISSN
- 0006-9248 (ISSN-L)
- 1336-0345
- OpenAlex
- W3131879347
- Cited by
- 15
- References
- 25
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 1
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Bratislavské lekárske listy/Bratislava medical journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- suicide attempts, suicide risk prediction, biochemical markers, C-reactive protein, mean platelet volume, neutrophil-to-lymphocyte ratio, triglycerides, cholesterol, white blood cell count, vitamin D, depression, anxiety, suicidal ideation, emergency department patients
- MeSH terms
- Emergency Service, Hospital, Humans, Leukocyte Count, Lymphocytes, Neutrophils, Suicide, Attempted
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