Autophagy-dependent cell death

Denton, Donna; Kumar, Sharad

doi:10.1038/s41418-018-0252-y

Cited by 777Autophagy in Disease and TherapyCell death mechanisms and regulationUbiquitin and proteasome pathways

Autophagy-dependent cell death

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Denton, Donna, Kumar, Sharad·2019·Cell Death & Differentiation

DOI 10.1038/s41418-018-0252-yPMC PMC6460387

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Abstract

Autophagy-dependent cell death can be defined as cell demise that has a strict requirement of autophagy. Although autophagy often accompanies cell death following many toxic insults, the requirement of autophagic machinery for cell death execution, as established through specific genetic or chemical inhibition of the process, is highly contextual. During animal development, perhaps the best validated model of autophagy-dependent cell death is the degradation of the larval midgut during larval-pupal metamorphosis, where a number of key autophagy genes are required for the removal of the tissues. Surprisingly though, even in the midgut, not all of the 'canonical' autophagic machinery appears to be required. In other organisms and cancer cells many variations of autophagy-dependent cell death are apparent, pointing to the lack of a unifying cell death pathway. It is thus possible that components of the autophagy machinery are selectively utilised or repurposed for this type of cell death. In this review, we discuss examples of cell death that utilise autophagy machinery (or part thereof), the current knowledge of the complexity of autophagy-dependent cellular demise and the potential mechanisms and regulatory pathways involved in such cell death.

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Autophagy is also a well-defined mechanism of cell death, autophagy-dependent cell death (ADCD).
“While autophagy is implicated in several paradigms of life extension and is generally considered an antiaging mechanism, autophagy is also a well-defined mechanism of cell death, autophagy-dependent cell death, ADCD [153,154,155].”
From The mitochondrial permeability transition: Nexus of aging, disease and longevity (2021) · cites this paper as [155]

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Authors: Denton, D., & Kumar, S.
Affiliations: South Australia Pathology (AU)
Corresponding author: Denton, Donna
Kumar, Sharad
ORCID: Denton, Donna
Kumar, Sharad
Venue: Cell Death & Differentiation
Publisher: Springer Science and Business Media LLC
Published: 2018-12-19
Volume: 26
Issue: 4
Pages: 605-616
ISSN: 1350-9047 (ISSN-L)
1476-5403
DOI: 10.1038/s41418-018-0252-y
PMC: PMC6460387
OpenAlex: W2905399276
Cited by: 777
References: 125
Citations by year: 2026: 65 · 2025: 88 · 2024: 157 · 2023: 134 · 2022: 122 · 2021: 110 · 2020: 69 · 2019: 32
FWCI: 7.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Cell Death and Differentiation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders: Department of Health | National Health and Medical Research Council (1124490, 1103006)
Topics: Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: autophagic cell death, autophagy, cell death pathways, larval-pupal metamorphosis, autophagy machinery, autophagy inhibition, cancer cell death, developmental cell death, cell death regulation
MeSH terms: Autophagic Cell Death, Animals, Autophagy, Drosophila, Humans, Metamorphosis, Biological, Signal Transduction, Apoptosis

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