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In search of an “autophagomometer”
Abstract
Recent years have seen the realization that macroautophagy (which we will call autophagy) is not only important in yeast but is necessary for diverse functions in plants and animals. Importantly, autophagy can have an impact on human pathologies including infectious diseases, cancers, and neurodegenerative conditions. Thus, we need to be able to measure autophagy accurately in order to understand how it can be regulated physiologically and with exogenous agents.
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The LAMP2 knockdown approach to block autophagosome-lysosome fusion is only valid when the knockdown is directed against the mRNA region specific for the LAMP2B spliced variant, as targeting the region common to the three variants would also inhibit chaperone-mediated autophagy, which may result in compensatory upregulation of autophagy.
“This approach, however, is only valid when the knockdown of LAMP2 is directed against the mRNA region specific for the LAMP2B spliced variant, as targeting the region common to the three variants would also inhibit chaperone-mediated autophagy (CMA), which may result in the compensatory upregulation of autophagy [135,309,310].”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [309]
Interference with the CMA pathway activates a compensatory form of autophagy that increases the overall degradation of long-lived proteins.
“Conversely, interference with the CMA pathway does seem to activate a compensatory form of autophagy that increases the overall degradation of long-lived proteins [135,309].”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [309]
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Metadata
- Authors
- Rubinsztein, D. C., Cuervo, A. M., Ravikumar, B., Sarkar, S., Korolchuk, V. I., Kaushik, S., & Klionsky, D. J.
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2009-07
- Volume
- 5
- Issue
- 5
- Pages
- 585-589
- ISSN
- 1554-8627
- 1554-8635
- Cited by
- 496
- References
- 0
- Language
- en
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