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Direct nose to brain drug delivery <i>via</i> integrated nerve pathways bypassing the blood–brain barrier: an excellent platform for brain targeting

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Intranasal insulin delivery and therapy1Abbreviations: α-CD, α-cyclodextrin; β-CD, β-cyclodextrin; γ-CD, γ-cyclodextrin; AUC, area under the plasma/serum concentration versus time curve; Cmax, maximum or peak plasma/serum concentration; Cmin, minimum plasma/serum concentration; DDPC, didecanoyl-L-α-phosphatidylcholine; DM-β-CD, dimethyl-β-cyclodextrin; EDTA, ethylenediaminetetraacetic acid; FITC, fluorescein isothiocyanate; HLB, hydrophile–lipophile balance; hGH, human growth hormone; HP-β-CD, hydroxy-propyl-β-cyclodextrin; HPC, hydroxypropylcellulose; HSA, human serum albumin; Hyaff 11, hyaluronic acid ester; IDDM, insulin-dependent diabetes mellitus; Ig, immunoglobulin; Laureth-9, polyoxyethylene-9-lauryl ether; LPC, lysophosphatidylcholine; LPG, lysophosphatidylglycerol; MCC, microcrystalline cellulose; MTR, mucociliary transport rate; NIDDM, non-insulin-dependent diabetes mellitus; PC, phosphatidylcholine; RAMEB, randomly methylated β-cyclodextrin; SDC, sodium deoxycholate; SGC, sodium glycocholate; STDHF, sodium taurodihydrofusidate; 99mTc, 99mtechnetium; TER, transepithelial resistance.1

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Exploiting mesoporous silica nanoparticles as versatile drug carriers for several routes of administration

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Micro- and Nanosized Carriers for Nose-to-Brain Drug Delivery in Neurodegenerative Disorders

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Nanotechnologies for intranasal drug delivery: an update of literature

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Chondroitin sulfate derived theranostic and therapeutic nanocarriers for tumor-targeted drug delivery

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Intranasal Delivery of Functionalized Polymeric Nanomaterials to the Brain

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Using nanotechnology to deliver biomolecules from nose to brain — peptides, proteins, monoclonal antibodies and RNA

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Intranasal delivery of paeoniflorin nanocrystals for brain targeting

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Biopolymer Nanoparticles for Nose-to-Brain Drug Delivery: A New Promising Approach for the Treatment of Neurological Diseases

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Targeted nanomedicine: Lessons learned and future directions

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Neuroprotective effect of chitosan nanoparticle gene delivery system grafted with acteoside (ACT) in Parkinson’s disease models

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The importance of pre-formulation studies and of 3D-printed nasal casts in the success of a pharmaceutical product intended for nose-to-brain delivery

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Mucus-penetrating nanoparticles based on chitosan grafted with various non-ionic polymers: Synthesis, structural characterisation and diffusion studies

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Exploiting BBB disruption for the delivery of nanocarriers to the diseased CNS

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Characterisation of nasal devices for delivery of insulin to the brain and evaluation in humans using functional magnetic resonance imaging

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Nanoparticle-Guided Brain Drug Delivery: Expanding the Therapeutic Approach to Neurodegenerative Diseases

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Nose-to-Brain Delivery by Nanosuspensions-Based in situ Gel for Breviscapine

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Spray dried powders for nasal delivery: Process and formulation considerations

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Intranasal nanotherapeutics for brain targeting and clinical studies in Parkinson's disease

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Nanoparticle designs for delivery of nucleic acid therapeutics as brain cancer therapies

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Recent Advances in the Therapeutic and Diagnostic Use of Liposomes and Carbon Nanomaterials in Ischemic Stroke

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Neurodegenerative disorders management: state-of-art and prospects of nano-biotechnology

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Nose-to-brain delivery: exploring newer domains for glioblastoma multiforme management

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A Brain-Targeted Approach to Ameliorate Memory Disorders in a Sporadic Alzheimer’s Disease Mouse Model via Intranasal Luteolin-Loaded Nanobilosomes

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Flexible polymeric nanosized micelles for ophthalmic drug delivery: research progress in the last three years

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The Potential Benefits of Nanotechnology in Treating Alzheimer’s Disease

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New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan

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QbD-driven development of intranasal lipid nanoparticles for depression treatment

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Pharmacokinetics, pharmacodynamics and toxicity of Baicalin liposome on cerebral ischemia reperfusion injury rats via intranasal administration

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Intranasal Delivery of BACE1 siRNA and Berberine via Engineered Stem Cell Exosomes for the Treatment of Alzheimer’s Disease

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Fabrication of a Thermosensitive In Situ Gel Nanoemulsion for Nose to Brain Delivery of Temozolomide

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Quality by design (QbD) optimization of diazepam-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery: Toxicological effect of surface charge on human neuronal cells

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Transport of nanomedicines across the blood-brain barrier: Challenges and opportunities for imaging and therapy

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Emerging well-tailored nanoparticulate delivery system based on in situ regulation of the protein corona

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Development, optimisation and evaluation of chitosan nanoparticles of alendronate against Alzheimer’s disease in intracerebroventricular streptozotocin model for brain delivery

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Receptor-Assisted Nanotherapeutics for Overcoming the Blood–Brain Barrier

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Nose to Brain: Exploring the Progress of Intranasal Delivery of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers

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Drug Nanocrystals: Focus on Brain Delivery from Therapeutic to Diagnostic Applications

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Impaired peri-olfactory cerebrospinal fluid clearance is associated with ageing, cognitive decline and dyssomnia

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Drug delivery pathways to the central nervous system via the brain glymphatic system circumventing the blood‐brain barrier

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Nasal delivery of neurotherapeutics via nanocarriers: Facets, aspects, and prospects

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Drug Delivery and Targeting to the Brain Through Nasal Route: Mechanisms, Applications and Challenges

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NOSE-TO-BRAIN DRUG DELIVERY: AN UPDATE TO THE ALTERNATIVE PATH TO SUCCESSFUL TARGETED ANTI-MIGRAINE DRUGS

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