Polyamine depletion inhibits the autophagic response modulatingTrypanosoma cruziinfectivity
Open accessAbstract
Autophagy is a cell process that in normal conditions serves to recycle cytoplasmic components and aged or damaged organelles. The autophagic pathway has been implicated in many physiological and pathological situations, even during the course of infection by intracellular pathogens. Many compounds are currently used to positively or negatively modulate the autophagic response. Recently it was demonstrated that the polyamine spermidine is a physiological inducer of autophagy in eukaryotic cells. We have previously shown that the etiological agent of Chagas disease, the protozoan parasite Trypanosoma cruzi, interacts with autophagic compartments during host cell invasion and that preactivation of autophagy significantly increases host cell colonization by this parasite. In the present report we have analyzed the effect of polyamine depletion on the autophagic response of the host cell and on T. cruzi infectivity. Our data showed that depleting intracellular polyamines by inhibiting the biosynthetic enzyme ornithine decarboxylase with difluoromethylornithine (DFMO) suppressed the induction of autophagy in response to starvation or rapamycin treatment in two cell lines. This effect was associated with a decrease in the levels of LC3 and ATG5, two proteins required for autophagosome formation. As a consequence of inhibiting host cell autophagy, DFMO impaired T. cruzi colonization, indicating that polyamines and autophagy facilitate parasite infection. Thus, our results point to DFMO as a novel autophagy inhibitor. While other autophagy inhibitors such as wortmannin and 3-methyladenine are nonspecific and potentially toxic, DFMO is an FDA-approved drug that may have value in limiting autophagy and the spread of the infection in Chagas disease and possibly other pathological settings.
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Inhibition of ornithine decarboxylase reduces cellular polyamine levels and suppresses autophagy in eukaryotic cells, thereby attenuating infection by Trypanosoma cruzi.
“Recent studies show that the inhibition of ornithine decarboxylase, which utilizes arginase-derived ornithine to generate putrescine, reduces cellular polyamine levels and suppresses autophagy in eukaryotic cells, thereby attenuating infection by Trypanosoma cruzi38.”
From Histone deacetylase 10 structure and molecular function as a polyamine deacetylase (2017) · cites this paper as [38]
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- Authors
- Vanrell, M. C., Cueto, J. A., Barclay, J. J., Carrillo, C., Colombo, M. I., Gottlieb, R. A., & Romano, P. S.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- San Diego State University (US)
- Corresponding author
- Romano, Patricia S.
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2013-07-11
- Volume
- 9
- Issue
- 7
- Pages
- 1080-1093
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- PMC
- PMC3722317
- OpenAlex
- W2076398088
- Cited by
- 39
- References
- 49
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 1 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 2 · 2014: 1
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Autophagy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Ministerio de Salud de la Nación
- Universidad Nacional de Cuyo
- Fundación Bunge y Born
- Agencia Nacional de Promoción Científica y Tecnológica
- Topics
- Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Keywords
- Trypanosoma cruzi, Chagas disease, polyamine depletion, spermidine, ornithine decarboxylase, difluoromethylornithine, host-parasite interactions, parasite colonization, LC3, ATG5, autophagy inhibitors, rapamycin, starvation
- MeSH terms
- Autophagy-Related Protein 5, Eflornithine, Animals, Autophagy, Cricetulus, Embryo, Mammalian, Epithelial Cells, Fibroblasts, Cricetinae, Microtubule-Associated Proteins, Phagosomes, Polyamines, Spermidine, Time Factors, Trypanosoma cruzi, CHO Cells, Mice, Knockout, Myocytes, Cardiac, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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