The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
miRNA Therapeutics: A New Class of Drugs with Potential Therapeutic Applications in the Heart
Open accessAbstract
miRNAs are small non-coding RNAs (ncRNAs), which regulate gene expression. Here, the authors describe the contribution of miRNAs to cardiac biology and disease. They discuss various strategies for manipulating miRNA activity including antisense oligonucleotides (antimiRs, blockmiRs), mimics, miRNA sponges, Tough Decoys and miRNA mowers. They review developments in chemistries (e.g., locked nucleic acid) and modifications (sugar, 'ZEN', peptide nucleic acids) and miRNA delivery tools (viral vectors, liposomes, nanoparticles, pHLIP). They summarize potential miRNA therapeutic targets for heart disease based on preclinical studies. Finally, the authors review current progress of miRNA therapeutics in clinical development for HCV and cancer, and discuss challenges that will need to be overcome for similar therapies to enter the clinic for patients with cardiac disease.
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Cites
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Cited by
miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges
Zhou, S.-S., Jin, J.-P., Wang, J.-Q., Zhang, Z.-G., Freedman, J. H., Zheng, Y., & Cai, L. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2018.30 · Cited by 675
Signaling pathways in rheumatoid arthritis: implications for targeted therapy
Ding, Q., Hu, W., Wang, R., Yang, Q., Zhu, M., Li, M., Cai, J., Rose, P., Mao, J., & Zhu, Y. Z. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01331-9 · Cited by 478
MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells
Bai, T., Liang, R., Zhu, R., Wang, W., Zhou, L., & Sun, Y. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29496 · Cited by 125
Potential Therapeutic Targeting of lncRNAs in Cholesterol Homeostasis
Ye, W.-C., Huang, S.-F., Hou, L.-J., Long, H.-J., Yin, K., Hu, C. Y., & Zhao, G.-J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.688546 · Cited by 19
Metadata
- Authors
- Bernardo, B. C., Ooi, J. Y., Lin, R. C., & McMullen, J. R.
- Venue
- Future Medicinal Chemistry
- Publisher
- Informa UK Limited
- Published
- 2015-09
- Volume
- 7
- Issue
- 13
- Pages
- 1771-1792
- ISSN
- 1756-8919 (ISSN-L)
- 1756-8927
- OpenAlex
- W2144208608
- Cited by
- 226
- References
- 25
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- green
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