Cited by 116Seaweed-derived Bioactive CompoundsCell death mechanisms and regulationEchinoderm biology and ecology

Antiproliferative activity of fucoidan was associated with the induction of apoptosis and autophagy in AGS human gastric cancer cells

Park, Hyun Soo, Kim, Gi‐Young, Nam, Taek‐Jeong, Deuk Kim, Nam, Hyun Choi, Yung·2011·Journal of Food Science

Abstract

Fucoidan, a sulfated polysaccharide purified from brown algae, possesses a variety of pharmacologic effects, including antiinflammatory, antioxidant, and anticancer properties; however, the underlying action mechanisms are not completely understood. This study investigated the possible mechanisms through which fucoidan exerts its antiproliferative action in cultured AGS human gastric adenocarcinoma cells. We found that fucoidan effectively inhibits the growth of AGS cells by inducing autophagy, as well as apoptosis. Apoptosis by fucoidan treatment was associated with the downregulation of antiapoptotic Bcl-2 and Bcl-xL expression, loss of mitochondrial membrane potential, activation of caspases, and concomitant degradation of poly-(ADP-ribose) polymerase protein. In addition, the morphological study indicated a characteristic finding of autophagy, such as the formation of autophagosomes in fucoidan-treated AGS cells. Furthermore, markers of autophagy, namely, the conversion of microtubule-associated protein light chain 3 (LC3)-I to LC3-II and increased beclin-1 accumulation, were observed. Overall, the present data suggest that fucoidan induces apoptotic and autophagic cell death, and both apoptotic and autophagic mechanisms contribute to the fucoidan-induced AGS cell death.

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Crossref · 10.1111/j.1750-3841.2011.02099.x

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  • Treatment of AGS human gastric adenocarcinoma cells with fucoidan from Fucus vesiculosus resulted in apoptosis and autophagy.

    “While using AGS human gastric adenocarcinoma cells and fucoidan from Fucus vesiculosus, it was established that treatment with fucoidan resulted not only in apoptosis of these cells, but also in autophagy with the formation of autophagosomes in fucoidan-treated cells, the conversion of microtubule-associated protein light chain 3 to light chain 3-II and the increase of beclin-1 level [35].”

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Authors
Park, H. S., Kim, G., Nam, T., Deuk Kim, N., & Hyun Choi, Y.
Affiliations
Dong-Eui University (KR)
Corresponding author
  • Park, Hyun Soo
  • Kim, Gi‐Young
  • Nam, Taek‐Jeong
Venue
Journal of Food Science
Publisher
Wiley
Published
2011-04
Volume
76
Issue
3
Pages
T77-83
ISSN
  • 0022-1147 (ISSN-L)
  • 1750-3841
OpenAlex
W2172230995
Cited by
116
References
36
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 11 · 2021: 13 · 2020: 15 · 2019: 9 · 2018: 9 · 2017: 8 · 2016: 8 · 2015: 9 · 2014: 8 · 2013: 7 · 2012: 3
FWCI
9.79
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Food Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Echinoderm biology and ecology
Keywords
fucoidan, sulfated polysaccharides, brown algae, gastric cancer, AGS cells, apoptosis, autophagy, antiproliferative activity, Bcl-2, Bcl-xL, mitochondrial membrane potential, caspase activation, PARP degradation, LC3, Beclin-1, autophagosomes, anticancer activity
MeSH terms
Beclin-1, Adenocarcinoma, Antineoplastic Agents, Autophagy, Cell Survival, Enzyme Activation, Humans, Membrane Proteins, Microtubule-Associated Proteins, Phagosomes, Poly(ADP-ribose) Polymerases, Polysaccharides, Stomach Neoplasms, Biomarkers, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Caspases, Cell Line, Tumor, Cell Proliferation, Apoptosis Regulatory Proteins, bcl-X Protein, Membrane Potential, Mitochondrial

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