Tumor microenvironment and the role of mesenchymal stromal cells
Open accessAbstract
UNLABELLED: Solid tumors are generally composed of two major components: heterogeneous malignant cells and non-malignant stromal part. The latter comprises several types of non-malignant cells of mesenchymal, endothelial and immune origin and together with the extracellular matrix significantly affects the biological properties of the tumor. This minireview is focused on recent advances in the understanding the role of tumor stromal component and its particular cell types in the tumor behavior. It summarizes the impact of mesenchymal stromal cells and the ways of their potential contribution to the tumor biology. As their role in the tumor development and the effects on the tumor cells remain controversial, we review the recent experimental evidence regarding the crucial molecular factors which determine their role in the tumors. KEYWORDS: tumor microenvironment, human mesenchymal stromal cells, paracrine interaction, malignant cells.
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Multicellular tumor spheroids are appropriate systems for modeling tumor heterogeneity and microenvironmental complexity.
“Multicellular tumor spheroids are appropriate systems for modeling tumor heterogeneity and microenvironmental complexity [204,205,206].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [205]
The Tumor microenvironment section describes heterogeneous tumor cells and complex interactions with surrounding cells, but does not discuss multicellular tumor spheroids or whether they model those features. Searches for “multicellular tumor spheroids” and “spheroid 3D three-dimensional culture model tumor heterogeneity” found no passage addressing their suitability. (LLM, conf=0.72)
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Human mesenchymal stem cells are resistant to cytotoxic and genotoxic effects of cisplatin in vitro
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- Authors
- KUCEROVA, L., & SKOLEKOVA, S.
- Affiliations
- Slovak Academy of Sciences (SK)
- Venue
- Neoplasma
- Publisher
- AEPress, s.r.o.
- Published
- 2012
- Volume
- 60
- Issue
- 01
- Pages
- 1-10
- ISSN
- 0028-2685 (ISSN-L)
- 1338-4317
- OpenAlex
- W2044088315
- Cited by
- 27
- References
- 90
- Citations by year
- 2025: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 3 · 2014: 3 · 2013: 3
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neoplasma (publishedVersion)
- PubMed (publishedVersion)
- Funders
- China Scholarship Council
- Agentúra na Podporu Výskumu a Vývoja (APVV-0230-11, APVV-0260-07)
- Vedecká Grantová Agentúra MŠVVaŠ SR a SAV (2/0088/11)
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- tumor microenvironment, mesenchymal stem cells, tumor stroma, paracrine signaling, tumor progression, extracellular matrix, tumor biology, tumor-stroma interactions
- MeSH terms
- Animals, Humans, Neoplasms, Tumor Microenvironment, Mesenchymal Stem Cells
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