A role for the membrane Golgi protein Ema in autophagy
Open accessAbstract
Autophagy is a cellular homeostatic response that involves degradation of self-components by the double-membraned autophagosome. The biogenesis of autophagosomes has been well described, but the ensuing processes after autophagosome formation are not clear. In our recent study, we proposed a model in which the Golgi complex contributes to the growth of autophagic structures, and that the Drosophila melanogaster membrane protein Ema promotes this process. In fat body cells of the D. melanogaster ema mutant, the recruitment of the Golgi complex protein Lava lamp (Lva) to autophagic structures is impaired and autophagic structures are very small. In addition, in the ema mutant autophagic turnover of SQSTM1/p62 and mitophagy are impaired. Our study not only identifies a role for Ema in autophagy, but also supports the hypothesis that the Golgi complex may be a potential membrane source for the biogenesis and development of autophagic structures.
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Studies in Drosophila with the homologue of Clec16a, ema, demonstrate the importance of the gene to the autophagy pathway and protein trafficking in the endosomal pathway.
“Studies in Drosophila with the homologue of Clec16a, ema, demonstrate the importance of the gene to the autophagy pathway and protein trafficking in the endosomal pathway89.”
From Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival (2016) · cites this paper as [8]
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Berge, T., Leikfoss, I., & Harbo, H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14034476 · Cited by 45 · see citing works
Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival
Redmann, V., Lamb, C. A., Hwang, S., Orchard, R. C., Kim, S., Razi, M., Milam, A., Park, S., Yokoyama, C. C., Kambal, A., et al. (2016) · Scientific Reports · doi:10.1038/srep23326 · Cited by 31 · see citing works
Self-citationSmits, D. J., Dekker, J., Schot, R., Tabarki, B. M., Alhashem, A. M., Demmers, J., Dekkers, D. H. W., Romito, A., van der Spek, P. J., van Ham, T. J., et al. (2022) · Human Genetics · doi:10.1007/s00439-022-02511-3 · Cited by 15 · see citing works
Tam, R. C.-Y., Lee, A. L.-H., Yang, W., Lau, C. S., & Chan, V. S. F. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160714428 · Cited by 10 · see citing works
- Authors
- Kim, S., & DiAntonio, A.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- DiAntonio, Aaron
- ORCID
- DiAntonio, Aaron
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2012-08-31
- Volume
- 8
- Issue
- 8
- Pages
- 1269-1270
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- OpenAlex
- W1969017105
- Semantic Scholar
- 44ba278b5c80ff9122ee0156a01f2e715fc9dcdd
- Cited by
- 5
- References
- 0
- Citations by year
- 2022: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2013: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Autophagy (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- EMA, Golgi apparatus, autophagosome formation, p62, mitophagy, fat body, Drosophila melanogaster
- MeSH terms
- Animals, Autophagy, Drosophila melanogaster, Fat Body, Golgi Apparatus, Membrane Proteins, Monosaccharide Transport Proteins, Phagosomes, Endosomes, Drosophila Proteins, Lectins, C-Type
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