Transferrin and the transferrin receptor for the targeted delivery of therapeutic agents to the brain and cancer cells
Abstract
The potential use of many promising novel drugs is limited by their inability to specifically reach their site of action after intravenous administration, without secondary effects on healthy tissues. In order to remediate this problem, the protein transferrin (Tf) has been extensively studied as a targeting molecule for the transport of drug and gene delivery systems to the brain and cancer cells. A wide range of delivery approaches have been developed to target the Tf receptor and they have already improved the specific delivery of Tf-bearing therapeutic agents to their site of action. This review provides a summary of the numerous delivery strategies used to target the Tf receptor and focuses on recent therapeutic advances.
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The exceptional capacity to transport drugs across the blood-brain barrier makes the Tf-TfR axis valuable for the treatment of brain tumors through TfR-mediated transcytosis.
“The exceptional capacity to transport drugs across the blood–brain barrier makes the Tf–TfR axis valuable for the treatment of brain tumors through TfR-mediated transcytosis [105].”
From Iron as a central player and promising target in cancer progression (2019) · cites this paper as [105]
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- Authors
- Dufès, C., Al Robaian, M., & Somani, S.
- Affiliations
- University of Strathclyde (GB)
- Strathclyde Institute of Pharmacy & Biomedical Sciences University of Strathclyde 161 Cathedral Street Glasgow G4 0RE UK
- Venue
- Therapeutic Delivery
- Publisher
- Informa UK Limited
- Published
- 2013-05
- Volume
- 4
- Issue
- 5
- Pages
- 629-640
- ISSN
- 2041-5990 (ISSN-L)
- 2041-6008
- OpenAlex
- W2106543868
- Cited by
- 110
- References
- 79
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 5 · 2023: 6 · 2022: 6 · 2021: 9 · 2020: 10 · 2019: 6 · 2018: 10 · 2017: 6 · 2016: 10 · 2015: 11 · 2014: 10 · 2013: 2
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Therapeutic Delivery (publishedVersion)
- PubMed (publishedVersion)
- Strathprints: The University of Strathclyde institutional repository (University of Strathclyde) (acceptedVersion)
- Funders
- Medical Research Council (MR/J007129/1)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- transferrin, transferrin receptor, targeted drug delivery, brain drug delivery, tumor targeting, receptor-mediated transport, gene delivery, intravenous administration, neurodegenerative disease treatment
- MeSH terms
- Animals, Brain, Humans, Neoplasms, Receptors, Transferrin, Transferrin, Drug Delivery Systems, Gene Transfer Techniques
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