The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.
The Nasal Approach to Delivering Treatment for Brain Diseases: An Anatomic, Physiologic, and Delivery Technology Overview
Open accessAbstract
The intricate pathophysiology of brain disorders, difficult access to the brain, and the complexity and high risks and costs of drug development represent major hurdles for improving therapies. Nose-to-brain drug transport offers an attractive alternative or addition to formulation-only strategies attempting to enhance drug penetration into the CNS. Although still a matter of controversy, many studies in animals claim direct nose-to-brain transport along the olfactory and trigeminal nerves, circumventing the traditional barriers to CNS entry. Some clinical trials in man also suggest nose-to-brain drug delivery, although definitive proof in man is lacking. This review focuses on new nasal delivery technologies designed to overcome inherent anatomical and physiological challenges and facilitate more efficient and targeted drug delivery for CNS disorders.
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Drug Transport across the Blood–Brain Barrier
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Sniffing neuropeptides: A transnasal approach to the human brain
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Dhuria, S. V., Hanson, L. R., & Frey, W. H. (2010) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21924 · Cited by 1,239
Intranasal delivery of biologics to the central nervous system
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Alzheimer's Disease: Treatment Strategies and Their Limitations.
Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F. T., & Arab-Tehrany, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213954 · Cited by 689
“This approach is increasingly used in clinical studies for the treatment of neurological diseases [251] like AD [32,252], brain injuries [253], and autism [254].”
MethodProgress in brain targeting drug delivery system by nasal route
Khan, A. R., Liu, M., Khan, M. W., & Zhai, G. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.001 · Cited by 402
Recent advances in carrier mediated nose-to-brain delivery of pharmaceutics
Bourganis, V., Kammona, O., Alexopoulos, A., & Kiparissides, C. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.05.009 · Cited by 357
Costa, C. P., Moreira, J. N., Sousa Lobo, J. M., & Silva, A. C. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.02.012 · Cited by 303
Metadata
- Authors
- Djupesland, P. G., Messina, J. C., & Mahmoud, R. A.
- Venue
- Therapeutic Delivery
- Publisher
- Informa UK Limited
- Published
- 2014-06
- Volume
- 5
- Issue
- 6
- Pages
- 709-733
- ISSN
- 2041-5990 (ISSN-L)
- 2041-6008
- OpenAlex
- W2045511561
- Cited by
- 295
- References
- 131
- FWCI
- 11.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Djupesland, P. G., Messina, J. C., & Mahmoud, R. A. (2014). The Nasal Approach to Delivering Treatment for Brain Diseases: An Anatomic, Physiologic, and Delivery Technology Overview. Therapeutic Delivery. https://doi.org/10.4155/tde.14.41
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
