Autophagy and Cancer Therapy

Kondo, Yasuko; Kondo, Seiji

doi:10.4161/auto.2.2.2463

Cited by 305Autophagy in Disease and TherapyCell death mechanisms and regulationUbiquitin and proteasome pathways

Autophagy and Cancer Therapy

Open access

Kondo, Yasuko, Kondo, Seiji·2006·Autophagy

DOI 10.4161/auto.2.2.2463

Open this paper in CoChat — free account Open PDF

Abstract

Autophagy is a dynamic process of protein degradation, which is typically observed during nutrient deprivation. Recently, interest in autophagy has been renewed among oncologists, because different types of cancer cells undergo autophagy after various anticancer therapies. This type of nonapoptotic cell death has been documented mainly by observing morphological changes, e.g., numerous autophagic vacuoles in the cytoplasm of dying cells. Thus, autophagic cell death is considered programmed cell death type II, whereas apoptosis is programmed cell death type I. These two types of cell death are predominantly distinctive, but many studies demonstrate cross-talk between them. Whether autophagy in cancer cells causes death or protects cells is controversial. In multiple studies, autophagy has been inhibited pharmacologically or genetically, resulting in contrasting outcomes--survival or death--depending on the specific context. Interestingly, the regulatory pathways of autophagy share several molecules with the oncogenic pathways activated by tyrosine kinase receptors. Tumor suppressors such as Beclin 1, PTEN and p53 also play an important role in autophagy induction. Taken together, these accumulating data may lead to development of new cancer therapies that manipulate autophagy.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.4161/auto.2.2.2463

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Oncogenes can inhibit autophagy and tumour suppressors can stimulate it.
“Indeed, although the available evidence indicates that oncogenes can inhibit autophagy and tumour suppressors can stimulate it, the exact mechanistic link between cancer and autophagy remains obscure (Fig. 3).”
From The common biology of cancer and ageing (2007) · cites this paper as [78]
In human malignancies, the BECN1 locus is commonly deleted, and tumour suppressors including Pten and p53 stimulate autophagy.
“This notion is also supported by observations that in human malignancies the BECN1 locus is commonly deleted and by experimental evidence that several tumour suppressors, including the phosphatase and tensin homologue Pten and p53, stimulate autophagy 78 .”
From The common biology of cancer and ageing (2007) · cites this paper as [78]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The publisher hasn’t deposited this paper’s reference list.

Research works printed but not linked: 63

Wang CW, Klionsky DJ. The molecular mechanism of autophagy. Mol Med 2003; 9:65-76.
Cuervo AM. Autophagy: In sickness and in health. Trends Cell Biol 2004; 14:70-7.
Shintani T, Klionsky DJ. Autophagy in health and disease: A double-edged sword. Science 2004; 306:990-5.
Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005; 5:726-34.
Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 2004; 15:1101-11.
Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophago- some membranes after processing. EMBO J 2000; 19:5720-8.
Bursch W, Ellinger A, Kienzl H, Torok L, Pandey S, Sikorska M, Walker R, Hermann RS. Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: The role of autophagy. Carcinogenesis 1996; 17:1595-607.
Bursch W, Hochegger K, Torok L, Marian B, Ellinger A, Hermann RS. Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments. J Cell Sci 2000; 113:1189-98.
Scarlatti F, Bauvy C, Ventruti A, Sala G, Cluzeaud F, Vandewalle A, Ghidoni R, Codogno P. Ceramide-mediated macroautophagy involves inhibition of protein kinase B and upregulation of beclin 1. J Biol Chem 2004; 279:18384-91.
Paglin S, Hollister T, Delohery T, Hackett N, McMahill M, Sphicas E, Domingo D, Yahalom J. A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles. Cancer Res 2001; 61:439-44.
Yao KC, Komata T, Kondo Y, Kanzawa T, Kondo S, Germano IM. Molecular response of human glioblastoma multiforme cells to ionizing radiation: Cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy. J Neurosurg 2003; 98:378-84.
Ito H, Daido S, Kanzawa T, Kondo S, Kondo Y. Radiation-induced autophagy is associat- ed with LC3 and its inhibition sensitizes malignant glioma cells. Int J Oncol 2005; 26:1401-10.
Daido S, Yamamoto A, Fujiwara K, Sawaya R, Kondo S, Kondo Y. Inhibition of the DNA-dependent protein kinase catalytic subunit radiosensitizes malignant glioma cells by inducing autophagy. Cancer Res 2005; 65:4368-75.
Kanzawa T, Kondo Y, Ito H, Kondo S, Germano I. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res 2003; 63:2103-8.
Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene 2005; 24:980-91.
Kanzawa T, Germano IM, Komata T, Ito H, Kondo Y, Kondo S. Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells. Cell Death Differ 2004; 11:448-57.
Opipari Jr AW, Tan L, Boitano AE, Sorenson DR, Aurora A, Liu JR. Resveratrol-induced autophagocytosis in ovarian cancer cells. Cancer Res 2004; 64:696-703.
Ellington AA, Berhow M, Singletary KW. Induction of macroautophagy in human colon cancer cells by soybean B-group triterpenoid saponins. Carcinogenesis 2005a; 26:159-67.
Ellington AA, Berhow MA, Singletary KW. Inhibition of Akt signaling and enhanced ERK1/2 activity are involved in induction of macroautophagy by triterpenoid B-group soy- asaponins in colon cancer cells. Carcinogenesis 2005b; In press.
Hoyer-Hansen M, Bastholm L, Mathiasen IS, Elling F, Jaattela M. Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ 2005; 12:1297-309.
Takeuchi H, Kondo Y, Fujiwara K, Kanzawa T, Aoki H, Mills GB, Kondo S. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phos- phatidylinositol 3-kinase/protein kinase B inhibitors. Cancer Res 2005; 65:3336-46.
Shao Y, Gao Z, Marks PA, Jiang X. Apoptotic and autophagic cell death induced by his- tone deacetylase inhibitors. Proc Natl Acad Sci USA 2004; 101:18030-5.
Cory S, Adams JM. The Bcl2 family: Regulators of the cellular life-or-death switch. Nat Rev Cancer 2002; 2:647-56.
Riedl SJ, Shi Y. Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol 2004; 5:897-907.
Clarke PG. Developmental cell death: Morphological diversity and multiple mechanisms. Anat Embryol 1990; 181:195-213.
Daido S, Kanzawa T, Yamamoto A, Takeuchi H, Kondo Y, Kondo S. Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. Cancer Res 2004; 64:4286-93.
Desagher S, Martinou JC. Mitochondria as the central control point of apoptosis. Trends Cell Biol 2000; 10:369-77.
Ferri KF, Kroemer G. Organelle-specific initiation of cell death pathways. Nat Cell Biol 2001; 3:E255-63.
Rodriguez-Enriquez S, He L, Lemasters JJ. Role of mitochondrial permeability transition pores in mitochondrial autophagy. Int J Biochem Cell Biol 2004; 36:2463-72.
Elmore SP, Qian T, Grissom SF, Lemasters JJ. The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J 2001; 15:2286-7.
Saeki K, Yuo A, Okuma E, Yazaki Y, Susin SA, Kroemer G, Takaku F. Bcl-2 downregula- tion causes autophagy in a caspase-independent manner in human leukemic HL60 cells. Cell Death and Differentiation 2000; 7:1263-9.
Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD, Levine B. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122:927-39.
Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH, Lenardo MJ. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 2004; 304:1500-2.
Boya P, Gonzalez-Polo RA, Casares N, Perfettini JL, Dessen P, Larochette N, Metivier D, Meley D, Souquere S, Yoshimori T, Pierron G, Codogno P, Kroemer G. Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol 2005; 25:1025-40.
Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN, Cho DH, Choi B, Lee H, Kim JH, Mizushima N, Oshumi Y, Jung YK. Essential roles of Atg5 and FADD in autophagic cell death: Dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem 2005; 280:20722-9.
Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Kobayashi S, Thompson CB, Tsujimoto Y. Role of Bcl-2 family proteins in a nonapoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 2004; 6:1221-8.
Lum JJ, Bauer DE, Kong M, Harris MH, Li C, Lindsten T, Thompson CB. Growth fac- tor regulation of autophagy and cell survival in the absence of apoptosis. Cell 2005; 120:237-48.
Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human can- cer. Nat Rev Cancer 2002; 2:489-501.
Blommaart EF, Luiken JJ, Meijer AJ. Autophagic proteolysis: Control and specificity. Histochem J 1997; 29:365-85.
Shigemitsu K, Tsujishita Y, Hara K, Nanahoshi M, Avruch J, Yonezawa K. Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling path- ways. Possible involvement of autophagy in cultured hepatoma cells. J Biol Chem 1999; 274:1058-65.
Beugnet A, Tee AR, Taylor PM, Proud CG. Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability. Biochem J 2003; 372:555-66.
Petiot A, Ogier-Denis E, Blommaart EF, Meijer AJ, Codogno P. Distinct classes of phos- phatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem 2000; 275:992-8.
Arico S, Petiot A, Bauvy C, Dubbelhuis PF, Meijer AJ, Codogno P, Ogier-Denis E. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phos- phatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 2001; 276:35243-6.
Feng Z, Zhang H, Levine AJ, Jin S. The coordinate regulation of the p53 and mTOR path- ways in cells. Proc Natl Acad Sci USA 2005; 102:8204-9.
Ogier-Denis E, Codogno P. Autophagy: A barrier or an adaptive response to cancer. Biochimica et Biophysica Acta 2003; 1603:113-28.
Pattingre S, Bauvy C, Codogno P. Amino acids interfere with the ERK1/2-dependent con- trol of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. J Biol Chem 2003; 278:16667-74.
Bos JL. Ras oncogenes in human cancer: A review. Cancer Res 1989; 49:4682-9.
Furuta S, Hidaka E, Ogata A, Yokota S, Kamata T. Ras is involved in the negative control of autophagy through the class I PI3-kinase. Oncogene 2004; 23:3898-904.
Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999; 402:672-6.
Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen EL, Mizushima N, Ohsumi Y, Cattoretti G, Levine B. Promotion of tumorigenesis by het- erozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003; 112:1809-20.
Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 2003; 100:15077-82.
Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T. Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep 2001; 2:330-5.
Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997; 275:1943-7.
Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH, Tavtigian SV. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997; 15:356-62.
Suzuki A, de la Pompa JL, Stambolic V, Elia AJ, Sasaki T, del Barco Barrantes I, Ho A, Wakeham A, Itie A, Khoo W, Fukumoto M, Mak TW. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol 1998; 8:1169-78.
Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000; 408:307-10.
Inbal B, Bialik S, Sabanay I, Shani G, Kimchi A. DAP kinase and DRP-1 mediate mem- brane blebbing and the formation of autophagic vesicles during programmed cell death. J Cell Biol 2002; 157:455-68.
Vande Velde C, Cizeau J, Dubik D, Alimonti J, Brown T, Israels S, Hakem R, Greenberg AH. BNIP3 and genetic control of necrosis-like cell death through the mitochondrial per- meability transition pore. Mol Cell Biol 2000; 20:5454-68.
Ogier-Denis E, Pattingre S, El Benna J, Codogno P. Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. J Biol Chem 2000; 275:39090-5.
Gozuacik D, Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 2004; 23:2891-906.
Fei P, El-Deiry WS. P53 and radiation responses. Oncogene 2003; 22:5774-83.
Pawlik TM, Keyomarsi K. Role of cell cycle in mediating sensitivity to radiotherapy. Int J Radiat Oncol Biol Phys 2004; 59:928-42.
Kawabe T. G 2 checkpoint abrogators as anticancer drugs. Mol Cancer Ther 2004; 3:513-9.

Sorted by citations

Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies
Pabla, N., & Dong, Z. (2008) · Kidney International · doi:10.1038/sj.ki.5002786 · Cited by 1,940 · see citing works
“In addition, autophagic cell death occurs independent of caspases.(69,70) Whether cisplatin induces autophagy and whether autophagy is involved in cisplatin-induced cell death is an interesting area for future investigation.”
Background
Autophagy and autophagy-related proteins in cancer
Li, X., He, S., & Ma, B. (2020) · Molecular Cancer · doi:10.1186/s12943-020-1138-4 · Cited by 1,653 · see citing works
Potential therapeutic applications of autophagy
Rubinsztein, D. C., Gestwicki, J. E., Murphy, L. O., & Klionsky, D. J. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2272 · Cited by 1,004 · see citing works
The common biology of cancer and ageing
Finkel, T., Serrano, M., & Blasco, M. A. (2007) · Nature · doi:10.1038/nature05985 · Cited by 988 · see citing works
Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment
Azad, M. B., Chen, Y., & Gibson, S. B. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2270 · Cited by 761 · see citing works
“3), it is not surprising that many existing treatment strategies involve the manipulation of one or the other or both of these factors (3, 63) (Fig.”
The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease
Pan, T., Kondo, S., Le, W., & Jankovic, J. J. (2008) · Brain · doi:10.1093/brain/awm318 · Cited by 546 · see citing works
“Defects in this pathway have been linked to neurodegenerative diseases (Ravikumar et al., 2002, 2004), cancer (Kondo and Kondo, 2006) and cardiomyopathy (Nakai et al., 2007).”
BackgroundSelf-citation
Evidence That Curcumin Suppresses the Growth of Malignant Gliomas in Vitro and in Vivo through Induction of Autophagy: Role of Akt and Extracellular Signal-Regulated Kinase Signaling Pathways
Aoki, H., Takada, Y., Kondo, S., Sawaya, R. A., Aggarwal, B. B., & Kondo, Y. (2007) · Molecular Pharmacology · doi:10.1124/mol.106.033167 · Cited by 523 · see citing works
“In contrast, treatment with 5 nM paclitaxel, which is known to induce apoptosis in malignant glioma cells (Kondo and Kondo, 2006), increased the percentage of the sub-G1 population to 22.”
BackgroundMethodInfluentialSelf-citation
Complex interplay between autophagy and oxidative stress in the development of pulmonary disease
Ornatowski, W., Lü, Q., Yegambaram, M., Flores, A. G., Zemskov, E. A., Maltepe, E., Fineman, J. R., Wang, T., & Black, S. M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101679 · Cited by 474 · see citing works
“As2O3 can induce apoptotic and autophagic cell death in many types of cancer cells [356] while ROS formation is essential for As2O3 cytotoxicity [357].”
Background
ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth
Hart, L. S., Cunningham, J. T., Datta, T., Dey, S., Tameire, F., Lehman, S. L., Qiu, B., Zhang, H., Cerniglia, G. J., Bi, M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62973 · Cited by 436 · see citing works
“However, it has also been postulated that under certain physiological conditions and in response to specific treatments, autophagy leads to enhanced clonogenic cell death (17, 61).”
PM2.5-induced oxidative stress triggers autophagy in human lung epithelial A549 cells
Deng, X., Zhang, F., Rui, W., Long, F., Wang, L., Feng, Z., Chen, D., & Ding, W. (2013) · Toxicology in Vitro · doi:10.1016/j.tiv.2013.05.004 · Cited by 400 · see citing works
Autophagy and cancer therapy
Maycotte, P., & Thorburn, A. M. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.2.14627 · Cited by 394 · see citing works
The independence of and associations among apoptosis, autophagy, and necrosis
Chen, Q., Kang, J., & Fu, C. (2018) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-018-0018-5 · Cited by 348 · see citing works
Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model
Li, J., Hou, N., Faried, A., Tsutsumi, S., & Kuwano, H. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.02.021 · Cited by 318 · see citing works
Autophagy and Human Disease
Huang, J., & Klionsky, D. J. (2007) · Cell Cycle · doi:10.4161/cc.6.15.4511 · Cited by 316 · see citing works
Sphingolipids and Cancer: Ceramide and Sphingosine-1-Phosphate in the Regulation of Cell Death and Drug Resistance
Ponnusamy, S., Meyers‐Needham, M., Senkal, C. E., Saddoughi, S. A., Sentelle, D., Selvam, S. P., Salas, A., & Öğretmen, B. (2010) · Future Oncology · doi:10.2217/fon.10.116 · Cited by 313 · see citing works
“Reports indicate that autophagic cell death plays a critical role in the development of certain cancers [137].”
Autophagy as a therapeutic target in cancer
Chen, N., & Karantza, V. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.2.14622 · Cited by 303 · see citing works
Targeting autophagy to sensitive glioma to temozolomide treatment
Yan, Y., Xu, Z., Dai, S., Qian, L., Sun, L., & Gong, Z. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0303-5 · Cited by 298 · see citing works
“These treatment strategies include the induction of autophagy to enhance its antitumor effects and the inhibition of autophagy to induce apoptosis [17].”
Background
Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response
Hombach‐Klonisch, S., Mehrpour, M., Shojaei, S., Harlos, C. H., Pitz, M. W., Hamaï, A., Siemianowicz, K., Likus, W., Wiecheć, E., Toyota, B. D., et al. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.10.017 · Cited by 290 · see citing works
“Consequently, modulation of autophagy has been the aim of many studies (Gomes, Vessoni, &Menck, 2016; Kondo et al., 2005; Kondo & Kondo, 2006).”
Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation
Li, L., Chen, Y., & Gibson, S. B. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.09.020 · Cited by 292 · see citing works
Autophagy and cancer
Choi, K. S. (2012) · Experimental & Molecular Medicine · doi:10.3858/emm.2012.44.2.033 · Cited by 284 · see citing works
“Autophagy as a pro-death mechanism: autophagic cell death Under extreme stress, tumor cells with apoptosisdefective genetic backgrounds die via other mechanisms (Kondo and Kondo, 2006; Gozuacik and Kimchi, 2007).”
Background
Regulation of the aging process by autophagy.
Salminen, A., & Kaarniranta, K. (2009) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2009.03.004 · Cited by 270 · see citing works
Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis
Betin, V. M. S., & Lane, J. D. (2009) · Journal of Cell Science · doi:10.1242/jcs.046250 · Cited by 261 · see citing works
“…2005; Pattingre and Levine, 2006), and its capacity both to protect and to kill cells suggests that autophagy will prove to be an important therapeutic target for neurodegenerative diseases and cancer (Botti et al., 2006; Jin and White, 2007; Kondo and Kondo, 2006; Shintani and Klionsky, 2004).”
Background
Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization
Qadir, M. A., Kwok, B., Dragowska, W. H., To, K.-C., Le, D., Bally, M. B., & Gorski, S. M. (2008) · Breast Cancer Research and Treatment · doi:10.1007/s10549-007-9873-4 · Cited by 260 · see citing works
“In the cellular response to cancer therapy, several therapeutic and experimental anticancer treatment modalities, such as irradiation, tamoxifen, sulindac sulfide, arsenic trioxide, and temozolomide (TMZ), have been shown to induce autophagy in cancer cells [26–28].”
Background
Monitoring autophagic flux by an improved tandem fluorescent-tagged LC3 (mTagRFP-mWasabi-LC3) reveals that high-dose rapamycin impairs autophagic flux in cancer cells
Zhou, C., Zhong, W., Zhou, J., Sheng, F., Fang, Z., Wei, Y., Chen, Y., Deng, X., Xia, B., & Lin, J. (2012) · Autophagy · doi:10.4161/auto.20284 · Cited by 253 · see citing works
“Autophagy inhibition has been proposed as a promising approach to improve the efficacy of cancer treatment.(29) Autophagy inhibitor chloroquine (CQ) can obviously enhance cell death of different cancer cells by inhibiting autophagic flux.”
Background
NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas
Liu, T.-J., Koul, D., LaFortune, T. A., Tiao, N., Shen, R., Maira, S.-M., Garcia-Echevrria, C., & Yung, W. K. A. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0160 · Cited by 254 · see citing works
“In addition, studies have shown that anticancer drugs induce a type II programmed cell death, namely, autophagy (13, 14).”
Background
Autophagy Facilitates the Development of Breast Cancer Resistance to the Anti-HER2 Monoclonal Antibody Trastuzumab
Vázquez‐Martín, A., Oliveras‐Ferraros, C., & Menéndez, J. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006251 · Cited by 245 · see citing works
“Indeed, cancer cells may undergo autophagic cell death (APCD; also referred to as active cell death II [ACDII]) following extreme autophagic degradation associated with exposure to several cancer therapies [40].”
BackgroundInfluential
Mutant p53 in cancer therapy—the barrier or the path
Zhou, X. Y., Hao, Q., & Lu, H. (2018) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjy072 · Cited by 244 · see citing works
“It has been well documented that many anti-cancer drugs induce autophagic cell death, particularly, in the cancer cells refractory to apoptosis (Kondo and Kondo, 2006).”
Background
Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
Donadelli, M., Dando, I., Zaniboni, T., Costanzo, C., Pozza, E. D., Scupoli, M. T., Scarpa, A., Zappavigna, S., Marra, M., Abbruzzese, A., et al. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.36 · Cited by 228 · see citing works
“Besides its cytoprotective role in cellular homeostasis, for example in situations of nutrient starvation, autophagy can be a form of programmed cell death, designated ‘type II programmed cell death’.(20) In the present study, we have investigated the effect of the combination between GEM and three different CB ligand…”
Background
Curcumin: A naturally occurring autophagy modulator
Shakeri, A., Cicero, A. F. G., Panahi, Y., Mohajeri, M., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27404 · Cited by 228 · see citing works
“Several naturally occurring products have also been identified with antitumor effects related to the induction of autophagy in cancer cells, namely resveratrol, triterpenoid saponins from soybean, vitamin D analog EB1089, and so on (Kondo & Kondo, 2006).”
Background
Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells
Miki, H., Uehara, N., Kimura, A., Sasaki, T., Yuri, T., Yoshizawa, K., & Tsubura, A. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1325 · Cited by 225 · see citing works
“On the other hand, autophagy results in cell death termed autophagic cell death or type II cell death (15,16).”
Background
Autophagy: Regulation and role in disease
Meijer, A. J., & Codogno, P. (2009) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360903044068 · Cited by 199 · see citing works
“Such drugs include rapamycin, tamoxifen (via ceramide production), arsenic trioxide, resveratrol, and temozolamide.(366,376) In some cases, this stimulation of autophagy is an attempt by the cell to protect itself.”
Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells
Suh, Y., Afaq, F., Khan, N., Johnson, J. J., Khusro, F. H., & Mukhtar, H. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq115 · Cited by 191 · see citing works
Aggregable Nanoparticles-Enabled Chemotherapy and Autophagy Inhibition Combined with Anti-PD-L1 Antibody for Improved Glioma Treatment
Ruan, S., Xie, R., Qin, L., Yu, M., Xiao, W., Hu, C., Yu, W., Qian, Z., Ouyang, L., He, Q., et al. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b03968 · Cited by 189 · see citing works
Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells
Zou, Z., Yuan, Z., Zhang, Q., Long, Z., Chen, J., Tang, Z., Zhu, Y., Chen, S., Xu, J., Yan, M., et al. (2012) · Autophagy · doi:10.4161/auto.22110 · Cited by 182 · see citing works
“In contrast, autophagy also plays a key role in supporting cell survival against apoptosis.(18,19) These findings have shed light from different directions on the role of autophagy in cancer and on the potential of manipulating autophagy as a novel therapeutic strategy in cancer.”
BackgroundMethodInfluential
Itraconazole suppresses the growth of glioblastoma through induction of autophagy: Involvement of abnormal cholesterol trafficking
Liu, R., Li, J., Zhang, T., Zou, L., Chen, Y., Wang, K., Lei, Y., Yuan, K., Li, Y., Lan, J., et al. (2014) · Autophagy · doi:10.4161/auto.28912 · Cited by 178 · see citing works
The Epidermal Growth Factor Receptor Antibody Cetuximab Induces Autophagy in Cancer Cells by Downregulating HIF-1α and Bcl-2 and Activating the Beclin 1/hVps34 Complex
Li, X., & Fan, Z. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0157 · Cited by 179 · see citing works
“to both tumorigenesis and cancer cell response to treatments (13, 14).”
The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway
Pedro, J. M. B., Niso‐Santano, M., Gómez‐Sánchez, R., Pizarro‐Estrella, E., Aiastui, A., Gorostidi, A., Climent, V. E., de Maturana, R. L., Sánchez‐Pernaute, R., de Munaín, A. L., et al. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1061-y · Cited by 175 · see citing works
“Autophagy has been associated with cellular dysfunction in various diseases such as cancer [24],”
Background
New Insights into the Mechanisms for Photodynamic Therapy-Induced Cancer Cell Death
Yoo, J., & Ha, K. (2012) · International review of cytology · doi:10.1016/b978-0-12-394306-4.00010-1 · Cited by 174 · see citing works
“Autophagy also mediates the cytotoxicity of anticancer agents and is a potential novel target for anticancer therapy (Kim et al., 2008; Kondo and Kondo, 2006; Kondo et al., 2005; Moretti et al., 2007).”
Background
Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer
Kim, K. W., Hwang, M., Moretti, L., Jaboin, J. J., Cha, Y. I., & Lu, J. (2008) · Autophagy · doi:10.4161/auto.6058 · Cited by 168 · see citing works
Cell-bound exopolysaccharide from probiotic bacteria induces autophagic cell death of tumour cells
Kim, Y., Oh, S., Yun, H. S., Oh, S., & Kim, S. H. (2010) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2010.02859.x · Cited by 164 · see citing works
“Indeed, various anticancer therapies that induce autophagy have been recently introduced (Kondo and Kondo 2006).”
Background
Dual‐Targeting to Cancer Cells and M2 Macrophages via Biomimetic Delivery of Mannosylated Albumin Nanoparticles for Drug‐Resistant Cancer Therapy
Zhao, P., Yin, W., Wu, A., Tang, Y., Wang, J., Pan, Z., Lin, T., Zhang, M., Chen, B., Duan, Y., et al. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201700403 · Cited by 160 · see citing works
The association between Parkinson's disease and melanoma
Pan, T., Li, X., & Jankovic, J. J. (2011) · International Journal of Cancer · doi:10.1002/ijc.25912 · Cited by 155 · see citing works
Diet, Autophagy, and Cancer: A Review
Singletary, K. W., & Milner, J. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-2917 · Cited by 157 · see citing works
Autophagy—A double‐edged sword in oncology
Apel, A., Zentgraf, H., Büchler, M. W., & Herr, I. (2009) · International Journal of Cancer · doi:10.1002/ijc.24500 · Cited by 154 · see citing works
Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment
Li, L., Ishdorj, G., & Gibson, S. B. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.011 · Cited by 153 · see citing works
Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells.
Kanematsu, S., Uehara, N., Miki, H., Yoshizawa, K., Kawanaka, A., Yuri, T., & Tsubura, A. (2010) · PubMed · Cited by 147 · see citing works
Malignant Precursor Cells Pre-Exist in Human Breast DCIS and Require Autophagy for Survival
Espina, V. A., Mariani, B. D., Gallagher, R. I., Tran, K., Banks, S., Wiedemann, J., Huryk, H., Mueller, C., Adamo, L., Deng, J., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010240 · Cited by 144 · see citing works
“Cancer cells may undergo autophagic cell death associated with extreme autophagic degradation after exposure to several cancer therapies [15].”
Background
Autophagic Cell Death of Human Pancreatic Tumor Cells Mediated by Oleandrin, a Lipid-Soluble Cardiac Glycoside
Newman, R. A., Kondo, Y., Yokoyama, T., Dixon, S., Cartwright, C., Chan, D., Johansen, M. J., & Yang, P. (2007) · Integrative Cancer Therapies · doi:10.1177/1534735407309623 · Cited by 141 · see citing works
“These subsequently fuse with endosomes and eventually with lysosomes to complete destruction of damaged organelles.(14,23,24) Our understanding of which agents mediate cell death through autophagy, recently referred to as a tumor suppressor mechanism, is limited, although Kondo and Kondo(23) recently showed a diverse…”
BackgroundSelf-citation
Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells
JIANG, K., Wang, W., Jin, X., Wang, Z., Ji, Z., & Meng, G. (2015) · Oncology Reports · doi:10.3892/or.2015.3915 · Cited by 134 · see citing works
PM2.5 exposure-induced autophagy is mediated by lncRNA loc146880 which also promotes the migration and invasion of lung cancer cells
Deng, X., Feng, N., Zheng, M., et al. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.11.009 · Cited by 129 · see citing works
“response to microenvironment stress [7-9].”
Saponin Formosanin C-Induced Ferritinophagy and Ferroptosis in Human Hepatocellular Carcinoma Cells
Lin, P.-L., Tang, H. F., Wu, S., Shaw, N.-S., & Su, C. (2020) · Antioxidants · doi:10.3390/antiox9080682 · Cited by 129 · see citing works
“As LC3-II stays with autophagosomes until the formation of autolysosomes, it has been used as a marker of autophagy [27].”
Method
SGK1 inhibition induces autophagy-dependent apoptosis via the mTOR-Foxo3a pathway
Liu, W., Wang, X., Liu, Z., Wang, Y., Yin, B., Pan, Y., Duan, X., Liao, Z., Chen, Y., Liu, C., et al. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.293 · Cited by 121 · see citing works
“Therapies targeting autophagy combined with other therapeutic strategies have been studied extensively (Kondo and Kondo, 2006; Koukourakis et al, 2016).”
Background
Antiproliferative activity of fucoidan was associated with the induction of apoptosis and autophagy in AGS human gastric cancer cells
Park, H. S., Kim, G., Nam, T., Deuk Kim, N., & Hyun Choi, Y. (2011) · Journal of Food Science · doi:10.1111/j.1750-3841.2011.02099.x · Cited by 116 · see citing works
“This suggests that mitochondrial dysfunction may be a point of overlap between autophagocytic, as well as apoptotic, processes (Kondo and Kondo 2006; Galluzzi and others 2008; Livesey and others 2009).”
Background
Autophagic activity dictates the cellular response to oncogenic RAS
Wang, Y., Wang, X. D., Lapi, E., Sullivan, A., Jia, W., He, Y.-W., Ratnayaka, I., Zhong, S., Goldin, R. D., Goemans, C. G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120193109 · Cited by 117 · see citing works
“ASPP2( 3/ 3) + RAS Tu m or W ei gh t ( g) vector (1-1128)(1-360) (123-1128) 0 20 40 60 ASPP2( 3/ 3) + RAS”
Background
Carnosol Induces ROS-Mediated Beclin1-Independent Autophagy and Apoptosis in Triple Negative Breast Cancer
Dhaheri, Y. A., Attoub, S., Ramadan, G. A., Arafat, K., Bajbouj, K., Karuvantevida, N. S., AbuQamar, S. F., Eid, A. H., & Iratni, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109630 · Cited by 118 · see citing works
“Increasing number of anticancer therapies has been shown to induce autophagy in different cancer cell types [32].”
Background
Programmed cell death and cancer
Sun, Y., & Zl, P. (2009) · Postgraduate Medical Journal · doi:10.1136/pgmj.2008.072629 · Cited by 117 · see citing works
Mechanisms of Resistance to Histone Deacetylase Inhibitors and Their Therapeutic Implications
Fantin, V. R., & Richon, V. M. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-2114 · Cited by 115 · see citing works
Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells
Zhou, J., Hu, S.-E., Tan, S.-H., Cao, R., Chen, Y., Xia, D., Zhu, X., Yang, X., Ong, C. N., & Shen, H. (2012) · Autophagy · doi:10.4161/auto.18721 · Cited by 108 · see citing works
“More importantly, many of the cancer therapeutic agents are capable of inducing autophagy via various pathways.(16,17) Among various cancer therapeutic agents, cisplatin is one of the most important anticancer drugs used in the treatment of solid tumors, especially for ovarian, testicular, cervical and small cell lung…”
Background
Natural products for combating multidrug resistance in cancer
Chen, T., Xiao, Z., Liu, X., Wang, T., Wang, Y., Ye, F., Su, J., Yao, X., Xiong, L., & Yang, D. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107099 · Cited by 115 · see citing works
Dihydromyricetin improves skeletal muscle insulin sensitivity by inducing autophagy via the AMPK-PGC-1α-Sirt3 signaling pathway
Shi, L., Zhang, T., Zhou, Y. G., Zeng, X., Ran, L., Zhang, Q., Zhu, J., & Mi, M. (2015) · Endocrine · doi:10.1007/s12020-015-0599-5 · Cited by 105 · see citing works
The role of autophagy in maintaining intestinal mucosal barrier
Wu, Y., Tang, L., Wang, B., Sun, Q., Zhao, P., & Li, W. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28722 · Cited by 105 · see citing works
“The most studied macroautophagy (hereafter referred to as autophagy), is the major delivery route of unwanted contents to the lysosome for degradation (Kondo & Kondo, 2006).”
Background
Regulation and function of mitophagy in development and cancer
Lu, H., Li, G., Liu, L., Feng, L., Wang, X., & Jin, H. (2013) · Autophagy · doi:10.4161/auto.26550 · Cited by 105 · see citing works
“Accordingly, some agents have been developed to induce mitophagy in cancer cells for anticancer treatment.(168) For instance, the lis/lin/GO (glucose oxidase) killer-suicide system has been recognized as a robust mitophagy trigger to induce cell death and growth inhibition of human cancer cells both in vitro and in vi…”
Background
Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer
Ye, M.-X., Li, Y., Yin, H., & Zhang, J. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13033959 · Cited by 104 · see citing works
“On the other side, prolonged autophagy in cancer cells can also lead to autophagic PCD, provoking the possibility of utilizing autophagy activation for cancer therapy [72–75].”
Background
TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway
Zhang, P., Liu, X., Li, H., Chen, Z., Yao, X., Jin, J., & Ma, X. (2017) · Scientific Reports · doi:10.1038/s41598-017-03230-w · Cited by 100 · see citing works
Polyphyllin VI, a saponin from Trillium tschonoskii Maxim. induces apoptotic and autophagic cell death via the ROS triggered mTOR signaling pathway in non-small cell lung cancer
Teng, J., Qin, D., Mei, Q., Qiu, W., Pan, R., Xiong, R., Zhao, Y., Law, B. Y. K., Wong, V. K. W., Tang, Y., et al. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104396 · Cited by 97 · see citing works
PRKCB/protein kinase C, beta and the mitochondrial axis as key regulators of autophagy
Patergnani, S., Marchi, S., Rimessi, A., Bonora, M., Giorgi, C., Mehta, K. D., & Pinton, P. (2013) · Autophagy · doi:10.4161/auto.25239 · Cited by 94 · see citing works
Mechanisms of oxidative stress, apoptosis, and autophagy involved in graphene oxide nanomaterial anti-osteosarcoma effect
Tang, Z., Zhao, L., Yang, Z., Liu, Z., Gu, J. L., Bai, B., Liu, J., Xu, J., & Yang, H. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s159388 · Cited by 94 · see citing works
“Both systems mediate vesicle expansion and completion.(33) In conclusion, we found that different mechanisms including oxidative stress, apoptosis, and autophagy were involved in GO-induced anti-OSA effect.”
Autophagy protects LNCaP cells under androgen deprivation conditions
Li, M., Jiang, X., Liu, D., et al. (2008) · Autophagy · doi:10.4161/auto.5209 · Cited by 93 · see citing works
Ursolic acid enhances the antitumor effects of sorafenib associated with Mcl-1-related apoptosis and SLC7A11-dependent ferroptosis in human cancer
Li, H., Yu, Y., Liu, Y., Luo, Z., Law, B. Y. K., Zheng, Y., Huang, X., & Li, W. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106306 · Cited by 94 · see citing works
Novel monofunctional platinum (II) complex Mono-Pt induces apoptosis-independent autophagic cell death in human ovarian carcinoma cells, distinct from cisplatin
Guo, W., Zhang, Y., Zhang, L., Huang, B., Tao, F.-F., Chen, W., Guo, Z., Xu, Q., & Sun, Y. (2013) · Autophagy · doi:10.4161/auto.24407 · Cited by 91 · see citing works
“However, because of the resistance which is often developed to apoptosis, researchers have been seeking alternative form of programmed cell death and demonstrated that autophagy plays an important role in cancer therapy.(7,8,14,16) So far, several chemotherapeutic agents such as paclitaxel, arsenic trioxide and doxoru…”
Background
Hydroxychavicol, a betel leaf component, inhibits prostate cancer through ROS-driven DNA damage and apoptosis
Gundala, S. R., Yang, C., Mukkavilli, R., Paranjpe, R., Brahmbhatt, M., Pannu, V., Cheng, A. S., Reid, M. D., & Aneja, R. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.07.012 · Cited by 94 · see citing works
“Electron microscopy, the gold standard to identify autophagosomes in the cells (Kondo and Kondo, 2006), was employed to demonstrate the effects of HC on PC-3 cells.”
Background
Paradoxical action of reactive oxygen species in creation and therapy of cancer
Kardeh, S., Ashkani‐Esfahani, S., & Alizadeh, A. M. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.04.023 · Cited by 91 · see citing works
Polyploid tumour cells elicit paradiploid progeny through depolyploidizing divisions and regulated autophagic degradation
Erenpreisa, J. A., Salmiņa, K., Huna, A., Kosmacek, E. A., Cragg, M. S., Ianzini, F., & Anisimov, A. P. (2011) · Cell Biology International · doi:10.1042/cbi20100762 · Cited by 91 · see citing works
“cellular senescence (Kondo and Kondo, 2006; Vellai, 2009), it is”
Background
The novel estrogen-induced gene EIG121 regulates autophagy and promotes cell survival under stress
Deng, L., Feng, J., & Broaddus, R. R. (2010) · Cell Death and Disease · doi:10.1038/cddis.2010.9 · Cited by 87 · see citing works
“excessive autophagy contributes to the execution of cell death.(28,29) We speculate that because of the metabolic catastrophe induced by excessive autophagy, EIG121 is”
Background
Molecular interplay between mutant p53 proteins and autophagy in cancer cells
Cordani, M., Butera, G., Pacchiana, R., & Donadelli, M. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.11.003 · Cited by 89 · see citing works
Induction of Reactive Oxygen Species-mediated Autophagy by a Novel Microtubule-modulating Agent
Karna, P., Zughaier, S. M., Pannu, V., Simmons, R. B., Narayan, S., & Aneja, R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.091694 · Cited by 88 · see citing works
The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma cells
Cheng, P., Ni, Z., Dai, X., Wang, B., Ding, W., Smith, A. R., Xu, L., Wu, D., He, F., & Lian, J. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.17 · Cited by 87 · see citing works
“Supported by our current study, targeting autophagy may become a new therapeutic strategy for overcoming autophagy-mediated chemoresistance.(41) NAC is well tolerated by humans and mice,(42,43) and has been shown to block ROS generation in mouse tumors.”
Background
Role of autophagy and lysosomal drug sequestration in acquired resistance to doxorubicin in MCF-7 cells
Guo, B., Tam, A., Santi, S., & Parissenti, A. (2016) · BMC Cancer · doi:10.1186/s12885-016-2790-3 · Cited by 79 · see citing works
Antioxidant and antiproliferative activity ofHypericum hircinumL. subsp.majus(Aiton) N. Robson essential oil
Quassinti, L., Lupidi, G., Maggi, F., et al. (2012) · Natural Product Research · doi:10.1080/14786419.2012.677044 · Cited by 85 · see citing works
Tanshinone IIA Induces Autophagic Cell Death via Activation of AMPK and ERK and Inhibition of mTOR and p70 S6K in KBM‐5 Leukemia Cells
Yun, S., Jung, J. H., Jeong, S., Sohn, E. J., Kim, B., & Kim, S. (2013) · Phytotherapy Research · doi:10.1002/ptr.5015 · Cited by 84 · see citing works
“Also, mTOR, a key regulator of cell growth, is a negative inducer of autophagy (Kondo and Kondo, 2006).”
Background
Global Gene Expression Analysis of Cellular Death Mechanisms Induced by Mesoporous Silica Nanoparticle-Based Drug Delivery System
Li, X., He, Q., & Shi, J. (2014) · ACS Nano · doi:10.1021/nn4046985 · Cited by 83 · see citing works
Neferine induces autophagy of human ovarian cancer cells via p38 MAPK/ JNK activation
Xu, L., Zhang, X., Li, Y., et al. (2016) · Tumor Biology · doi:10.1007/s13277-015-4737-8 · Cited by 83 · see citing works
Thermoresponsive nanocomposite gel for local drug delivery to suppress the growth of glioma by inducing autophagy
Ding, L., Wang, Q., Shen, M., Sun, Y., Zhang, X., Huang, C., Chen, J., Li, R., & Duan, Y. (2017) · Autophagy · doi:10.1080/15548627.2017.1320634 · Cited by 85 · see citing works
“Studies have found that many antitumor drugs can induce autophagy in tumor cells.(12,13) Temozolomide (TMZ) directly”
Background
Autophagy: A challengeable paradox in cancer treatment
Ahmadi‐Dehlaghi, F., Mohammadi, P., Valipour, E., Pournaghi, P., Kiani, S., & Mansouri, K. (2023) · Cancer Medicine · doi:10.1002/cam4.5577 · Cited by 85 · see citing works
3-Methyladenine suppresses cell migration and invasion of HT1080 fibrosarcoma cells through inhibiting phosphoinositide 3-kinases independently of autophagy inhibition
Ito, S., Koshikawa, N., Mochizuki, S., & Takenaga, K. (2007) · International Journal of Oncology · doi:10.3892/ijo.31.2.261 · Cited by 78 · see citing works
Dual-drug codelivery nanosystems: An emerging approach for overcoming cancer multidrug resistance
Gong, J., Shi, T., Liu, J., Pei, Z., Liu, J., Ren, X., Li, F., & Qiu, F. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114505 · Cited by 82 · see citing works
N4-Phenyl-substituted 2-acetylpyridine thiosemicarbazones: Cytotoxicity against human tumor cells, structure–activity relationship studies and investigation on the mechanism of action
Soares, M. A., Lessa, J. A., Mendes, I. C., et al. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.04.027 · Cited by 76 · see citing works
Energy deprivation by silibinin in colorectal cancer cells
Raina, K., Agarwal, C., Wadhwa, R., Serkova, N. J., & Agarwal, R. (2013) · Autophagy · doi:10.4161/auto.23960 · Cited by 75 · see citing works
“Nevertheless, new evidence establishes the potential of macroautophagy (referred to as autophagy in the text) to lead to “type II programmed cell-death,” a degradative process that involves sequestration of cytoplasmic components in double-membrane vesicles (autophagic vesicles/autophagosomes) that fuse with lysosomes…”
BackgroundMethodInfluential
Autophagy regulation in cancer development and therapy.
White, E. J., Martı́n, V., Liu, J.-L., Klein, S. R., Piya, S., Gomez‐Manzano, C., Fueyo-Margareto, J., & Jiang, H. (2011) · Europe PMC (PubMed Central) · Cited by 75 · see citing works
Over-expression of the Beclin1 gene upregulates chemosensitivity to anti-cancer drugs by enhancing therapy-induced apoptosis in cervix squamous carcinoma CaSki cells
Sun, Y., Liu, J., Jin, L. G., Lin, S., Yang, Y., Sui, Y., & Shi, H. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.02.001 · Cited by 75 · see citing works
Drug-induced apoptosis in yeast
Almeida, B., Silva, A., Mesquita, A., Sampaio‐Marques, B., Rodrigues, F. J. S., & Ludovico, P. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.01.005 · Cited by 72 · see citing works
“Exposure to high concentrations of VPA induces cell death with morphological features similar to those of autophagic cell death (ACD), which is independent of Yca1p [57], while low VPA concentrations result in apoptotic cell death associated with DNA fragmentation, ROS accumulation, phosphatidylserine exposure and mor…”
BackgroundInfluential
Andrographolide Analogue Induces Apoptosis and Autophagy Mediated Cell Death in U937 Cells by Inhibition of PI3K/Akt/mTOR Pathway
Kumar, D., Das, B., Sen, R., Kundu, P., Manna, A., Sarkar, A., Chowdhury, C., Chatterjee, M., & Das, P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139657 · Cited by 68 · see citing works
Crosstalk Between ROS and Autophagy in Tumorigenesis: Understanding the Multifaceted Paradox
Hasan, A., Rizvi, S. F., Parveen, S., Pathak, N., Nazir, A., & Mir, S. S. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.852424 · Cited by 71 · see citing works
8‐C‐(E‐phenylethenyl)quercetin from onion/beef soup induces autophagic cell death in colon cancer cells through ERK activation
Zhao, Y., Fan, D., Zheng, Z., Li, E. T. S., Chen, F., Cheng, K., & Wang, M. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600437 · Cited by 71 · see citing works
The Delicate Equilibrium between Oxidants and Antioxidants in Brain Glioma
Ramı́rez-Expósito, M. J., & Martı́nez-Martos, J. M. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180302120925 · Cited by 70 · see citing works
Targeting Autophagy Sensitizes BRAF-Mutant Thyroid Cancer to Vemurafenib
Wang, W., Kang, H. H., Zhao, Y., Min, I. M., Wyrwas, B., Moore, M. D., Teng, L., Zarnegar, R., Jiang, X., & Fahey, T. J. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1999 · Cited by 71 · see citing works
“The MAPK pathway is 1 of the signaling pathways that regulates autophagy in mammalian cells (28).”
Background
Induction of autophagy by valproic acid enhanced lymphoma cell chemosensitivity through HDAC-independent and IP3-mediated PRKAA activation
Ji, M.-M., Wang, L., Zhan, Q., Xue, W., Zhao, Y., Zhao, X., Xu, P., Shen, Y., Liu, H., Janin, A., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1082024 · Cited by 67 · see citing works
“Dysregulation of autophagy plays a pivotal role in lymphoma cell resistance to chemotherapy,(15) suggesting that autophagy can be a potential therapeutic target.(16) Growing evidence has suggested that autophagy is modulated by PRKAA, a key energy Figure 4.”
Background
YAP Enhances Autophagic Flux to Promote Breast Cancer Cell Survival in Response to Nutrient Deprivation
Song, Q., Mao, B., Cheng, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120790 · Cited by 66 · see citing works
Super-resolution observation of lysosomal dynamics with fluorescent gold nanoparticles
Qiu, K., Du, Y., Liu, J., et al. (2020) · Theranostics · doi:10.7150/thno.42134 · Cited by 65 · see citing works
Autophagy-related MicroRNAs in chronic lung diseases and lung cancer
Rezaei, S., Mahjoubin‐Tehran, M., Aghaee‐Bakhtiari, S. H., Jalili, A., Movahedpour, A., Khan, H. Z., Moghoofei, M., Shojaei, Z., Hamblin, M. R., & Mirzaei, H. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.103063 · Cited by 63 · see citing works

Authors: Kondo, Y., & Kondo, S.
Affiliations: The University of Texas MD Anderson Cancer Center (US)
ORCID: Kondo, Seiji
Venue: Autophagy
Publisher: Informa UK Limited
Published: 2006-01-26
Volume: 2
Issue: 2
Pages: 85-90
ISSN: 1554-8627 (ISSN-L)
1554-8635
DOI: 10.4161/auto.2.2.2463
OpenAlex: W2041033535
Cited by: 305
References: 0
Citations by year: 2026: 1 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 17 · 2021: 13 · 2020: 22 · 2019: 10 · 2018: 13 · 2017: 19 · 2016: 22 · 2015: 14 · 2014: 21 · 2013: 22 · 2012: 33
FWCI: 1.76
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Autophagy (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (1r01ca108558-01)
U.S. Public Health Service
National Cancer Institute (CA 108558, R01CA088936, CA-088936)
Topics: Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: autophagic cell death, cancer therapy, apoptosis, non-apoptotic cell death, autophagy inhibition, Beclin-1, PTEN, p53, receptor tyrosine kinase, oncogenic signaling, tumor suppressor, nutrient deprivation, autophagy regulation
MeSH terms: Antineoplastic Agents, Autophagy, Neoplasms, Signal Transduction, Genes, Tumor Suppressor, Cell Death

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Autophagy and Cancer Therapy

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks