Transferrin receptor-targeted pH-sensitive micellar system for diminution of drug resistance and targetable delivery in multidrug-resistant breast cancer
Open accessAbstract
Abstract: The emergence of drug resistance is partially associated with overproduction of transferrin receptor (TfR). To overcome multidrug resistance (MDR) and achieve tumor target delivery, we designed a novel biodegradable pH-sensitive micellar system modified with HAIYPRH, a TfR ligand (7pep). First, the polymers poly(l-histidine)-coupled polyethylene glycol-2000 (PHIS-PEG 2000 ) and 7pep-modified 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000 (7pep-DSPE-PEG 2000 ) were synthesized, and the mixed micelles were prepared by blending of PHIS-PEG 2000 and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000 (DSPE-PEG 2000 ) or 7pep-DSPE-PEG 2000 (7-pep HD micelles). The micelles exhibited good size uniformity, high encapsulation efficiency, and a low critical micelle concentration. By changing the polymer ratio in the micellar formulation, the pH response range was specially tailored to pH ~6.0. When loaded with antitumor drug doxorubicin (DOX), the micelle showed an acid pH-triggering drug release profile. The cellular uptake and cytotoxicity study demonstrated that 7-pep HD micelles could significantly enhance the intracellular level and antitumor efficacy of DOX in multidrug-resistant cells (MCF-7/Adr), which attributed to the synergistic effect of poly(l-histidine)-triggered endolysosom escape and TfR-mediated endocytosis. Most importantly, the in vivo imaging study confirmed the targetability of 7-pep HD micelles to MDR tumor. These findings indicated that 7-pep HD micelles would be a promising drug delivery system in the treatment of drug-resistant tumors. Keywords: poly(l-histidine), DSPE-PEG 2000 , HAIYPRH, MCF-7Adr
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The transferrin receptor-targeted pH-sensitive micellar system can be utilized as smart nanoparticles to overcome multi-drug resistance and reduce side effects, achieving targeted delivery of tumors.
“For example, the transferrin receptor-targeted pH-sensitive micellar system can be utilized as smart nanoparticles to overcome multi-drug resistance and reduce side effects of the system, so as to achieve targeted delivery of tumors.41”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [41]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Analysis of nanoparticle delivery to tumours
Wilhelm, S., Tavares, A. J., Dai, Q., Ohta, S., Audet, J., Dvorak, H. F., & Chan, W. C. W. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.14 · Cited by 5,218 · see citing works
Bertrand, N., Wu, J., Xu, X., Kamaly, N., & Farokhzad, O. C. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.11.009 · Cited by 2,865 · see citing works
Kathawala, R. J., Gupta, P., Ashby, C. R., & Chen, Z. (2014) · Drug Resistance Updates · doi:10.1016/j.drup.2014.11.002 · Cited by 783 · see citing works
Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor
Lee, E. S., Na, K., & Bae, Y. H. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.12.018 · Cited by 577 · see citing works
Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis.
Arola, O., Saraste, A., Pulkki, K. J., Kallajoki, M. A., Parvinen, M., & Voipio-Pulkki, L. M. (2000) · PubMed · Cited by 490 · see citing works
Core–shell-type lipid–polymer hybrid nanoparticles as a drug delivery platform
Mandal, B., Bhattacharjee, H., Mittal, N. K., Sah, H., Balabathula, P., Thoma, L. A., & Wood, G. C. (2012) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2012.11.010 · Cited by 468 · see citing works
Poly(l-histidine)–PEG block copolymer micelles and pH-induced destabilization
Lee, E. S., Shin, H. J., Na, K., & Bae, Y. H. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00205-0 · Cited by 452 · see citing works
Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor
Yin, Q., Shen, J., Zhang, Z., Yu, H., & Li, Y. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.04.011 · Cited by 366 · see citing works
Nanomicellar formulations for sustained drug delivery: strategies and underlying principles
Trivedi, R., & Kompella, U. B. (2010) · Nanomedicine · doi:10.2217/nnm.10.10 · Cited by 358 · see citing works
pH-sensitive poly (histidine)-PEG/DSPE-PEG co-polymer micelles for cytosolic drug delivery
Wu, H., Zhu, L., & Torchilin, V. P. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2012.08.072 · Cited by 355 · see citing works
Fernandez-Fernandez, A., Manchanda, R., & McGoron, A. J. (2011) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-011-9383-z · Cited by 333 · see citing works
Prediction of drug–ABC-transporter interaction — Recent advances and future challenges
Montanari, F., & Ecker, G. F. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.03.001 · Cited by 256 · see citing works
Qiu, L., Li, Z., Qiao, M., Long, M., Wang, M., Zhang, X., Tian, C., & Chen, D. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.12.025 · Cited by 175 · see citing works
Yin, H., Lee, E. S., Kim, D., Lee, K. H., Oh, K. T., & Bae, Y. H. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.11.014 · Cited by 168 · see citing works
Du, W., Fan, Y., Zheng, N., He, B., Yuan, L., Zhang, H., Wang, X., Wang, J., Zhang, X., & Zhang, Q. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.10.003 · Cited by 146 · see citing works
Chen, S., Yang, K., Tuguntaev, R. G., Mozhi, A., Zhang, J., Wang, P. C., & Liang, X. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.10.020 · Cited by 126 · see citing works
Bae, Y. M., Park, Y. I., Nam, S. H., Kim, J. H., Lee, K., Kim, H. M., Yoo, B., Choi, J. S., Lee, K. T., Hyeon, T., et al. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.08.039 · Cited by 123 · see citing works
Core-Shell type lipid/rPAA-Chol polymer hybrid nanoparticles for in vivo siRNA delivery
Gao, L.-Y., Liu, X.-Y., Chen, C.-J., Wang, J.-C., Feng, Q., Yu, M.-Z., Ma, X.-F., Pei, X.-W., Niu, Y.-J., Qiu, C., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.046 · Cited by 114 · see citing works
Johnson, R. P., Jeong, Y., John, J. V., Chung, C., Kang, D. H., Selvaraj, M., Suh, H., & Kim, I. (2013) · Biomacromolecules · doi:10.1021/bm400089m · Cited by 112 · see citing works
Dufès, C., Al Robaian, M., & Somani, S. (2013) · Therapeutic Delivery · doi:10.4155/tde.13.21 · Cited by 110 · see citing works
Zhao, Y. S., Zhou, Y., Wang, D., Gao, Y., Li, J., Ma, S., Zhao, L., Zhang, C., Liu, Y., & Li, X. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.01.010 · Cited by 100 · see citing works
Cai, D., Gao, W., He, B., Dai, W., Zhang, H., Wang, X., Wang, J., Zhang, X., & Zhang, Q. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.088 · Cited by 95 · see citing works
Self-citationParticle Carriers for Combating Multidrug-Resistant Cancer
Yan, Y., Björnmalm, M., & Caruso, F. (2013) · ACS Nano · doi:10.1021/nn405632s · Cited by 89 · see citing works
Basta, L. A. B., Bolduc, B., Kass, J. L., Felice, K. M., Noren, C. J., & Hall, M. F. (2007) · Analytical Biochemistry · doi:10.1016/j.ab.2007.10.015 · Cited by 83 · see citing works
Mohajer, G., Lee, E. S., & Bae, Y. H. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9277-5 · Cited by 73 · see citing works
Dawar, S., Singh, N., Kanwar, R. K., Kennedy, R. L., Veedu, R. N., Zhou, S., Krishnakumar, S., Hazra, S., Sasidharan, S., Duan, W., et al. (2013) · Drug Discovery Today · doi:10.1016/j.drudis.2013.09.009 · Cited by 67 · see citing works
Zhang, X., Chen, D., Ba, S., Zhu, J., Zhang, J., Hong, W., Zhao, X., Hu, H., & Qiao, M. (2014) · Biomacromolecules · doi:10.1021/bm5010756 · Cited by 60 · see citing works
Li, X., Yang, X., Lin, Z., Wang, D., Mei, D., He, B., Wang, X., Wang, X., Zhang, Q., & Gao, W. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.04.018 · Cited by 56 · see citing works
Self-citationTransferrin-Conjugated Nanocarriers as Active-Targeted Drug Delivery Platforms for Cancer Therapy
Nogueira-Librelotto, D. R., Codevilla, C. F., Farooqı, A. A., & Rolim, C. M. B. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666161026162347 · Cited by 55 · see citing works
Xu, F., Yang, T., Fang, D., Xu, Q., & Chen, Y. (2014) · Journal of Proteomics · doi:10.1016/j.jprot.2014.05.016 · Cited by 34 · see citing works
Adelantado, C., Fariñas, N. R., Martín-Doimeadios, R. C. R., Zougagh, M., & Ríos, Á. (2016) · Analytica Chimica Acta · doi:10.1016/j.aca.2016.03.055 · Cited by 32 · see citing works
Sheng, Y., Xu, J., You, Y., Xu, F., & Chen, Y. (2015) · Molecular Pharmaceutics · doi:10.1021/mp500386y · Cited by 30 · see citing works
Bionano Interactions of MCF-7 Breast Tumor Cells with a Transferrin Receptor Targeted Nanoparticle
Du, W., Fan, Y., He, B., Zheng, N., Yuan, L., Dai, W., Zhang, H., Wang, X., Wang, J., Zhang, X., et al. (2015) · Molecular Pharmaceutics · doi:10.1021/mp500796d · Cited by 29 · see citing works
Nano-cage-mediated refolding of insulin by PEG-PE micelle
Fang, X., Yang, T., Wang, L., Yu, J., Wei, X., Zhou, Y., Wang, C., & Liang, W. P. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.11.007 · Cited by 29 · see citing works
렌지스, 김일, 존슨VJ, & 송송이 (2013) · 한국고분자학회 학술대회 연구논문 초록집 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
Recent advances in surface decoration of nanoparticles in drug delivery
Ly, P.-D., Ly, K.-N., Phan, H.-L., Nguyen, H. H. T., Duong, V., & Nguyen, H. V. (2024) · Frontiers in Nanotechnology · doi:10.3389/fnano.2024.1456939 · Cited by 250 · see citing works
Advances in Receptor‐Mediated, Tumor‐Targeted Drug Delivery
Large, D. E., Soucy, J. R., Hebert, J. M., & Auguste, D. T. (2018) · Advanced Therapeutics · doi:10.1002/adtp.201800091 · Cited by 189 · see citing works
Zhang, J., Tang, H., Liu, Z., & Chen, B. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s148359 · Cited by 174 · see citing works
Advances in nanomedical applications: diagnostic, therapeutic, immunization, and vaccine production
El-Sayed, A., & Kamel, M. S. (2019) · Environmental Science and Pollution Research · doi:10.1007/s11356-019-06459-2 · Cited by 141 · see citing works
Li, R., Peng, F., Cai, J., Yang, D., & Zhang, P. (2019) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2019.06.003 · Cited by 139 · see citing works
Kumar, H., Gupta, N., Jain, R., Madhunapantula, S. V., Babu, C. S., Kesharwani, S. S., Dey, S., & Jain, V. K. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.02.005 · Cited by 138 · see citing works
Drug uptake-based chemoresistance in breast cancer treatment
Muley, H., Fadó, R., Rodríguez‐Rodríguez, R., & Casals, N. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113959 · Cited by 138 · see citing works
Yan, T., He, J., Liu, R., Liu, Z., & Cheng, J. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115706 · Cited by 119 · see citing works
Rational design of polymeric micelles for targeted therapeutic delivery
Zheng, Y., Oz, Y., Gu, Y., Ahamad, N., Shariati, K., Chevalier, J. M., Kapur, D., & Annabi, N. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102147 · Cited by 118 · see citing works
Huang, L., Liu, J., Gao, F., Cheng, Q., Lü, B., Zheng, H. S., Xu, H., Xu, P., Zhang, X., & Zeng, X. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb00989a · Cited by 107 · see citing works
Nanocomposites as biomolecules delivery agents in nanomedicine
Bamburowicz‐Klimkowska, M., Popławska, M., & Grudziński, I. P. (2019) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0479-x · Cited by 106 · see citing works
“Smart” drug delivery: A window to future of translational medicine
Rana, A., Adhikary, M., Singh, P. K., Das, B. C., & Bhatnagar, S. (2023) · Frontiers in Chemistry · doi:10.3389/fchem.2022.1095598 · Cited by 95 · see citing works
Belluati, A., Thamboo, S., Najer, A., Maffeis, V., von Planta, C., Craciun, I., Palivan, C. G., & Meier, W. P. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202002949 · Cited by 91 · see citing works
Nanoparticles Targeting Receptors on Breast Cancer for Efficient Delivery of Chemotherapeutics
Jahan, S., Karim, M. E., & Chowdhury, E. H. (2021) · Biomedicines · doi:10.3390/biomedicines9020114 · Cited by 92 · see citing works
Polymeric micelles: A novel drug delivery system for the treatment of breast cancer
Chaudhuri, A., Ramesh, K., Kumar, D. N., Dehari, D., Singh, S. K., Kumar, D. K., & Agrawal, A. K. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103886 · Cited by 76 · see citing works
The role of iron homeostasis and iron-mediated ROS in cancer.
Ying, J., Lu, Z.-B., Fu, L., Tong, Y., Wang, Z., Li, W., & Mou, X. (2021) · PubMed Central · Cited by 74 · see citing works
Gao, L., Wang, H., Nan, L., Peng, T., Sun, L., Zhou, J., Xiao, Y., Wang, J., Sun, J., Lu, W., et al. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00428 · Cited by 64 · see citing works
Famta, P., Shah, S., Chatterjee, E., Singh, H., Dey, B., Guru, S. K., Singh, S. B., & Srivastava, S. (2021) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2021.100054 · Cited by 60 · see citing works
Li, Y., Chen, M., Yao, B., Lu, X., Zhang, X., He, P., Vasilatos, S. N., Ren, X., Bian, W., & Yao, C. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00651f · Cited by 61 · see citing works
Tashima, T. (2018) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2018.07.012 · Cited by 58 · see citing works
Overcoming multiple drug resistance in cancer using polymeric micelles
Kesharwani, S. S., Kaur, S., Tummala, H., & Sangamwar, A. T. (2018) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2018.1537261 · Cited by 57 · see citing works
Casals, E., Gustà, M. F., Cobaleda‐Siles, M., García, A., & Puntes, V. (2017) · Cancer Nanotechnology · doi:10.1186/s12645-017-0030-4 · Cited by 56 · see citing works
Nanocarriers based oral lymphatic drug targeting: Strategic bioavailability enhancement approaches
Pandya, P., Giram, P. S., Bhole, R. P., Chang, H., & Raut, S. Y. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102585 · Cited by 48 · see citing works
Jabri, T., Imran, M., Aziz, A., Rao, K., Kawish, M., Irfan, M., Malik, M. I., Sımjee, S. U., Arfan, M., & Shah, M. R. (2018) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2018.1550091 · Cited by 46 · see citing works
Li, N., Mai, Y., Liu, Q., Gou, G., & Yang, J. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00720-9 · Cited by 46 · see citing works
Trastuzumab targeted micellar delivery of docetaxel using dendron–polymer conjugates
Bolu, B. S., Golba, B., Sanyal, A., & Sanyal, R. (2020) · Biomaterials Science · doi:10.1039/c9bm01764j · Cited by 45 · see citing works
Liu, Y., Zhou, C., Wei, S., Yang, T., Yang, L., Cao, A., Yang, J., & Hou, Y. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.06.024 · Cited by 39 · see citing works
Kepinská, M., Kizek, R., & Milnerowicz, H. (2018) · Electrophoresis · doi:10.1002/elps.201800148 · Cited by 38 · see citing works
A Review on Targeting Nanoparticles for Breast Cancer
Alqaraghuli, H. G. J., Kashanian, S., & Rafipour, R. (2019) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201020666190731130001 · Cited by 38 · see citing works
Wang, C., Li, T., Wang, Z., Li, Y., Liu, Y., Xu, M., Zhang, Z., Deng, Y., Cai, L., Zhang, C., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02220-7 · Cited by 37 · see citing works
Li, P., Zhou, X., Qu, D., Guo, M., Fan, C., Zhou, T., & Ling, Y. (2017) · Drug Delivery · doi:10.1080/10717544.2017.1326540 · Cited by 37 · see citing works
The role of iron metabolism in cancer therapy focusing on tumor‐associated macrophages
Dong, D., Zhang, G., Yang, J., Zhao, B., Wang, S., Wang, L., Zhang, G., & Shang, P. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27569 · Cited by 37 · see citing works
Ye, G., Jiang, Y., Yang, X., Hu, H., Wang, B., Sun, L., Yang, V. C.-M., Sun, D., & Gao, W. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b15978 · Cited by 37 · see citing works
Self-citationLiu, X., Fang, R., Feng, R., Li, Q., Su, M., Hou, C., Zhuang, K., Dai, Y., Lei, N., Jiang, Y., et al. (2022) · Drug Resistance Updates · doi:10.1016/j.drup.2022.100887 · Cited by 35 · see citing works
Jiang, Y., Guo, Z., Fang, J., Wang, B., Lin, Z., Chen, Z., Chen, Y., Zhang, N., Yang, X., & Gao, W. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110224 · Cited by 32 · see citing works
Self-citationRecent advances in biomedical applications of smart nanomaterials: a comprehensive review
Goshisht, M. K., Goshisht, A., Bajpai, A., & Bajpai, A. (2025) · RSC Pharmaceutics · doi:10.1039/d5pm00137d · Cited by 35 · see citing works
Xu, B., Li, Y., Hu, Y., Xu, Z., Qin, J., & Cheng, X. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.598155 · Cited by 24 · see citing works
Co–encapsulation of flavonoids with anti–cancer drugs: A challenge ahead
Renault‐Mahieux, M., Mignet, N., Séguin, J., Alhareth, K., Paul, M., & Andrieux, K. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121942 · Cited by 20 · see citing works
Breast tumor‐targeted drug delivery via polymer nanocarriers: Endogenous and exogenous strategies
Zhu, M., Wang, X., Zhou, Y., Li, M., Wang, Y., Wang, Y., Li, T., Song, Y., Zhang, B., Hezam, K., et al. (2023) · Journal of Applied Polymer Science · doi:10.1002/app.54227 · Cited by 19 · see citing works
Smart drug delivery: a DFT study of C 24 fullerene and doped analogs for pyrazinamide
Moumivand, A., Naderi, F., Moradi, O., & Makiabadi, B. (2024) · Nanoscale Advances · doi:10.1039/d4na00560k · Cited by 17 · see citing works
Recent advanced lipid-based nanomedicines for overcoming cancer resistance
Dechbumroong, P., Hu, R., Keaswejjareansuk, W., Namdee, K., & Liang, X. (2024) · Cancer Drug Resistance · doi:10.20517/cdr.2024.19 · Cited by 16 · see citing works
Emerging nano-delivery systems for targeting mitochondria
Burska, A. N., Raish, K., Bayandy, D., & Paunov, V. N. (2025) · Nanoscale · doi:10.1039/d5nr03935e · Cited by 17 · see citing works
Polymeric Micelles in Targeted Breast Cancer Therapy：Recent Advances and Future Trends
Soni, A., & Jaiswal, V. P. (2025) · Nano Biomedicine and Engineering · doi:10.26599/nbe.2025.9290122 · Cited by 11 · see citing works
A modular, reversible sealing, and reusable microfluidic device for drug screening
Vit, F. F., Nunes, R., Wu, Y. T., Soares, M. C. P., Godoi, N., Fujiwara, E., Carvalho, H. F., & de la Torre, L. G. (2021) · Analytica Chimica Acta · doi:10.1016/j.aca.2021.339068 · Cited by 11 · see citing works
Recent advances in nanoagents delivery system-based phototherapy for osteosarcoma treatment
Ji, L., Huang, J., Yu, L., Jin, H., Hu, X., Sun, Y., Yin, F., & Cai, Y. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124633 · Cited by 8 · see citing works
Emerging nanocarriers designed for the enhanced delivery of doxorubicin
Kong, W., Chen, W., Hui, J., & Qiu, L. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2523234 · Cited by 8 · see citing works
Biogenic nanoparticles: Understanding their potential role in cancer theranostics
Yasin, D., Sami, N., Afzal, B., Zaki, A., Naaz, H., Husain, S., Siddiqui, T., Rizvi, M. M. A., & Fatma, T. (2025) · Next Nanotechnology · doi:10.1016/j.nxnano.2025.100149 · Cited by 6 · see citing works
Emerging Nanomaterials for Cancer Therapy
Kumar, S., Kumari, P., & Singh, R. (2019) · Springer eBooks · doi:10.1007/978-981-13-8954-2_2 · Cited by 5 · see citing works
"Active Targeting of Breast Cancer Cells Using Nanocarriers"
Franco, M. S. (2017) · Modern applications in Pharmacy & Pharmacology · doi:10.31031/mapp.2017.01.000507 · Cited by 2 · see citing works
Poly(Amino Acid) Nanoparticles as a Promising Tool for Anticancer Therapeutics
Abdelaziz, H. M., Abdelmoneem, M. A., Abd-Elsalam, K., Freag, M. S., Elkhodairy, K. A., & Elzoghby, A. O. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816963-6.00009-1 · Cited by 2 · see citing works
Inhalable Therapeutics in Lung Cancer: Overcoming Barriers for Effective Treatment
Paliwal, H., Rangbhal, T., Khedkar, P., Kasture, A., Kharche, P. A., Gaikwad, S. S., & Prajapati, B. G. (2026) · AAPS PharmSciTech · doi:10.1208/s12249-026-03408-4 · Cited by 1 · see citing works
Nanoparticles Targeting and Uptake: Current Advances in Breast Cancer Research
Lugun, O., & Pandey, A. K. (2022) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9781681089522112010011
Novel Theranostics for Parkinson's Disease
Schlichtmann, B. W. (2021) · doi:10.31274/td-20240329-549
Receptor-ligand-based targeting approaches in breast cancer
Yadav, P., Jaiswal, S., Tripathi, S., Mishra, K., Rana, R., & Chourasia, M. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33349-1.00004-1
Wang, C., Li, T., Wang, Z., Li, Y., Liu, Y., Xu, M., Zhang, Z., Deng, Y., Cai, L., Zhang, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24741905
- Authors
- Gao, W., Ye, G., Duan, X., Yang, X., & Yang, V. C.
- Affiliations
- Tianjin Medical University (CN)
- University of Michigan (US)
- Corresponding author
- Gao, Wei
- Venue
- International Journal of Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2017-02
- Volume
- Volume 12
- Pages
- 1047-1064
- ISSN
- 1176-9114 (ISSN-L)
- 1178-2013
- PMC
- PMC5304995
- OpenAlex
- W2586835360
- Cited by
- 57
- References
- 35
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 4 · 2021: 8 · 2020: 4 · 2019: 9 · 2018: 8 · 2017: 6
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Nanomedicine (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- National Science Foundation
- National Natural Science Foundation of China (813611403, 81402857)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- transferrin receptor, multidrug resistance, breast cancer, pH-responsive micelles, drug delivery, doxorubicin, poly-L-histidine, endolysosomal escape, endocytosis, tumor targeting, MCF-7/ADR cells, biodegradable polymers, mixed micelles
- MeSH terms
- Animals, Antineoplastic Agents, Breast Neoplasms, Doxorubicin, Endocytosis, Female, Histidine, Humans, Hydrogen-Ion Concentration, Mice, Nude, Micelles, Phosphatidylethanolamines, Polyethylene Glycols, Receptors, Transferrin, Drug Delivery Systems, Drug Resistance, Multiple, Drug Resistance, Neoplasm, MCF-7 Cells, Drug Liberation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
