From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A

An integrated encyclopedia of DNA elements in the human genome

The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072 · see citing works

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351 · see citing works

Haploview: analysis and visualization of LD and haplotype maps

Barrett, J., Fry, B., Maller, J., & Daly, M. (2005) · Bioinform. · doi:10.1093/bioinformatics/bth457 · Cited by 15,086 · see citing works

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

Maurano, M. T., Humbert, R., Rynes, E., Thurman, R. E., Haugen, E., Wang, H., Reynolds, A. P., Sandstrom, R., Qu, H., Brody, J., et al. (2012) · Science · doi:10.1126/science.1222794 · Cited by 3,716 · see citing works

Multiple Sequence Alignment Using ClustalW and ClustalX

Thompson, J., Gibson, T. J., & Higgins, D. G. (2002) · Current Protocols in Bioinformatics · doi:10.1002/0471250953.bi0203s00 · Cited by 2,989 · see citing works

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

The International Multiple Sclerosis Genetics Consortium & The Wellcome Trust Case Control Consortium 2 (2011) · Nature · doi:10.1038/nature10251 · Cited by 2,697 · see citing works

National Center for Biotechnology Information

Gressner, A. M., & Arndt, T. (2019) · Springer Reference Medizin · doi:10.1007/978-3-662-48986-4_301184 · Cited by 2,610 · see citing works

Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study

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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

Finland, G. O. T. 1. D. I., Todd, J. A., the Wellcome Trust Case Control Consortium, Walker, N. M., Cooper, J. D., Smyth, D. J., Downes, K., Plagnol, V., Bailey, R., Nejentsev, S., et al. (2007) · Nature Genetics · doi:10.1038/ng2068 · Cited by 1,456 · see citing works

The C‐type lectin‐like domain superfamily

Zelensky, A. N., & Gready, J. E. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.05031.x · Cited by 1,411 · see citing works

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Wellcome Trust Case Control Consortium, & The Australo-Anglo-American Spondylitis Consortium (TASC) (2007) · Nature Genetics · doi:10.1038/ng.2007.17 · Cited by 1,374 · see citing works

Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS

Nicolae, D. L., Gamazon, E., Zhang, W., Duan, S., Dolan, M. E., & Cox, N. J. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000888 · Cited by 1,292 · see citing works

CDD: specific functional annotation with the Conserved Domain Database

Marchler‐Bauer, A., Anderson, J. B., Chitsaz, F., Derbyshire, M. K., DeWeese-Scott, C., Fong, J. H., Geer, L. Y., Geer, R. C., Gonzales, N. R., Gwadz, M., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn845 · Cited by 1,067 · see citing works

Splicing in disease: disruption of the splicing code and the decoding machinery

Wang, G., & Cooper, T. A. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2164 · Cited by 1,040 · see citing works

Mapping complex disease traits with global gene expression

Cookson, W., Liang, L., Abecasis, G., Moffatt, M., & Lathrop, M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2537 · Cited by 849 · see citing works

Prediction of the Coding Sequences of Unidentified Human Genes. IX. The Complete Sequences of 100 New cDNA Clones from Brain Which Can Code for Large Proteins in vitro

Nagase, T. (1998) · DNA Research · doi:10.1093/dnares/5.1.31 · Cited by 845 · see citing works

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

International MS Genetics Consortium, De Jager, P. L., Jia, X., Wang, J., de Bakker, P. I. W., Ottoboni, L., Aggarwal, N. T., Piccio, L., Raychaudhuri, S., Tran, D., et al. (2009) · Nature Genetics · doi:10.1038/ng.401 · Cited by 800 · see citing works

Phospho.ELM: a database of phosphorylation sites--update 2011

Dinkel, H., Chica, C., Via, A., Gould, C., Jensen, L. J., Gibson, T. J., & Diella, F. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq1104 · Cited by 736 · see citing works

Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis

Simpson, S., Blizzard, L., Otahal, P., Van der Mei, I., & Taylor, B. (2011) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2011.240432 · Cited by 718 · see citing works

Linking disease associations with regulatory information in the human genomePreprint

Schaub, M. A., Boyle, A. P., Kundaje, A. B., Batzoglou, S., & Snyder, M. P. (2012) · Genome Research · doi:10.1101/gr.136127.111 · Cited by 715 · see citing works

Temporal trends in the incidence of multiple sclerosis

Alonso, Á., & Hernán, M. Á. (2008) · Neurology · doi:10.1212/01.wnl.0000316802.35974.34 · Cited by 695 · see citing works

Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis

for the Multiple Sclerosis Genetics Group, Gregory, S. G., Schmidt, S., Seth, P., Oksenberg, J. R., Hart, J., Prokop, A., Caillier, S. J., Ban, M., Goris, A., et al. (2007) · Nature Genetics · doi:10.1038/ng2103 · Cited by 657 · see citing works

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

Syndicate, B. I. R. A. G. A. G. S., Eyre, S., Wellcome Trust Case Control Consortium, Bowes, J., Diogo, D., Lee, A., Barton, A., Martin, P., Zhernakova, A., Stahl, E., et al. (2012) · Nature Genetics · doi:10.1038/ng.2462 · Cited by 653 · see citing works

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

The Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene) (2009) · Nature Genetics · doi:10.1038/ng.396 · Cited by 550 · see citing works

A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene

Hakonarson, H., Grant, S. F. A., Bradfield, J. P., Marchand, L., Kim, C. E., Glessner, J. T., Grabs, R., Casalunovo, T., Taback, S. P., Frackelton, E. C., et al. (2007) · Nature · doi:10.1038/nature06010 · Cited by 542 · see citing works

Variation in interleukin 7 receptor α chain (IL7R) influences risk of multiple sclerosis

Lundmark, F., Duvefelt, K., Iacobaeus, E., Kockum, I., Wallström, E., Khademi, M., Oturai, A., Ryder, L. P., Saarela, J., Harbo, H. F., et al. (2007) · Nature Genetics · doi:10.1038/ng2106 · Cited by 483 · see citing works

Promise and pitfalls of the Immunochip

Cortes, A., & Brown, M. A. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3204 · Cited by 479 · see citing works

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

Baranzini, S. E., Wang, J., Gibson, R. A., Galwey, N., Naegelin, Y., Barkhof, F., Radue, E.-W., Lindberg, R. L. P., Uitdehaag, B. M. G., Johnson, M. R., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddn388 · Cited by 476 · see citing works

Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis

The UK PBC Consortium, Mells, G. F., The Wellcome Trust Case Control Consortium 3, Floyd, J. A. B., Morley, K. I., Cordell, H. J., Franklin, C. S., Shin, S.-Y., Heneghan, M. A., Neuberger, J. M., et al. (2011) · Nature Genetics · doi:10.1038/ng.789 · Cited by 464 · see citing works

Candidate Causal Regulatory Effects by Integration of Expression QTLs with Complex Trait Genetic Associations

Nica, A. C., Montgomery, S. B., Dimas, A. S., Stranger, B. E., Beazley, C., Barroso, I., & Dermitzakis, E. T. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000895 · Cited by 423 · see citing works

Genome‐wide meta‐analysis identifies novel multiple sclerosis susceptibility loci

Patsopoulos, N. A., the Bayer Pharma MS Genetics Working Group, T. S. C. O. S. E. I. A. A. C., & de Bakker, P. I. W. (2011) · Annals of Neurology · doi:10.1002/ana.22609 · Cited by 353 · see citing works

Mice Lacking the MHC Class II Transactivator (CIITA) Show Tissue-Specific Impairment of MHC Class II Expression

Chang, C., Guerder, S., Hong, S., van Ewijk, W., & Flavell, R. A. (1996) · Immunity · doi:10.1016/s1074-7613(00)80681-0 · Cited by 350 · see citing works

MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction

Swanberg, M., Lidman, O., Padyukov, L., Eriksson, P. O., Åkesson, E., Jagodic, M., Lobell, A., Khademi, M., Börjesson, O., Lindgren, C. M., et al. (2005) · Nature Genetics · doi:10.1038/ng1544 · Cited by 339 · see citing works

HL-A ANTIGENS AND MULTIPLE SCLEROSIS

Jersild, C., Svejgaard, A., & Fog, T. (1972) · The Lancet · doi:10.1016/s0140-6736(72)90962-2 · Cited by 324 · see citing works

I-type Lectins

Powell, L. D., & Varki, A. P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.24.14243 · Cited by 312 · see citing works

Astrocytes in multiple sclerosis: A product of their environment

Nair, A., Frederick, T., & Miller, S. D. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8059-5 · Cited by 312 · see citing works

Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity

Fenner, J. E., Starr, R., Cornish, A. L., Zhang, J., Metcalf, D., Schreiber, R. D., Sheehan, K. C. F., Hilton, D. J., Alexander, W. S., & Hertzog, P. J. (2005) · Nature Immunology · doi:10.1038/ni1287 · Cited by 296 · see citing works

Multiple sclerosis: a modifying influence of HLA class I genes in an HLA class II associated autoimmune disease

Fogdell‐Hahn, A., Ligers, A., Grønning, M., Hillert, J. A., & Olerup, O. (2000) · Tissue Antigens · doi:10.1034/j.1399-0039.2000.550205.x · Cited by 295 · see citing works

The genetics of multiple sclerosis: an up‐to‐date review

Gourraud, P., Harbo, H. F., Hauser, S. L., & Baranzini, S. E. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01134.x · Cited by 278 · see citing works

APCs Express DCIR, a Novel C-Type Lectin Surface Receptor Containing an Immunoreceptor Tyrosine-Based Inhibitory Motif

Bates, E. E. M., Fournier, N., Garcia, E., Valladeau‐Guilemond, J., Durand, I., Pin, J., Zurawski, S., Patel, S., Abrams, J. S., Lebecque, S., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.1973 · Cited by 269 · see citing works

Class II transactivator regulates the expression of multiple genes involved in antigen presentation.

Chang, C., & Flavell, R. A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.2.765 · Cited by 267 · see citing works

SOCS, Inflammation, and Autoimmunity

Yoshimura, A., Suzuki, M., Sakaguchi, R., Hanada, T., & Yasukawa, H. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00020 · Cited by 254 · see citing works

Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling

Shin, D., Yuk, J., Lee, H., Lee, S., Son, J. W., Harding, C. V., Kim, J., Modlin, R. L., & Jo, E. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01497.x · Cited by 248 · see citing works

Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene

Jakkula, E., Leppä, V., Sulonen, A.-M., Varilo, T., Kallio, S., Kemppinen, A., Purcell, S., Koivisto, K., Tienari, P., Sumelahti, M.-L., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.01.017 · Cited by 245 · see citing works

C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses

Kingeter, L. M., & Lin, X. (2012) · Cellular and Molecular Immunology · doi:10.1038/cmi.2011.58 · Cited by 240 · see citing works

Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population

Zhou, S., Lu, X., Lv, J., Yang, H.-Z., qin, L. X., Zhao, M., Su, Y., Li, Z., & Zhang, H. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.140111 · Cited by 240 · see citing works

When cell biology meets development: endocytic regulation of signaling pathwaysPreprint

Seto, E., Bellen, H. J., & Lloyd, T. E. (2002) · Genes & Development · doi:10.1101/gad.989602 · Cited by 224 · see citing works

Dcir deficiency causes development of autoimmune diseases in mice due to excess expansion of dendritic cells

Fujikado, N., Saijo, S., Yonezawa, T., Shimamori, K., Ishii, A., Sugai, S., Kotaki, H., Sudo, K., Nose, M., & Iwakura, Y. (2008) · Nature Medicine · doi:10.1038/nm1697 · Cited by 209 · see citing works

Environmental Risk Factors for Multiple Sclerosis: A Review with a Focus on Molecular Mechanisms

O’Gorman, C., Lucas, R. M., & Taylor, B. V. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms130911718 · Cited by 209 · see citing works

HLA-A Confers an HLA-DRB1 Independent Influence on the Risk of Multiple Sclerosis

Brynedal, B., Duvefelt, K., Jonasdottir, G., Roos, I. M., Åkesson, E., Palmgren, J., & Hillert, J. A. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000664 · Cited by 202 · see citing works

Prediction of the Coding Sequences of Unidentified Human Genes. VII. The Complete Sequences of 100 New cDNA Clones from Brain Which Can Code for Large Proteins in vitro

Nagase, T. (1997) · DNA Research · doi:10.1093/dnares/4.2.141 · Cited by 200 · see citing works

The role of the CD58 locus in multiple sclerosis

Jager, P. L. D., Baecher‐Allan, C., Maier, L. M., Arthur, A. T., Ottoboni, L., Barcellos, L. F., McCauley, J. L., Sawcer, S. J., Goris, A., Saarela, J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813310106 · Cited by 198 · see citing works

Divergent roles for C-type lectins expressed by cells of the innate immune system

McGreal, E. P., Martínez‐Pomares, L., & Gordon, S. (2004) · Molecular Immunology · doi:10.1016/j.molimm.2004.06.013 · Cited by 197 · see citing works

Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis

Sanna, S., Pitzalis, M., Zoledziewska, M., Zara, I., Sidore, C., Murru, R., Whalen, M. B., Busonero, F., Maschio, A., Costa, G., et al. (2010) · Nature Genetics · doi:10.1038/ng.584 · Cited by 187 · see citing works

The expanding genetic overlap between multiple sclerosis and type I diabetes

Booth, D. R., Heard, R. N., Stewart, G. J., Goris, A., Dobosi, R., Dubois, B., Lorentzen, Å. R., Celius, E. G., Harbo, H. F., Spurkland, A., et al. (2008) · Genes and Immunity · doi:10.1038/gene.2008.83 · Cited by 168 · see citing works

Genetic variation in the autophagy gene ULK1 and risk of Crohnʼs disease

Henckaerts, L., Cleynen, I., Brinar, M., John, J. M., Steen, K. V., Rutgeerts, P. J., & Vermeire, S. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21486 · Cited by 156 · see citing works

Role of autophagy in immunity and autoimmunity, with a special focus on systemic lupus erythematosus

Pierdominici, M., Vomero, M., Barbati, C., Colasanti, T., Maselli, A., Vacirca, D., Giovannetti, A., Malorni, W., & Ortona, E. (2012) · The FASEB Journal · doi:10.1096/fj.11-194175 · Cited by 155 · see citing works

Seven newly identified loci for autoimmune thyroid disease

Cooper, J. D., Simmonds, M. J., Walker, N. M., Burren, O. S., Brand, O. J., Guo, H., Wallace, C., Stevens, H. E., Coleman, G., Franklyn, J. A., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds357 · Cited by 149 · see citing works

Genetic Analysis of Adult-Onset Autoimmune Diabetes

Howson, J. M. M., Rosinger, S., Smyth, D. J., Boehm, B. O., the ADBW-END Study Group, & Todd, J. A. (2011) · Diabetes · doi:10.2337/db11-0364 · Cited by 143 · see citing works

Follow-Up Study of the First Genome-Wide Association Scan in Alopecia Areata: IL13 and KIAA0350 as Susceptibility Loci Supported with Genome-Wide Significance

Jagielska, D., Redler, S., Brockschmidt, F. F., Herold, C., Pasternack, S. M., Bartels, N. G., Hanneken, S., Eigelshoven, S., Refke, M., Barth, S., et al. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2012.129 · Cited by 138 · see citing works

Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians

Rubio, J. P., Stankovich, J. M., Field, J., Tubridy, N. J., Marriott, M. P., Chapman, C., Bahlo, M., Perera, D., Johnson, L., Tait, B. D., et al. (2008) · Genes and Immunity · doi:10.1038/gene.2008.59 · Cited by 132 · see citing works

Systematic review of disease-modifying therapies to assess unmet needs in multiple sclerosis: tolerability and adherence

Giovannoni, G., Southam, E., & Waubant, E. L. (2012) · Multiple Sclerosis Journal · doi:10.1177/1352458511433302 · Cited by 128 · see citing works

Multiple sclerosis susceptibility alleles in African Americans

Johnson, B. A., Wang, J., Taylor, E. M., Caillier, S. J., Herbert, J., Khan, O. A., Cross, A. H., Jager, P. L. D., Gourraud, P., Cree, B., et al. (2009) · Genes and Immunity · doi:10.1038/gene.2009.81 · Cited by 126 · see citing works

The Centrosome Regulates the Rab11- Dependent Recycling Endosome Pathway at Appendages of the Mother Centriole

Hehnly, H., Chen, C.-T., Powers, C. M., Liu, H.-L., & Doxsey, S. (2012) · Current Biology · doi:10.1016/j.cub.2012.08.022 · Cited by 124 · see citing works

Polymorphisms inCLEC16AandCIITAat 16p13 Are Associated with Primary Adrenal Insufficiency

Skinningsrud, B., Husebye, E. S., Pearce, S. H. S., McDonald, D., Brandal, K., Wolff, A. S. B., Løvås, K., Egeland, T., & Undlien, D. E. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0821 · Cited by 119 · see citing works

HLA‐DRB101 subtyping by allele‐specific PCR amplification: A sensitive, specific and rapid technique

Olerup, O., & Zetterquist, H. (1991) · Tissue Antigens · doi:10.1111/j.1399-0039.1991.tb01872.x · Cited by 119 · see citing works

Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene

Davison, L. J., Wallace, C., Cooper, J. D., Cope, N. F., Wilson, N. K., Smyth, D. J., Howson, J. M. M., Saleh, N. M., Aljeffery, A., Angus, K. L., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr468 · Cited by 107 · see citing works

Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci

The International Multiple Sclerosis Genetics Consortium (IMSGC), McCauley, J. L., Zuvich, R. L., Beecham, A. H., De Jager, P. L., Konidari, I., Whitehead, P. L., Aubin, C., Ban, M., Pobywajlo, S., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddp542 · Cited by 106 · see citing works

Identification of a Novel Risk Locus for Multiple Sclerosis at 13q31.3 by a Pooled Genome-Wide Scan of 500,000 Single Nucleotide Polymorphisms

Comabella, M., Craig, D. W., Camiña-Tato, M., Morcillo, C., Lopez, C., Navarro, A., Rio, J., BiomarkerMS Study Group, Montalban, X., & Martin, R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003490 · Cited by 105 · see citing works

MS prevalence in New Zealand, an ethnically and latitudinally diverse country

Taylor, B. V., Pearson, J. F., Clarke, G., Mason, D. F., Abernethy, D. A., Willoughby, E., & Sabel, C. E. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458510379614 · Cited by 103 · see citing works

Association of primary biliary cirrhosis with variants in the CLEC16A, SOCS1, SPIB and SIAE immunomodulatory genes

Hirschfield, G. M., Xie, G., Lu, E., Sun, Y., Juran, B. D., Chellappa, V, Coltescu, C., Mason, A. L., Milkiewicz, P., Myers, R. P., et al. (2012) · Genes & Immunity · doi:10.1038/gene.2011.89 · Cited by 85 · see citing works

Variation within the CLEC16A gene shows consistent disease association with both multiple sclerosis and type 1 diabetes in Sardinia

Żołędziewska, M., Costa, G., Pitzalis, M., Cocco, E. E., Melis, C., Moi, L., Zavattari, P., Murru, R., Lampis, R., Morelli, L., et al. (2008) · Genes and Immunity · doi:10.1038/gene.2008.84 · Cited by 85 · see citing works

The novel endosomal membrane protein Ema interacts with the class C Vps–HOPS complex to promote endosomal maturation

Kim, S., Wairkar, Y. P., Daniels, R. W., & DiAntonio, A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200911126 · Cited by 82 · see citing works

Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis

Nischwitz, S., Cepok, S., Kroner, A., Wolf, C., Knop, M., Müller-Sarnowski, F., Pfister, H., Roeske, D., Rieckmann, P., Hemmer, B., et al. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.06.003 · Cited by 79 · see citing works

Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis

Hoppenbrouwers, I. A., Aulchenko, Y. S., Janssens, A. C. J. W., Ramagopalan, S. V., Broer, L., Kayser, M., Ebers, G. C., Oostra, B. A., van Duijn, C. M., & Hintzen, R. Q. (2009) · Journal of Human Genetics · doi:10.1038/jhg.2009.96 · Cited by 78 · see citing works

The CD40-Autophagy Pathway Is Needed for Host Protection Despite IFN-Γ-Dependent Immunity and CD40 Induces Autophagy via Control of P21 Levels

Portillo, J., Okenka, G., Reed, E., Subauste, A. R., Grol, J. V., Gentil, K., Komatsu, M., Tanaka, K., Landreth, G., Levine, B., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014472 · Cited by 75 · see citing works

R-type Lectins

Rd, C., & Schnaar, L. R. (2009) · Europe PMC (PubMed Central) · Cited by 73 · see citing works

Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene

Westlake, C. J., Junutula, J. R., Simon, G. C., Pilli, M., Prekeris, R., Scheller, R. H., Jackson, P. K., & Eldridge, A. G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610500104 · Cited by 68 · see citing works

Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility

Zuvich, R. L., McCauley, J. L., Oksenberg, J. R., Sawcer, S. J., Jager, P. L. D., Aubin, C., Cross, A. H., Piccio, L. M., Aggarwal, N. T., Evans, D. A., et al. (2010) · Human Genetics · doi:10.1007/s00439-010-0789-4 · Cited by 62 · see citing works

A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-cyclic citrullinated peptide antibody negative rheumatoid arthritis

Skinningsrud, B., Lie, B. A., Husebye, E. S., Kvien, T. K., Førre, Ø. T., Flatø, B., Stormyr, A., Joner, G., Njølstad, P. R., Egeland, T., et al. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.114934 · Cited by 62 · see citing works

Risk alleles for multiple sclerosis in multiplex families

D’Netto, M. J., Ward, H., Morrison, K., Ramagopalan, S. V., Dyment, D. A., DeLuca, G. C., Handunnetthi, L., Sadovnick, A. D., & Ebers, G. C. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a92c25 · Cited by 61 · see citing works

Chromosomal region 16p13: further evidence of increased predisposition to immune diseases

Martínez, A., Perdigones, N., Cénit, M. C., Espino‐Paisán, L., Varadé, J., Lamas, J. R., Santiago, J. L., Fernández‐Arquero, M., de la Calle, H., Arroyo, R., et al. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.098376 · Cited by 61 · see citing works

A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis

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Oligoclonal Band Status in Scandinavian Multiple Sclerosis Patients Is Associated with Specific Genetic Risk Alleles

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Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival

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Effect of Vitamin D on Experimental Autoimmune Neuroinflammation Is Dependent on Haplotypes Comprising Naturally Occurring Allelic Variants of CIITA (Mhc2ta)

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JAK/STAT inhibitor therapy partially rescues the lipodystrophic autoimmune phenotype in Clec16a KO mice

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Identification of 67 Pleiotropic Genes Associated With Seven Autoimmune/Autoinflammatory Diseases Using Multivariate Statistical Analysis

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Inducible knockout of Clec16a in mice results in sensory neurodegeneration

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Systemic Lupus Erythematosus Patients Exhibit Reduced Expression of CLEC16A Isoforms in Peripheral Leukocytes

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www.mdpi.com/journal/ijms From Identification to Characterization of the Multiple

Susceptibility, S., Cleca, G., Berge, T., Leikfoss, I. S., & Harbo, H. F. (2013)

More CLEC16A gene variants associated with multiple sclerosis

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Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus

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Exploring genetic variation in multiple sclerosis

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