Cited by 27Mesenchymal stem cell researchCancer Cells and MetastasisTGF-β signaling in diseases

Tumor microenvironment and the role of mesenchymal stromal cells

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KUCEROVA, L., SKOLEKOVA, S.·2012·Neoplasma

Abstract

UNLABELLED: Solid tumors are generally composed of two major components: heterogeneous malignant cells and non-malignant stromal part. The latter comprises several types of non-malignant cells of mesenchymal, endothelial and immune origin and together with the extracellular matrix significantly affects the biological properties of the tumor. This minireview is focused on recent advances in the understanding the role of tumor stromal component and its particular cell types in the tumor behavior. It summarizes the impact of mesenchymal stromal cells and the ways of their potential contribution to the tumor biology. As their role in the tumor development and the effects on the tumor cells remain controversial, we review the recent experimental evidence regarding the crucial molecular factors which determine their role in the tumors. KEYWORDS: tumor microenvironment, human mesenchymal stromal cells, paracrine interaction, malignant cells.

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Crossref · 10.4149/neo_2013_001

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  • Multicellular tumor spheroids are appropriate systems for modeling tumor heterogeneity and microenvironmental complexity.

    “Multicellular tumor spheroids are appropriate systems for modeling tumor heterogeneity and microenvironmental complexity [204,205,206].”

    From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [205]

    The Tumor microenvironment section describes heterogeneous tumor cells and complex interactions with surrounding cells, but does not discuss multicellular tumor spheroids or whether they model those features. Searches for “multicellular tumor spheroids” and “spheroid 3D three-dimensional culture model tumor heterogeneity” found no passage addressing their suitability. (LLM, conf=0.72)

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Research works printed but not linked: 2

  1. FIDLER IJ, POSTE G The "seed and soil" hypothesis revisited. Lancet Oncol 2008; 9: 808. http://dx.doi.org/10.1016/S1470- 2045(08)70201-8 · DOI
  2. SALEM HK, THIEMERMANN C Mesenchymal stromal cells: current understanding and clinical status. Stem Cells 2010; 28: 585-596.

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Authors
KUCEROVA, L., & SKOLEKOVA, S.
Affiliations
Slovak Academy of Sciences (SK)
Venue
Neoplasma
Published
2012
Volume
60
Issue
01
Pages
1-10
ISSN
  • 0028-2685 (ISSN-L)
  • 1338-4317
OpenAlex
W2044088315
Cited by
27
References
90
Citations by year
2025: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 3 · 2014: 3 · 2013: 3
FWCI
0.38
Type
journal article
Language
en
Open access
Locations
  • Neoplasma (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • China Scholarship Council
  • Agentúra na Podporu Výskumu a Vývoja (APVV-0230-11, APVV-0260-07)
  • Vedecká Grantová Agentúra MŠVVaŠ SR a SAV (2/0088/11)
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords
tumor microenvironment, mesenchymal stem cells, tumor stroma, paracrine signaling, tumor progression, extracellular matrix, tumor biology, tumor-stroma interactions
MeSH terms
Animals, Humans, Neoplasms, Tumor Microenvironment, Mesenchymal Stem Cells

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